HK81088A - 1-(cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives - Google Patents

1-(cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Info

Publication number
HK81088A
HK81088A HK810/88A HK81088A HK81088A HK 81088 A HK81088 A HK 81088A HK 810/88 A HK810/88 A HK 810/88A HK 81088 A HK81088 A HK 81088A HK 81088 A HK81088 A HK 81088A
Authority
HK
Hong Kong
Prior art keywords
parts
reaction
formula
phenyl
fluorophenyl
Prior art date
Application number
HK810/88A
Other languages
German (de)
English (en)
French (fr)
Inventor
Raymond Stokbroekx
Marcel Luychx
Joannes A. Willems
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HK81088A publication Critical patent/HK81088A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK810/88A 1980-01-24 1988-10-06 1-(cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives HK81088A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
HK81088A true HK81088A (en) 1988-10-14

Family

ID=26812674

Family Applications (1)

Application Number Title Priority Date Filing Date
HK810/88A HK81088A (en) 1980-01-24 1988-10-06 1-(cyclohexyl or cyclohexenyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Country Status (25)

Country Link
US (1) US4369184A (cs)
EP (1) EP0034415B1 (cs)
AU (1) AU538130B2 (cs)
BG (2) BG35465A3 (cs)
CA (1) CA1187080A (cs)
CS (1) CS221818B2 (cs)
DE (1) DE3163787D1 (cs)
DK (1) DK152670C (cs)
ES (2) ES498793A0 (cs)
FI (1) FI76562C (cs)
GR (1) GR71898B (cs)
HK (1) HK81088A (cs)
HU (1) HU183293B (cs)
IE (1) IE50706B1 (cs)
IL (1) IL61968A (cs)
LU (1) LU88220I2 (cs)
MA (1) MA19046A1 (cs)
MY (1) MY8700593A (cs)
NL (1) NL930017I2 (cs)
NO (1) NO1994012I1 (cs)
NZ (1) NZ196117A (cs)
PH (1) PH16611A (cs)
PL (2) PL127679B1 (cs)
SU (1) SU1230467A3 (cs)
YU (1) YU48446B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
SE9400447D0 (sv) * 1994-02-11 1994-02-11 Astra Ab New compounds
AU1716995A (en) * 1994-03-18 1995-10-09 Ciba-Geigy Ag Aqueous solution of levocabastine for ophthalmic use
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
EP0954326B2 (en) 1996-04-19 2009-07-22 Grifols Inc. A process for viral inactivation of lyophilized blood proteins
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
WO2004019955A1 (en) * 2002-08-30 2004-03-11 Altana Pharma Ag The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
KR101294014B1 (ko) * 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
JP5175278B2 (ja) 2006-06-01 2013-04-03 エムエスディー コンシューマー ケア， インコーポレイテッド 結腸吸収のためのフェニレフリン薬学的製剤および組成物
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
AU2008343045A1 (en) * 2007-12-21 2009-07-09 Msd Consumer Care, Inc. Enhancing photostabilization of oxymetazoline
JP6083818B2 (ja) 2011-11-18 2017-02-22 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ ムスカリンｍ１受容体アゴニスト
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (cs) * 1965-06-29

Also Published As

Publication number Publication date
DK152670C (da) 1988-08-22
ES8204421A1 (es) 1982-05-01
AU6625581A (en) 1981-07-30
IL61968A0 (en) 1981-02-27
DK152670B (da) 1988-04-11
HU183293B (en) 1984-04-28
US4369184A (en) 1983-01-18
BG35465A3 (en) 1984-04-15
CA1187080A (en) 1985-05-14
EP0034415B1 (en) 1984-05-30
DK29381A (da) 1981-07-25
MA19046A1 (fr) 1981-10-01
GR71898B (cs) 1983-08-11
AU538130B2 (en) 1984-08-02
YU18381A (en) 1983-10-31
ES508441A0 (es) 1983-07-01
IL61968A (en) 1984-09-30
NL930017I2 (nl) 1993-07-16
PL229365A1 (cs) 1982-03-29
PH16611A (en) 1983-11-24
FI76562B (fi) 1988-07-29
PL127483B1 (en) 1983-10-31
FI76562C (fi) 1988-11-10
DE3163787D1 (en) 1984-07-05
YU48446B (sh) 1998-07-10
ES498793A0 (es) 1982-05-01
IE50706B1 (en) 1986-06-25
MY8700593A (en) 1987-12-31
ES8307219A1 (es) 1983-07-01
LU88220I2 (cs) 1994-02-03
FI810193L (fi) 1981-07-25
CS221818B2 (en) 1983-04-29
NO1994012I1 (no) 1994-08-30
NL930017I1 (nl) 1993-05-03
PL233921A1 (cs) 1982-06-21
PL127679B1 (en) 1983-11-30
EP0034415A1 (en) 1981-08-26
SU1230467A3 (ru) 1986-05-07
IE810125L (en) 1981-07-24
BG60472B2 (bg) 1995-04-28
NZ196117A (en) 1984-05-31

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Legal Events

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PE Patent expired