HK65397A - Heterocylic amines having central nervous system activity - Google Patents

Heterocylic amines having central nervous system activity

Info

Publication number
HK65397A
HK65397A HK65397A HK65397A HK65397A HK 65397 A HK65397 A HK 65397A HK 65397 A HK65397 A HK 65397A HK 65397 A HK65397 A HK 65397A HK 65397 A HK65397 A HK 65397A
Authority
HK
Hong Kong
Prior art keywords
nervous system
central nervous
system activity
compounds
alkyl
Prior art date
Application number
HK65397A
Other languages
English (en)
Inventor
Malcolm W Moon
Richard F Heier
Jeanette K Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK65397A publication Critical patent/HK65397A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK65397A 1989-06-09 1997-05-15 Heterocylic amines having central nervous system activity HK65397A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36437489A 1989-06-09 1989-06-09
PCT/US1990/002621 WO1990015058A1 (fr) 1989-06-09 1990-05-15 Amines heterocycliques agissant sur le systeme nerveux central

Publications (1)

Publication Number Publication Date
HK65397A true HK65397A (en) 1997-05-23

Family

ID=23434241

Family Applications (1)

Application Number Title Priority Date Filing Date
HK65397A HK65397A (en) 1989-06-09 1997-05-15 Heterocylic amines having central nervous system activity

Country Status (15)

Country Link
EP (1) EP0480939B1 (fr)
JP (1) JP2955358B2 (fr)
KR (1) KR0167346B1 (fr)
AT (1) ATE117688T1 (fr)
AU (1) AU626427B2 (fr)
CA (1) CA2051697C (fr)
DE (1) DE69016430T2 (fr)
DK (1) DK0480939T3 (fr)
ES (1) ES2067744T3 (fr)
FI (2) FI96310C (fr)
HK (1) HK65397A (fr)
HU (2) HU210264B (fr)
NO (1) NO301421B1 (fr)
RU (1) RU2023712C1 (fr)
WO (1) WO1990015058A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な３環性キノキサリンジオン誘導体
TW260660B (fr) * 1993-04-22 1995-10-21 Sumitomo Pharma
DE4314593A1 (de) * 1993-04-28 1994-11-03 Schering Ag Pyrido(1,2,3-de)chinoxalinderivate, Verfahren zu deren Herstellung und ihre Verwendung von Arzneimitteln
USRE40278E1 (en) * 1993-07-27 2008-04-29 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity
FR2719843B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique.
EP0705834A1 (fr) * 1994-07-27 1996-04-10 Ciba-Geigy Ag Quinoxaline-2,3-diones à anneau fusionné azahétérocyclique
EP0705835A1 (fr) * 1994-09-01 1996-04-10 Ciba-Geigy Ag Quinoxaline-2,3-diones à anneau fusionné oxa- ou thiahétérocyclique
JPH11514969A (ja) 1995-08-10 1999-12-21 バイエル・アクチエンゲゼルシヤフト ハロベンゾイミダゾール類および殺微生物剤としてのそれらの使用
FR2760237B1 (fr) * 1997-02-28 1999-04-16 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
US6288075B1 (en) 1998-02-26 2001-09-11 Rhone-Poulenc Rorer S.A. Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same
US6197339B1 (en) * 1997-09-30 2001-03-06 Pharmacia & Upjohn Company Sustained release tablet formulation to treat Parkinson's disease
US6455564B1 (en) * 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
PL349912A1 (en) * 1999-02-05 2002-10-07 Upjohn Co Process to prepare (5r)-(methylamino)-5,6-dihydro-4h-imidazo[4,5,1-ij]-quinolin-2(1h)-one
US7074927B2 (en) 1999-05-13 2006-07-11 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity
DE19954707A1 (de) * 1999-11-13 2001-05-17 Merck Patent Gmbh Imidazolverbindungen als Phosphodiesterase VII-Hemmer
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
WO2001081343A2 (fr) 2000-04-21 2001-11-01 Pharmacia & Upjohn Company Composes permettant de traiter la fibromyalgie et le syndrome de fatigue chronique
AR033520A1 (es) * 2000-04-27 2003-12-26 Upjohn Co (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona
AU8339301A (en) 2000-08-16 2002-02-25 Upjohn Co Compounds for the treatment of addictive disorders
AR031200A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
AR031199A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
AR031202A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TWI312781B (en) * 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
US20070196481A1 (en) * 2002-07-25 2007-08-23 Amidon Gregory E Sustained-release tablet composition
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
US20050079217A1 (en) * 2002-07-25 2005-04-14 Ganorkar Loksidh D. Sustained-release tablet composition comprising a dopamine receptor agonist
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
AU2003267769A1 (en) * 2002-10-25 2004-05-13 Pharmacia & Upjohn Company Llc Use of heterocyclic amine-type compounds as neuroprotective agents
CN100471856C (zh) * 2003-07-31 2009-03-25 Irm责任有限公司 作为pdf抑制剂的二环化合物和组合物
WO2005051488A1 (fr) * 2003-11-26 2005-06-09 Pfizer Products Inc. Association d'agonistes de la dopamine et d'inhibiteurs de recaptage de la monoamine
NZ553645A (en) 2004-08-13 2010-09-30 Boehringer Ingelheim Int Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
CN101005830B (zh) 2004-08-13 2010-09-29 贝林格尔·英格海姆国际有限公司 包含普拉克索或其可药用盐的延长释放片剂、其制备方法及用途
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
TW200635926A (en) * 2004-11-05 2006-10-16 Wyeth Corp Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof
CN101193892A (zh) 2005-06-14 2008-06-04 先灵公司 大环杂环天冬氨酰基蛋白酶抑制剂
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
PE20150777A1 (es) 2012-09-14 2015-06-20 AbbVie Deutschland GmbH and Co KG Derivados triciclicos de quinolinas y de quinoxalinas
US20140080813A1 (en) 2012-09-14 2014-03-20 AbbVie Deutschland GmbH & Co. KG Tricyclic quinoline and quinoxaline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010741A1 (fr) * 1988-05-09 1989-11-16 The Upjohn Company 2,3-dihydro-1h-phenalen-2-amines anxiolytiques/anti-depresseurs

Also Published As

Publication number Publication date
RU2023712C1 (ru) 1994-11-30
FI915715A0 (fi) 1991-12-04
DK0480939T3 (da) 1995-07-10
ES2067744T3 (es) 1995-04-01
EP0480939A1 (fr) 1992-04-22
FI944704A (fi) 1994-10-07
HU211702A9 (en) 1995-12-28
JPH04506071A (ja) 1992-10-22
KR0167346B1 (ko) 1999-01-15
HUT60269A (en) 1992-08-28
DE69016430D1 (de) 1995-03-09
ATE117688T1 (de) 1995-02-15
EP0480939B1 (fr) 1995-01-25
NO914827D0 (no) 1991-12-06
FI96310C (fi) 1996-06-10
FI96687C (fi) 1996-08-12
CA2051697C (fr) 1996-10-08
AU5743890A (en) 1991-01-07
DE69016430T2 (de) 1995-06-01
CA2051697A1 (fr) 1990-12-10
AU626427B2 (en) 1992-07-30
FI96687B (fi) 1996-04-30
HU905216D0 (en) 1992-02-28
WO1990015058A1 (fr) 1990-12-13
NO301421B1 (no) 1997-10-27
FI944704A0 (fi) 1994-10-07
JP2955358B2 (ja) 1999-10-04
FI96310B (fi) 1996-02-29
NO914827L (no) 1992-02-07
HU210264B (en) 1995-03-28
KR920701204A (ko) 1992-08-11

Similar Documents

Publication Publication Date Title
HK65397A (en) Heterocylic amines having central nervous system activity
FI102175B (fi) Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten v almistamiseksi
BG104187A (en) 4-phenyl-pyridine derivatives
DE3681517D1 (de) Thiazolidinderivate, verfahren zu deren herstellung und deren anwendung.
DE68906309D1 (de) Methode zur behandlung von kachexie und bestimmte dafuer anzuwendende verbindungen.
EP0428313A3 (en) Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders
PT85008A (en) Process for the preparation of 2-thiazolil-imidazo ]1,2-c" pyrimidines of their salts of acid addition and of pharmaceutical composicoes containing them
YU46706B (sh) Postupak za dobijanje amidnih jedinjenja
KR900012893A (ko) 치환된-아세트 아미드 화합물 및 그 제조방법
KR910004559A (ko) 중추 신경계에 작용하는 무스카린성 약제인 4-(n-치환 아미노)-2-부티닐-1-우레아 및 티오우레아와 그의 유도체
UA41928C2 (uk) Похідні оксазолідину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання, спосіб лікування захворювань
KR920701122A (ko) 신규 이환식 아미노-치환 화합물
HUT49879A (en) Process for producing new 1',2'-dihydrospiro square brackets open imidazolidine-4,4'(3'h)-quinoline square brackets closed derivatives and pharmaceutical compositions comprising these compounds as active ingredient
WO1999024421A8 (fr) Imidazoylalkyle substitue par un noyau heterocyclique a cinq, six ou sept chainons contenant un atome d'azote
ZA922625B (en) Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
DE69906728D1 (de) Verwendung von 4-piperidinmethanolderivaten zur behandlung von neuralentwicklungsstörungen
ZA869500B (en) 1-phenyl-3-benzazepines
KR840007726A (ko) 미토마이신 유사체의 제조방법
DE60005525D1 (de) 2-aminotetraline zur behandlung von glaukom
KR910700236A (ko) 치환된 3-아자비사이클로[3,1,1]헵탄, 이의 제조방법 및 이의 용도
ATE186912T1 (de) Carbamoylpyrrolidon-derivate zur behandlung von depressionen und cerebrovasculären störungen
FI831068A0 (fi) Foerfarande foer framstaellning av enantiomerer av substituerade fenylazacykloalkaner med farmaceutaktivitet
EP0420464A3 (en) 3-isoxazolone derivatives, their preparation and their therapeutic uses
PT85429A (en) Process for the preparation of pharmaceutical compositions

Legal Events

Date Code Title Description
PF Patent in force