CA2051697A1 - Amines heterocycliques ayant une activite sur le systeme nerveux central - Google Patents
Amines heterocycliques ayant une activite sur le systeme nerveux centralInfo
- Publication number
- CA2051697A1 CA2051697A1 CA2051697A CA2051697A CA2051697A1 CA 2051697 A1 CA2051697 A1 CA 2051697A1 CA 2051697 A CA2051697 A CA 2051697A CA 2051697 A CA2051697 A CA 2051697A CA 2051697 A1 CA2051697 A1 CA 2051697A1
- Authority
- CA
- Canada
- Prior art keywords
- nervous system
- central nervous
- system activity
- carboalkoxyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Heterocyclic amines Chemical class 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36437489A | 1989-06-09 | 1989-06-09 | |
| US364,374 | 1989-06-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2051697A1 true CA2051697A1 (fr) | 1990-12-10 |
| CA2051697C CA2051697C (fr) | 1996-10-08 |
Family
ID=23434241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002051697A Expired - Fee Related CA2051697C (fr) | 1989-06-09 | 1990-05-15 | Amines heterocycliques ayant une activite sur le systeme nerveux central |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0480939B1 (fr) |
| JP (1) | JP2955358B2 (fr) |
| KR (1) | KR0167346B1 (fr) |
| AT (1) | ATE117688T1 (fr) |
| AU (1) | AU626427B2 (fr) |
| CA (1) | CA2051697C (fr) |
| DE (1) | DE69016430T2 (fr) |
| DK (1) | DK0480939T3 (fr) |
| ES (1) | ES2067744T3 (fr) |
| FI (2) | FI96310C (fr) |
| HK (1) | HK65397A (fr) |
| HU (2) | HU210264B (fr) |
| NO (1) | NO301421B1 (fr) |
| RU (1) | RU2023712C1 (fr) |
| WO (1) | WO1990015058A1 (fr) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な３環性キノキサリンジオン誘導体 |
| TW260660B (fr) * | 1993-04-22 | 1995-10-21 | Sumitomo Pharma | |
| DE4314593A1 (de) * | 1993-04-28 | 1994-11-03 | Schering Ag | Pyrido(1,2,3-de)chinoxalinderivate, Verfahren zu deren Herstellung und ihre Verwendung von Arzneimitteln |
| USRE40278E1 (en) * | 1993-07-27 | 2008-04-29 | Pharmacia & Upjohn Company | Heterocyclic amines having central nervous system activity |
| FR2719843B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique. |
| EP0705834A1 (fr) * | 1994-07-27 | 1996-04-10 | Ciba-Geigy Ag | Quinoxaline-2,3-diones à anneau fusionné azahétérocyclique |
| EP0705835A1 (fr) * | 1994-09-01 | 1996-04-10 | Ciba-Geigy Ag | Quinoxaline-2,3-diones à anneau fusionné oxa- ou thiahétérocyclique |
| JPH11514969A (ja) | 1995-08-10 | 1999-12-21 | バイエル・アクチエンゲゼルシヤフト | ハロベンゾイミダゾール類および殺微生物剤としてのそれらの使用 |
| FR2760237B1 (fr) * | 1997-02-28 | 1999-04-16 | Rhone Poulenc Rorer Sa | Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant |
| US6288075B1 (en) | 1998-02-26 | 2001-09-11 | Rhone-Poulenc Rorer S.A. | Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same |
| US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
| US6455564B1 (en) * | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
| PL349912A1 (en) * | 1999-02-05 | 2002-10-07 | Upjohn Co | Process to prepare (5r)-(methylamino)-5,6-dihydro-4h-imidazo[4,5,1-ij]-quinolin-2(1h)-one |
| US7074927B2 (en) | 1999-05-13 | 2006-07-11 | Pharmacia & Upjohn Company | Heterocyclic amines having central nervous system activity |
| DE19954707A1 (de) * | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| GB0008939D0 (en) * | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| WO2001081343A2 (fr) | 2000-04-21 | 2001-11-01 | Pharmacia & Upjohn Company | Composes permettant de traiter la fibromyalgie et le syndrome de fatigue chronique |
| AR033520A1 (es) * | 2000-04-27 | 2003-12-26 | Upjohn Co | (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona |
| AU8339301A (en) | 2000-08-16 | 2002-02-25 | Upjohn Co | Compounds for the treatment of addictive disorders |
| AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
| AR031199A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
| AR031202A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
| TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
| TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| US20070196481A1 (en) * | 2002-07-25 | 2007-08-23 | Amidon Gregory E | Sustained-release tablet composition |
| US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
| US20050079217A1 (en) * | 2002-07-25 | 2005-04-14 | Ganorkar Loksidh D. | Sustained-release tablet composition comprising a dopamine receptor agonist |
| FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
| AU2003267769A1 (en) * | 2002-10-25 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Use of heterocyclic amine-type compounds as neuroprotective agents |
| CN100471856C (zh) * | 2003-07-31 | 2009-03-25 | Irm责任有限公司 | 作为pdf抑制剂的二环化合物和组合物 |
| WO2005051488A1 (fr) * | 2003-11-26 | 2005-06-09 | Pfizer Products Inc. | Association d'agonistes de la dopamine et d'inhibiteurs de recaptage de la monoamine |
| NZ553645A (en) | 2004-08-13 | 2010-09-30 | Boehringer Ingelheim Int | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
| CN101005830B (zh) | 2004-08-13 | 2010-09-29 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放片剂、其制备方法及用途 |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| TW200635926A (en) * | 2004-11-05 | 2006-10-16 | Wyeth Corp | Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
| CN101193892A (zh) | 2005-06-14 | 2008-06-04 | 先灵公司 | 大环杂环天冬氨酰基蛋白酶抑制剂 |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| PE20150777A1 (es) | 2012-09-14 | 2015-06-20 | AbbVie Deutschland GmbH and Co KG | Derivados triciclicos de quinolinas y de quinoxalinas |
| US20140080813A1 (en) | 2012-09-14 | 2014-03-20 | AbbVie Deutschland GmbH & Co. KG | Tricyclic quinoline and quinoxaline derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989010741A1 (fr) * | 1988-05-09 | 1989-11-16 | The Upjohn Company | 2,3-dihydro-1h-phenalen-2-amines anxiolytiques/anti-depresseurs |
-
1990
- 1990-05-15 ES ES90908816T patent/ES2067744T3/es not_active Expired - Lifetime
- 1990-05-15 HU HU905216A patent/HU210264B/hu not_active IP Right Cessation
- 1990-05-15 WO PCT/US1990/002621 patent/WO1990015058A1/fr active IP Right Grant
- 1990-05-15 AT AT90908816T patent/ATE117688T1/de not_active IP Right Cessation
- 1990-05-15 DE DE69016430T patent/DE69016430T2/de not_active Expired - Fee Related
- 1990-05-15 EP EP90908816A patent/EP0480939B1/fr not_active Expired - Lifetime
- 1990-05-15 AU AU57438/90A patent/AU626427B2/en not_active Ceased
- 1990-05-15 JP JP2508489A patent/JP2955358B2/ja not_active Expired - Fee Related
- 1990-05-15 DK DK90908816.3T patent/DK0480939T3/da active
- 1990-05-15 KR KR1019910701790A patent/KR0167346B1/ko not_active IP Right Cessation
- 1990-05-15 CA CA002051697A patent/CA2051697C/fr not_active Expired - Fee Related
-
1991
- 1991-12-04 FI FI915715A patent/FI96310C/fi active
- 1991-12-06 RU SU915010471A patent/RU2023712C1/ru not_active IP Right Cessation
- 1991-12-06 NO NO914827A patent/NO301421B1/no unknown
-
1994
- 1994-10-07 FI FI944704A patent/FI96687C/fi active
-
1995
- 1995-06-30 HU HU95P/P00660P patent/HU211702A9/hu unknown
-
1997
- 1997-05-15 HK HK65397A patent/HK65397A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2023712C1 (ru) | 1994-11-30 |
| FI915715A0 (fi) | 1991-12-04 |
| DK0480939T3 (da) | 1995-07-10 |
| ES2067744T3 (es) | 1995-04-01 |
| EP0480939A1 (fr) | 1992-04-22 |
| FI944704A (fi) | 1994-10-07 |
| HU211702A9 (en) | 1995-12-28 |
| JPH04506071A (ja) | 1992-10-22 |
| KR0167346B1 (ko) | 1999-01-15 |
| HUT60269A (en) | 1992-08-28 |
| DE69016430D1 (de) | 1995-03-09 |
| ATE117688T1 (de) | 1995-02-15 |
| EP0480939B1 (fr) | 1995-01-25 |
| NO914827D0 (no) | 1991-12-06 |
| HK65397A (en) | 1997-05-23 |
| FI96310C (fi) | 1996-06-10 |
| FI96687C (fi) | 1996-08-12 |
| CA2051697C (fr) | 1996-10-08 |
| AU5743890A (en) | 1991-01-07 |
| DE69016430T2 (de) | 1995-06-01 |
| AU626427B2 (en) | 1992-07-30 |
| FI96687B (fi) | 1996-04-30 |
| HU905216D0 (en) | 1992-02-28 |
| WO1990015058A1 (fr) | 1990-12-13 |
| NO301421B1 (no) | 1997-10-27 |
| FI944704A0 (fi) | 1994-10-07 |
| JP2955358B2 (ja) | 1999-10-04 |
| FI96310B (fi) | 1996-02-29 |
| NO914827L (no) | 1992-02-07 |
| HU210264B (en) | 1995-03-28 |
| KR920701204A (ko) | 1992-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |