FI944704A0 - Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliiniamiinien valmistamiseksi - Google Patents

Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliiniamiinien valmistamiseksi

Info

Publication number
FI944704A0
FI944704A0 FI944704A FI944704A FI944704A0 FI 944704 A0 FI944704 A0 FI 944704A0 FI 944704 A FI944704 A FI 944704A FI 944704 A FI944704 A FI 944704A FI 944704 A0 FI944704 A0 FI 944704A0
Authority
FI
Finland
Prior art keywords
quinolinamines
preparation
pharmacologically active
compounds
alkyl
Prior art date
Application number
FI944704A
Other languages
English (en)
Swedish (sv)
Other versions
FI944704A (fi
FI96687C (fi
FI96687B (fi
Inventor
Malcolm W Moon
Richard F Heier
Jeannette K Morris
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI944704A publication Critical patent/FI944704A/fi
Publication of FI944704A0 publication Critical patent/FI944704A0/fi
Application granted granted Critical
Publication of FI96687B publication Critical patent/FI96687B/fi
Publication of FI96687C publication Critical patent/FI96687C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI944704A 1989-06-09 1994-10-07 Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliiniamiinien valmistamiseksi FI96687C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36437489A 1989-06-09 1989-06-09
US36437489 1989-06-09
US9002621 1990-05-15
PCT/US1990/002621 WO1990015058A1 (en) 1989-06-09 1990-05-15 Heterocyclic amines having central nervous system activity

Publications (4)

Publication Number Publication Date
FI944704A FI944704A (fi) 1994-10-07
FI944704A0 true FI944704A0 (fi) 1994-10-07
FI96687B FI96687B (fi) 1996-04-30
FI96687C FI96687C (fi) 1996-08-12

Family

ID=23434241

Family Applications (2)

Application Number Title Priority Date Filing Date
FI915715A FI96310C (fi) 1989-06-09 1991-12-04 Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliini-amiinien valmistamiseksi
FI944704A FI96687C (fi) 1989-06-09 1994-10-07 Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliiniamiinien valmistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI915715A FI96310C (fi) 1989-06-09 1991-12-04 Menetelmä farmakologisesti aktiivisten trisyklisesti kondensoituneiden kinoliini-amiinien valmistamiseksi

Country Status (15)

Country Link
EP (1) EP0480939B1 (fi)
JP (1) JP2955358B2 (fi)
KR (1) KR0167346B1 (fi)
AT (1) ATE117688T1 (fi)
AU (1) AU626427B2 (fi)
CA (1) CA2051697C (fi)
DE (1) DE69016430T2 (fi)
DK (1) DK0480939T3 (fi)
ES (1) ES2067744T3 (fi)
FI (2) FI96310C (fi)
HK (1) HK65397A (fi)
HU (2) HU210264B (fi)
NO (1) NO301421B1 (fi)
RU (1) RU2023712C1 (fi)
WO (1) WO1990015058A1 (fi)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05117276A (ja) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd 新規な３環性キノキサリンジオン誘導体
TW260660B (fi) * 1993-04-22 1995-10-21 Sumitomo Pharma
DE4314593A1 (de) * 1993-04-28 1994-11-03 Schering Ag Pyrido(1,2,3-de)chinoxalinderivate, Verfahren zu deren Herstellung und ihre Verwendung von Arzneimitteln
DK0724584T3 (da) * 1993-07-27 1998-05-25 Upjohn Co Heterocycliske aminer med CNS-virkning
FR2719843B1 (fr) * 1994-05-10 1996-06-07 Synthelabo Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique.
EP0705834A1 (de) * 1994-07-27 1996-04-10 Ciba-Geigy Ag Azaaliphatisch Überbrückte Chinoxalin-2,3-dione
EP0705835A1 (de) * 1994-09-01 1996-04-10 Ciba-Geigy Ag Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione
NZ315634A (en) * 1995-08-10 1998-11-25 Bayer Ag Halobenzimidazoles and their use as microbicides
US6288075B1 (en) 1998-02-26 2001-09-11 Rhone-Poulenc Rorer S.A. Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same
FR2760237B1 (fr) * 1997-02-28 1999-04-16 Rhone Poulenc Rorer Sa Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
US6197339B1 (en) * 1997-09-30 2001-03-06 Pharmacia & Upjohn Company Sustained release tablet formulation to treat Parkinson's disease
US6455564B1 (en) * 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
CA2358865A1 (en) 1999-02-05 2000-08-10 Pharmacia & Upjohn Company Process to prepare (5r)-(methylamino)-5,6-dihydro-4h-imidazo[4,5,1-ij]-quinolin-2(1h)-one
US7074927B2 (en) 1999-05-13 2006-07-11 Pharmacia & Upjohn Company Heterocyclic amines having central nervous system activity
DE19954707A1 (de) * 1999-11-13 2001-05-17 Merck Patent Gmbh Imidazolverbindungen als Phosphodiesterase VII-Hemmer
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
NZ522112A (en) * 2000-04-21 2004-10-29 Upjohn Co Substituted phenylazacycloalkane-type compounds for treating fibromyalgia and chronic fatigue syndrome
AR033520A1 (es) * 2000-04-27 2003-12-26 Upjohn Co (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona
JP2004506621A (ja) * 2000-08-16 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー 嗜癖障害治療用の化合物
AR031199A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados
AR031202A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados
AR031200A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TWI312781B (en) * 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
MY136318A (en) * 2002-07-25 2008-09-30 Pharmacia Corp Sustained-release tablet composition
US20050079217A1 (en) * 2002-07-25 2005-04-14 Ganorkar Loksidh D. Sustained-release tablet composition comprising a dopamine receptor agonist
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
CN1728998A (zh) * 2002-10-25 2006-02-01 法玛西雅厄普约翰有限责任公司 杂环胺类化合物作为神经保护剂的用途
MXPA06001081A (es) * 2003-07-31 2006-04-24 Irm Llc Compuestos biciclicos y composiciones como inhibidores de pdf.
US20050250803A1 (en) * 2003-11-26 2005-11-10 Pfizer Inc Combination of dopamine agonists and monoamine reuptake inhibitors
JP4971159B2 (ja) 2004-08-13 2012-07-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング プラミペキソール又はその薬学的に許容しうる塩を含有する徐放性ペレット製剤、その製法及び使用
CN101849921A (zh) 2004-08-13 2010-10-06 贝林格尔·英格海姆国际有限公司 包含普拉克索或其可药用盐的延长释放片剂
TW200635926A (en) * 2004-11-05 2006-10-16 Wyeth Corp Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
CN101193892A (zh) 2005-06-14 2008-06-04 先灵公司 大环杂环天冬氨酰基蛋白酶抑制剂
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
UA116216C2 (uk) 2012-09-14 2018-02-26 Еббві Дойчланд Гмбх Унд Ко. Кг Трициклічні хінолінові і хіноксалінові похідні
US20140080813A1 (en) 2012-09-14 2014-03-20 AbbVie Deutschland GmbH & Co. KG Tricyclic quinoline and quinoxaline derivatives

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WO1989010741A1 (en) * 1988-05-09 1989-11-16 The Upjohn Company Anxiolytic/anti-depressant 2,3-dihydro-1h-phenalen-2-amines

Also Published As

Publication number Publication date
HU211702A9 (en) 1995-12-28
CA2051697C (en) 1996-10-08
NO301421B1 (no) 1997-10-27
ES2067744T3 (es) 1995-04-01
FI944704A (fi) 1994-10-07
AU626427B2 (en) 1992-07-30
FI915715A0 (fi) 1991-12-04
DK0480939T3 (da) 1995-07-10
NO914827D0 (no) 1991-12-06
ATE117688T1 (de) 1995-02-15
RU2023712C1 (ru) 1994-11-30
HK65397A (en) 1997-05-23
DE69016430T2 (de) 1995-06-01
NO914827L (no) 1992-02-07
FI96310C (fi) 1996-06-10
HU210264B (en) 1995-03-28
FI96687C (fi) 1996-08-12
FI96687B (fi) 1996-04-30
CA2051697A1 (en) 1990-12-10
HU905216D0 (en) 1992-02-28
KR0167346B1 (ko) 1999-01-15
WO1990015058A1 (en) 1990-12-13
KR920701204A (ko) 1992-08-11
EP0480939A1 (en) 1992-04-22
AU5743890A (en) 1991-01-07
JP2955358B2 (ja) 1999-10-04
EP0480939B1 (en) 1995-01-25
DE69016430D1 (de) 1995-03-09
HUT60269A (en) 1992-08-28
JPH04506071A (ja) 1992-10-22
FI96310B (fi) 1996-02-29

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Legal Events

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Owner name: PHARMACIA & UPJOHN COMPANY