CH649469A5
(de)
*
|
1978-07-04 |
1985-05-31 |
Nyegaard & Co As |
Loesung eines roentgenkontrastmittels und eines puffers und ihre verwendung zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels.
|
DE2909439A1
(de)
*
|
1979-03-08 |
1980-09-18 |
Schering Ag |
Neue nichtionische roentgenkontrastmittel
|
US4256729A
(en)
*
|
1979-03-23 |
1981-03-17 |
Mallinckrodt, Inc. |
N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
|
DE2928417A1
(de)
*
|
1979-07-12 |
1981-01-29 |
Schering Ag |
Trijodierte basen
|
IT1193211B
(it)
*
|
1979-08-09 |
1988-06-15 |
Bracco Ind Chimica Spa |
Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
|
IT1207226B
(it)
*
|
1979-08-09 |
1989-05-17 |
Bracco Ind Chimica Spa |
Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
|
DE3001292A1
(de)
*
|
1980-01-11 |
1981-07-16 |
Schering Ag Berlin Und Bergkamen, 1000 Berlin |
Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
|
DE3038853A1
(de)
|
1980-10-10 |
1982-05-27 |
Schering Ag, 1000 Berlin Und 4619 Bergkamen |
Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
|
JPS58102200A
(ja)
*
|
1981-12-14 |
1983-06-17 |
日本原子力事業株式会社 |
沈降分離槽
|
DE3150916A1
(de)
*
|
1981-12-18 |
1983-06-30 |
Schering Ag, 1000 Berlin Und 4619 Bergkamen |
N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
|
US4396598A
(en)
*
|
1982-01-11 |
1983-08-02 |
Mallinckrodt, Inc. |
Triiodoisophthalamide X-ray contrast agent
|
DK162045C
(da)
*
|
1982-10-01 |
1992-02-10 |
Nyegaard & Co As |
Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser
|
US5204086A
(en)
*
|
1982-10-01 |
1993-04-20 |
Nycomed Imaging As |
X-ray contrast agent
|
EP0108638B1
(de)
*
|
1982-11-08 |
1986-07-16 |
NYEGAARD & CO. A/S |
Röntgenkontrastmittel
|
US4584401A
(en)
*
|
1983-10-20 |
1986-04-22 |
Biophysica Foundation |
Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
|
US5191119A
(en)
*
|
1983-10-20 |
1993-03-02 |
Cook Imaging Corp. |
Process for producing non-ionic radiographic contrast media utilizing N-allylation
|
JPS6091807U
(ja)
*
|
1983-11-30 |
1985-06-22 |
松下電器産業株式会社 |
テ−ブル
|
JPS634809Y2
(de)
*
|
1984-10-04 |
1988-02-08 |
|
|
US5035877A
(en)
*
|
1985-08-09 |
1991-07-30 |
Cook Imaging Corporation |
Non-ionic contrast media from ionic contrast media
|
US4954348A
(en)
*
|
1985-08-09 |
1990-09-04 |
Cook Imaging Corporation |
Non-ionic polyol contrast media from ionic contrast media
|
DE3689330T2
(de)
*
|
1985-08-09 |
1994-05-19 |
Cook Imaging Corp |
Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
|
JPH0637447B2
(ja)
*
|
1987-10-31 |
1994-05-18 |
東洋紡績株式会社 |
新規アミド化合物
|
US5698739A
(en)
*
|
1989-07-05 |
1997-12-16 |
Schering Aktiengesellschaft |
Carboxamide non-ionic contrast media
|
GB8919929D0
(en)
*
|
1989-09-04 |
1989-10-18 |
Nycomed As |
Compositions
|
US5232685A
(en)
*
|
1989-11-03 |
1993-08-03 |
Schering Aktiengesellschaft |
Nonionic x-ray contrast medium with high iodine content
|
DE3937118A1
(de)
*
|
1989-11-03 |
1991-05-08 |
Schering Ag |
Nichtionische roentgenkontrastmittel mit hohem jodgehalt
|
US5869024A
(en)
*
|
1989-11-29 |
1999-02-09 |
Bracco International B.V. |
Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
|
IL96324A
(en)
*
|
1989-11-29 |
1995-01-24 |
Squibb & Sons Inc |
History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents
|
US5614638A
(en)
*
|
1989-11-29 |
1997-03-25 |
Bracco International B.V. |
Nonionic radiographic contrast agents
|
US5191120A
(en)
*
|
1989-12-13 |
1993-03-02 |
Mallinckrodt Medical, Inc. |
Process for preparing nonionic X-ray contrast agents
|
US4997983A
(en)
*
|
1990-01-31 |
1991-03-05 |
Mallinckrodt, Inc. |
Process for production of ioversol
|
US5527926A
(en)
*
|
1990-11-26 |
1996-06-18 |
Bracco International B.V. |
Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
|
US5356613A
(en)
*
|
1991-03-18 |
1994-10-18 |
Mallinckrodt Medical, Inc. |
X-ray contrast agents, compositions and methods
|
DE4109169A1
(de)
*
|
1991-03-20 |
1992-09-24 |
Koehler Chemie Dr Franz |
Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
|
US5169864A
(en)
*
|
1991-11-15 |
1992-12-08 |
Baxter International Inc. |
Unbuffered premixed ranitidine formulation
|
WO1993010825A1
(en)
*
|
1991-12-03 |
1993-06-10 |
Mallinckrodt Medical, Inc. |
Nonionic x-ray contrast agents, compositions and methods
|
US5278311A
(en)
*
|
1992-06-05 |
1994-01-11 |
E. R. Squibb & Sons, Inc. |
Nonionic radiographic contrast agents
|
AU5093993A
(en)
*
|
1992-09-02 |
1994-03-29 |
Mallinckrodt Medical, Inc. |
Nonionic X-ray contrast agents compositions and methods
|
IL110391A
(en)
*
|
1993-07-30 |
1998-12-06 |
Zambon Spa |
Process for the formation of infamidol
|
US5665331A
(en)
*
|
1995-01-10 |
1997-09-09 |
Nanosystems L.L.C. |
Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
|
US5662883A
(en)
*
|
1995-01-10 |
1997-09-02 |
Nanosystems L.L.C. |
Microprecipitation of micro-nanoparticulate pharmaceutical agents
|
US5716642A
(en)
*
|
1995-01-10 |
1998-02-10 |
Nano Systems L.L.C. |
Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
|
US5560932A
(en)
*
|
1995-01-10 |
1996-10-01 |
Nano Systems L.L.C. |
Microprecipitation of nanoparticulate pharmaceutical agents
|
US5543133A
(en)
*
|
1995-02-14 |
1996-08-06 |
Nanosystems L.L.C. |
Process of preparing x-ray contrast compositions containing nanoparticles
|
DE19510864A1
(de)
*
|
1995-03-16 |
1996-09-19 |
Schering Ag |
Röntgenkontrastmittel für die Computertomographie und Urographie
|
IT1275429B
(it)
*
|
1995-05-18 |
1997-08-07 |
Zambon Spa |
Processo per la preparazione di un intermedio utile nella sintesi di composti organici
|
CN1078201C
(zh)
*
|
1995-11-20 |
2002-01-23 |
江苏省原子医学研究所 |
一种碘海醇的制备方法
|
GB9618055D0
(en)
*
|
1996-08-29 |
1996-10-09 |
Nycomed Imaging As |
Process
|
GB9618056D0
(en)
*
|
1996-08-29 |
1996-10-09 |
Nycomed Imaging As |
Process
|
US5840967A
(en)
|
1996-08-29 |
1998-11-24 |
Nycomed Imaging As |
Process for the preparation of contrast agents
|
US5705692A
(en)
*
|
1996-09-27 |
1998-01-06 |
Abbott Laboratories |
Process for the preparation of iohexol
|
PT101919B
(pt)
*
|
1996-09-30 |
2000-01-31 |
Hovione Sociedade Quimica Sa |
Um processo para a purificacao de tohexol
|
US5861138A
(en)
*
|
1996-11-20 |
1999-01-19 |
Hoechst Celanese Corp. |
Ligands for MRI contrast agent
|
US5861140A
(en)
*
|
1996-11-20 |
1999-01-19 |
Hoechst Celanese Corp. |
Tripodal paramagnetic contrast agents for MR imaging
|
US5824821A
(en)
*
|
1997-02-07 |
1998-10-20 |
Nycomed Imaging As |
Process for the preparation of iodinated contrast agents and intermediates therefor
|
US5847212A
(en)
*
|
1997-04-21 |
1998-12-08 |
Abbott Laboratories |
Process for the preparation of iohexol
|
GB9710726D0
(en)
|
1997-05-23 |
1997-07-16 |
Nycomed Imaging As |
Compound
|
GB9710728D0
(en)
*
|
1997-05-23 |
1997-07-16 |
Nycomed Imaging As |
Method
|
GB9710725D0
(en)
|
1997-05-23 |
1997-07-16 |
Nycomed Imaging As |
Process
|
US6137006A
(en)
*
|
1997-05-23 |
2000-10-24 |
Nycomed Imaging As |
Preparation of tri-iodo benzene compounds
|
IT1292037B1
(it)
*
|
1997-05-30 |
1999-01-25 |
Bracco Spa |
Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
|
US5824288A
(en)
*
|
1997-08-21 |
1998-10-20 |
Hoechst Celanese Corporation |
Thio-substituted pyridines as MRI ligand precursors
|
US5820851A
(en)
*
|
1997-08-21 |
1998-10-13 |
Hoechst Celanese Corporation |
Tripodal pyridine ligands as MRI contrast agents
|
US5869026A
(en)
*
|
1997-08-21 |
1999-02-09 |
Hoechst Celanese Corp. |
Tripodal carboxamide ligands for MRI contrast agents
|
US5858329A
(en)
*
|
1997-08-21 |
1999-01-12 |
Hoechst Celanese Corporation |
MRI diagnostic procedures using tripodal pyridinyl metal complexes
|
US5869025A
(en)
*
|
1997-08-21 |
1999-02-09 |
Hoechst Celanese Corporation |
Tripodal aromatic heterocycle carboxamide MRI contrast agents
|
GB9720969D0
(en)
*
|
1997-10-02 |
1997-12-03 |
Nycomed Imaging As |
Process
|
GB9725010D0
(en)
*
|
1997-11-26 |
1998-01-28 |
Nycomed Imaging As |
Process
|
US6723746B2
(en)
*
|
1998-09-08 |
2004-04-20 |
Veritas Pharmaceuticals, Inc. |
Functional radiographic imaging methods and agents
|
US20040170561A1
(en)
*
|
1998-09-08 |
2004-09-02 |
Jesse Salb |
Functional radiographic imaging methods and agents
|
US6226352B1
(en)
|
1998-09-08 |
2001-05-01 |
Veritas Pharmaceuticals, Inc. |
System and method for radiographic imaging of tissue
|
US6751290B2
(en)
|
1998-09-08 |
2004-06-15 |
Veritas Pharmaceuticals, Inc. |
Radiographic assessment of tissue after exposure to a compound
|
GB9825095D0
(en)
|
1998-11-16 |
1999-01-13 |
Nycomed Imaging As |
Chemical process
|
EP1263324B1
(de)
|
2000-03-16 |
2009-12-02 |
Veritas Pharmaceuticals |
Radiographische bewertung von gewebereaktionen auf chemische verbindungen
|
US6660248B2
(en)
|
2000-11-10 |
2003-12-09 |
William Marsh Rice University |
Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
|
IT1319670B1
(it)
|
2000-12-01 |
2003-10-23 |
Bracco Spa |
Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'-
|
ITMI20010773A1
(it)
*
|
2001-04-11 |
2002-10-11 |
Chemi Spa |
Processo per la produzione di ioexolo ad elevata purezza
|
KR20030032185A
(ko)
*
|
2001-10-16 |
2003-04-26 |
동국제약 주식회사 |
N,n'-비스[2,3-디히드록시프로필]-2,4,6-트리요오드-5-아세틸아미도 이소 프탈아미드의 결정화방법
|
CN101098916A
(zh)
|
2005-01-13 |
2008-01-02 |
金文申有限公司 |
含有碳纳米颗粒的复合材料
|
WO2006100731A1
(ja)
*
|
2005-03-18 |
2006-09-28 |
Manac Inc. |
5−アミノ−2,4,6−トリヨードイソフタル酸誘導体のアセチル化方法
|
PT103391B
(pt)
|
2005-11-24 |
2008-10-30 |
Hovione Farmaciencia S A |
Processo para fabrico de lohexol
|
CN100344606C
(zh)
*
|
2005-12-28 |
2007-10-24 |
江苏省原子医学研究所 |
一种碘昔兰的制备方法
|
EP2093206A1
(de)
|
2008-02-20 |
2009-08-26 |
BRACCO IMAGING S.p.A. |
Verfahren zur Iodierung aromatischer Verbindungen
|
JP2012514622A
(ja)
|
2009-01-09 |
2012-06-28 |
ジーイー・ヘルスケア・アクスイェ・セルスカプ |
造影製剤組成物
|
DK2451994T3
(da)
|
2009-07-07 |
2014-01-20 |
Bracco Imaging Spa |
Fremgangsmåde til fremstilling af et ioderende middel
|
US20110021821A1
(en)
*
|
2009-07-21 |
2011-01-27 |
Ge Healthcare As |
Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
|
EP2277851A1
(de)
*
|
2009-07-21 |
2011-01-26 |
GE Healthcare AS |
Acetylierung mit reduziertem Volumen Essigsäureanhydrid zur Herstellung nicht ionischer Röntgenkontrastmittel
|
EP2277859A1
(de)
*
|
2009-07-21 |
2011-01-26 |
GE Healthcare AS |
Acetylierung unter Verwendung einer geringeren Essigsäureanhydridkonzentration zur Synthetisierung von nichtionischen Röntgenkontrastmitteln
|
KR101585751B1
(ko)
*
|
2010-07-12 |
2016-01-14 |
지이 헬스케어 에이에스 |
저농도의 조영제 및/또는 저방사선량의 x-선 영상화
|
CN102249948B
(zh)
*
|
2011-05-23 |
2014-01-29 |
苏州昊帆生物科技有限公司 |
5-乙酰氨基-n,n’-双-(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺的合成方法
|
EP2606912A1
(de)
*
|
2011-12-23 |
2013-06-26 |
Central Medical Service Co., Ltd. |
Kontrastmittelzusammensetzung mit Kontrastverstärkungseffekt aufgrund des Umfassens eines hoch konzentrierten Mittels
|
ES2683712T3
(es)
*
|
2013-12-06 |
2018-09-27 |
Ge Healthcare As |
Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos
|
US9834504B2
(en)
|
2013-12-06 |
2017-12-05 |
Ge Healthcare As |
Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents
|
ES2638645T3
(es)
*
|
2013-12-06 |
2017-10-23 |
Ge Healthcare As |
Procedimiento alternativo de acetilación en la síntesis de agentes de contraste para rayos X no iónicos
|
JP6571100B2
(ja)
*
|
2014-03-04 |
2019-09-04 |
大塚製薬株式会社 |
イオヘキソール粉末及びそれを使用する方法
|
PT108524B
(pt)
*
|
2015-06-02 |
2017-12-15 |
Hovione Farmaciência S A |
Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
|
CN107778191A
(zh)
*
|
2016-08-26 |
2018-03-09 |
正大天晴药业集团股份有限公司 |
一种碘普罗胺及其中间体的制备方法
|
RU2655619C1
(ru)
*
|
2017-06-13 |
2018-05-29 |
Алексей Георгиевич Александров |
Способ получения фармацевтической субстанции на основе йогексола
|
CN107857714B
(zh)
*
|
2017-11-29 |
2020-11-13 |
上海司太立制药有限公司 |
一种碘海醇中间体杂质的制备方法和用途
|
CN108191689A
(zh)
*
|
2017-12-11 |
2018-06-22 |
天津河清化学工业有限公司 |
一种新型碘海醇节能环保的连续化制备方法
|
CN108191690A
(zh)
*
|
2017-12-11 |
2018-06-22 |
天津河清化学工业有限公司 |
碘海醇节能环保的连续化制备方法
|
EP4001261A1
(de)
|
2020-11-23 |
2022-05-25 |
Justesa Imagen S.A.U |
Verfahren zur gewinnung von hochreinem iohexol
|