HK142395A - Phenylquinolinecarboxylic acids and derivatives as antitumor agents - Google Patents
Phenylquinolinecarboxylic acids and derivatives as antitumor agentsInfo
- Publication number
- HK142395A HK142395A HK142395A HK142395A HK142395A HK 142395 A HK142395 A HK 142395A HK 142395 A HK142395 A HK 142395A HK 142395 A HK142395 A HK 142395A HK 142395 A HK142395 A HK 142395A
- Authority
- HK
- Hong Kong
- Prior art keywords
- carbon atoms
- compound
- solvent
- alkyl
- pharmaceutical carrier
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51631983A | 1983-07-22 | 1983-07-22 | |
| US60510484A | 1984-04-30 | 1984-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK142395A true HK142395A (en) | 1995-09-15 |
Family
ID=27058797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK142395A HK142395A (en) | 1983-07-22 | 1995-09-07 | Phenylquinolinecarboxylic acids and derivatives as antitumor agents |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0133244B1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU583793B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1288436C (cg-RX-API-DMAC10.html) |
| DE (1) | DE3483704D1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK358784A (cg-RX-API-DMAC10.html) |
| ES (1) | ES8507498A1 (cg-RX-API-DMAC10.html) |
| FI (1) | FI86987C (cg-RX-API-DMAC10.html) |
| GR (1) | GR82234B (cg-RX-API-DMAC10.html) |
| HK (1) | HK142395A (cg-RX-API-DMAC10.html) |
| HU (1) | HU194832B (cg-RX-API-DMAC10.html) |
| IE (1) | IE57627B1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL72471A (cg-RX-API-DMAC10.html) |
| NO (1) | NO167510C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ208966A (cg-RX-API-DMAC10.html) |
| PT (1) | PT78960B (cg-RX-API-DMAC10.html) |
| SU (2) | SU1393314A3 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889862A (en) * | 1986-08-28 | 1989-12-26 | E. I. Du Pont De Nemours And Company | Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids |
| WO1989006227A1 (en) * | 1987-12-28 | 1989-07-13 | The Dow Chemical Company | Phenoxyphenoxypropionates, intermediates thereof and methods of preparation |
| US4861783A (en) * | 1988-04-26 | 1989-08-29 | E. I. Du Pont De Nemours And Company | 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases |
| US4968702A (en) * | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| DE3905339A1 (de) * | 1989-02-22 | 1990-09-06 | Basf Ag | Chinolin-4-carbonsaeurederivate und deren verwendung |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
| BR9809501A (pt) * | 1997-05-28 | 2000-06-20 | Rhone Poulenc Rorer Pharma | Composto, composição farmacêutica, e, processos para inibir a atividade da tirosina quinase pdgf, para inibir a atividade da tirosina quinase lck, para inibir a proliferação celular, diferenciação ou liberação de mediador em um paciente, para tratar uma patologia ligada a um distúrbio hiperproliferativo, para tratar a restenose, e, para tratar inflamação em um paciente |
| CA2315226A1 (en) * | 1997-12-19 | 1999-07-01 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| CA2493854A1 (en) * | 2002-06-26 | 2004-01-08 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| TW200804288A (en) * | 2005-12-12 | 2008-01-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| US8232310B2 (en) | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| CA2869513C (en) | 2012-04-12 | 2020-07-07 | Georgetown University | Methods and compositions for treating ewings sarcoma family of tumors |
| CA2927148A1 (en) | 2013-10-24 | 2015-04-30 | Georgetown University | Methods and compositions for treating cancer |
| MX2016006678A (es) | 2013-11-22 | 2016-09-13 | Genzyme Corp | Nuevos metodos para tratar enfermedades neurodegenerativas. |
| CN107108580B (zh) | 2014-10-09 | 2020-06-30 | 英克特诺治疗公司 | 吲哚酮化合物及其用途 |
| DK3436434T3 (da) | 2016-03-31 | 2020-09-21 | Oncternal Therapeutics Inc | Indolin-analoger og anvendelser deraf |
| MX395539B (es) | 2016-07-29 | 2025-03-25 | Oncternal Therapeutics Inc | Usos de compuestos de indolinona |
| CN115361948A (zh) * | 2019-12-26 | 2022-11-18 | 俄亥俄州国家创新基金会 | 抑制二氢乳清酸脱氢酶的方法和组合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE502610A (cg-RX-API-DMAC10.html) * | 1950-04-18 | |||
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
-
1984
- 1984-07-19 DE DE8484108523T patent/DE3483704D1/de not_active Expired - Lifetime
- 1984-07-19 AU AU30852/84A patent/AU583793B2/en not_active Ceased
- 1984-07-19 EP EP84108523A patent/EP0133244B1/en not_active Expired - Lifetime
- 1984-07-19 CA CA000459263A patent/CA1288436C/en not_active Expired - Lifetime
- 1984-07-20 SU SU843776940A patent/SU1393314A3/ru active
- 1984-07-20 IE IE1873/84A patent/IE57627B1/en not_active IP Right Cessation
- 1984-07-20 NZ NZ208966A patent/NZ208966A/en unknown
- 1984-07-20 GR GR75386A patent/GR82234B/el unknown
- 1984-07-20 NO NO842969A patent/NO167510C/no unknown
- 1984-07-20 ES ES534509A patent/ES8507498A1/es not_active Expired
- 1984-07-20 IL IL72471A patent/IL72471A/xx not_active IP Right Cessation
- 1984-07-20 HU HU842824A patent/HU194832B/hu not_active IP Right Cessation
- 1984-07-20 FI FI842928A patent/FI86987C/fi not_active IP Right Cessation
- 1984-07-20 DK DK358784A patent/DK358784A/da not_active Application Discontinuation
- 1984-07-20 PT PT78960A patent/PT78960B/pt not_active IP Right Cessation
-
1986
- 1986-01-06 SU SU864000869A patent/SU1452480A3/ru active
-
1995
- 1995-09-07 HK HK142395A patent/HK142395A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SU1452480A3 (ru) | 1989-01-15 |
| NO842969L (no) | 1985-01-23 |
| EP0133244B1 (en) | 1990-12-05 |
| IE841873L (en) | 1985-01-22 |
| DK358784D0 (da) | 1984-07-20 |
| FI842928A0 (fi) | 1984-07-20 |
| AU583793B2 (en) | 1989-05-11 |
| FI842928L (fi) | 1985-01-23 |
| FI86987C (fi) | 1992-11-10 |
| IE57627B1 (en) | 1993-02-10 |
| FI86987B (fi) | 1992-07-31 |
| NO167510B (no) | 1991-08-05 |
| ES534509A0 (es) | 1985-09-01 |
| HU194832B (en) | 1988-03-28 |
| CA1288436C (en) | 1991-09-03 |
| HUT35248A (en) | 1985-06-28 |
| PT78960B (en) | 1986-10-20 |
| SU1393314A3 (ru) | 1988-04-30 |
| PT78960A (en) | 1984-08-01 |
| IL72471A (en) | 1988-11-15 |
| NO167510C (no) | 1991-11-13 |
| DE3483704D1 (de) | 1991-01-17 |
| EP0133244A2 (en) | 1985-02-20 |
| ES8507498A1 (es) | 1985-09-01 |
| GR82234B (cg-RX-API-DMAC10.html) | 1984-12-13 |
| EP0133244A3 (en) | 1985-12-11 |
| IL72471A0 (en) | 1984-11-30 |
| AU3085284A (en) | 1985-01-24 |
| DK358784A (da) | 1985-01-23 |
| NZ208966A (en) | 1986-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4680299A (en) | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof | |
| EP0133244B1 (en) | Phenylquinolinecarboxylic acids and derivatives as antitumor agents | |
| CA1087205A (en) | 2-amino-3-(5-and 6-)benzoylphenylacetic acids, esters and metal salts thereof | |
| JPS6089474A (ja) | モルフイナン誘導体，その製造方法，及び該化合物を含有する抗腫瘍剤 | |
| US4374990A (en) | Cyclic diamine derivatives | |
| JPH0684336B2 (ja) | 殺生物性芳香族化合物、その合成および医薬としてのその使用 | |
| US4639454A (en) | Phenylquinazolinecarboxylic acids and derivatives as cancer chemotherapeutic agents | |
| JPS62103065A (ja) | ピリジン誘導体 | |
| SK27598A3 (en) | Piperazine derivatives and process for the preparation thereof | |
| US4053607A (en) | Aryloxypyridine for treating hyperglycaemia | |
| JPH0741461A (ja) | スルホン酸エステル誘導体 | |
| EP2208725A1 (en) | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | |
| Aytemir et al. | Anticonvulsant and neurotoxicity evaluation of some novel kojic acids and allomaltol derivatives | |
| EP1142885B1 (en) | 2-(n-cyanoimino)thiazolidin-4-one derivatives | |
| EP0145010B1 (en) | Carbostyril derivatives | |
| EP0228959B1 (en) | Aminostyryl compound, leukotriene antagonistic composition containing the same as effective ingredients and method of antagonizing srs by employing the same | |
| JP4001636B2 (ja) | ガンおよびａｉｄｓの処置のための活性化ヨード誘導体 | |
| US5032597A (en) | Method of using phenylquinolinecarboxylic acids and derivatives for lymthoid leukemia treatment in a mammal | |
| CA2007529A1 (en) | 3-phenyl-5, 6-dihydrobenz [c] acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents | |
| CA1138457A (en) | 2-hydroxy-5-(1-hydroxy-2- piperazinylethyl)benzoic acid derivatives | |
| US20190330142A1 (en) | Inhibitors of mtor-deptor interactions and methods of use thereof | |
| US4297357A (en) | N-Phenethylacetamide compounds and process for preparation thereof | |
| JPH0519549B2 (cg-RX-API-DMAC10.html) | ||
| JPH01250316A (ja) | 抗脂血剤 | |
| EP0282077A2 (en) | Pyridyloxy derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |