HK1252348A1 - 用於持續療法的納米顆粒組合物 - Google Patents

用於持續療法的納米顆粒組合物

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Publication number
HK1252348A1
HK1252348A1 HK18111633.0A HK18111633A HK1252348A1 HK 1252348 A1 HK1252348 A1 HK 1252348A1 HK 18111633 A HK18111633 A HK 18111633A HK 1252348 A1 HK1252348 A1 HK 1252348A1
Authority
HK
Hong Kong
Prior art keywords
nanoparticle compositions
sustained therapy
sustained
therapy
nanoparticle
Prior art date
Application number
HK18111633.0A
Other languages
English (en)
Inventor
Pedro Santmaria
Original Assignee
Uti Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uti Lp filed Critical Uti Lp
Publication of HK1252348A1 publication Critical patent/HK1252348A1/zh

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Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
CA2887486A1 (en) * 2012-11-30 2014-06-05 Roche Glycart Ag Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class i comprising multi-function proteins
MX361076B (es) 2012-12-21 2018-11-27 Hoffmann La Roche Proteínas multifunción que comprenden complejo mayor de histocompatibilidad (cmh) de clase i multivalente unido mediante disulfuro.
MX2016005822A (es) 2013-11-04 2016-12-02 Uti Limited Partnership Metodos y composiciones para inmunoterpia sostenida.
WO2015188839A2 (en) 2014-06-13 2015-12-17 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
CA2984485A1 (en) 2015-05-06 2016-12-15 Uti Limited Partnership Nanoparticle compositions for sustained therapy
EP3538559A4 (en) * 2016-11-09 2020-06-24 UTI Limited Partnership RECOMBINANT PMHC CLASS II MOLECULES
US20190352363A1 (en) 2016-12-22 2019-11-21 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
AU2018234628B2 (en) 2017-03-15 2023-07-20 Cue Biopharma, Inc. Methods for modulating an immune response
WO2018185564A2 (en) * 2017-04-07 2018-10-11 Uti Limited Partnership Assay to measure the potency of receptor-ligand interactions in nanomedicines
JP7270946B2 (ja) * 2017-08-08 2023-05-11 国立大学法人浜松医科大学 自己免疫疾患の治療又は予防剤
CN111741746A (zh) * 2017-11-29 2020-10-02 乌第有限合伙公司 治疗自身免疫性疾病的方法
EP3737689A4 (en) 2018-01-09 2021-12-01 Cue Biopharma, Inc. MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF
US10709792B1 (en) * 2018-04-06 2020-07-14 Verily Life Sciences Llc Passivated magnetic nanoparticles for cell targeting and methods of preparation and use
CN109126648B (zh) * 2018-06-05 2021-09-03 青岛明月生物医用材料有限公司 一种壳聚糖和藻酸丙二醇酯共混微胶囊的制备及其应用
TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 前列腺新抗原及其用途
WO2020180501A1 (en) * 2019-03-06 2020-09-10 Cue Biopharma, Inc. T-cell modulatory antigen-presenting polypeptides and methods of use thereof
JP2022533459A (ja) * 2019-05-23 2022-07-22 ユーティアイ・リミテッド・パートナーシップ 肝疾患の治療方法
WO2021122185A1 (en) * 2019-12-20 2021-06-24 Miltenyi Biotec B.V. & Co. KG Reversible cell detection via mhc with conjugates having an enzymatically cleavable detection moiety
GB201919222D0 (en) * 2019-12-23 2020-02-05 Apitope Int Nv Composition
CN112955460B (zh) * 2019-12-31 2022-05-10 厦门大学 一种拟穴青蟹抗菌肽Scyreprocin及其应用
TW202144389A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在多發性骨髓瘤中表現之新抗原及其用途
TW202144388A (zh) 2020-02-14 2021-12-01 美商健生生物科技公司 在卵巢癌中表現之新抗原及其用途
CN111514306B (zh) * 2020-04-23 2022-05-13 中国科学院化学研究所 一种增强抗肿瘤免疫治疗的富勒烯纳米颗粒
CN116096405A (zh) 2020-05-12 2023-05-09 Cue生物制药股份有限公司 多聚体t细胞调节多肽及其使用方法
CA3235813A1 (en) * 2021-10-21 2023-04-27 John J. Puisis Treatment of primary biliary cholangitis (pbc) with tolerizing nanoparticles
WO2023102132A1 (en) * 2021-12-01 2023-06-08 Emory University Multi-cytokine surface loaded particles and uses in stimulating immune cells for therapeutic applications
WO2023137227A1 (en) * 2022-01-14 2023-07-20 Karma Biotechnologies Multi-vesicular lipid nanoparticle tolerogenic vaccines for induction of systemic immune tolerance in vivo
CN114601920A (zh) * 2022-03-23 2022-06-10 宁波御坊堂生物科技有限公司 一种用于改善骨关节健康的口服脂质体组合物及其制备方法
CN116082483B (zh) * 2022-09-09 2024-05-28 大连工业大学 一种具有改善骨质疏松、增强骨密度的多肽制备方法及应用
FR3139820A1 (fr) * 2022-09-15 2024-03-22 Universite Toulouse III – Paul Sabatier Molécule hybride comprenant un fragment Fc d’anticorps et au moins un peptide se liant à un lymphocyte auto-réactif impliqué dans une vascularite auto-immune, et ses utilisations
CN115594776B (zh) * 2022-09-19 2024-03-15 山东大学 一种ROS响应性聚合物Mal-PHB-Dextran及细胞背包载药系统

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US112292A (en) * 1871-02-28 Improvement in numbering and paging machines
US4367110A (en) 1979-07-02 1983-01-04 Toppan Printing Co. Decorative laminate and a manufacturing method therefor
US4452901A (en) 1980-03-20 1984-06-05 Ciba-Geigy Corporation Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
FR2504010B1 (fr) 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
GB2097032B (en) 1981-04-22 1984-09-19 Teron International Urban Dev A combined ceiling air and services distribution system mechanical chasse and structural roof member
US4478946A (en) 1981-07-02 1984-10-23 South African Inventions Development Corporation Carrier bound immunosorbent
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
DE3377484D1 (en) 1982-04-19 1988-09-01 Nissan Motor Method for controlling reduction ratio of continuously variable transmission with acceleration compensation
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4542225A (en) 1984-08-29 1985-09-17 Dana-Farber Cancer Institute, Inc. Acid-cleavable compound
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
DE3680924D1 (de) 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5171582A (en) 1985-07-31 1992-12-15 Ghent William R Treatment of iodine deficiency diseases
US4680338A (en) 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
US4699784A (en) 1986-02-25 1987-10-13 Center For Molecular Medicine & Immunology Tumoricidal methotrexate-antibody conjugate
US5258499A (en) 1988-05-16 1993-11-02 Vestar, Inc. Liposome targeting using receptor specific ligands
US6106840A (en) 1988-06-23 2000-08-22 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US5260422A (en) 1988-06-23 1993-11-09 Anergen, Inc. MHC conjugates useful in ameliorating autoimmunity
US4859839A (en) 1988-07-08 1989-08-22 Counter Computer Corporation Point-of-sale terminal for laundry or dry cleaning establishments
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5200189A (en) 1991-07-23 1993-04-06 Ecolab Inc. Peroxyacid antimicrobial composition
CA2130997A1 (en) 1992-02-27 1993-09-02 C. Garrison Fathman Early antigen for autoimmune diabetes
US5972336A (en) 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
ZA952485B (en) 1994-03-28 1995-12-15 Nycomed Imaging As Liposomes
US6103379A (en) 1994-10-06 2000-08-15 Bar-Ilan University Process for the preparation of microspheres and microspheres made thereby
DE19508058A1 (de) 1995-02-21 1996-08-22 Schering Ag Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840839A (en) 1996-02-09 1998-11-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
US20050003431A1 (en) 1996-08-16 2005-01-06 Wucherpfennig Kai W. Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
US6270772B1 (en) 1997-09-16 2001-08-07 Oregon Health Sciences University Recombinant MHC molecules useful for manipulation of antigen-specific T-cells
JP2002504342A (ja) 1998-02-19 2002-02-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 一価ｍｈｃ結合ドメイン融合タンパク質および接合体、多価ｍｈｃ結合ドメイン融合タンパク質および接合体、ならびに多量体ｍｈｃ結合ドメイン融合タンパク質および接合体、そしてそれらのための使用
WO1999056763A1 (en) 1998-05-07 1999-11-11 The Regents Of The University Of California Use of neglected target tissue antigens in modulation of immune responses
US7807377B2 (en) 1998-10-20 2010-10-05 Salvatore Albani Method of isolating antigen-specific T cells employing artificial antigen presenting cells
US6150022A (en) 1998-12-07 2000-11-21 Flex Products, Inc. Bright metal flake based pigments
JP2000213425A (ja) 1999-01-20 2000-08-02 Hino Motors Ltd Ｅｇｒク―ラ
CN1377279A (zh) 1999-05-06 2002-10-30 遗传研究所有限公司 可溶性共同刺激分子增强免疫应答的用途
JP2003510341A (ja) 1999-10-06 2003-03-18 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 細胞ターゲッティング組成物及びそれらを使用する方法
US6585947B1 (en) 1999-10-22 2003-07-01 The Board Of Trustess Of The University Of Illinois Method for producing silicon nanoparticles
US6651655B1 (en) 2000-01-18 2003-11-25 Quadrant Technologies Limited Inhaled vaccines
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
KR100379250B1 (ko) 2000-12-04 2003-04-08 한국과학기술연구원 나노 단위 크기의 금속 입자가 함유된 고분자 복합 소재및 그 제조 방법
DE10117858A1 (de) 2001-04-10 2002-10-24 Gsf Forschungszentrum Umwelt MHC-Tetramere
US20050129617A1 (en) 2001-06-22 2005-06-16 Rusung Tan Type1 diabetes diagnostics and therapeutics
US20070129307A1 (en) 2001-06-22 2007-06-07 The University Of British Columbia Insulin epitopes for the treatment of type 1 diabetes
US20030124149A1 (en) 2001-07-06 2003-07-03 Shalaby Shalaby W. Bioactive absorbable microparticles as therapeutic vaccines
CA2453417A1 (en) 2001-07-10 2003-06-26 North Carolina State University Nanoparticle delivery vehicle
DE10144252A1 (de) 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
AU2002365279B2 (en) 2001-12-17 2009-08-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
US6688494B2 (en) 2001-12-20 2004-02-10 Cima Nanotech, Inc. Process for the manufacture of metal nanoparticle
US7285289B2 (en) 2002-04-12 2007-10-23 Nagy Jon O Nanoparticle vaccines
US20040115216A1 (en) 2002-07-12 2004-06-17 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
DE10310261A1 (de) 2003-03-05 2004-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Identifizierung von Antigen-Epitopen
US6929675B1 (en) 2003-04-24 2005-08-16 Sandia Corporation Synthesis metal nanoparticle
US20050118102A1 (en) 2003-04-28 2005-06-02 Intematix Corporation Spin resonance heating and/or imaging in medical applications
US8758767B2 (en) 2003-05-20 2014-06-24 Albert Einstein College Of Medicine Of Yeshiva University Antigens targeted by prevalent pathogennic T cells in type 1 diabetes and uses thereof
US7060121B2 (en) 2003-06-25 2006-06-13 Hsing Kuang Lin Method of producing gold nanoparticle
WO2005020933A2 (en) 2003-09-02 2005-03-10 University Of South Florida Nanoparticles for drug-delivery
GB0321937D0 (en) 2003-09-19 2003-10-22 Univ Liverpool Nanoparticle conjugates and method of production thereof
US8100382B2 (en) 2003-10-09 2012-01-24 Brooks Instrument, LLP Valve assembly
AU2005326322B2 (en) 2004-07-01 2009-02-05 Yale University Targeted and high density drug loaded polymeric materials
US9079765B2 (en) 2004-10-01 2015-07-14 Midatech Ltd. Nanoparticles comprising antigens and adjuvants, and immunogenic structures
US20070059775A1 (en) 2005-03-29 2007-03-15 The Trustees Of Columbia University In The City Of New York Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques
US7562421B2 (en) 2005-04-03 2009-07-21 Magen Eco Energy A.C.S. Ltd. Connecting clasp
US7326399B2 (en) 2005-04-15 2008-02-05 Headwaters Technology Innovation, Llc Titanium dioxide nanoparticles and nanoparticle suspensions and methods of making the same
EP1932538A4 (en) 2005-08-25 2009-10-21 Taiho Pharmaceutical Co Ltd BIODEGRADABLE NANOTEHICLES WITH IMMOBILIZED OR CAPACITATED T-CELL-RECOGNIZABLE EPITOPEPEPID
US9393215B2 (en) 2005-12-02 2016-07-19 Novartis Ag Nanoparticles for use in immunogenic compositions
WO2007084775A2 (en) 2006-01-20 2007-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for modulation of suppressor t cell activation
ES2657480T3 (es) 2006-08-11 2018-03-05 Life Sciences Research Partners Vzw Péptidos inmunogénicos y su uso en trastornos inmunitarios
JP2010530955A (ja) 2006-12-29 2010-09-16 ユニヴァーシティ オブ ワシントン 二重機能性非汚染表面および材料
US8889117B2 (en) 2007-02-15 2014-11-18 Yale University Modular nanoparticles for adaptable vaccines
US20150250871A1 (en) 2007-03-07 2015-09-10 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
JP5650406B2 (ja) 2007-03-07 2015-01-07 ユーティーアイ リミテッド パートナーシップ 自己免疫状態の予防および治療のための組成物および方法
US20140105980A1 (en) * 2012-10-11 2014-04-17 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
US20100151031A1 (en) 2007-03-23 2010-06-17 Desimone Joseph M Discrete size and shape specific organic nanoparticles designed to elicit an immune response
EP3023436A1 (en) 2007-07-03 2016-05-25 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
WO2009013741A2 (en) 2007-07-22 2009-01-29 Camtek Ltd Method and system for controlling a manufacturing process
JP5085240B2 (ja) 2007-09-03 2012-11-28 日本電波工業株式会社 水晶デバイス及び水晶デバイスの製造方法
EP2399610A3 (en) 2007-09-24 2012-09-05 Bar-Ilan University Polymer nanoparticles coated by magnetic metal oxide and uses thereof
US8779088B2 (en) 2007-12-17 2014-07-15 Marfl Ab Vaccine for the treatment of Mycobacterium related disorders
US8629098B2 (en) 2008-01-15 2014-01-14 Yale University Compositions and methods for adoptive and active immunotherapy
EP2240782A2 (en) 2008-02-04 2010-10-20 Ulive Enterprises Limited Nanoparticle conjugates
US20110151015A1 (en) 2008-03-04 2011-06-23 Liquikia Technologies, Inc. Immunomodulator particles and methods of treating
WO2009126835A2 (en) 2008-04-09 2009-10-15 University Of Washington Techtransfer Invention Licensing Magnetic nanoparticle and method for imaging t cells
US20090258355A1 (en) 2008-04-11 2009-10-15 Brookhaven Science Associates, Llc Nanoscale Clusters and Methods of Making Same
US20110223188A1 (en) 2008-08-25 2011-09-15 Solomon Langermann Targeted costimulatory polypeptides and methods of use to treat cancer
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
WO2010037397A1 (en) 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
WO2010037395A2 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CA2642141A1 (en) 2008-10-20 2010-04-20 Innovative Microelectronics Inc. Flange alignment pin
US9267945B2 (en) 2008-11-12 2016-02-23 Yeda Research And Development Co. Ltd. Diagnosis of multiple sclerosis
WO2010080032A2 (en) 2009-01-09 2010-07-15 Stichting Het Nederlands Kanker Instituut Bead-assisted viral transduction
SG193843A1 (en) 2009-01-20 2013-10-30 Univ Northwestern Compositions and methods for induction of antigen-specific tolerance
GB0922066D0 (en) 2009-12-17 2010-02-03 Univ Belfast Modulator
GB201003088D0 (en) 2010-02-24 2010-04-14 Univ Exeter Method for the preparation of a novel nanoparticle conjugate
EP3235506B1 (en) 2010-07-26 2023-12-06 Qu Biologics Inc. Immunogenic anti-inflammatory compositions
US20130171179A1 (en) 2010-09-03 2013-07-04 Oregon Health & Science University Recombinant t-cell receptor ligands with covalently bound peptides
EP2621523B1 (en) * 2010-09-29 2017-08-09 UTI Limited Partnership Methods for treating autoimmune disease using biocompatible bioabsorbable nanospheres
US9511151B2 (en) * 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
JP6077544B2 (ja) 2011-09-07 2017-02-08 ミダテック リミテッド ナノ粒子−ペプチド組成物
US20140251917A1 (en) 2011-09-22 2014-09-11 Marv Enterprises,LLC Method for the treatment of multiple sclerosis
EP2591801A1 (en) * 2011-11-14 2013-05-15 Universitätsklinikum Hamburg-Eppendorf Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions
US20130128138A1 (en) 2011-11-18 2013-05-23 Shenzhen China Star Optoelectronics Technolog Co., LTD. Flat Panel Display Device, Stereoscopic Display Device, Plasma Display Device
US10758487B2 (en) 2011-12-09 2020-09-01 The Johns Hopkins University Artificial antigen presenting cells having a defined and dynamic shape
US10988516B2 (en) * 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
US20150150996A1 (en) 2012-06-06 2015-06-04 Northwestern University Compositions and methods for antigen-specific tolerance
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
MX2016005822A (es) 2013-11-04 2016-12-02 Uti Limited Partnership Metodos y composiciones para inmunoterpia sostenida.
EA201692512A1 (ru) 2014-06-25 2017-07-31 Селекта Байосайенсиз, Инк. Способы и композиции для лечения синтетическими наноносителями и ингибиторами иммунной контрольной точки
CA2984485A1 (en) 2015-05-06 2016-12-15 Uti Limited Partnership Nanoparticle compositions for sustained therapy
EP3538559A4 (en) 2016-11-09 2020-06-24 UTI Limited Partnership RECOMBINANT PMHC CLASS II MOLECULES

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MX2017014199A (es) 2018-03-28
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US20170095544A1 (en) 2017-04-06
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IL255426A0 (en) 2017-12-31
CO2017011437A2 (es) 2018-01-31
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