HK1250517A1 - 增强功效的car t细胞疗法 - Google Patents

增强功效的car t细胞疗法 Download PDF

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Publication number
HK1250517A1
HK1250517A1 HK18109868.0A HK18109868A HK1250517A1 HK 1250517 A1 HK1250517 A1 HK 1250517A1 HK 18109868 A HK18109868 A HK 18109868A HK 1250517 A1 HK1250517 A1 HK 1250517A1
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Hong Kong
Prior art keywords
car
cell therapies
enhanced efficacy
methods
cells
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HK18109868.0A
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English (en)
Chinese (zh)
Inventor
Frederic Dixon BUSHMAN
Joseph A. FRAIETTA
Carl H. June
Jan J. MELENHORST
Christopher Loren NOBLES
Regina M. YOUNG
Gregory MOTZ
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Novartis Ag
The Trustees Of The University Of Pennsylvania
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Publication of HK1250517A1 publication Critical patent/HK1250517A1/zh

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • A61K35/14—Blood; Artificial blood
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/11—Antigen recognition domain
    • A61K2239/13—Antibody-based
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    • A61K2239/21—Transmembrane domain
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    • A61K2239/22—Intracellular domain
    • A—HUMAN NECESSITIES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2310/00—Structure or type of the nucleic acid
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HK18109868.0A 2015-09-17 2016-09-16 增强功效的car t细胞疗法 HK1250517A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562220196P 2015-09-17 2015-09-17
US62/220,196 2015-09-17
PCT/US2016/052260 WO2017049166A1 (en) 2015-09-17 2016-09-16 Car t cell therapies with enhanced efficacy

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HK1250517A1 true HK1250517A1 (zh) 2018-12-21

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US (2) US20180258149A1 (enExample)
EP (1) EP3350320A1 (enExample)
JP (3) JP7530702B2 (enExample)
KR (1) KR20180051625A (enExample)
CN (1) CN108633287A (enExample)
AU (3) AU2016323985B2 (enExample)
BR (1) BR112018005295A2 (enExample)
CA (1) CA2999070A1 (enExample)
HK (1) HK1250517A1 (enExample)
IL (2) IL297003A (enExample)
MX (2) MX2018003353A (enExample)
MY (1) MY201101A (enExample)
PH (1) PH12018500494A1 (enExample)
SG (1) SG10202110257UA (enExample)
WO (1) WO2017049166A1 (enExample)

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