HK1250371A1 - 具有修饰的脱氧糖胺糖的大环内酯及其用途 - Google Patents

具有修饰的脱氧糖胺糖的大环内酯及其用途 Download PDF

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Publication number
HK1250371A1
HK1250371A1 HK18109724.4A HK18109724A HK1250371A1 HK 1250371 A1 HK1250371 A1 HK 1250371A1 HK 18109724 A HK18109724 A HK 18109724A HK 1250371 A1 HK1250371 A1 HK 1250371A1
Authority
HK
Hong Kong
Prior art keywords
macrolides
inflammatory conditions
membered
sugars
modified
Prior art date
Application number
HK18109724.4A
Other languages
English (en)
Chinese (zh)
Inventor
Andrew G. Myers
Ian Bass SEIPLE
Ziyang Zhang
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of HK1250371A1 publication Critical patent/HK1250371A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK18109724.4A 2015-03-25 2016-03-25 具有修饰的脱氧糖胺糖的大环内酯及其用途 HK1250371A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562138198P 2015-03-25 2015-03-25
US201562138168P 2015-03-25 2015-03-25
US201562138198P 2015-03-25
US201562138168P 2015-03-25
PCT/US2016/024333 WO2016154591A1 (en) 2015-03-25 2016-03-25 Macrolides with modified desosamine sugars and uses thereof

Publications (1)

Publication Number Publication Date
HK1250371A1 true HK1250371A1 (zh) 2018-12-14

Family

ID=56977809

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109724.4A HK1250371A1 (zh) 2015-03-25 2016-03-25 具有修饰的脱氧糖胺糖的大环内酯及其用途

Country Status (7)

Country Link
US (2) US10640528B2 (https=)
EP (1) EP3273969A4 (https=)
JP (1) JP2018509452A (https=)
CN (1) CN107530365A (https=)
CA (1) CA2980315A1 (https=)
HK (1) HK1250371A1 (https=)
WO (1) WO2016154591A1 (https=)

Families Citing this family (6)

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JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
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EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
WO2018201076A2 (en) 2017-04-28 2018-11-01 Macrolide Pharmaceuticals Inc. Macrolides with modified desosamine sugars and uses thereof
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DK3883647T3 (da) * 2018-11-19 2026-03-23 Zikani Therapeutics Inc C10-alkylensubstituerede 13-ledede makrolider og anvendelser deraf

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Also Published As

Publication number Publication date
US20180066008A1 (en) 2018-03-08
CN107530365A (zh) 2018-01-02
US20200377542A1 (en) 2020-12-03
EP3273969A1 (en) 2018-01-31
EP3273969A4 (en) 2018-11-21
US10640528B2 (en) 2020-05-05
CA2980315A1 (en) 2016-09-29
JP2018509452A (ja) 2018-04-05
US11535643B2 (en) 2022-12-27
WO2016154591A1 (en) 2016-09-29

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