CN107530365A - 具有修饰的脱氧糖胺糖的大环内酯及其用途 - Google Patents

具有修饰的脱氧糖胺糖的大环内酯及其用途 Download PDF

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Publication number
CN107530365A
CN107530365A CN201680028253.7A CN201680028253A CN107530365A CN 107530365 A CN107530365 A CN 107530365A CN 201680028253 A CN201680028253 A CN 201680028253A CN 107530365 A CN107530365 A CN 107530365A
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CN
China
Prior art keywords
optionally substituted
compound
alkyl
formula
hydrogen
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Pending
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CN201680028253.7A
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English (en)
Chinese (zh)
Inventor
A.G.迈尔斯
I.B.塞普尔
Z.张
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Harvard University
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Harvard University
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Publication of CN107530365A publication Critical patent/CN107530365A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201680028253.7A 2015-03-25 2016-03-25 具有修饰的脱氧糖胺糖的大环内酯及其用途 Pending CN107530365A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562138168P 2015-03-25 2015-03-25
US201562138198P 2015-03-25 2015-03-25
US62/138,198 2015-03-25
US62/138,168 2015-03-25
PCT/US2016/024333 WO2016154591A1 (en) 2015-03-25 2016-03-25 Macrolides with modified desosamine sugars and uses thereof

Publications (1)

Publication Number Publication Date
CN107530365A true CN107530365A (zh) 2018-01-02

Family

ID=56977809

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680028253.7A Pending CN107530365A (zh) 2015-03-25 2016-03-25 具有修饰的脱氧糖胺糖的大环内酯及其用途

Country Status (7)

Country Link
US (2) US10640528B2 (https=)
EP (1) EP3273969A4 (https=)
JP (1) JP2018509452A (https=)
CN (1) CN107530365A (https=)
CA (1) CA2980315A1 (https=)
HK (1) HK1250371A1 (https=)
WO (1) WO2016154591A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途
CN113646319A (zh) * 2018-11-19 2021-11-12 齐卡尼治疗股份有限公司 C11-环取代的13元大环内酯及其用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof

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WO2014165792A2 (en) * 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use

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Patent Citations (3)

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EP2772254A2 (en) * 2003-03-10 2014-09-03 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
CN102223794A (zh) * 2008-10-24 2011-10-19 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
WO2014165792A2 (en) * 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113573779A (zh) * 2018-11-19 2021-10-29 齐卡尼治疗股份有限公司 C10-亚烷基取代的13元大环内酯及其用途
CN113646319A (zh) * 2018-11-19 2021-11-12 齐卡尼治疗股份有限公司 C11-环取代的13元大环内酯及其用途

Also Published As

Publication number Publication date
WO2016154591A1 (en) 2016-09-29
US10640528B2 (en) 2020-05-05
US20180066008A1 (en) 2018-03-08
US11535643B2 (en) 2022-12-27
HK1250371A1 (zh) 2018-12-14
CA2980315A1 (en) 2016-09-29
US20200377542A1 (en) 2020-12-03
EP3273969A4 (en) 2018-11-21
JP2018509452A (ja) 2018-04-05
EP3273969A1 (en) 2018-01-31

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Application publication date: 20180102