HK1246354A1 - 产生差向异构酶和苄基异喹啉生物碱的方法 - Google Patents

产生差向异构酶和苄基异喹啉生物碱的方法 Download PDF

Info

Publication number
HK1246354A1
HK1246354A1 HK18105781.2A HK18105781A HK1246354A1 HK 1246354 A1 HK1246354 A1 HK 1246354A1 HK 18105781 A HK18105781 A HK 18105781A HK 1246354 A1 HK1246354 A1 HK 1246354A1
Authority
HK
Hong Kong
Prior art keywords
host cell
gene
engineered host
examples
enzyme
Prior art date
Application number
HK18105781.2A
Other languages
English (en)
Chinese (zh)
Inventor
克里斯蒂娜．D.．斯默克
斯蒂芬妮．格兰尼
伊西斯．特伦查德
斯蒂芬妮．格蘭尼
凯瑟琳．托蒂
李嫣然
伊西斯．特倫查德
凱瑟琳．托蒂
Original Assignee
小利兰.斯坦福大学托管委员会
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57248432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1246354(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 小利兰.斯坦福大学托管委员会 filed Critical 小利兰.斯坦福大学托管委员会
Publication of HK1246354A1 publication Critical patent/HK1246354A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01247—Codeinone reductase (NADPH) (1.1.1.247)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/99—Racemaces and epimerases (5.1) acting on other compounds (5.1.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18105781.2A 2015-05-08 2016-05-09 产生差向异构酶和苄基异喹啉生物碱的方法 HK1246354A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562159122P 2015-05-08 2015-05-08
US62/159,122 2015-05-08
US201562174475P 2015-06-11 2015-06-11
US62/174,475 2015-06-11
PCT/US2016/031506 WO2016183023A1 (en) 2015-05-08 2016-05-09 Methods of producing epimerases and benzylisoquinoline alkaloids

Publications (1)

Publication Number Publication Date
HK1246354A1 true HK1246354A1 (zh) 2018-09-07

Family

ID=57248432

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105781.2A HK1246354A1 (zh) 2015-05-08 2016-05-09 产生差向异构酶和苄基异喹啉生物碱的方法

Country Status (12)

Country Link
US (2) US11859225B2 (https=)
EP (2) EP3294865B1 (https=)
JP (3) JP7266966B2 (https=)
CN (1) CN107960102A (https=)
AU (3) AU2016261490B2 (https=)
CA (1) CA2983445A1 (https=)
DK (1) DK3294865T3 (https=)
ES (1) ES2945359T3 (https=)
GB (1) GB2555044B (https=)
HK (1) HK1246354A1 (https=)
IL (1) IL255136B2 (https=)
WO (1) WO2016183023A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP6783655B2 (ja) 2013-12-04 2020-11-11 エピメロン インコーポレイテッドＥｐｉｍｅｒｏｎ Ｉｎｃ． （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法
WO2016081371A1 (en) * 2014-11-17 2016-05-26 The Board Of Trustees Of The Leland Stanford Junior University Noscapinoid-producing microbes and methods of making and using the same
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
AU2017309313B2 (en) * 2016-08-09 2023-11-02 River Stone Biotech, Inc. Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors
EP3577220A2 (en) * 2017-02-06 2019-12-11 Zymergen, Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
WO2019028390A1 (en) * 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
US20200325509A1 (en) * 2017-09-08 2020-10-15 Intrexon Corporation Microorganisms and Methods in the Fermentation of Benzylisoquinoline Alkaloids
WO2019109170A1 (en) * 2017-12-05 2019-06-13 Serturner Corp. Neopinone isomerase and methods of using
WO2019157383A2 (en) * 2018-02-08 2019-08-15 Antheia, Inc. Methods of producing morphinan alkaloids and derivatives
AU2018419533A1 (en) 2018-04-19 2020-11-12 Abbvie Inc. Methods of treating heavy menstrual bleeding
WO2019243624A1 (en) 2018-06-22 2019-12-26 Valorbec, Limited Partnership Production of benzylisoquinoline alkaloids in recombinant hosts
CN109468351B (zh) * 2018-11-27 2020-07-14 湖南美可达生物资源股份有限公司 高效酶催化合成血根碱与白屈菜红碱的方法
CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
WO2020198373A1 (en) * 2019-03-26 2020-10-01 Antheia, Inc. Methods of improving production of morphinan alkaloids and derivatives
CN112516143B (zh) * 2020-11-30 2023-03-21 重庆医科大学 双苄四氢异喹啉衍生物在制备抗冠状病毒药物中的应用
AU2023376563A1 (en) 2022-11-08 2025-05-01 River Stone Biotech Aps Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression
CN116536285B (zh) * 2023-05-26 2024-09-17 浙江中医药大学 一种粉防己乌药碱氮甲基转移酶cnmt及应用
CN119432631A (zh) * 2023-08-04 2025-02-14 陈云 一种重组菌及其在生产苯骈菲啶生物碱中的应用
CN121065117B (zh) * 2025-11-04 2026-01-13 中国水产科学研究院黄海水产研究所 非辅因子依赖性p450bm3突变体及其在降解木质素衍生酚类中的应用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2778832A (en) 1954-06-22 1957-01-22 Merck & Co Inc Reduction of codeinone to codeine
US3785927A (en) 1973-02-12 1974-01-15 Merck & Co Inc Process for converting(-)reticuline to(+)salutaridine
EP0268710B1 (en) 1986-11-25 1991-05-15 Council of Scientific and Industrial Research Improved process for the preparation of codeine from morphine
CA1324969C (en) 1988-05-06 1993-12-07 Jeffrey R. Shuster High level expression of proteins in yeast
GB8910958D0 (en) 1989-05-12 1989-06-28 Bruce Neil C Assay
CS277517B6 (sk) 1990-12-12 1993-02-17 Slovakofarma S P Spósob čistenia kodeinu připraveného metylizáciou morfínu
US6204337B1 (en) 1996-11-19 2001-03-20 The Board Of Regents Of The University And Community College System Of Neveda Solid-phase synthesis of codeine from morphine
AUPO887297A0 (en) 1997-08-29 1997-09-25 Johnson & Johnson Research Pty. Limited Cytochrome p450 reductase from poppy plants
AUPP946399A0 (en) 1999-03-26 1999-04-22 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy
US7045290B2 (en) 2001-02-15 2006-05-16 The University Of Chicago Yeast screens for treatment of human disease
EP1270727A1 (en) 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-O-acetyltransferase and derivatives thereof
DE10232930A1 (de) 2002-07-19 2004-02-05 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen Herstellung von Aminosäuren und Aminosäure-Derivaten der Phosphoglycerat-Familie
US6579985B1 (en) 2002-10-21 2003-06-17 Mallinckrodt Inc. Preparation of codeine from morphine
EP1512748A1 (en) * 2003-09-03 2005-03-09 Johnson & Johnson Research Pty Limited O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum
JPWO2005033305A1 (ja) 2003-09-17 2007-11-29 国立大学法人京都大学 ＲＮＡｉ法を用いた有用アルカロイド生合成中間体の生産法
TWI223707B (en) 2003-12-30 2004-11-11 Univ Nat Yunlin Sci & Tech Drug sensor for the alkaloid measurement, the preparation thereof, and measuring systems comprising the same
US6949645B1 (en) 2004-05-20 2005-09-27 Acura Pharmaceuticals, Inc. Process for the production of opiates
US7482140B2 (en) 2004-06-15 2009-01-27 Ajinomoto Co., Inc. L-tyrosine-producing bacterium and a method for producing L-tyrosine
EP1632565A1 (en) 2004-08-12 2006-03-08 Johnson & Johnson Research Pty Limited Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis
US7531345B2 (en) 2005-05-16 2009-05-12 Massachusetts Institute Of Technology Mutations for enhanced tyrosine production
US8318474B1 (en) 2005-05-23 2012-11-27 California Institute Of Technology Engineered yeast cells and uses thereof
US20070199090A1 (en) 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
EP1837396A1 (en) 2006-03-23 2007-09-26 Institut für Pflanzenbiochemie-IPB Salutaridine reductase and morphine biosynthesis
WO2008067070A2 (en) 2006-10-19 2008-06-05 California Institute Of Technology Compositions and methods for producing benzylisoquinolines alkaloids
US20080102499A1 (en) 2006-10-27 2008-05-01 Lori Jean Templeton Method of enhancing L-tyrosine production in recombinant bacteria
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
EP2169075B1 (en) 2007-06-12 2016-09-14 Kyoto University Method for production of alkaloid
JP2009225669A (ja) 2008-03-19 2009-10-08 Ishikawa Pref Gov 植物ベンジルイソキノリンアルカロイドの生産方法
KR20110014974A (ko) 2008-03-31 2011-02-14 썬 파마슈티컬 인더스트리스 리미티드 모르피난 유사체의 개선된 제조 방법
US8541647B2 (en) 2008-05-29 2013-09-24 Tasmania Alkaloids Pty, Ltd. Papaver somniferum with high concentration of codeine
JP2011525194A (ja) 2008-06-20 2011-09-15 キネメッド， インコーポレイテッド 線維性疾患または病態を治療するための組成物
WO2011058446A2 (en) 2009-11-12 2011-05-19 Uti Limited Partnership Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum
ES2742755T3 (es) 2010-06-22 2020-02-17 Sun Pharmaceutical Industries Australia Pty Ltd Acidos nucleicos y polipéptidos de la metiltransferasa
EP2596012B1 (en) 2010-07-22 2017-12-06 Sun Pharmaceutical Industries (Australia) Pty Limited Plant cytochrome p450
JP5761723B2 (ja) 2010-09-22 2015-08-12 石川県公立大学法人 植物ベンジルイソキノリンアルカロイドの生産方法
US20140013465A1 (en) 2010-11-01 2014-01-09 Tpi Enterprises Ltd. Papaver bracteatum with modified alkaloid content
US20130340119A1 (en) 2010-11-05 2013-12-19 Basf Plant Science Company Gmbh Method for Increasing Yield and Fine Chemical Production in Plants
CN102657652A (zh) 2011-03-10 2012-09-12 李宏 通式ⅰ所述的双苄基异喹啉生物碱衍生物或类似物的新用途
WO2012135389A2 (en) 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
EP2565262A1 (en) 2011-08-31 2013-03-06 VTU Holding GmbH Protein expression
US8809028B2 (en) 2011-11-07 2014-08-19 University Of Georgia Research Foundation, Inc. Biosynthesis of caffeic acid and caffeic acid derivatives by recombinant microorganisms
AR089442A1 (es) 2011-12-27 2014-08-20 Commw Scient Ind Res Org Procesos para producir lipidos
GB201204407D0 (en) 2012-03-13 2012-04-25 Glaxosmithkline Australia Pty Ltd Nucleic acid molecule
DK3553177T3 (da) 2013-03-15 2021-02-15 Univ Leland Stanford Junior Benzylisoquinolinalkaloider (bia) som producerer mikrober, og fremgangsmåder til fremstilling og anvendelse deraf
EP3033347B1 (en) 2013-08-16 2021-10-06 Antheia, Inc. Methods for making noscapine and synthesis intermediates thereof
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP6783655B2 (ja) 2013-12-04 2020-11-11 エピメロン インコーポレイテッドＥｐｉｍｅｒｏｎ Ｉｎｃ． （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法
WO2015103711A1 (en) 2014-01-13 2015-07-16 Valorbec Société en Commandite Method of making a benzylisoquinoline alkaloid (bia) metabolite, enzymes therefore
EP3137618A4 (en) 2014-04-29 2017-12-13 Epimeron Inc. Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
WO2015173590A1 (en) 2014-05-16 2015-11-19 The Unversity Of York Novel cytochrome p450 fusion protein
US10119155B2 (en) 2014-06-19 2018-11-06 Epimeron Inc. Compositions and methods for making (S)-norcoclaurine and (S)-norlaudanosoline, and synthesis intermediates thereof
WO2016026048A1 (en) 2014-08-22 2016-02-25 Epimeron Inc. Compositions and methods for making alkaloid morphinans
US10457918B2 (en) 2014-09-26 2019-10-29 The Regents Of The University Of California Tyrosine hydroxylase variants and methods of use thereof
WO2016081371A1 (en) 2014-11-17 2016-05-26 The Board Of Trustees Of The Leland Stanford Junior University Noscapinoid-producing microbes and methods of making and using the same
WO2016109769A1 (en) 2015-01-02 2016-07-07 Georgia Tech Research Corporation Pterin-dependent biocatalysts and uses thereof
CA3104099A1 (en) 2015-03-10 2016-09-15 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine
WO2016149821A1 (en) 2015-03-23 2016-09-29 Valorbec Société en Commandite Methods of making morphinan alkaloids and enzymes therefore
EP3292203A4 (en) 2015-05-04 2019-10-09 The Board of Trustees of the Leland Stanford Junior University BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof
WO2016179231A1 (en) 2015-05-04 2016-11-10 Board Of Trustees Of Michigan State University Compositions and methods for inhibiting bacterial growth
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
GB201511156D0 (en) 2015-06-24 2015-08-05 Glaxosmithkline Australia Pty Ltd And University Of York Production of alkaloids
IL241462A0 (en) 2015-09-10 2015-11-30 Yeda Res & Dev Heterologous engineering of betalain pigments in plants
WO2017083632A1 (en) 2015-11-13 2017-05-18 President And Fellows Of Harvard College Host cells and systems for membrane protein expression
GB2546285A (en) 2016-01-13 2017-07-19 Sun Pharmaceutical Ind Australia Pty Ltd Modified plant
JP6368328B2 (ja) 2016-02-10 2018-08-01 株式会社豊田自動織機 レジスタおよび車両
EP3475426A4 (en) 2016-06-27 2020-08-19 Serturner Corp. POLYNUCLEOTIDES AND POLYPEPTIDES USEFUL FOR THE MANUFACTURE OF ALKALOID COMPOUNDS
AU2017290594B2 (en) 2016-06-27 2022-02-17 Intrexon Corporation Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
AU2017309313B2 (en) 2016-08-09 2023-11-02 River Stone Biotech, Inc. Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors
CA2941315C (en) 2016-08-12 2018-03-06 Api Labs Inc. High thebaine poppy and methods of producing the same
WO2018039749A1 (en) 2016-09-02 2018-03-08 Tasmanian Alkaloids Pty Ltd P. somniferum plants for the production of codeine
EP3570842A1 (en) 2017-01-19 2019-11-27 Donald Danforth Plant Science Center Morphinan n-demethylase isolated from themethylobacterium
EP3577220A2 (en) 2017-02-06 2019-12-11 Zymergen, Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
EP3652311A1 (en) 2017-07-14 2020-05-20 Chrysea Limited Microbial cells for spermidine production
WO2019157383A2 (en) 2018-02-08 2019-08-15 Antheia, Inc. Methods of producing morphinan alkaloids and derivatives
CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法

Also Published As

Publication number Publication date
BR112017023816A2 (pt) 2018-07-31
EP3294865A1 (en) 2018-03-21
US12497638B2 (en) 2025-12-16
JP7266966B2 (ja) 2023-05-01
US20240218408A1 (en) 2024-07-04
AU2019246920B2 (en) 2022-05-12
EP4253525A3 (en) 2023-10-18
US11859225B2 (en) 2024-01-02
NZ775919A (en) 2025-03-28
EP3294865A4 (en) 2019-06-26
JP2018515093A (ja) 2018-06-14
AU2022215268B2 (en) 2025-04-10
AU2019246920A1 (en) 2019-11-14
KR20180016396A (ko) 2018-02-14
ES2945359T3 (es) 2023-06-30
GB2555044A (en) 2018-04-18
GB201719939D0 (en) 2018-01-17
CN107960102A (zh) 2018-04-24
AU2022215268A1 (en) 2022-09-01
US20180163241A1 (en) 2018-06-14
IL255136B1 (en) 2023-05-01
JP2024038497A (ja) 2024-03-19
CA2983445A1 (en) 2016-11-17
EP3294865B1 (en) 2023-04-12
WO2016183023A1 (en) 2016-11-17
JP2021129587A (ja) 2021-09-09
AU2016261490A1 (en) 2017-11-09
IL255136B2 (en) 2023-09-01
IL255136A0 (en) 2017-12-31
DK3294865T3 (da) 2023-05-08
EP4253525A2 (en) 2023-10-04
GB2555044B (en) 2021-03-17
AU2016261490B2 (en) 2019-10-31

Similar Documents

Publication Publication Date Title
US12497638B2 (en) Methods of producing epimerases and benzylisoquinoline alkaloids
US12180525B2 (en) Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
JP7199417B2 (ja) 遺伝子操作されたベンジルイソキノリンアルカロイドエピメラーゼおよびベンジルイソキノリンアルカロイドの生成方法
JP2021513346A (ja) モルフィナンアルカロイドおよび誘導体を生成する方法
CN107002103B (zh) 产生类诺斯卡品的微生物以及其制备和使用方法
CN116964190A (zh) 提高吗啡喃类生物碱和衍生物的产量的方法
CN114302951A (zh) 提高吗啡喃生物碱和衍生物的产量的方法
KR102960980B1 (ko) 에피머라제 및 벤질아이소퀴놀린 알칼로이드를 제조하는 방법
CN120239749A (zh) 改善吗啡喃生物碱及衍生物的产生的方法
BR112017023816B1 (pt) Método de epimerização de um alcaloide (s)-1-benzilisoquinolina em um alcaloide (r)-1- benzilisoquinolina, dentro de uma célula não vegetal engenheirada
HK1246353B (en) Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same