HK1245793A1 - 作为adamts抑制剂用於治疗骨关节炎的5-[(哌嗪-1-基)-3-氧代-丙基]-咪唑烷-2，4-二酮衍生物 - Google Patents

作为adamts抑制剂用於治疗骨关节炎的5-[(哌嗪-1-基)-3-氧代-丙基]-咪唑烷-2，4-二酮衍生物 Download PDF

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Publication number
HK1245793A1
HK1245793A1 HK18105455.7A HK18105455A HK1245793A1 HK 1245793 A1 HK1245793 A1 HK 1245793A1 HK 18105455 A HK18105455 A HK 18105455A HK 1245793 A1 HK1245793 A1 HK 1245793A1
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HK
Hong Kong
Prior art keywords
methyl
dione
piperazin
imidazolidine
oxo
Prior art date
Application number
HK18105455.7A
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German (de)
English (en)
French (fr)
Other versions
HK1245793B (zh
Inventor
Franck Laurent BREBION
Luke Jonathan ALVEY
David Amantini
Pierre Marc Marie Joseph DEPREZ
Romain Luc Marie Gosmini
Helène Marie JARY
Christophe Peixoto
Marie Laurence Claire VARIN
Frédéric André DE CEUNINCK
Iuliana Ecaterina POP-BOTEZ
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Galapagos Nv
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Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
Priority claimed from PCT/EP2015/080430 external-priority patent/WO2016102347A1/en
Publication of HK1245793A1 publication Critical patent/HK1245793A1/zh
Publication of HK1245793B publication Critical patent/HK1245793B/zh

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HK18105455.7A 2014-12-22 2015-12-18 作为adamts抑制剂用於治疗骨关节炎的5-[(哌嗪-1-基)-3-氧代-丙基]-咪唑烷-2，4-二酮衍生物 HK1245793B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14307129 2014-12-22
EP14307129 2014-12-22
PCT/EP2015/080430 WO2016102347A1 (en) 2014-12-22 2015-12-18 5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as adamts inhibitors for the treatment of osteoarthritis

Publications (2)

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HK1245793A1 true HK1245793A1 (zh) 2018-08-31
HK1245793B HK1245793B (zh) 2020-01-03

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HK18105455.7A HK1245793B (zh) 2014-12-22 2015-12-18 作为adamts抑制剂用於治疗骨关节炎的5-[(哌嗪-1-基)-3-氧代-丙基]-咪唑烷-2，4-二酮衍生物

Country Status (50)

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US (4) US9926281B2 (zh)
EP (2) EP3237406B1 (zh)
JP (2) JP6636539B2 (zh)
KR (1) KR102711990B1 (zh)
CN (1) CN107108579B (zh)
AR (1) AR103170A1 (zh)
AU (1) AU2015371400B2 (zh)
BR (1) BR112017013258B1 (zh)
CA (1) CA2971110C (zh)
CL (1) CL2017001650A1 (zh)
CO (1) CO2017006174A2 (zh)
CR (1) CR20170248A (zh)
CU (1) CU20170085A7 (zh)
CY (1) CY1121692T1 (zh)
DK (1) DK3237406T3 (zh)
DO (1) DOP2017000139A (zh)
EA (1) EA030637B1 (zh)
EC (1) ECSP17046848A (zh)
ES (1) ES2724989T3 (zh)
GE (1) GEP20197043B (zh)
GT (1) GT201700107A (zh)
HK (1) HK1245793B (zh)
HR (1) HRP20190514T1 (zh)
HU (1) HUE042840T2 (zh)
IL (1) IL252981B (zh)
JO (1) JO3501B1 (zh)
LT (1) LT3237406T (zh)
MA (1) MA41238B1 (zh)
MD (1) MD3237406T2 (zh)
ME (1) ME03374B (zh)
MX (1) MX2017008048A (zh)
MY (1) MY189764A (zh)
NI (1) NI201700081A (zh)
NZ (1) NZ732909A (zh)
PE (1) PE20171099A1 (zh)
PH (1) PH12017501160A1 (zh)
PL (1) PL3237406T3 (zh)
PT (1) PT3237406T (zh)
RS (1) RS58617B1 (zh)
RU (1) RU2693459C2 (zh)
SA (1) SA517381743B1 (zh)
SG (1) SG11201705030SA (zh)
SI (1) SI3237406T1 (zh)
TN (1) TN2017000213A1 (zh)
TR (1) TR201904158T4 (zh)
TW (1) TWI687414B (zh)
UA (1) UA122065C2 (zh)
UY (1) UY36470A (zh)
WO (1) WO2016102347A1 (zh)
ZA (1) ZA201703905B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3501B1 (ar) * 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)
GB201610055D0 (en) * 2016-06-09 2016-07-27 Galapagos Nv And Laboratoires Servier Les Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis
GB201610056D0 (en) * 2016-06-09 2016-07-27 Galapagos Nv And Laboratoires Servier Les Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis
CN107652277A (zh) * 2017-08-09 2018-02-02 江苏工程职业技术学院 一种依帕列净的制备方法
CN107540648A (zh) * 2017-08-09 2018-01-05 江苏工程职业技术学院 一种达格列净的制备方法
WO2021011723A1 (en) * 2019-07-18 2021-01-21 Avidence Therapeutics, Inc. Anti-osteoarthritis hydantoin compounds and related compositions and methods
CN115052596B (zh) * 2020-02-04 2024-06-14 江苏恒瑞医药股份有限公司 Adamts抑制剂、其制备方法和医药用途
WO2021204185A1 (zh) * 2020-04-10 2021-10-14 深圳信立泰药业股份有限公司 一种苯并[d]氮杂卓类衍生物蛋白聚糖酶2抑制剂及其制备方法和医药用途
CN113735825B (zh) * 2020-05-27 2024-08-27 成都康弘药业集团股份有限公司 1,2,3,6-四氢吡啶类化合物及其制备方法和用途
CN113754635B (zh) * 2020-06-02 2024-06-21 成都康弘药业集团股份有限公司 稠环类化合物及其制备方法和用途
CN115720578B (zh) * 2020-07-09 2025-06-13 深圳信立泰药业股份有限公司 并三环类衍生物、其制备方法及其在医药上的应用
CN113943255B (zh) * 2020-07-17 2024-08-06 深圳信立泰药业股份有限公司 一种手性3-(4-环丙基-2,5-二氧杂咪唑啉-4-基)丙酸的制备方法
CN116723840A (zh) * 2020-12-15 2023-09-08 加拉帕戈斯股份有限公司 (5s)-环丙基-5-[3-[(3s)-4-(3,5-二氟苯基)-3-甲基-哌嗪-1-基]-3-氧代-丙基]咪唑烷-2,4-二酮的固体形式
WO2022128849A1 (en) 2020-12-15 2022-06-23 Galapagos Nv Solid forms of (5s)-cyclopropyl-5-[3-[(3s)-4-(3,5-difluorophenyl)-3-methyl-piperazin-1-yl]-3-oxo-propyl]imidazolidine-2,4-dione
TW202304886A (zh) * 2021-04-02 2023-02-01 中國大陸商江蘇恒瑞醫藥股份有限公司 Adamts抑制劑的前藥及其製備方法與醫藥用途
TW202321221A (zh) * 2021-08-03 2023-06-01 大陸商江蘇恒瑞醫藥股份有限公司 抑制adamts-5和/或adamts-4功能的化合物的晶型及其製備方法和應用
US20250313558A1 (en) 2023-03-17 2025-10-09 Cellus Inc. Imidazolidine derivative or pharmaceutically acceptable salt thereof, and use thereof

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US4680306A (en) * 1984-07-20 1987-07-14 Pfizer Inc. Sprio-imidazolones for treatment of diabetes complications
US5043447A (en) * 1987-04-24 1991-08-27 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
ATE445400T1 (de) 2001-05-25 2009-10-15 Bristol Myers Squibb Co Hydantion-derivate als hemmer von matrix- metalloproteinasen
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US7504424B2 (en) * 2004-07-16 2009-03-17 Schering Corporation Compounds for the treatment of inflammatory disorders
EP2650310B1 (en) 2012-04-13 2016-06-08 Rottapharm Biotech S.r.l. Anti-ADAMTS-5 antibody, derivatives and uses thereof
AR092971A1 (es) * 2012-10-26 2015-05-06 Lilly Co Eli Inhibidores de agrecanasa
AU2014214325B2 (en) 2013-02-06 2018-06-07 Merck Patent Gmbh Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis
JO3501B1 (ar) 2014-12-22 2020-07-05 Servier Lab مشتقات 5-{(بيبرازين - 1-يل)-3-أوكسو - بروبيل}- إيميدازوليدين-2، 4 - دايون كمثبطات ل adamts لمعالجة هشاشة العظام)

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