HK1243642A1 - Anti-mutant KRAS T cell receptor - Google Patents

Anti-mutant KRAS T cell receptor

Info

Publication number
HK1243642A1
HK1243642A1 HK18103250.9A HK18103250A HK1243642A1 HK 1243642 A1 HK1243642 A1 HK 1243642A1 HK 18103250 A HK18103250 A HK 18103250A HK 1243642 A1 HK1243642 A1 HK 1243642A1
Authority
HK
Hong Kong
Prior art keywords
cell receptors
mutated kras
kras
mutated
receptors
Prior art date
Application number
HK18103250.9A
Other languages
English (en)
Inventor
Qiong J Wang
Zhiya Yu
James C Yang
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201462084654P priority Critical
Priority to US201562171321P priority
Priority to PCT/US2015/062269 priority patent/WO2016085904A1/en
Application filed by Us Health filed Critical Us Health
Publication of HK1243642A1 publication Critical patent/HK1243642A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001164GTPases, e.g. Ras, Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y306/00Hydrolases acting on acid anhydrides (3.6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5152Tumor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
HK18103250.9A 2014-11-26 2018-03-07 Anti-mutant KRAS T cell receptor HK1243642A1 (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201462084654P true 2014-11-26 2014-11-26
US201562171321P true 2015-06-05 2015-06-05
PCT/US2015/062269 WO2016085904A1 (en) 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors

Publications (1)

Publication Number Publication Date
HK1243642A1 true HK1243642A1 (zh) 2018-07-20

Family

ID=54838442

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103250.9A HK1243642A1 (zh) 2014-11-26 2018-03-07 Anti-mutant KRAS T cell receptor

Country Status (16)

Country Link
US (1) US20170304421A1 (zh)
EP (2) EP3666288A1 (zh)
JP (1) JP2017536825A (zh)
KR (1) KR20170099905A (zh)
CN (1) CN107223134A (zh)
AU (2) AU2015353720B2 (zh)
CA (1) CA2968399A1 (zh)
ES (1) ES2784261T3 (zh)
HK (1) HK1243642A1 (zh)
IL (1) IL252258D0 (zh)
MX (1) MX2017006865A (zh)
PL (1) PL3223850T3 (zh)
PT (1) PT3223850T (zh)
SG (2) SG10201913978RA (zh)
SI (1) SI3223850T1 (zh)
WO (1) WO2016085904A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108350059A (zh) 2015-09-15 2018-07-31 美国卫生和人力服务部 识别hla-cw8限制性突变kras的t细胞受体
SG11201900654QA (en) 2016-08-02 2019-02-27 Us Health Anti-kras-g12d t cell receptors
WO2018069871A2 (en) * 2016-10-13 2018-04-19 Sorrento Therapeutics, Inc. Anti-kras binding proteins
CN108395479A (zh) * 2017-02-06 2018-08-14 高军 一种有关kras基因突变的t细胞受体
AU2018266562A1 (en) * 2017-05-12 2019-12-05 Augusta University Research Institute, Inc. Human alpha fetoprotein-specific T cell receptors and uses thereof
CA3076339A1 (en) * 2017-09-20 2019-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted t cell receptors against mutated ras
BR112020011111A2 (pt) * 2017-12-04 2020-11-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services receptores de células t restritos a hla da classe i contra ras mutado
CN110016074A (zh) * 2018-01-08 2019-07-16 中国科学院广州生物医药与健康研究院 Mage-a3人源化t细胞受体
WO2020154275A1 (en) * 2019-01-22 2020-07-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted t cell receptors against ras with g12r mutation
WO2020210202A1 (en) * 2019-04-11 2020-10-15 The Board Of Trustees Of The Leland Stanford Junior University Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer
CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709002B1 (en) * 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
GB2328689A (en) * 1997-08-27 1999-03-03 Norsk Hydro As Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer
NO315238B1 (no) * 1998-05-08 2003-08-04 Gemvax As Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy
US8034334B2 (en) 2002-09-06 2011-10-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
CA2674445C (en) * 2007-01-12 2016-06-07 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Gp100-specific t cell receptors and related materials and methods of use
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
EP2478120B1 (en) * 2009-09-17 2015-09-02 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2012129201A1 (en) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
CN108395479A (zh) * 2017-02-06 2018-08-14 高军 一种有关kras基因突变的t细胞受体

Also Published As

Publication number Publication date
MX2017006865A (es) 2018-01-11
ES2784261T3 (es) 2020-09-23
AU2015353720B2 (en) 2020-02-27
CA2968399A1 (en) 2016-06-02
US20170304421A1 (en) 2017-10-26
SG11201704155UA (en) 2017-06-29
IL252258D0 (en) 2017-07-31
PT3223850T (pt) 2020-04-13
CN107223134A (zh) 2017-09-29
AU2020203465A1 (en) 2020-06-18
JP2017536825A (ja) 2017-12-14
PL3223850T3 (pl) 2020-08-24
KR20170099905A (ko) 2017-09-01
AU2015353720A1 (en) 2017-06-08
EP3223850B1 (en) 2020-01-08
EP3666288A1 (en) 2020-06-17
SG10201913978RA (en) 2020-03-30
SI3223850T1 (sl) 2020-09-30
EP3223850A1 (en) 2017-10-04
WO2016085904A1 (en) 2016-06-02

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