CN112646024B - 一种识别kras突变的t细胞受体及其编码序列 - Google Patents
一种识别kras突变的t细胞受体及其编码序列 Download PDFInfo
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Abstract
Description
Claims (36)
Priority Applications (10)
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CN201910960523.3A CN112646024B (zh) | 2019-10-10 | 2019-10-10 | 一种识别kras突变的t细胞受体及其编码序列 |
BR112022006943A BR112022006943A2 (pt) | 2019-10-10 | 2020-10-10 | Receptor de célula t que reconhece mutação de kras e sequência de codificação da mesma |
PCT/CN2020/120191 WO2021068938A1 (zh) | 2019-10-10 | 2020-10-10 | 一种识别kras突变的t细胞受体及其编码序列 |
EP20875414.3A EP4043486A4 (en) | 2019-10-10 | 2020-10-10 | T CELL RECEPTOR RECOGNIZING KRAS MUTATION AND ASSOCIATED CODING SEQUENCE |
JP2022521508A JP2022551514A (ja) | 2019-10-10 | 2020-10-10 | Kras突然変異を識別するt細胞受容体およびそのコード配列 |
CA3154224A CA3154224A1 (en) | 2019-10-10 | 2020-10-10 | T cell receptor recognising kras mutation and encoding sequence thereof |
KR1020227015618A KR20220079645A (ko) | 2019-10-10 | 2020-10-10 | Kras 돌연변이를 식별하는 t 세포 수용체 및 그 코딩서열 |
US17/767,695 US20230159613A1 (en) | 2019-10-10 | 2020-10-10 | T cell receptor recognising kras mutation and encoding sequence thereof |
AU2020363138A AU2020363138B2 (en) | 2019-10-10 | 2020-10-10 | T cell receptor recognising KRAS mutation and encoding sequence thereof |
TW109135145A TW202115109A (zh) | 2019-10-10 | 2020-10-12 | 一種識別kras突變的t細胞受體及其編碼序列 |
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CN201910960523.3A CN112646024B (zh) | 2019-10-10 | 2019-10-10 | 一种识别kras突变的t细胞受体及其编码序列 |
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CN112646024A CN112646024A (zh) | 2021-04-13 |
CN112646024B true CN112646024B (zh) | 2023-03-24 |
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EP (1) | EP4043486A4 (zh) |
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KR (1) | KR20220079645A (zh) |
CN (1) | CN112646024B (zh) |
AU (1) | AU2020363138B2 (zh) |
BR (1) | BR112022006943A2 (zh) |
CA (1) | CA3154224A1 (zh) |
TW (1) | TW202115109A (zh) |
WO (1) | WO2021068938A1 (zh) |
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CN113631172A (zh) * | 2019-01-25 | 2021-11-09 | 宾夕法尼亚大学理事会 | 用于靶向突变型ras的组合物和方法 |
KR20230101283A (ko) * | 2021-12-29 | 2023-07-06 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
KR20230101287A (ko) * | 2021-12-29 | 2023-07-06 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
KR20230101286A (ko) * | 2021-12-29 | 2023-07-06 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
KR20230101284A (ko) * | 2021-12-29 | 2023-07-06 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
KR20230101285A (ko) * | 2021-12-29 | 2023-07-06 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
CN114835800B (zh) * | 2022-05-27 | 2023-10-13 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
CN117264043B (zh) * | 2022-06-14 | 2024-05-10 | 上海镔铁生物科技有限责任公司 | 靶向kras g12v突变多肽的t细胞受体及其用途 |
CN117430689A (zh) * | 2022-11-04 | 2024-01-23 | 新景智源生物科技(苏州)有限公司 | Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞 |
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GB0511124D0 (en) * | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
NZ715815A (en) | 2013-06-26 | 2017-02-24 | Guangzhou Xiangxue Pharmaceutical Co Ltd | High-stability t-cell receptor and preparation method and application thereof |
EP4286407A3 (en) * | 2014-11-26 | 2024-03-06 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-mutated kras t cell receptors |
CN108395479B (zh) * | 2017-02-06 | 2021-07-16 | 高军 | 一种有关kras基因突变的t细胞受体 |
US11466071B2 (en) * | 2017-12-04 | 2022-10-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HLA class I-restricted t cell receptors against mutated RAS |
CN110272482B (zh) * | 2018-03-14 | 2022-08-19 | 中国科学院广州生物医药与健康研究院 | 识别prame抗原短肽的t细胞受体 |
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