HK1219761A1 - 基於限制酶斷片的分子標記的高通量檢測 - Google Patents

基於限制酶斷片的分子標記的高通量檢測

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Publication number
HK1219761A1
HK1219761A1 HK16107675.9A HK16107675A HK1219761A1 HK 1219761 A1 HK1219761 A1 HK 1219761A1 HK 16107675 A HK16107675 A HK 16107675A HK 1219761 A1 HK1219761 A1 HK 1219761A1
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HK
Hong Kong
Prior art keywords
high throughput
molecular markers
restriction fragments
markers based
throughput detection
Prior art date
Application number
HK16107675.9A
Other languages
English (en)
Inventor
Eijk Michael Josephus Theresia Van
Ren Cornelis Josephus Hogers
Original Assignee
Keygene Nv
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Publication date
Application filed by Keygene Nv filed Critical Keygene Nv
Publication of HK1219761A1 publication Critical patent/HK1219761A1/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK16107675.9A 2006-04-04 2016-07-01 基於限制酶斷片的分子標記的高通量檢測 HK1219761A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78870606P 2006-04-04 2006-04-04
US88005207P 2007-01-12 2007-01-12

Publications (1)

Publication Number Publication Date
HK1219761A1 true HK1219761A1 (zh) 2017-04-13

Family

ID=38508899

Family Applications (2)

Application Number Title Priority Date Filing Date
HK16107675.9A HK1219761A1 (zh) 2006-04-04 2016-07-01 基於限制酶斷片的分子標記的高通量檢測
HK18103703.2A HK1244301A1 (zh) 2006-04-04 2018-03-16 基於aflp和高突變序列的高通量檢測分子標記

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK18103703.2A HK1244301A1 (zh) 2006-04-04 2018-03-16 基於aflp和高突變序列的高通量檢測分子標記

Country Status (9)

Country Link
US (6) US20090253581A1 (zh)
EP (3) EP2963127B1 (zh)
JP (2) JP5389638B2 (zh)
DK (2) DK2002017T3 (zh)
ES (3) ES2645661T3 (zh)
HK (2) HK1219761A1 (zh)
PL (1) PL2963127T3 (zh)
PT (1) PT2963127T (zh)
WO (1) WO2007114693A2 (zh)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006122215A2 (en) 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
ATE557105T1 (de) 2005-06-23 2012-05-15 Keygene Nv Strategien für eine hohe durchsatzidentifikation und erkennung von polymorphismen
DK1929039T4 (en) 2005-09-29 2014-02-17 Keygene Nv High throughput-screening af mutageniserede populationer
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
ES2882401T3 (es) 2005-12-22 2021-12-01 Keygene Nv Método de detección de polimorfismos basado en AFLP de alto rendimiento
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
GB2477439B (en) * 2008-11-07 2012-02-15 Sequenta Inc Methods for correlating clonotypes with a disease in a patient
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
ES2568509T3 (es) 2009-01-15 2016-04-29 Adaptive Biotechnologies Corporation Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
JP5843614B2 (ja) * 2009-01-30 2016-01-13 オックスフォード ナノポア テクノロジーズ リミテッド 膜貫通配列決定における核酸構築物のためのアダプター
GB2472371B (en) * 2009-04-24 2011-10-26 Selectamark Security Systems Plc Synthetic nucleotide containing compositions for use in security marking of property and/or for marking a thief or attacker
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2248914A1 (en) * 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
RU2014144463A (ru) 2009-06-25 2015-06-20 Фред Хатчинсон Кансэр Рисёч Сентер Способ измерения адаптивного иммунитета
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
PL2556171T3 (pl) 2010-04-05 2016-04-29 Prognosys Biosciences Inc Oznaczenia biologiczne kodowane przestrzennie
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US8766054B2 (en) 2010-12-08 2014-07-01 Hm.Clause Phytophthora resistance in sweet peppers
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
AU2012288629B2 (en) 2011-07-25 2017-02-02 Oxford Nanopore Technologies Limited Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
ES2683037T3 (es) 2011-12-09 2018-09-24 Adaptive Biotechnologies Corporation Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US20130184165A1 (en) 2012-01-13 2013-07-18 Data2Bio Genotyping by next-generation sequencing
PT3363901T (pt) 2012-02-17 2021-01-22 Hutchinson Fred Cancer Res Composições e métodos para identificar mutações com precisão
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
EP4234713A3 (en) 2012-03-20 2024-02-14 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US9150905B2 (en) 2012-05-08 2015-10-06 Adaptive Biotechnologies Corporation Compositions and method for measuring and calibrating amplification bias in multiplexed PCR reactions
CN105189779B (zh) 2012-10-01 2018-05-11 适应生物技术公司 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
WO2014135838A1 (en) 2013-03-08 2014-09-12 Oxford Nanopore Technologies Limited Enzyme stalling method
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
AU2015339191A1 (en) 2014-10-29 2017-05-18 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
WO2016086029A1 (en) 2014-11-25 2016-06-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
AU2016222788B2 (en) 2015-02-24 2022-03-31 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining HLA status using immune repertoire sequencing
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
ES2955916T3 (es) 2015-04-10 2023-12-11 Spatial Transcriptomics Ab Análisis múltiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos
US11332784B2 (en) 2015-12-08 2022-05-17 Twinstrand Biosciences, Inc. Adapters, methods, and compositions for duplex sequencing
CN105441572B (zh) * 2016-01-07 2019-10-22 南京中医药大学 鉴别当归早薹的dna分子标记及其应用
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
JP6515884B2 (ja) 2016-06-29 2019-05-22 トヨタ自動車株式会社 Dnaプローブの作製方法及びdnaプローブを用いたゲノムdna解析方法
JP7343264B2 (ja) 2016-06-29 2023-09-12 トヨタ自動車株式会社 Dnaライブラリーの作製方法及びdnaライブラリーを用いたゲノムdna解析方法
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018175798A1 (en) * 2017-03-24 2018-09-27 Life Technologies Corporation Polynucleotide adapters and methods of use thereof
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
JP7056012B2 (ja) 2017-05-19 2022-04-19 トヨタ自動車株式会社 ランダムプライマーセット、及びこれを用いたdnaライブラリーの作製方法
SG11202003885UA (en) 2017-11-08 2020-05-28 Twinstrand Biosciences Inc Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
JP7047373B2 (ja) 2017-12-25 2022-04-05 トヨタ自動車株式会社 次世代シーケンサー用プライマー並びにその製造方法、次世代シーケンサー用プライマーを用いたdnaライブラリー並びにその製造方法、及びdnaライブラリーを用いたゲノムdna解析方法
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
WO2020014693A1 (en) 2018-07-12 2020-01-16 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
EP3894592A2 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Generating spatial arrays with gradients
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4025711A2 (en) 2019-11-08 2022-07-13 10X Genomics, Inc. Enhancing specificity of analyte binding
JP2023505712A (ja) 2019-12-12 2023-02-10 キージーン ナムローゼ フェンノートシャップ 半固体状態での核酸操作
JP2023506631A (ja) 2019-12-20 2023-02-17 キージーン ナムローゼ フェンノートシャップ 共有結合で閉端された核酸分子末端を使用したngsライブラリー調製
EP3891300B1 (en) 2019-12-23 2023-03-29 10X Genomics, Inc. Methods for spatial analysis using rna-templated ligation
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
CN111304341A (zh) * 2020-04-10 2020-06-19 西北民族大学 一种鉴定食品中猪源性成分的pcr-aflp方法
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4158054A1 (en) 2020-06-02 2023-04-05 10X Genomics, Inc. Spatial transcriptomics for antigen-receptors
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
EP4162074B1 (en) 2020-06-08 2024-04-24 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
EP4165207A1 (en) 2020-06-10 2023-04-19 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
CN116034166A (zh) 2020-06-25 2023-04-28 10X基因组学有限公司 Dna甲基化的空间分析
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
EP4301870A1 (en) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0456721A4 (en) 1989-01-31 1992-06-03 University Of Miami Microdissection and amplification of chromosomal dna
CZ291877B6 (cs) 1991-09-24 2003-06-18 Keygene N.V. Způsob amplifikace přinejmenším jednoho restrikčního fragmentu z výchozí DNA a způsob přípravy sestavy amplifikovaných restrikčních fragmentů
US20100267023A1 (en) * 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
WO1995019697A1 (en) 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
DE69507646T2 (de) * 1994-11-28 1999-09-16 Du Pont Mikrosatelliteverbindung für detektion genetisches polymorphismen
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
AU6024598A (en) * 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
DE69801749T2 (de) 1997-05-13 2002-07-04 Azign Bioscience As Kopenhagen Eine methode zum klonieren von mrna und darstellung von differentiell exprimierten transcripten (dodet)
EP0930370B1 (en) 1997-12-15 2007-08-08 CSL Behring GmbH Labeled primer for use in detection of target nucleic acids
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
ATE244771T1 (de) 1998-07-29 2003-07-15 Keygene Nv Verfahren zur erkennung von nukleinsäuremethylierungen durch aflp
EP1105529B2 (en) 1998-07-30 2013-05-29 Illumina Cambridge Limited Arrayed biomolecules and their use in sequencing
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
JP2002528096A (ja) 1998-10-27 2002-09-03 アフィメトリックス インコーポレイテッド ゲノムdnaの複雑性制御および分析
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
EP1131153A1 (en) 1998-11-06 2001-09-12 Solexa Ltd. A method for reproducing molecular arrays
WO2000040755A2 (en) 1999-01-06 2000-07-13 Cornell Research Foundation, Inc. Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
WO2000058507A1 (en) 1999-03-30 2000-10-05 Solexa Ltd. Polynucleotide sequencing
EP1190092A2 (en) * 1999-04-06 2002-03-27 Yale University Fixed address analysis of sequence tags
WO2000061801A2 (en) 1999-04-09 2000-10-19 Keygene N.V. METHOD FOR THE DETECTION AND/OR ANALYSIS, BY MEANS OF PRIMER EXTENSION TECHNIQUES, OF SINGLE NUCLEOTIDE POLYMORPHISMS IN RESTRICTION FRAGMENTS, IN PARTICULAR IN AMPLIFIED RESTRICTION FRAGMENTS GENERATED USING AFLP$m(3)
US20020119448A1 (en) 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
AU7712400A (en) 1999-09-23 2001-04-24 Gene Logic, Inc. Indexing populations
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
WO2001038572A1 (fr) 1999-11-19 2001-05-31 Takara Bio Inc. Methode d'amplification d'acides nucleiques
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
WO2001075167A1 (en) 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
EP1282729A2 (en) 2000-05-15 2003-02-12 Keygene N.V. Microsatellite-aflp
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
JP4287652B2 (ja) 2000-10-24 2009-07-01 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ ゲノムdnaの直接多重処理による性状分析
DE60222628T2 (de) 2001-01-30 2008-07-17 Solexa Ltd., Saffron Walden Herstellung von matrizen aus polynukleotiden
US20040053236A1 (en) * 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002086163A1 (en) 2001-04-20 2002-10-31 Karolinska Innovations Ab Methods for high throughput genome analysis using restriction site tagged microarrays
US20050009022A1 (en) 2001-07-06 2005-01-13 Weiner Michael P. Method for isolation of independent, parallel chemical micro-reactions using a porous filter
GB0119719D0 (en) 2001-08-13 2001-10-03 Solexa Ltd DNA sequence analysis
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US20040086912A1 (en) * 2002-06-21 2004-05-06 Shujun Luo Method for detecting foreign DNA in a host Genome
HUE032483T2 (en) 2002-08-23 2017-09-28 Illumina Cambridge Ltd Marked nucleotides
JP2006509040A (ja) 2002-08-23 2006-03-16 ソレックサ リミテッド 修飾されたヌクレオチド
ATE358182T1 (de) 2002-09-05 2007-04-15 Plant Bioscience Ltd Genomteilung
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
WO2004050915A1 (en) 2002-12-02 2004-06-17 Solexa Limited Determination of methylation of nucleic acid sequences
WO2004057017A2 (en) 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
JP2004208586A (ja) 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Hlaの検出
JP4690307B2 (ja) 2003-01-10 2011-06-01 ケイヘーネ・エヌ・ブイ 物理的および遺伝的地図を統合するためのaflpに基づいた方法
EP2159285B1 (en) 2003-01-29 2012-09-26 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
GB0304371D0 (en) 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
JP4691014B2 (ja) 2003-02-26 2011-06-01 カリダ ゲノミクス,インコーポレーテッド ハイブリダイゼーションによるランダムアレイdna分析
JP4888876B2 (ja) 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
GB0320059D0 (en) 2003-08-27 2003-10-01 Solexa Ltd A method of sequencing
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
BRPI0415468A (pt) 2003-10-24 2007-03-27 Mmi Genomics Inc métodos e sistemas para inferir caracterìsticas para controlar criação não de gado
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
EP3673986A1 (en) * 2004-01-07 2020-07-01 Illumina Cambridge Limited Improvements in or relating to molecular arrays
GB0400584D0 (en) 2004-01-12 2004-02-11 Solexa Ltd Nucleic acid chacterisation
GB0400974D0 (en) 2004-01-16 2004-02-18 Solexa Ltd Multiple inexact matching
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
GB0402895D0 (en) 2004-02-10 2004-03-17 Solexa Ltd Arrayed polynucleotides
ATE451478T1 (de) 2004-02-12 2009-12-15 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
EP1721014B1 (en) 2004-02-18 2013-07-17 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (en) 2004-03-12 2005-09-14 Plant Research International B.V. Method for selective amplification of DNA fragments for genetic fingerprinting
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006122215A2 (en) 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
ATE557105T1 (de) 2005-06-23 2012-05-15 Keygene Nv Strategien für eine hohe durchsatzidentifikation und erkennung von polymorphismen
CA2613248A1 (en) 2005-06-23 2006-12-28 Keygene N.V. Improved strategies for sequencing complex genomes using high throughput sequencing technologies
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
DK1929039T4 (en) 2005-09-29 2014-02-17 Keygene Nv High throughput-screening af mutageniserede populationer
ES2422288T3 (es) 2005-11-14 2013-09-10 Keygene Nv Método para el cribado ultrarrápido de poblaciones de transposón etiquetado e identificación masiva de la secuencia en paralelo de los sitios de inserción
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting

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