HK1216310A1 - 脂質合成的雜環調節劑 - Google Patents
脂質合成的雜環調節劑Info
- Publication number
- HK1216310A1 HK1216310A1 HK16104111.8A HK16104111A HK1216310A1 HK 1216310 A1 HK1216310 A1 HK 1216310A1 HK 16104111 A HK16104111 A HK 16104111A HK 1216310 A1 HK1216310 A1 HK 1216310A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lipid synthesis
- heterocyclic modulators
- modulators
- heterocyclic
- lipid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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US201161450561P | 2011-03-08 | 2011-03-08 | |
US201161450482P | 2011-03-08 | 2011-03-08 | |
US201161508611P | 2011-07-16 | 2011-07-16 | |
US201261585642P | 2012-01-11 | 2012-01-11 |
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US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
KR102071095B1 (ko) | 2012-07-03 | 2020-01-29 | 3-브이 바이오사이언시스, 인코포레이티드 | 지질 합성의 헤테로사이클릭 조절인자 |
AR092211A1 (es) * | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
SG11201504740UA (en) * | 2012-12-27 | 2015-07-30 | Univ Drexel | Novel antiviral agents against hbv infection |
JP2016511761A (ja) * | 2013-02-14 | 2016-04-21 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 4−ピペリジン−4−イル−ベンゼン−1,3−ジオール及びその塩の合成方法、並びに新規化合物tert−ブチル4−(2,4−ジヒドロキシ−フェニル)−4−ヒドロキシ−ピペリジン−1−カルボキシレート |
EP2964635B1 (en) * | 2013-03-06 | 2018-05-02 | F.Hoffmann-La Roche Ag | Antiviral compounds |
RS59411B1 (sr) | 2013-03-13 | 2019-11-29 | Forma Therapeutics Inc | Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodna jedinjenja kao inhibitori sintaze masnih kiselina (fasn) za lečenje kancera |
CN106061963B (zh) * | 2013-12-20 | 2019-10-22 | 3-V生物科学股份有限公司 | 脂质合成的杂环调节剂和其组合 |
MX2016008841A (es) | 2014-01-07 | 2016-10-13 | 3-V Biosciences Inc | Moduladores heterociclicos de la sintesis de lipidos para su uso contra el cancer e infecciones virales. |
CN104774204A (zh) * | 2014-01-15 | 2015-07-15 | 鲁南贝特制药有限公司 | 一种制备奈韦拉平及其中间体的方法 |
WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
WO2016025816A1 (en) * | 2014-08-15 | 2016-02-18 | 3-V Biosciences, Inc. | Fatty acid synthase inhibitor for use in the treatment of drug resistant cancer |
JP6758314B2 (ja) | 2015-03-19 | 2020-09-23 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式調節因子 |
CN105175277B (zh) * | 2015-05-18 | 2018-04-03 | 中山大学肿瘤防治中心 | 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用 |
ES2849951T3 (es) | 2015-06-18 | 2021-08-24 | 89Bio Ltd | Derivados de piperidina 4-bencil y 4-benzoil sustituidos |
PE20180572A1 (es) | 2015-06-18 | 2018-04-04 | Cephalon Inc | Derivados de piperidina 1,4-sustituidos |
MX2018002732A (es) * | 2015-09-04 | 2018-04-13 | Poli Elena | Composicion y dispositivo medico que comprenden acido acetilsalicilico para el tratamiento de infecciones cutaneas por virus de papiloma humano. |
AU2017356214B2 (en) * | 2016-11-11 | 2023-11-23 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
CN107043347B (zh) * | 2016-11-18 | 2019-07-02 | 泰州禾益新材料科技有限公司 | 一种阿加曲班中间体(2r,4r)-4-甲基哌啶-2-甲酸乙酯的合成方法 |
CN108456005B (zh) * | 2018-04-20 | 2021-04-27 | 郑州大学 | 石墨抗氧化涂层 |
CN109212056B (zh) * | 2018-08-19 | 2021-05-07 | 丁立平 | 一种测定水源水中三种痕量单卤代甲基苯甲酸的气相色谱-质谱联用法 |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
WO2021229533A1 (en) * | 2020-05-14 | 2021-11-18 | Palani Llc | A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections |
CN114469945A (zh) * | 2020-10-28 | 2022-05-13 | 歌礼生物科技(杭州)有限公司 | 脂肪酸合酶抑制剂的用途和药物组合物 |
CN113584044A (zh) * | 2021-08-28 | 2021-11-02 | 青岛农业大学 | 一种牙鲆socs3基因及其真核表达载体、表达系统和异源表达方法 |
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