HK1205524A1 - Engineered conformationally-stabilized proteins - Google Patents

Engineered conformationally-stabilized proteins

Info

Publication number
HK1205524A1
HK1205524A1 HK15106163.1A HK15106163A HK1205524A1 HK 1205524 A1 HK1205524 A1 HK 1205524A1 HK 15106163 A HK15106163 A HK 15106163A HK 1205524 A1 HK1205524 A1 HK 1205524A1
Authority
HK
Hong Kong
Prior art keywords
conformationally
engineered
stabilized proteins
stabilized
proteins
Prior art date
Application number
HK15106163.1A
Other languages
English (en)
Chinese (zh)
Inventor
Jacob E Corn
Yingnan Zhang
Aaron H Phillips
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1205524A1 publication Critical patent/HK1205524A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK15106163.1A 2012-03-16 2015-06-29 Engineered conformationally-stabilized proteins HK1205524A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261612228P 2012-03-16 2012-03-16
PCT/US2012/043177 WO2013137920A1 (en) 2012-03-16 2012-06-19 Engineered conformationally-stabilized proteins

Publications (1)

Publication Number Publication Date
HK1205524A1 true HK1205524A1 (en) 2015-12-18

Family

ID=49161640

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106163.1A HK1205524A1 (en) 2012-03-16 2015-06-29 Engineered conformationally-stabilized proteins

Country Status (9)

Country Link
EP (1) EP2825549B1 (es)
JP (1) JP6198807B2 (es)
KR (1) KR20140142293A (es)
CN (1) CN104254541A (es)
CA (1) CA2866835A1 (es)
HK (1) HK1205524A1 (es)
MX (1) MX2014010943A (es)
RU (1) RU2014141617A (es)
WO (1) WO2013137920A1 (es)

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KR102282107B1 (ko) * 2017-08-08 2021-07-26 차의과학대학교 산학협력단 효모 이중 혼성 스크리닝을 위한 벡터 라이브러리 및 이를 이용한 표적 단백질에 결합하는 탈유비퀴틴화 효소의 동정방법
CN112135904A (zh) 2018-01-03 2020-12-25 帕利昂制药有限公司 重组人唾液酸酶、唾液酸酶融合蛋白及其使用方法
KR20190135393A (ko) * 2018-05-28 2019-12-06 주식회사 원진바이오테크놀로지 폴리유비퀴틴 스캐폴드에 결합된 생체분자들의 선형 멀티머 중합체 및 이의 용도
KR102181377B1 (ko) * 2019-09-11 2020-11-20 한국과학기술연구원 유비퀴틴 특이적 프로테아제 및 임포틴알파 단백질 복합체의 3차원 결정구조 및 이의 결정화 방법
BR112022010445A2 (pt) * 2019-11-27 2022-09-06 Onegene Biotechnology Inc Polímero biomolecular multifuncional, multiespecífico, multimérico , método para preparar um polímero biomolecular multifuncional, multiespecífico, multimérico
KR20210134245A (ko) * 2020-04-29 2021-11-09 주식회사 원진바이오테크놀로지 신규한 단백질 결합체, 및 이의 비알콜성 지방간염, 비만 및 당뇨 질환의 예방 또는 치료 용도
JP2023521933A (ja) * 2020-06-01 2023-05-25 エー－アルファ バイオ，インコーポレイテッド タンパク質間相互作用を特徴付け、且つ遺伝子操作する方法
CN115803047A (zh) * 2020-07-03 2023-03-14 帕利昂制药有限公司 具有降低的蛋白酶敏感性的重组唾液酸酶、唾液酸酶融合蛋白及其使用方法

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Also Published As

Publication number Publication date
JP6198807B2 (ja) 2017-09-20
JP2015520730A (ja) 2015-07-23
MX2014010943A (es) 2014-11-26
RU2014141617A (ru) 2016-05-10
EP2825549A1 (en) 2015-01-21
EP2825549A4 (en) 2016-01-27
CN104254541A (zh) 2014-12-31
KR20140142293A (ko) 2014-12-11
WO2013137920A1 (en) 2013-09-19
EP2825549B1 (en) 2018-10-10
CA2866835A1 (en) 2013-09-19

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