HK1203350A1 - 軸突變性的調節 - Google Patents
軸突變性的調節Info
- Publication number
- HK1203350A1 HK1203350A1 HK15102710.8A HK15102710A HK1203350A1 HK 1203350 A1 HK1203350 A1 HK 1203350A1 HK 15102710 A HK15102710 A HK 15102710A HK 1203350 A1 HK1203350 A1 HK 1203350A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- modulation
- axon degeneration
- axon
- degeneration
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11025—Mitogen-activated protein kinase kinase kinase (2.7.11.25), i.e. MAPKKK or MAP3K
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25419009P | 2009-10-22 | 2009-10-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203350A1 true HK1203350A1 (zh) | 2015-10-30 |
Family
ID=43900692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102710.8A HK1203350A1 (zh) | 2009-10-22 | 2012-12-05 | 軸突變性的調節 |
Country Status (14)
Country | Link |
---|---|
US (3) | US20120328609A1 (zh) |
EP (2) | EP2490698A4 (zh) |
JP (2) | JP2013508401A (zh) |
KR (1) | KR20120102642A (zh) |
CN (2) | CN102573855A (zh) |
AU (1) | AU2010310589A1 (zh) |
BR (1) | BR112012009257A2 (zh) |
CA (1) | CA2778483A1 (zh) |
HK (1) | HK1203350A1 (zh) |
IL (1) | IL219232A0 (zh) |
MX (1) | MX2012004638A (zh) |
RU (1) | RU2012120783A (zh) |
SG (1) | SG10201406763WA (zh) |
WO (1) | WO2011050192A1 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
WO2012112674A2 (en) | 2011-02-15 | 2012-08-23 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
WO2013134766A2 (en) * | 2012-03-09 | 2013-09-12 | The Johns Hopkins University | Identification of molecular pathways and methods of use thereof for treating retinal neurodegeneration and other neurodegenerative disorders |
RU2014148732A (ru) | 2012-05-22 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные дипиридиламины и их применение |
WO2013177367A2 (en) | 2012-05-23 | 2013-11-28 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
CN104387391A (zh) * | 2013-01-18 | 2015-03-04 | 韩冰 | 一种蛋白酶抑制剂及其制备方法和用途 |
CA2896187A1 (en) | 2013-01-18 | 2014-07-24 | F. Hoffmann-La Roche Ag | 3-substituted pyrazoles and use as dlk inhibitors |
CN104370925A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
CN104370926A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类具有神经保护作用的化合物及其制备方法和用途 |
CN104370880A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
WO2014134349A1 (en) * | 2013-02-28 | 2014-09-04 | Genentech, Inc. | Methods of modulating dlk stability |
CA2907912A1 (en) * | 2013-05-01 | 2014-11-06 | F. Hoffmann-La Roche Ag | C-linked heterocycloalkyl substituted pyrimidines and their uses |
MY182082A (en) | 2013-05-01 | 2021-01-18 | Hoffmann La Roche | Biheteroaryl compounds and uses thereof |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
JP2016523274A (ja) | 2013-06-26 | 2016-08-08 | ザイジェン インフラメーション リミテッド | 種々の疾患を処置するためのjnkシグナル伝達経路の新規の細胞透過性ペプチド阻害剤の使用 |
MX2016008110A (es) * | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
EP3268373B1 (en) | 2015-03-09 | 2022-04-27 | F. Hoffmann-La Roche AG | Tricyclic dlk inhibitors and uses thereof |
GB201516905D0 (en) * | 2015-09-24 | 2015-11-11 | Stratified Medical Ltd | Treatment of Neurodegenerative diseases |
WO2019023650A1 (en) * | 2017-07-28 | 2019-01-31 | Duke University | COMPOSITIONS AND METHODS FOR PROMOTING REGENERATION OF HEMATOPOIETIC STEM CELLS |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN114748622A (zh) | 2017-10-05 | 2022-07-15 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
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2010
- 2010-10-21 CN CN2010800475388A patent/CN102573855A/zh active Pending
- 2010-10-21 BR BR112012009257A patent/BR112012009257A2/pt not_active IP Right Cessation
- 2010-10-21 WO PCT/US2010/053596 patent/WO2011050192A1/en active Application Filing
- 2010-10-21 KR KR1020127013025A patent/KR20120102642A/ko not_active Application Discontinuation
- 2010-10-21 CA CA2778483A patent/CA2778483A1/en not_active Abandoned
- 2010-10-21 EP EP10825693.4A patent/EP2490698A4/en not_active Withdrawn
- 2010-10-21 RU RU2012120783/15A patent/RU2012120783A/ru not_active Application Discontinuation
- 2010-10-21 JP JP2012535378A patent/JP2013508401A/ja active Pending
- 2010-10-21 AU AU2010310589A patent/AU2010310589A1/en not_active Abandoned
- 2010-10-21 CN CN201410255391.1A patent/CN104043126A/zh active Pending
- 2010-10-21 EP EP15189899.6A patent/EP3011970A3/en not_active Withdrawn
- 2010-10-21 MX MX2012004638A patent/MX2012004638A/es not_active Application Discontinuation
- 2010-10-21 SG SG10201406763WA patent/SG10201406763WA/en unknown
- 2010-10-21 US US13/503,101 patent/US20120328609A1/en not_active Abandoned
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2015
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US20140328940A1 (en) | 2014-11-06 |
KR20120102642A (ko) | 2012-09-18 |
JP2013508401A (ja) | 2013-03-07 |
IL219232A0 (en) | 2012-06-28 |
EP3011970A3 (en) | 2016-06-08 |
SG10201406763WA (en) | 2014-11-27 |
EP3011970A2 (en) | 2016-04-27 |
JP2015172054A (ja) | 2015-10-01 |
WO2011050192A1 (en) | 2011-04-28 |
AU2010310589A1 (en) | 2012-05-10 |
CN102573855A (zh) | 2012-07-11 |
US20120328609A1 (en) | 2012-12-27 |
CN104043126A (zh) | 2014-09-17 |
EP2490698A1 (en) | 2012-08-29 |
RU2012120783A (ru) | 2013-11-27 |
MX2012004638A (es) | 2012-07-04 |
CA2778483A1 (en) | 2011-04-28 |
BR112012009257A2 (pt) | 2016-11-22 |
EP2490698A4 (en) | 2013-09-25 |
US20160199457A1 (en) | 2016-07-14 |
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