HK1202921A1 - Method for the detection of a binding partner of a multispecific binder - Google Patents

Method for the detection of a binding partner of a multispecific binder

Info

Publication number
HK1202921A1
HK1202921A1 HK15103324.4A HK15103324A HK1202921A1 HK 1202921 A1 HK1202921 A1 HK 1202921A1 HK 15103324 A HK15103324 A HK 15103324A HK 1202921 A1 HK1202921 A1 HK 1202921A1
Authority
HK
Hong Kong
Prior art keywords
detection
binding partner
multispecific binder
multispecific
binder
Prior art date
Application number
HK15103324.4A
Other languages
English (en)
Chinese (zh)
Inventor
Kay-Gunnar Stubenrauch
Uwe Wessels
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1202921A1 publication Critical patent/HK1202921A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
HK15103324.4A 2012-02-01 2015-04-01 Method for the detection of a binding partner of a multispecific binder HK1202921A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12153457 2012-02-01
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

Publications (1)

Publication Number Publication Date
HK1202921A1 true HK1202921A1 (en) 2015-10-09

Family

ID=47624068

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103324.4A HK1202921A1 (en) 2012-02-01 2015-04-01 Method for the detection of a binding partner of a multispecific binder

Country Status (11)

Country Link
US (3) US9945869B2 (xx)
EP (1) EP2810074B1 (xx)
JP (3) JP2015507193A (xx)
KR (1) KR20140128314A (xx)
CN (2) CN106443016B (xx)
BR (1) BR112014017630A8 (xx)
CA (1) CA2859268A1 (xx)
HK (1) HK1202921A1 (xx)
MX (1) MX349661B (xx)
RU (1) RU2620563C2 (xx)
WO (1) WO2013113663A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
WO2014009474A1 (en) 2012-07-13 2014-01-16 F. Hoffmann-La Roche Ag Method for the detection of a multispecific binder
WO2015067547A1 (en) 2013-11-05 2015-05-14 Roche Diagnostics Gmbh A method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
MA43028B1 (fr) 2015-10-02 2021-09-30 Hoffmann La Roche Anticorps bispécifiques pour pd1 et tim3
WO2017055399A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
HRP20221254T1 (hr) 2017-04-03 2022-12-23 F. Hoffmann - La Roche Ag Imunokonjugati protutijela anti-pd-1 s mutacijskim polipeptidom interleukina-2 ili interleukina-15
JP6997212B2 (ja) 2017-04-05 2022-02-04 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｐｄ１及びｌａｇ３に特異的に結合する二重特異性抗体
WO2019235420A1 (ja) 2018-06-04 2019-12-12 中外製薬株式会社 複合体を検出する方法
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Ｊｖｃケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
WO1987002778A1 (en) 1985-10-22 1987-05-07 Cooper-Lipotech Solid-phase liposome immunoassay system
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
JP2992974B2 (ja) 1988-11-03 1999-12-20 イゲン，インコーポレーテッド 電気化学ルミネセンス検定
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
DE69332377T2 (de) 1992-07-13 2003-07-03 Bionebraska Inc Verfahren zur modifizierung rekombinanter polypeptide
JPH097096A (ja) 1995-06-20 1997-01-10 Alpine Electron Inc 緊急車両接近時の報知方法
JPH0975096A (ja) * 1995-09-14 1997-03-25 Snow Brand Milk Prod Co Ltd ラクトフェリンの測定法
WO1999027368A1 (en) 1997-11-21 1999-06-03 Unilever Plc Improvements in or relating to displacement assays
JPH11352129A (ja) * 1998-06-04 1999-12-24 Mizuho Medeii:Kk 検出装置及び検出方法
US6753189B1 (en) * 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
NZ518363A (en) * 1999-11-16 2003-01-31 Genentech Inc Elisa for vascular endothelial growth factor using monoclonal and polyclonal antibodies
GB0007088D0 (en) * 2000-03-23 2000-05-17 Torsana A S Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
US7341837B2 (en) 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
EP1861708A2 (en) 2005-03-08 2007-12-05 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
US7494776B2 (en) * 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
CA2615846A1 (en) 2005-07-21 2007-01-25 Genmab A/S Potency assays for antibody drug substance binding to an fc receptor
CN101268372A (zh) * 2005-07-21 2008-09-17 根马布股份公司 与fc受体结合的抗体药物的药效测定
NZ613646A (en) * 2006-10-04 2015-03-27 Genentech Inc Elisa for vegf
EP1917854A1 (en) 2006-11-06 2008-05-07 F. Hoffmann-La Roche Ag Method for producing anti idiotypic antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
BRPI0913406A2 (pt) 2008-06-03 2018-01-09 Abbott Lab imunoglobulinas de domínio variável duplo e usos das mesmas
WO2010042031A1 (en) * 2008-10-07 2010-04-15 Gyros Patent Ab Semi-sequential assay for detection of an analyte in a sample
BRPI1014089A2 (pt) 2009-04-02 2016-04-19 Roche Glycart Ag anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
WO2010115589A1 (en) 2009-04-07 2010-10-14 Roche Glycart Ag Trivalent, bispecific antibodies
JP5719354B2 (ja) 2009-05-27 2015-05-20 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 三重又は四重特異性抗体
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
CA2776576C (en) * 2009-10-19 2018-01-02 F. Hoffmann-La Roche Ag Non-cross-reactive anti-igg antibodies
CN102207504A (zh) * 2011-03-23 2011-10-05 北京华创远航科技有限公司 一种酶联检测试剂盒及其制备方法
MX349003B (es) 2011-12-19 2017-07-06 Hoffmann La Roche Metodo para la deteccion del asociado de union libre de un aglutinante multiespecifico.
WO2013113663A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
WO2013130412A1 (en) * 2012-02-27 2013-09-06 Bio-Rad Laboratories, Inc. Anti-immune complex antibodies
WO2014009474A1 (en) 2012-07-13 2014-01-16 F. Hoffmann-La Roche Ag Method for the detection of a multispecific binder

Also Published As

Publication number Publication date
US9945869B2 (en) 2018-04-17
US10761097B2 (en) 2020-09-01
RU2014133701A (ru) 2016-03-27
EP2810074B1 (en) 2017-08-23
CN104105966A (zh) 2014-10-15
US20140342382A1 (en) 2014-11-20
MX2014008762A (es) 2014-08-27
JP2017223710A (ja) 2017-12-21
JP6678792B2 (ja) 2020-04-08
CN106443016B (zh) 2019-08-13
KR20140128314A (ko) 2014-11-05
JP6502441B2 (ja) 2019-04-17
US20210055304A1 (en) 2021-02-25
CN106443016A (zh) 2017-02-22
JP2015507193A (ja) 2015-03-05
RU2620563C2 (ru) 2017-05-26
BR112014017630A8 (pt) 2017-07-11
CN104105966B (zh) 2016-10-26
MX349661B (es) 2017-08-08
WO2013113663A1 (en) 2013-08-08
JP2019113564A (ja) 2019-07-11
CA2859268A1 (en) 2013-08-08
EP2810074A1 (en) 2014-12-10
BR112014017630A2 (xx) 2017-06-20
US20180328942A1 (en) 2018-11-15

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