HK1201873A1 - Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells - Google Patents
Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cellsInfo
- Publication number
- HK1201873A1 HK1201873A1 HK15102321.9A HK15102321A HK1201873A1 HK 1201873 A1 HK1201873 A1 HK 1201873A1 HK 15102321 A HK15102321 A HK 15102321A HK 1201873 A1 HK1201873 A1 HK 1201873A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cells
- derivation
- human pluripotent
- dopaminergic neurons
- pluripotent stem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261637797P | 2012-04-24 | 2012-04-24 | |
US201261637784P | 2012-04-24 | 2012-04-24 | |
PCT/US2013/037860 WO2013163228A1 (fr) | 2012-04-24 | 2013-04-23 | Obtention de cellules souches neuronales et de neurones dopaminergiques à partir de cellules souches pluripotentes humaines |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1201873A1 true HK1201873A1 (en) | 2015-09-11 |
Family
ID=49483836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102321.9A HK1201873A1 (en) | 2012-04-24 | 2015-03-06 | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
Country Status (13)
Country | Link |
---|---|
US (1) | US9926529B2 (fr) |
EP (1) | EP2841566B1 (fr) |
JP (1) | JP6262205B2 (fr) |
KR (1) | KR20150004834A (fr) |
CN (1) | CN104379732B (fr) |
AU (1) | AU2013251749B2 (fr) |
CA (1) | CA2871337C (fr) |
HK (1) | HK1201873A1 (fr) |
IL (1) | IL235109B (fr) |
MX (1) | MX368315B (fr) |
RU (1) | RU2014147015A (fr) |
SG (2) | SG11201406825WA (fr) |
WO (1) | WO2013163228A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010096496A2 (fr) | 2009-02-17 | 2010-08-26 | Memorial Sloan-Kettering Cancer Center | Procédés de conversion neurale de cellules souches embryonnaires humaines |
PT2773748T (pt) | 2011-11-04 | 2020-03-26 | Memorial Sloan Kettering Cancer Center | Neurónios dopaminérgicos (da) do mesencéfalo para enxerto |
EP2961277A4 (fr) * | 2013-02-15 | 2016-12-28 | Int Stem Cell Corp | Utilisation de neurones issus de céllules souches pluripotentes humaines pour le traitement de maladies neurodégénératives |
EP3498824A1 (fr) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Interneurones corticaux et autres cellules neuronales produits par la différentiation dirigée de cellules pluripotentes et multipotentes |
EP3183338B1 (fr) | 2014-08-19 | 2020-03-04 | FUJIFILM Cellular Dynamics, Inc. | Réseaux neuronaux formés à partir de cellules issues de cellules souches pluripotentes |
EP3313420B1 (fr) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Procédés et compositions se rapportant à l'expansion, l'enrichissement et la conservation de cellules souches hématopoïétiques |
LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
EP3430132A4 (fr) * | 2016-03-14 | 2019-12-25 | Agency for Science, Technology and Research | Génération d'organoïdes spécifiques du mésencéphale à partir de cellules souches pluripotentes humaines |
EP3429603B1 (fr) | 2016-03-15 | 2021-12-29 | Children's Medical Center Corporation | Procédés et compositions concernant l'expansion de cellules souches hématopoïétiques |
US11702630B2 (en) | 2016-05-31 | 2023-07-18 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | In vitro methods of differentiating stem cells into neurons and neurons generated using the same |
KR20200046099A (ko) * | 2017-09-07 | 2020-05-06 | 메모리얼 슬로안 케터링 캔서 센터 | 줄기 세포-유도 외배엽 계통 전구체의 분화 방법 |
JP2019106895A (ja) | 2017-12-15 | 2019-07-04 | インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ | 神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法 |
CN108559726A (zh) * | 2017-12-28 | 2018-09-21 | 上海安集协康生物技术股份有限公司 | 一种对脑损伤类疾病有治疗作用的细胞亚群及其制备方法 |
KR102119148B1 (ko) * | 2018-03-08 | 2020-06-04 | 고려대학교 산학협력단 | 신경조직 오가노이드의 제조방법, 이를 이용한 신경조직 형성 억제 물질의 스크리닝 방법 및 운동신경세포의 제조방법 |
TW202117009A (zh) * | 2019-07-05 | 2021-05-01 | 丹麥商諾佛 儂迪克股份有限公司 | 衍生自人類富潛能幹細胞的神經幹細胞株的製備方法 |
CN110432888B (zh) * | 2019-08-15 | 2021-11-23 | 任鹏宇 | 一种前庭神经权重信息编码神经元的筛选方法 |
WO2021054806A1 (fr) * | 2019-09-20 | 2021-03-25 | 한국생명공학연구원 | Procédé de production de progéniteurs neuronaux dopaminergiques induits par reprogrammation directe |
JP2023503302A (ja) * | 2019-11-22 | 2023-01-27 | ノヴォ ノルディスク アー/エス | スピン凝集した神経系マイクロスフェアおよびその応用 |
JP2021084882A (ja) * | 2019-11-28 | 2021-06-03 | 学校法人慶應義塾 | 脊髄損傷治療用ニューロスフェア誘導剤及びその使用 |
CN111269887B (zh) * | 2020-02-28 | 2021-11-16 | 上海市东方医院(同济大学附属东方医院) | 一种人多能干细胞向外胚层分化的方法 |
CA3226992A1 (fr) * | 2021-07-19 | 2023-01-26 | Trailhead Biosystems Inc. | Procedes et compositions pour generer des cellules progenitrices neurales du cerveau humain |
CA3231278A1 (fr) | 2021-09-10 | 2023-03-16 | Deepika Rajesh | Compositions de cellules derivees de cellules souches pluripotentes induites et leurs procedes d'utilisation |
AU2022376962A1 (en) | 2021-10-29 | 2024-04-18 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic neurons comprising mutations and methods of use thereof |
CN114292807A (zh) * | 2021-12-28 | 2022-04-08 | 深圳市夏同生物医药科技有限公司 | 一种外泌体的提取方法及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US6251671B1 (en) | 1996-02-28 | 2001-06-26 | Vanderbilt University | Compositions and methods of making embryonic stem cells |
EP1441737B1 (fr) * | 2001-10-30 | 2006-08-09 | Novartis AG | Derives de staurosporine inhibiteurs de l'activite tyrosine kinase du recepteur flt3 |
US8158420B2 (en) * | 2003-04-04 | 2012-04-17 | The Trustees Of Columbia University In The City Of New York | Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5 |
US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
US20110136145A1 (en) | 2008-05-22 | 2011-06-09 | The Johns Hopkins University | Methods for promoting fusion and reprogramming of somatic cells |
ES2590036T3 (es) * | 2009-08-12 | 2016-11-17 | Kyoto University | Método para inducir la diferenciación de células madre pluripotentes en células precursoras neurales |
KR101168053B1 (ko) | 2009-11-06 | 2012-07-24 | 연세대학교 산학협력단 | 효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법 |
US9376664B2 (en) * | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
-
2013
- 2013-04-23 MX MX2014013054A patent/MX368315B/es active IP Right Grant
- 2013-04-23 JP JP2015509088A patent/JP6262205B2/ja active Active
- 2013-04-23 US US14/396,180 patent/US9926529B2/en active Active
- 2013-04-23 RU RU2014147015A patent/RU2014147015A/ru not_active Application Discontinuation
- 2013-04-23 AU AU2013251749A patent/AU2013251749B2/en active Active
- 2013-04-23 SG SG11201406825WA patent/SG11201406825WA/en unknown
- 2013-04-23 EP EP13782178.1A patent/EP2841566B1/fr active Active
- 2013-04-23 CA CA2871337A patent/CA2871337C/fr active Active
- 2013-04-23 KR KR1020147031621A patent/KR20150004834A/ko not_active Application Discontinuation
- 2013-04-23 SG SG10201608838QA patent/SG10201608838QA/en unknown
- 2013-04-23 WO PCT/US2013/037860 patent/WO2013163228A1/fr active Application Filing
- 2013-04-23 CN CN201380024659.4A patent/CN104379732B/zh active Active
-
2014
- 2014-10-19 IL IL235109A patent/IL235109B/en not_active IP Right Cessation
-
2015
- 2015-03-06 HK HK15102321.9A patent/HK1201873A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2871337A1 (fr) | 2013-10-31 |
EP2841566A4 (fr) | 2015-12-23 |
RU2014147015A (ru) | 2016-06-10 |
US20150087541A1 (en) | 2015-03-26 |
EP2841566B1 (fr) | 2019-03-13 |
IL235109B (en) | 2020-05-31 |
WO2013163228A1 (fr) | 2013-10-31 |
JP6262205B2 (ja) | 2018-01-17 |
US9926529B2 (en) | 2018-03-27 |
CN104379732A (zh) | 2015-02-25 |
AU2013251749B2 (en) | 2019-01-17 |
MX2014013054A (es) | 2016-12-20 |
JP2015514437A (ja) | 2015-05-21 |
CN104379732B (zh) | 2018-08-17 |
MX368315B (es) | 2019-09-27 |
SG11201406825WA (en) | 2014-11-27 |
IL235109A0 (en) | 2014-12-31 |
CA2871337C (fr) | 2021-04-20 |
AU2013251749A1 (en) | 2014-11-13 |
EP2841566A1 (fr) | 2015-03-04 |
SG10201608838QA (en) | 2016-12-29 |
KR20150004834A (ko) | 2015-01-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1201873A1 (en) | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells | |
HK1218927A1 (zh) | 人類多能幹細胞在限定條件下進行血液內皮分化的方法和材料 | |
SG11201803043VA (en) | Derivation of human skin organoids from pluripotent stem cells | |
HK1205203A1 (en) | Methods and processes for non-invasive assessment of genetic variations | |
HK1215358A1 (zh) | 由人多能幹細胞衍生的神經細胞在治療神經退行性疾病上的用途 | |
HK1207885A1 (en) | Differentiation of human embryonic stem cells into pancreatic endoderm | |
EP2640403A4 (fr) | Génération de cellules souches neurales à partir de cellules souches trophoblastiques humaines | |
IL260824A (en) | Differentiation of human pluripotent stem cells into cortical neurons | |
EP2909313A4 (fr) | Production de globules rouges et de plaquettes à partir de cellules souches | |
EP2658966A4 (fr) | Différenciation de cellules souches pluripotentes humaines en cellules de crête neurale multipotente | |
EP2925863A4 (fr) | Cellules souches cardiaques et leurs procédés d'identification et d'utilisation | |
EP2861224A4 (fr) | Nanoparticules d'épinéphrine, procédé pour les fabriquer et procédés pour les utiliser pour le traitement d'affections répondant à l'épinéphrine | |
EP3555262A4 (fr) | Production et utilisations thérapeutiques de cellules pluripotentes d'epinul et cellules différenciées dérivées de celles-ci | |
IL244808A0 (en) | Direct differentiation of astrocytes from human pluripotent stem cells for use in drug screening and treatment of amyotrophic lateral sclerosis (ALS) | |
EP2814947A4 (fr) | Profil phénotypique de cellules progénitrices humaines de la rétine | |
IL260380B1 (en) | Induction of differentiation from human pluripotent stem cells into hypothalamic neurons | |
IL237887A0 (en) | Devices and methods for encouraging hair growth | |
HK1208249A1 (en) | Method of extracting neural stem cells using nanoparticles | |
IL274995A (en) | Stem cells extracted from brown fat and their use | |
EP2849712A4 (fr) | Procédés et dispositifs d'application d'une stimulation mécanique au corps | |
HK1223967A1 (zh) | 人誘導多能幹細胞衍生的心肌細胞的內向整流的電子表達 | |
EP2911748A4 (fr) | Vaccination et traitement de cellule souche cancéreuse | |
HK1243648A1 (zh) | 利用神經幹細胞與il12p40增强神經再生的方法 | |
SG11201406771PA (en) | Stem cell preparations and methods of use | |
GB201322323D0 (en) | Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons |