SG10201608838QA - Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells - Google Patents
Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cellsInfo
- Publication number
- SG10201608838QA SG10201608838QA SG10201608838QA SG10201608838QA SG10201608838QA SG 10201608838Q A SG10201608838Q A SG 10201608838QA SG 10201608838Q A SG10201608838Q A SG 10201608838QA SG 10201608838Q A SG10201608838Q A SG 10201608838QA SG 10201608838Q A SG10201608838Q A SG 10201608838QA
- Authority
- SG
- Singapore
- Prior art keywords
- stem cells
- derivation
- human pluripotent
- dopaminergic neurons
- pluripotent stem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261637797P | 2012-04-24 | 2012-04-24 | |
| US201261637784P | 2012-04-24 | 2012-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201608838QA true SG10201608838QA (en) | 2016-12-29 |
Family
ID=49483836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406825WA SG11201406825WA (en) | 2012-04-24 | 2013-04-23 | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
| SG10201608838QA SG10201608838QA (en) | 2012-04-24 | 2013-04-23 | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406825WA SG11201406825WA (en) | 2012-04-24 | 2013-04-23 | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9926529B2 (en) |
| EP (1) | EP2841566B1 (en) |
| JP (1) | JP6262205B2 (en) |
| KR (1) | KR20150004834A (en) |
| CN (1) | CN104379732B (en) |
| AU (1) | AU2013251749B2 (en) |
| CA (1) | CA2871337C (en) |
| HK (1) | HK1201873A1 (en) |
| IL (1) | IL235109B (en) |
| MX (1) | MX368315B (en) |
| RU (1) | RU2014147015A (en) |
| SG (2) | SG11201406825WA (en) |
| WO (1) | WO2013163228A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642334B2 (en) | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| ES2779453T3 (en) | 2011-11-04 | 2020-08-17 | Memorial Sloan Kettering Cancer Center | Midbrain dopamine (DA) neurons for graft |
| EP2961277A4 (en) | 2013-02-15 | 2016-12-28 | Int Stem Cell Corp | Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| CN106574248B (en) | 2014-08-19 | 2020-11-24 | 富士胶片细胞动力有限公司 | Neural networks formed by cells derived from pluripotent stem cells |
| US10669528B2 (en) | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
| SG10201913687VA (en) * | 2016-03-14 | 2020-03-30 | Agency Science Tech & Res | Generation of midbrain-specific organoids from human pluripotent stem cells |
| WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| WO2017210138A1 (en) | 2016-05-31 | 2017-12-07 | The J. David Gladstone Institutes | In vitro methods of differentiating stem cells into neurons and neurons generated using the same |
| AU2018327341A1 (en) * | 2017-09-07 | 2020-04-23 | Memorial Sloan-Kettering Cancer Center | Methods of differentiating stem cell-derived ectodermal lineage precursors |
| JP2019106895A (en) * | 2017-12-15 | 2019-07-04 | インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ | Method of differentiating neural stem cells or neural precursor cells into dopamine neurons |
| CN108559726A (en) * | 2017-12-28 | 2018-09-21 | 上海安集协康生物技术股份有限公司 | It is a kind of to medicative cell subsets of cerebral injury class disease and preparation method thereof |
| KR102119148B1 (en) * | 2018-03-08 | 2020-06-04 | 고려대학교 산학협력단 | Method for preparing nerve tissue organoid, method for screening of nerve tissue formation inhibitory substance and preparing motor never cell using the same |
| US20220233602A1 (en) * | 2019-07-05 | 2022-07-28 | Novo Nordisk A/S | Generation of neural stem cell lines derived from human pluripotent stem cells |
| CN110432888B (en) * | 2019-08-15 | 2021-11-23 | 任鹏宇 | Screening method of vestibular nerve weight information coding neurons |
| JP2022549224A (en) * | 2019-09-20 | 2022-11-24 | コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー | Method for producing inducible dopaminergic neural progenitor cells using direct reprogramming |
| WO2021099532A1 (en) * | 2019-11-22 | 2021-05-27 | Novo Nordisk A/S | Spin-aggregated neural microspheres and the application thereof |
| JP2021084882A (en) * | 2019-11-28 | 2021-06-03 | 学校法人慶應義塾 | Neurosphere induction agent for treating spinal cord injury and use thereof |
| CN111269887B (en) * | 2020-02-28 | 2021-11-16 | 上海市东方医院（同济大学附属东方医院） | Method for differentiating human pluripotent stem cells to ectoderm |
| WO2023003621A1 (en) * | 2021-07-19 | 2023-01-26 | Trailhead Biosystems Inc. | Methods and compositions for generating human midbrain neural progenitor cells |
| US20230183644A1 (en) | 2021-09-10 | 2023-06-15 | FUJIFILM Cellular Dynamics, Inc. | Compositions of induced pluripotent stem cell-derived cells and methods of use thereof |
| WO2023077050A1 (en) | 2021-10-29 | 2023-05-04 | FUJIFILM Cellular Dynamics, Inc. | Dopaminergic neurons comprising mutations and methods of use thereof |
| CN114292807A (en) * | 2021-12-28 | 2022-04-08 | 深圳市夏同生物医药科技有限公司 | Method for extracting exosome and application thereof |
| CN115521903A (en) * | 2022-09-30 | 2022-12-27 | 中国科学院生态环境研究中心 | Method for inducing human pluripotent stem cells to differentiate into dopaminergic neurons in vitro |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| EP0885308A4 (en) | 1996-02-28 | 2002-02-27 | Univ Vanderbilt | Compositions and methods of making embryonic stem cells |
| PL211461B1 (en) * | 2001-10-30 | 2012-05-31 | Dana Farber Cancer Inst Inc | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
| US8158420B2 (en) * | 2003-04-04 | 2012-04-17 | The Trustees Of Columbia University In The City Of New York | Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5 |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| US20110136145A1 (en) | 2008-05-22 | 2011-06-09 | The Johns Hopkins University | Methods for promoting fusion and reprogramming of somatic cells |
| ES2590036T3 (en) * | 2009-08-12 | 2016-11-17 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
| KR101168053B1 (en) * | 2009-11-06 | 2012-07-24 | 연세대학교 산학협력단 | Efficient and Universal Method for Neural Differentiation of Pluripotent Stem Cells |
| US9376664B2 (en) * | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
-
2013
- 2013-04-23 AU AU2013251749A patent/AU2013251749B2/en active Active
- 2013-04-23 RU RU2014147015A patent/RU2014147015A/en not_active Application Discontinuation
- 2013-04-23 US US14/396,180 patent/US9926529B2/en active Active
- 2013-04-23 EP EP13782178.1A patent/EP2841566B1/en active Active
- 2013-04-23 MX MX2014013054A patent/MX368315B/en active IP Right Grant
- 2013-04-23 JP JP2015509088A patent/JP6262205B2/en active Active
- 2013-04-23 SG SG11201406825WA patent/SG11201406825WA/en unknown
- 2013-04-23 KR KR1020147031621A patent/KR20150004834A/en not_active Application Discontinuation
- 2013-04-23 CN CN201380024659.4A patent/CN104379732B/en active Active
- 2013-04-23 CA CA2871337A patent/CA2871337C/en active Active
- 2013-04-23 SG SG10201608838QA patent/SG10201608838QA/en unknown
- 2013-04-23 WO PCT/US2013/037860 patent/WO2013163228A1/en active Application Filing
-
2014
- 2014-10-19 IL IL235109A patent/IL235109B/en not_active IP Right Cessation
-
2015
- 2015-03-06 HK HK15102321.9A patent/HK1201873A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL235109A0 (en) | 2014-12-31 |
| SG11201406825WA (en) | 2014-11-27 |
| RU2014147015A (en) | 2016-06-10 |
| MX368315B (en) | 2019-09-27 |
| CN104379732A (en) | 2015-02-25 |
| EP2841566B1 (en) | 2019-03-13 |
| KR20150004834A (en) | 2015-01-13 |
| JP2015514437A (en) | 2015-05-21 |
| EP2841566A1 (en) | 2015-03-04 |
| EP2841566A4 (en) | 2015-12-23 |
| US20150087541A1 (en) | 2015-03-26 |
| US9926529B2 (en) | 2018-03-27 |
| IL235109B (en) | 2020-05-31 |
| WO2013163228A1 (en) | 2013-10-31 |
| CA2871337C (en) | 2021-04-20 |
| AU2013251749B2 (en) | 2019-01-17 |
| MX2014013054A (en) | 2016-12-20 |
| CA2871337A1 (en) | 2013-10-31 |
| AU2013251749A1 (en) | 2014-11-13 |
| JP6262205B2 (en) | 2018-01-17 |
| CN104379732B (en) | 2018-08-17 |
| HK1201873A1 (en) | 2015-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1201873A1 (en) | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells | |
| HK1218927A1 (en) | Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions | |
| SG11201803043VA (en) | Derivation of human skin organoids from pluripotent stem cells | |
| HK1215358A1 (en) | Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases | |
| HK1205203A1 (en) | Methods and processes for non-invasive assessment of genetic variations | |
| HK1207885A1 (en) | Differentiation of human embryonic stem cells into pancreatic endoderm | |
| EP2640403A4 (en) | Generation of neural stem cells from human trophoblast stem cells | |
| IL260824A (en) | Differentiation of cortical neurons from human pluripotent stem cells | |
| EP2909313A4 (en) | Production of red blood cells and platelets from stem cells | |
| EP2658966A4 (en) | Differentiation of human pluripotent stem cells to multipotent neural crest cells | |
| EP2925863A4 (en) | Cardiac stem cells and methods of identifying and using the same | |
| EP2861224A4 (en) | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinphrine | |
| EP2814947A4 (en) | Phenotype profile of human retinal progenitor cells | |
| IL237887A0 (en) | Devices and methods for stimulation of hair growth | |
| EP3555262A4 (en) | Production and therapeutic uses of epinul pluripotent cells and differentiated cells derived therefrom | |
| IL244808B (en) | Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als) | |
| HK1208249A1 (en) | Method of extracting neural stem cells using nanoparticles | |
| IL274995B (en) | Human brown adipose derived stem cells and uses | |
| EP2849712A4 (en) | Methods and devices of providing mechanical stimulation to the body | |
| HK1223967A1 (en) | Electronic expression of the inward rectifier in cardiocytes derived from human induced pluripotent stem cells | |
| EP2911748A4 (en) | Cancer stem cell vaccination and treatment | |
| HK1243648A1 (en) | Methods to enhance nerve regeneration utilizing neural stem cells and il12p40 | |
| SG11201406771PA (en) | Stem cell preparations and methods of use | |
| GB201322323D0 (en) | Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons |