HK1201873A1 - 從人多能幹細胞衍生的神經幹細胞和多巴胺能神經元 - Google Patents

從人多能幹細胞衍生的神經幹細胞和多巴胺能神經元

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Publication number
HK1201873A1
HK1201873A1 HK15102321.9A HK15102321A HK1201873A1 HK 1201873 A1 HK1201873 A1 HK 1201873A1 HK 15102321 A HK15102321 A HK 15102321A HK 1201873 A1 HK1201873 A1 HK 1201873A1
Authority
HK
Hong Kong
Prior art keywords
stem cells
derivation
human pluripotent
dopaminergic neurons
pluripotent stem
Prior art date
Application number
HK15102321.9A
Other languages
English (en)
Inventor
Rodolfo Gonzalez
Ibon Garitaonandia
Ruslan Semechkin
Original Assignee
Int Stem Cell Corp
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Filing date
Publication date
Application filed by Int Stem Cell Corp filed Critical Int Stem Cell Corp
Publication of HK1201873A1 publication Critical patent/HK1201873A1/zh

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
HK15102321.9A 2012-04-24 2015-03-06 從人多能幹細胞衍生的神經幹細胞和多巴胺能神經元 HK1201873A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261637797P 2012-04-24 2012-04-24
US201261637784P 2012-04-24 2012-04-24
PCT/US2013/037860 WO2013163228A1 (en) 2012-04-24 2013-04-23 Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells

Publications (1)

Publication Number Publication Date
HK1201873A1 true HK1201873A1 (zh) 2015-09-11

Family

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HK15102321.9A HK1201873A1 (zh) 2012-04-24 2015-03-06 從人多能幹細胞衍生的神經幹細胞和多巴胺能神經元

Country Status (13)

Country Link
US (1) US9926529B2 (zh)
EP (1) EP2841566B1 (zh)
JP (1) JP6262205B2 (zh)
KR (1) KR20150004834A (zh)
CN (1) CN104379732B (zh)
AU (1) AU2013251749B2 (zh)
CA (1) CA2871337C (zh)
HK (1) HK1201873A1 (zh)
IL (1) IL235109B (zh)
MX (1) MX368315B (zh)
RU (1) RU2014147015A (zh)
SG (2) SG10201608838QA (zh)
WO (1) WO2013163228A1 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
US10280398B2 (en) 2011-11-04 2019-05-07 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (DA) neurons for engraftment
US10039794B2 (en) 2013-02-15 2018-08-07 International Stem Cell Corporation Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases
CA2910394A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
WO2016028880A1 (en) 2014-08-19 2016-02-25 Cellular Dynamics International, Inc. Neural networks formed from cells derived from pluripotent stem cells
WO2016210292A1 (en) 2015-06-25 2016-12-29 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
LU92845B1 (en) 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
US20190169576A1 (en) * 2016-03-14 2019-06-06 Agency For Science, Technology And Research Generation of midbrain-specific organoids from human pluripotent stem cells
US20190119642A1 (en) 2016-03-15 2019-04-25 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
EP3464569A4 (en) 2016-05-31 2020-03-11 The J. David Gladstone Institutes IN VITRO METHODS FOR DIFFERENTIATING STEM CELLS INTO NEURONES AND GENERATED NEURONES USING THE SAME IN VITRO METHODS FOR DIFFERENTIATING STEM CELLS IN NEURONES
CA3075036A1 (en) * 2017-09-07 2019-03-14 Memorial Sloan-Kettering Cancer Center Methods of differentiating stem cell-derived ectodermal lineage precursors
JP2019106895A (ja) 2017-12-15 2019-07-04 インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ 神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法
CN108559726A (zh) * 2017-12-28 2018-09-21 上海安集协康生物技术股份有限公司 一种对脑损伤类疾病有治疗作用的细胞亚群及其制备方法
KR102119148B1 (ko) * 2018-03-08 2020-06-04 고려대학교 산학협력단 신경조직 오가노이드의 제조방법, 이를 이용한 신경조직 형성 억제 물질의 스크리닝 방법 및 운동신경세포의 제조방법
EP3994250A1 (en) * 2019-07-05 2022-05-11 Novo Nordisk A/S Generation of neural stem cell lines derived from human pluripotent stem cells
CN110432888B (zh) * 2019-08-15 2021-11-23 任鹏宇 一种前庭神经权重信息编码神经元的筛选方法
WO2021054806A1 (ko) * 2019-09-20 2021-03-25 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 신경세포 전구체의 제조방법
CN114729323A (zh) * 2019-11-22 2022-07-08 诺和诺德股份有限公司 旋转聚集的神经微球及其应用
JP2021084882A (ja) * 2019-11-28 2021-06-03 学校法人慶應義塾 脊髄損傷治療用ニューロスフェア誘導剤及びその使用
CN111269887B (zh) * 2020-02-28 2021-11-16 上海市东方医院（同济大学附属东方医院） 一种人多能干细胞向外胚层分化的方法
WO2023003621A1 (en) * 2021-07-19 2023-01-26 Trailhead Biosystems Inc. Methods and compositions for generating human midbrain neural progenitor cells
KR20240055838A (ko) 2021-09-10 2024-04-29 후지필름 셀룰러 다이내믹스, 인코포레이티드 유도된 만능 줄기 세포 유래된 세포의 조성물 및 이의 사용 방법
US20240034992A1 (en) 2021-10-29 2024-02-01 FUJIFILM Cellular Dynamics, Inc. Dopaminergic neurons comprising mutations and methods of use thereof
CN114292807A (zh) * 2021-12-28 2022-04-08 深圳市夏同生物医药科技有限公司 一种外泌体的提取方法及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
CA2247502A1 (en) 1996-02-28 1997-09-04 Vanderbilt University Compositions and methods of making embryonic stem cells
PT1441737E (pt) * 2001-10-30 2006-12-29 Dana Farber Cancer Inst Inc Derivados de estrutura como inibidores da actividade do receptor de tirosina cinase flt3
US8158420B2 (en) 2003-04-04 2012-04-17 The Trustees Of Columbia University In The City Of New York Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5
US20090291134A1 (en) * 2006-11-21 2009-11-26 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
US20110136145A1 (en) 2008-05-22 2011-06-09 The Johns Hopkins University Methods for promoting fusion and reprogramming of somatic cells
US10119120B2 (en) * 2009-08-12 2018-11-06 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
KR101168053B1 (ko) * 2009-11-06 2012-07-24 연세대학교 산학협력단 효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법
WO2011159726A2 (en) * 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate

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Publication number Publication date
US9926529B2 (en) 2018-03-27
EP2841566A1 (en) 2015-03-04
WO2013163228A1 (en) 2013-10-31
CA2871337C (en) 2021-04-20
IL235109A0 (en) 2014-12-31
MX368315B (es) 2019-09-27
IL235109B (en) 2020-05-31
EP2841566A4 (en) 2015-12-23
EP2841566B1 (en) 2019-03-13
SG11201406825WA (en) 2014-11-27
CN104379732A (zh) 2015-02-25
US20150087541A1 (en) 2015-03-26
KR20150004834A (ko) 2015-01-13
CA2871337A1 (en) 2013-10-31
JP2015514437A (ja) 2015-05-21
AU2013251749A1 (en) 2014-11-13
AU2013251749B2 (en) 2019-01-17
JP6262205B2 (ja) 2018-01-17
CN104379732B (zh) 2018-08-17
RU2014147015A (ru) 2016-06-10
MX2014013054A (es) 2016-12-20
SG10201608838QA (en) 2016-12-29

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