HK1200095A1 - Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof - Google Patents

Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

Info

Publication number
HK1200095A1
HK1200095A1 HK15100523.9A HK15100523A HK1200095A1 HK 1200095 A1 HK1200095 A1 HK 1200095A1 HK 15100523 A HK15100523 A HK 15100523A HK 1200095 A1 HK1200095 A1 HK 1200095A1
Authority
HK
Hong Kong
Prior art keywords
bendamustine
formulations
combination
histone deacetylase
deacetylase inhibitor
Prior art date
Application number
HK15100523.9A
Other languages
English (en)
Chinese (zh)
Inventor
David J Loury
Joseph J Buggy
Tarak D Mody
Erik J Verner
Norbert Purro
Sriram Balasubramanian
Ioana Kloos
Stphane Depil
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of HK1200095A1 publication Critical patent/HK1200095A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
HK15100523.9A 2011-09-13 2015-01-16 Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof HK1200095A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/051470 WO2013039488A1 (fr) 2011-09-13 2011-09-13 Formulations d'un inhibiteur d'histone désacétylase en combinaison avec la bendamustine et leurs utilisations

Publications (1)

Publication Number Publication Date
HK1200095A1 true HK1200095A1 (en) 2015-07-31

Family

ID=47883567

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15100523.9A HK1200095A1 (en) 2011-09-13 2015-01-16 Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

Country Status (15)

Country Link
US (1) US9492423B2 (fr)
EP (1) EP2755648B1 (fr)
JP (1) JP6330118B2 (fr)
KR (1) KR101892788B1 (fr)
CN (1) CN103917231B (fr)
AU (1) AU2011376953B2 (fr)
CA (1) CA2845806C (fr)
ES (1) ES2627820T3 (fr)
HK (1) HK1200095A1 (fr)
MX (1) MX365393B (fr)
NZ (1) NZ621221A (fr)
RU (1) RU2609833C2 (fr)
SG (1) SG2014014419A (fr)
UA (1) UA110853C2 (fr)
WO (1) WO2013039488A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007340129B2 (en) 2006-12-26 2012-02-02 Pharmacyclics Llc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
RU2609833C2 (ru) 2011-09-13 2017-02-06 Фармасайкликс Элэлси Лекарственные формы ингибитора гистондиацетилазы в комбинации с бендамутином и их применение
TWI573792B (zh) 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
JP2017537164A (ja) * 2014-12-05 2017-12-14 ユニヴァーシティ・オブ・モデナ・アンド・レッジョ・エミリア リンパ腫の治療に使用されるヒストン脱アセチル化酵素阻害剤とベンダムスチンとの組み合わせ
US20180185345A1 (en) * 2015-06-19 2018-07-05 Trustees Of Boston University Methods and compositions for treating herpesvirus induced conditions
US20200179381A1 (en) * 2016-04-08 2020-06-11 Cereno Scientific Ab Compounds and compositions for the treatment or prevention of pathological conditions associated with excess fibrin deposition and/or thrombus formation
BR112018070415A2 (pt) * 2016-04-21 2019-02-05 Valcuria Ab composição farmacêutica, kit, inibidor e inibidor para uso
AU2016426574B2 (en) 2016-10-11 2023-07-13 Euro-Celtique S.A. Hodgkin lymphoma therapy
SG10201609137PA (en) * 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Gamma-polyglutamic acid and zinc compositions
SG10201609131YA (en) 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Zinc-pga compositions and methods for treating cancer
GB201706544D0 (en) 2017-04-25 2017-06-07 Plasticell Ltd Method
GB201709406D0 (en) 2017-06-13 2017-07-26 Euro-Cletique S A Compounds for treating TNBC
GB201709402D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating t-pll
GB201709405D0 (en) 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating ovarian cancer
GB201709403D0 (en) * 2017-06-13 2017-07-26 Euro Celtique Sa Compounds for treating sarcoma
SG10201900072VA (en) * 2018-01-05 2019-08-27 Gnt Biotech & Medicals Corp A pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy
KR20220034736A (ko) 2019-05-31 2022-03-18 비락타 서브시디어리 인크. 히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법
WO2022159852A1 (fr) * 2021-01-25 2022-07-28 Icahn School Of Medicine At Mount Sinai Méthodes et compositions pour le traitement du carcinome adénoïde kystique
WO2024086688A1 (fr) * 2022-10-21 2024-04-25 Viracta Subsidiary, Inc. Procédés de dosage pour composés inhibiteurs de hdac

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
US2789118A (en) 1956-03-30 1957-04-16 American Cyanamid Co 16-alpha oxy-belta1, 4-pregnadienes
US2990401A (en) 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3048581A (en) 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3749712A (en) 1970-09-25 1973-07-31 Sigma Tau Ind Farmaceuti Triamcinolone acetonide esters and process for their preparation
BE794063A (fr) 1972-01-17 1973-07-16 Henkel & Cie Gmbh Anti-inflammatoires pour compositions cosmetiques
SE378110B (fr) 1972-05-19 1975-08-18 Bofors Ab
SE378109B (fr) 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3775656A (en) 1972-05-22 1973-11-27 Aviat Inc Platform stabilization system
CH581818A5 (fr) 1973-02-27 1976-11-15 Cierva Juan J De
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
EP0084236A3 (fr) 1981-12-22 1983-08-03 Fbc Limited Composés hétérocycliques fongiques et compositions les contenant
US4498038A (en) 1983-02-15 1985-02-05 Malueg Richard M Stabilization system for soft-mounted platform
US4624848A (en) 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
GB8518301D0 (en) 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
DE3684446D1 (de) 1985-12-28 1992-04-23 Sumitomo Pharma Arzneimittel mit verzoegerter stossweiser freisetzung.
US4968509A (en) 1987-07-27 1990-11-06 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
KR970006890B1 (ko) 1987-10-20 1997-04-30 오스카 세이야꾸 가부시끼가이샤 페닐카르복시산 유도체 및 그 염
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5612059A (en) 1988-08-30 1997-03-18 Pfizer Inc. Use of asymmetric membranes in delivery devices
IL92966A (en) 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
JPH03215470A (ja) 1990-01-22 1991-09-20 Suntory Ltd プロピオン酸アミド誘導体，その製造法及びそれを有効成分として含有する除草剤
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
AU1537292A (en) 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
DE4124345A1 (de) 1991-07-23 1993-01-28 Gruenenthal Gmbh Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5229135A (en) 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
CA2122479C (fr) 1991-11-22 1998-08-25 Richard John Dansereau Compositions de risedronate a liberation retardee
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5260068A (en) 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
CA2147283C (fr) 1992-10-16 2007-01-16 Kouichi Nakamichi Methode de fabrication de matrices de cire
US5260069A (en) 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5686105A (en) 1993-10-19 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery
DE4327365A1 (de) 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung
US5448938A (en) 1993-10-18 1995-09-12 Guardian Technologies International, Inc. Removable ballistic resistant armor seat cover and floor mat
US5567441A (en) 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
JPH11505258A (ja) 1995-05-17 1999-05-18 セダーシナイ メディカル センター 小腸における消化および吸収を改善させる脂肪酸を含む組成物
US5798119A (en) 1995-06-13 1998-08-25 S. C. Johnson & Son, Inc. Osmotic-delivery devices having vapor-permeable coatings
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5958957A (en) 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6718130B2 (en) 1999-05-28 2004-04-06 David E. Grober Stabilized camera and marker buoy for media coverage of aquatic events
JP2003500772A (ja) 1999-05-28 2003-01-07 グロバー、デイビッド、イー 自主的なセルフレベリング自動修正式安定台
JP2003506100A (ja) 1999-08-10 2003-02-18 パンジーン・コーポレイション Ｒａｄ５１関連分子および方法を用いる癌治療および診断
AU6936500A (en) 1999-08-24 2001-03-19 Regents Of The University Of California, The Non-quinoline inhibitors of malaria parasites
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
CA2385747A1 (fr) 1999-09-17 2001-03-22 Gavin C. Hirst Pyrazolopyrimidines en tant qu'agents therapeutiques
KR20020070285A (ko) 1999-11-23 2002-09-05 메틸진, 인크. 히스톤 디아세틸라제의 억제제
BR0113626A (pt) 2000-08-30 2003-06-17 Pfizer Prod Inc Formulações de liberação sustentada para secretores de hormÈnio do crescimento
GB0023983D0 (en) 2000-09-29 2000-11-15 Prolifix Ltd Therapeutic compounds
EP1328510B1 (fr) 2000-09-29 2013-11-20 TopoTarget UK Limited Composés (e)-n-hydroxy-3-(3-sulfamoyl-phenyl)-acrylamide et leur utilisation thérapeutique
ATE399766T1 (de) 2000-10-20 2008-07-15 Eisai R&D Man Co Ltd Stickstoff enthaltende aromatische heterozyklen
CA2432339A1 (fr) 2000-12-28 2002-07-11 Epidauros Biotechnologie Ag Identification des determinants genetiques de l'expression polymorphe de cyp3a5
MXPA01013172A (es) 2001-02-14 2002-08-21 Warner Lambert Co Inhibidores sulfonamida de metaloproteinasa de matriz.
US6465014B1 (en) 2001-03-21 2002-10-15 Isp Investments Inc. pH-dependent sustained release, drug-delivery composition
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
EE05357B1 (et) 2001-06-28 2010-12-15 Ucb, Farchim, S.A. Tablett, mis sisaldab v„hemalt kahte eristatavat segmenti, ning selle kasutamine
US7247426B2 (en) 2001-08-02 2007-07-24 Agilent Technologies, Inc. Classifying cancers
ITMI20011733A1 (it) 2001-08-07 2003-02-07 Italfarmaco Spa Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
US8470783B2 (en) 2001-08-21 2013-06-25 Astellas Pharma Inc. Medicinal use of histone deacetylase inhibitor and method of evaluating antitumor effect thereof
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20030166026A1 (en) 2002-01-09 2003-09-04 Lynx Therapeutics, Inc. Identification of specific biomarkers for breast cancer cells
JP2005516626A (ja) 2002-02-04 2005-06-09 エピダウロス バイオテクノロジー アーゲー Ｔｐｍｔのヒト遺伝子における多型ならびに診断的適用および治療的適用におけるその使用方法
WO2003070691A1 (fr) 2002-02-21 2003-08-28 Osaka Industrial Promotion Organization Derive de n-hydroxycarboxamide
US20040132825A1 (en) 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
MXPA05001334A (es) 2002-08-02 2005-09-08 Argenta Discovery Ltd Acidos tienil-hidroxamicos sustituidos como inhibidores de la desacetilasa de histona.
EP1400806A1 (fr) 2002-09-18 2004-03-24 G2M Cancer Drugs AG Criblage pour inhibiteurs de l'histone déacétylase
US6769347B1 (en) 2002-11-26 2004-08-03 Recon/Optical, Inc. Dual elevation weapon station and method of use
US20080233562A1 (en) 2003-02-19 2008-09-25 Astellas Pharma Inc. Method of Estimating Antitumor Effect of Histone Deacetylase Inhibitor
GB0303910D0 (en) 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
EP1608628A2 (fr) 2003-03-17 2005-12-28 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
CN1768031A (zh) * 2003-04-07 2006-05-03 Axys药物公司 作为治疗剂的异羟肟酸酯
EP1611088B1 (fr) 2003-04-07 2009-06-17 Pharmacyclics, Inc. Hydroxamates et leur utilisation comme agents therapeutiques
PE20050206A1 (es) 2003-05-26 2005-03-26 Schering Ag Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
DE602004027824D1 (de) 2003-09-25 2010-08-05 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
US20070099190A1 (en) 2003-11-04 2007-05-03 Martin Dugas Method for distinguishing leukemia subtypes
CA2549324A1 (fr) 2003-12-12 2005-06-30 Bayer Pharmaceuticals Corporation Profils d'expression geniques et procedes d'utilisation
CA2558808A1 (fr) 2004-03-05 2005-09-22 Rosetta Inpharmatics Llc Classification de patients du cancer du sein utilisant une combinaison de criteres cliniques et d'ensembles genetiques informatifs
GB2427405A (en) 2004-04-07 2006-12-27 Pharmacyclics Inc Novel hydroxamates as therapeutic agents
ES2308065T3 (es) 2004-04-30 2008-12-01 Topotarget Germany Ag Formulacion que comprende un inhibidor de histona desacetilasa, que exhibe una liberacion bifasica.
JP2008501677A (ja) 2004-06-04 2008-01-24 ファイザー・プロダクツ・インク 異常な細胞増殖を治療する方法
US20090239214A1 (en) 2004-07-30 2009-09-24 Hongyue Dai Prognosis of breast cancer patients
WO2006042035A2 (fr) 2004-10-07 2006-04-20 Pharmacyclics, Inc. Procede permettant de surveiller l'activite antitumorale d'un inhibiteur d'hdac
CA2585659A1 (fr) 2004-11-05 2006-06-22 Cephalon, Inc. Traitements anti-cancereux
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
WO2006101454A1 (fr) 2005-03-21 2006-09-28 S*Bio Pte Ltd Derives du benzothiophene: preparation et applications pharmaceutiques
US8338416B2 (en) 2006-03-16 2012-12-25 Pharmacylics, Inc. Indole derivatives as inhibitors of histone deacetylase
AU2007296256B2 (en) 2006-09-15 2013-05-30 Janssen Pharmaceutica Nv Histone deacetylase inhibitors with combined activity on class-I and class-IIB histone deacetylases in combination with proteasome inhibitors
AU2007340129B2 (en) * 2006-12-26 2012-02-02 Pharmacyclics Llc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
WO2008095050A1 (fr) 2007-01-30 2008-08-07 Pharmacyclics, Inc. Procédés permettant de déterminer la résistance du cancer aux inhibiteurs de l'histone déacétylase
EP2060565A1 (fr) * 2007-11-16 2009-05-20 4Sc Ag Nouveaux composés bifonctionnels inhibiteurs de protéine kinases et d'histone deacetylases
EP2110377A1 (fr) * 2008-04-15 2009-10-21 DAC S.r.l. Dérivés spirocycliques en tant qu'inhibiteurs de l'histone déacétylase
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
UY34295A (es) 2011-09-08 2013-04-30 Servier Lab Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida
RU2609833C2 (ru) 2011-09-13 2017-02-06 Фармасайкликс Элэлси Лекарственные формы ингибитора гистондиацетилазы в комбинации с бендамутином и их применение
JP6800750B2 (ja) 2013-08-02 2020-12-16 ファーマサイクリックス エルエルシー 固形腫瘍の処置方法

Also Published As

Publication number Publication date
JP6330118B2 (ja) 2018-05-30
UA110853C2 (uk) 2016-02-25
AU2011376953A1 (en) 2014-03-06
WO2013039488A1 (fr) 2013-03-21
JP2014526503A (ja) 2014-10-06
RU2609833C2 (ru) 2017-02-06
US9492423B2 (en) 2016-11-15
RU2014111069A (ru) 2015-10-20
CN103917231A (zh) 2014-07-09
US20140341989A1 (en) 2014-11-20
NZ621221A (en) 2016-07-29
KR101892788B1 (ko) 2018-08-28
EP2755648B1 (fr) 2017-03-08
EP2755648A1 (fr) 2014-07-23
CA2845806A1 (fr) 2013-03-21
EP2755648A4 (fr) 2015-03-11
SG2014014419A (en) 2014-07-30
MX2014002942A (es) 2014-09-15
MX365393B (es) 2019-05-31
CA2845806C (fr) 2019-06-11
ES2627820T3 (es) 2017-07-31
KR20140073503A (ko) 2014-06-16
AU2011376953B2 (en) 2017-08-24
CN103917231B (zh) 2016-09-28

Similar Documents

Publication Publication Date Title
HK1200095A1 (en) Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
HRP20180953T1 (hr) Supstituirani 3-haloalilaminski inhibitori za ssao i njihove uporabe
EP2678018A4 (fr) Combinaison d'inhibiteurs des kinases et utilisations associées
EP2696682A4 (fr) Facteurs d'inhibition de la migration des macrophages (mif) et leurs utilisations
HK1173440A1 (en) N-(imidazopyrimidin-7-yl)-heteroarylamide derivatives and their use as pde10a inhibitors n-(-7-)- pde10a
HK1202244A1 (en) Prebiotic formulations and methods of use
EP2592933A4 (fr) Inhibiteurs mif et leurs utilisations
HK1198827A1 (en) Dyrk1 inhibitors and uses thereof dyrk1
IL227379A0 (en) Histone deacetylase inhibitors and compositions and methods of using them
EP2563372A4 (fr) Formulations prébiotiques et méthodes d'utilisation
IL257069B (en) Inhibitors of cell death and uses thereof
IL214244A (en) Diastylase Heisone Inhibitors and their use in healing
EP2536709A4 (fr) Inhibiteurs de la prolylhydroxylase et procédés d'utilisation
HK1204998A1 (en) Combinations of histone deacetylase inhibitor and pazopanib and uses thereof
IL236686A0 (en) Inhibitors of histone deacetylase and compositions and methods of using them
IL223514A0 (en) Benzamide derivatives and their use as hsp90 inhibitors
EP2725013A4 (fr) Nouvel inhibiteur d'histone désacétylase de benzamides et son utilisation
SG10201607620YA (en) Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof

Legal Events

Date Code Title Description
CORR Corrigendum

Free format text: CORRECTED DATA OF SECTION 27 TO JOURNAL OF 20180302: (54) FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF

CORR Corrigendum

Free format text: CORRECTED DATA OF SECTION 27 TO JOURNAL OF 20180302: (54) FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR IN COMBINATION WITH BENDAMUSTINE AND USES THEREOF