HK1179614A1 - Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases - Google Patents

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Info

Publication number
HK1179614A1
HK1179614A1 HK13106699.6A HK13106699A HK1179614A1 HK 1179614 A1 HK1179614 A1 HK 1179614A1 HK 13106699 A HK13106699 A HK 13106699A HK 1179614 A1 HK1179614 A1 HK 1179614A1
Authority
HK
Hong Kong
Prior art keywords
apoptosis
immune
cancer
treatment
autoimmune diseases
Prior art date
Application number
HK13106699.6A
Other languages
English (en)
Chinese (zh)
Inventor
Hong Ding
Steven Elmore
Laura Hexamer
Aaron R Kunzer
Cheol-Min Park
Andrew J Souers
Gerard Sullivan
Michael Wendt
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of HK1179614A1 publication Critical patent/HK1179614A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
HK13106699.6A 2010-03-25 2013-06-06 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases HK1179614A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31757510P 2010-03-25 2010-03-25
PCT/US2011/027895 WO2011119345A2 (en) 2010-03-25 2011-03-10 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
HK1179614A1 true HK1179614A1 (en) 2013-10-04

Family

ID=43858249

Family Applications (3)

Application Number Title Priority Date Filing Date
HK15100726.4A HK1200444A1 (en) 2010-03-25 2013-06-06 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK13106699.6A HK1179614A1 (en) 2010-03-25 2013-06-06 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
HK16107017.6A HK1219092A1 (zh) 2010-03-25 2016-06-17 用於治療癌症和免疫以及自身免疫性疾病的細胞凋亡誘導劑

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK15100726.4A HK1200444A1 (en) 2010-03-25 2013-06-06 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16107017.6A HK1219092A1 (zh) 2010-03-25 2016-06-17 用於治療癌症和免疫以及自身免疫性疾病的細胞凋亡誘導劑

Country Status (26)

Country Link
US (2) US8188077B2 (xx)
EP (3) EP2957558A3 (xx)
JP (1) JP5959501B2 (xx)
KR (1) KR20130040834A (xx)
CN (2) CN105218483A (xx)
AU (1) AU2011229862B2 (xx)
BR (1) BR112012024382A2 (xx)
CA (1) CA2792276A1 (xx)
DK (1) DK2550258T3 (xx)
ES (1) ES2553143T3 (xx)
HK (3) HK1200444A1 (xx)
HR (1) HRP20151218T1 (xx)
HU (1) HUE026241T2 (xx)
IL (2) IL221771A (xx)
MX (1) MX2012011086A (xx)
NZ (2) NZ602055A (xx)
PL (1) PL2550258T3 (xx)
PT (1) PT2550258E (xx)
RS (1) RS54388B1 (xx)
RU (2) RU2568611C2 (xx)
SG (2) SG184094A1 (xx)
SI (1) SI2550258T1 (xx)
SM (1) SMT201600016B (xx)
TW (2) TWI535713B (xx)
WO (1) WO2011119345A2 (xx)
ZA (1) ZA201206837B (xx)

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Also Published As

Publication number Publication date
KR20130040834A (ko) 2013-04-24
RU2012145298A (ru) 2014-04-27
CA2792276A1 (en) 2011-09-29
SG10201406608YA (en) 2014-12-30
RU2015141713A (ru) 2018-12-28
JP2013523636A (ja) 2013-06-17
HRP20151218T1 (hr) 2016-01-01
RU2015141713A3 (xx) 2018-12-28
ZA201206837B (en) 2013-05-29
US8343967B2 (en) 2013-01-01
TWI535713B (zh) 2016-06-01
SI2550258T1 (sl) 2016-01-29
EP2550258B1 (en) 2015-08-19
HK1200444A1 (en) 2015-08-07
RU2568611C2 (ru) 2015-11-20
SMT201600016B (it) 2016-02-25
EP2957558A3 (en) 2016-03-02
WO2011119345A2 (en) 2011-09-29
CN105218483A (zh) 2016-01-06
SG184094A1 (en) 2012-10-30
WO2011119345A3 (en) 2011-12-22
HK1219092A1 (zh) 2017-03-24
AU2011229862A1 (en) 2012-09-20
US20120214796A1 (en) 2012-08-23
HUE026241T2 (en) 2016-06-28
RS54388B1 (en) 2016-04-28
US20110237553A1 (en) 2011-09-29
JP5959501B2 (ja) 2016-08-02
DK2550258T3 (en) 2015-12-07
BR112012024382A2 (pt) 2017-08-08
US8188077B2 (en) 2012-05-29
NZ602055A (en) 2014-08-29
CN102947283A (zh) 2013-02-27
MX2012011086A (es) 2013-03-21
NZ628298A (en) 2015-11-27
EP2957558A2 (en) 2015-12-23
CN102947283B (zh) 2015-10-07
EP2757105A1 (en) 2014-07-23
TW201139418A (en) 2011-11-16
TW201623291A (zh) 2016-07-01
IL221771A0 (en) 2012-12-02
ES2553143T3 (es) 2015-12-04
PT2550258E (pt) 2015-11-30
IL221771A (en) 2015-11-30
PL2550258T3 (pl) 2016-01-29
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AU2011229862B2 (en) 2014-07-24
IL231702A0 (en) 2014-04-30

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