HK1176629A1 - 不透射線的、不能生物降解的、水不溶性聚 乙烯醇 的碘化苄基醚，其製備方法，含有其的注射栓塞組合物及其用途 - Google Patents

不透射線的、不能生物降解的、水不溶性聚 乙烯醇 的碘化苄基醚，其製備方法，含有其的注射栓塞組合物及其用途

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Publication number
HK1176629A1
HK1176629A1 HK13103365.6A HK13103365A HK1176629A1 HK 1176629 A1 HK1176629 A1 HK 1176629A1 HK 13103365 A HK13103365 A HK 13103365A HK 1176629 A1 HK1176629 A1 HK 1176629A1
Authority
HK
Hong Kong
Prior art keywords
radiopaque
biodegradable
poly
preparation
water
Prior art date
Application number
HK13103365.6A
Other languages
English (en)
Inventor
伊夫．謝瓦利埃
傑拉爾丁．阿古斯蒂
柯拉麗．紐芬愛格
埃裡克．德爾克
奧利弗．喬丹
格特．安德森
Original Assignee
克勞德伯納德裡昂第大學
國家科學研究中心
安蒂亞治療公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 克勞德伯納德裡昂第大學, 國家科學研究中心, 安蒂亞治療公司 filed Critical 克勞德伯納德裡昂第大學
Publication of HK1176629A1 publication Critical patent/HK1176629A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04—Acyclic compounds
    • C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F16/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F16/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F16/04—Acyclic compounds
    • C08F16/06—Polyvinyl alcohol ; Vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/18—Introducing halogen atoms or halogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D129/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Coating compositions based on hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Coating compositions based on derivatives of such polymers
    • C09D129/02—Homopolymers or copolymers of unsaturated alcohols
    • C09D129/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
HK13103365.6A 2010-03-10 2013-03-18 不透射線的、不能生物降解的、水不溶性聚 乙烯醇 的碘化苄基醚，其製備方法，含有其的注射栓塞組合物及其用途 HK1176629A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10156039A EP2365009A1 (en) 2010-03-10 2010-03-10 Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof
PCT/EP2011/053536 WO2011110589A1 (en) 2010-03-10 2011-03-09 Radiopaque, non- biodegradable, water - insoluble iodinated benzyl ethers of poly (vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof

Publications (1)

Publication Number Publication Date
HK1176629A1 true HK1176629A1 (zh) 2013-08-02

Family

ID=42035808

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13103365.6A HK1176629A1 (zh) 2010-03-10 2013-03-18 不透射線的、不能生物降解的、水不溶性聚 乙烯醇 的碘化苄基醚，其製備方法，含有其的注射栓塞組合物及其用途

Country Status (13)

Country Link
US (2) US9115230B2 (zh)
EP (2) EP2365009A1 (zh)
JP (1) JP5696165B2 (zh)
KR (1) KR101753441B1 (zh)
CN (1) CN102781974B (zh)
AU (1) AU2011226138B2 (zh)
BR (1) BR112012019754B1 (zh)
CA (1) CA2786398C (zh)
DK (1) DK2545085T3 (zh)
ES (1) ES2603607T3 (zh)
HK (1) HK1176629A1 (zh)
PL (1) PL2545085T3 (zh)
WO (1) WO2011110589A1 (zh)

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US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
CA2777171C (en) 2009-10-26 2017-09-19 Microvention, Inc. Embolization device constructed from expansile polymer
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
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WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
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JP7014728B2 (ja) * 2016-03-14 2022-02-01 バイオコンパティブルズ ユーケー リミテッド 粒子を含むエマルジョン
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JP7362598B2 (ja) * 2017-10-09 2023-10-17 マイクロベンション インコーポレイテッド 放射性液体塞栓物質
CN107899064A (zh) * 2017-10-27 2018-04-13 华威（深圳）医疗器械有限责任公司 一种可载药且兼具显影性的液体栓塞剂的制备方法及其用途
CN107754007A (zh) * 2017-12-06 2018-03-06 华威（深圳）医疗器械有限责任公司 一种核素的载体组合物及制备方法、液体栓塞剂及使用方法以及核素混合物
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
GB201810784D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
US11702498B2 (en) 2018-06-29 2023-07-18 Biocompatibles Uk Limited Radiopaque polymers
CN109224119B (zh) * 2018-10-30 2021-02-23 北京大学深圳医院 一种π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂
TW202031299A (zh) * 2018-11-13 2020-09-01 大陸商上海盛迪醫藥有限公司 一種聚合物及其組合物
US11986571B2 (en) 2019-04-03 2024-05-21 Sree Chitra Tirunal Institute For Medical Sciences And Technology Radiopaque polymeric liquid embolic system
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
CN110372484B (zh) * 2019-07-23 2020-05-22 赵修文 一种不透射线的聚乙烯醇微球
US20230001043A1 (en) * 2019-11-20 2023-01-05 The Regents Of The University Of California Liquid embolic material composition
JP2023518271A (ja) * 2020-03-17 2023-04-28 マイクロベンション インコーポレイテッド 液体塞栓物質
CN113651906B (zh) * 2020-05-12 2024-02-20 上海盛迪医药有限公司 一种共聚物及其组合物
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CN113995884A (zh) * 2021-09-10 2022-02-01 苏州浩微生物医疗科技有限公司 一种液体栓塞剂及其制备方法
CN118215510A (zh) * 2021-11-12 2024-06-18 重庆百迈腾世医药科技有限公司 活性金属微球、基于活性金属微球的复合栓塞剂
CN114146190B (zh) * 2021-12-30 2024-01-26 科睿驰（深圳）医疗科技发展有限公司 一种高悬浮性显影微球及其制备方法
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法
CN114805644B (zh) * 2022-06-24 2022-09-16 苏州美创医疗科技有限公司 一种不透射聚合物及其制备方法和应用
CN115490639B (zh) * 2022-09-19 2023-05-16 科睿驰（深圳）医疗科技发展有限公司 X射线显影化合物及其制备方法、x射线显影栓塞材料及其制备方法
CN115590984B (zh) * 2022-09-22 2023-07-14 科睿驰（深圳）医疗科技发展有限公司 X射线显影化合物及其制备方法、x射线显影微球及其制备方法
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Also Published As

Publication number Publication date
US9115230B2 (en) 2015-08-25
ES2603607T3 (es) 2017-02-28
DK2545085T3 (en) 2016-12-05
PL2545085T3 (pl) 2017-08-31
JP5696165B2 (ja) 2015-04-08
WO2011110589A1 (en) 2011-09-15
BR112012019754B1 (pt) 2020-10-20
KR101753441B1 (ko) 2017-07-03
CA2786398A1 (en) 2011-09-15
BR112012019754A2 (pt) 2016-05-10
KR20130051916A (ko) 2013-05-21
US20130108574A1 (en) 2013-05-02
JP2013521087A (ja) 2013-06-10
US20150335779A1 (en) 2015-11-26
AU2011226138B2 (en) 2015-01-22
CN102781974B (zh) 2014-10-15
EP2365009A1 (en) 2011-09-14
EP2545085B1 (en) 2016-10-19
AU2011226138A1 (en) 2012-07-26
CN102781974A (zh) 2012-11-14
US9434800B2 (en) 2016-09-06
EP2545085A1 (en) 2013-01-16
CA2786398C (en) 2017-06-13

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