HK1166078A1 - Pyrimidyl cyclopentanes as akt protein kinase inhibitors akt - Google Patents
Pyrimidyl cyclopentanes as akt protein kinase inhibitors aktInfo
- Publication number
- HK1166078A1 HK1166078A1 HK12106808.5A HK12106808A HK1166078A1 HK 1166078 A1 HK1166078 A1 HK 1166078A1 HK 12106808 A HK12106808 A HK 12106808A HK 1166078 A1 HK1166078 A1 HK 1166078A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- akt
- protein kinase
- kinase inhibitors
- pyrimidyl cyclopentanes
- cyclopentanes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94814707P | 2007-07-05 | 2007-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1166078A1 true HK1166078A1 (en) | 2012-10-19 |
Family
ID=39830222
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10104442.4A HK1136832A1 (en) | 2007-07-05 | 2010-05-06 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
HK12106808.5A HK1166078A1 (en) | 2007-07-05 | 2012-07-11 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors akt |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10104442.4A HK1136832A1 (en) | 2007-07-05 | 2010-05-06 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
Country Status (16)
Country | Link |
---|---|
US (1) | US8377937B2 (xx) |
EP (2) | EP2404907B1 (xx) |
JP (2) | JP5542282B2 (xx) |
KR (2) | KR101624361B1 (xx) |
CN (1) | CN101918373B (xx) |
AT (1) | ATE522509T1 (xx) |
AU (1) | AU2008272832B2 (xx) |
BR (1) | BRPI0813993A2 (xx) |
CA (1) | CA2692506C (xx) |
ES (1) | ES2533557T3 (xx) |
HK (2) | HK1136832A1 (xx) |
IL (1) | IL202617A0 (xx) |
MX (1) | MX2009014013A (xx) |
SI (1) | SI2173723T1 (xx) |
WO (1) | WO2009006569A1 (xx) |
ZA (1) | ZA200908901B (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2009006567A2 (en) * | 2007-07-05 | 2009-01-08 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
NZ586720A (en) | 2008-01-09 | 2012-11-30 | Array Biopharma Inc | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
CA2711741A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
CN101970415A (zh) | 2008-01-09 | 2011-02-09 | 阵列生物制药公司 | 作为AKT蛋白激酶抑制剂的5H-环戊二烯并[d]嘧啶 |
GB201110546D0 (en) * | 2011-06-22 | 2011-08-03 | Imp Innovations Ltd | Compositions |
CN104487430B (zh) | 2012-05-17 | 2016-08-24 | 阵列生物制药公司 | 用于制造羟基化的环戊基嘧啶化合物的方法 |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
SG11201903483VA (en) | 2016-10-28 | 2019-05-30 | Icahn School Med Mount Sinai | Compositions and methods for treating ezh2-mediated cancer |
AU2017370694A1 (en) | 2016-12-08 | 2019-07-25 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating CDK4/6-mediated cancer |
WO2019173516A1 (en) | 2018-03-06 | 2019-09-12 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (akt) degradation / disruption compounds and methods of use |
TW202136269A (zh) | 2020-03-17 | 2021-10-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合二環類衍生物、其製備方法及其在醫藥上的應用 |
CN113444110B (zh) * | 2020-03-25 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |
TW202328138A (zh) | 2021-09-17 | 2023-07-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 稠合二環類衍生物的可藥用鹽、晶型及其製備方法 |
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TW200808325A (en) | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
JP5283620B2 (ja) | 2006-07-06 | 2013-09-04 | グラクソ グループ リミテッド | P2x7受容体アンタゴニストとしての置換n−フェニルメチル−5−オキソ−プロリン−2−アミドおよびそれらの使用方法 |
CN103288753A (zh) | 2006-07-06 | 2013-09-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的环戊二烯并[d]嘧啶 |
GB0613518D0 (en) | 2006-07-06 | 2006-08-16 | Phytopharm Plc | Chemical compounds |
WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
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2008
- 2008-07-03 US US12/667,850 patent/US8377937B2/en active Active
- 2008-07-03 AU AU2008272832A patent/AU2008272832B2/en not_active Ceased
- 2008-07-03 EP EP11169324.8A patent/EP2404907B1/en active Active
- 2008-07-03 KR KR1020107002547A patent/KR101624361B1/ko active IP Right Grant
- 2008-07-03 SI SI200830441T patent/SI2173723T1/sl unknown
- 2008-07-03 CA CA2692506A patent/CA2692506C/en not_active Expired - Fee Related
- 2008-07-03 KR KR1020157020348A patent/KR20150091196A/ko not_active Application Discontinuation
- 2008-07-03 JP JP2010515270A patent/JP5542282B2/ja active Active
- 2008-07-03 CN CN2008801058708A patent/CN101918373B/zh active Active
- 2008-07-03 AT AT08781340T patent/ATE522509T1/de not_active IP Right Cessation
- 2008-07-03 ES ES11169324.8T patent/ES2533557T3/es active Active
- 2008-07-03 MX MX2009014013A patent/MX2009014013A/es not_active Application Discontinuation
- 2008-07-03 EP EP08781340.8A patent/EP2173723B3/en active Active
- 2008-07-03 BR BRPI0813993-8A patent/BRPI0813993A2/pt not_active Application Discontinuation
- 2008-07-03 WO PCT/US2008/069147 patent/WO2009006569A1/en active Application Filing
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2009
- 2009-12-09 IL IL202617A patent/IL202617A0/en unknown
- 2009-12-14 ZA ZA2009/08901A patent/ZA200908901B/en unknown
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2010
- 2010-05-06 HK HK10104442.4A patent/HK1136832A1/xx unknown
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2012
- 2012-07-11 HK HK12106808.5A patent/HK1166078A1/xx unknown
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EP2173723B3 (en) | 2014-11-19 |
HK1136832A1 (en) | 2010-07-09 |
WO2009006569A1 (en) | 2009-01-08 |
RU2010103811A (ru) | 2011-08-10 |
JP2014040489A (ja) | 2014-03-06 |
BRPI0813993A2 (pt) | 2015-06-16 |
KR101624361B1 (ko) | 2016-05-25 |
US8377937B2 (en) | 2013-02-19 |
CA2692506C (en) | 2015-11-24 |
AU2008272832B2 (en) | 2014-02-20 |
EP2404907A1 (en) | 2012-01-11 |
JP2010532387A (ja) | 2010-10-07 |
ZA200908901B (en) | 2011-10-26 |
SI2173723T1 (sl) | 2011-12-30 |
CN101918373A (zh) | 2010-12-15 |
IL202617A0 (en) | 2010-06-30 |
US20110160221A1 (en) | 2011-06-30 |
CN101918373B (zh) | 2013-06-05 |
EP2173723A1 (en) | 2010-04-14 |
KR20100029846A (ko) | 2010-03-17 |
KR20150091196A (ko) | 2015-08-07 |
JP5542282B2 (ja) | 2014-07-09 |
AU2008272832A1 (en) | 2009-01-08 |
ATE522509T1 (de) | 2011-09-15 |
EP2173723B1 (en) | 2011-08-31 |
CA2692506A1 (en) | 2009-01-08 |
MX2009014013A (es) | 2010-01-28 |
EP2404907B1 (en) | 2015-01-14 |
ES2533557T3 (es) | 2015-04-13 |
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