HK1159628A1 - Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c] - Google Patents

Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c]

Info

Publication number
HK1159628A1
HK1159628A1 HK12100183.3A HK12100183A HK1159628A1 HK 1159628 A1 HK1159628 A1 HK 1159628A1 HK 12100183 A HK12100183 A HK 12100183A HK 1159628 A1 HK1159628 A1 HK 1159628A1
Authority
HK
Hong Kong
Prior art keywords
thieno
cancer
treatment
kinase inhibitors
pyridine derivatives
Prior art date
Application number
HK12100183.3A
Other languages
English (en)
Chinese (zh)
Inventor
Michael R Michaelides
Robin R Frey
Michael L Curtin
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of HK1159628A1 publication Critical patent/HK1159628A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK12100183.3A 2008-12-05 2012-01-06 Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c] HK1159628A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12028108P 2008-12-05 2008-12-05
US22376009P 2009-07-08 2009-07-08
PCT/US2009/066725 WO2010065825A2 (en) 2008-12-05 2009-12-04 Kinase inhibitors with improved cyp safety profile

Publications (1)

Publication Number Publication Date
HK1159628A1 true HK1159628A1 (en) 2012-08-03

Family

ID=41559043

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12100183.3A HK1159628A1 (en) 2008-12-05 2012-01-06 Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c]

Country Status (26)

Country Link
US (2) US20100144783A1 (ru)
EP (1) EP2373662B1 (ru)
JP (1) JP5588458B2 (ru)
KR (1) KR101639642B1 (ru)
CN (1) CN102239171B (ru)
AR (1) AR074481A1 (ru)
AU (1) AU2009322270B2 (ru)
BR (1) BRPI0921392A2 (ru)
CA (1) CA2743592A1 (ru)
CL (1) CL2011001312A1 (ru)
CO (1) CO6382131A2 (ru)
DO (1) DOP2011000153A (ru)
EC (1) ECSP11011172A (ru)
ES (1) ES2524966T3 (ru)
HK (1) HK1159628A1 (ru)
IL (1) IL212716A (ru)
MX (1) MX2011005943A (ru)
MY (1) MY179042A (ru)
NZ (1) NZ592714A (ru)
PA (1) PA8852401A1 (ru)
PE (1) PE20110830A1 (ru)
RU (2) RU2480472C2 (ru)
TW (2) TWI441827B (ru)
UA (1) UA103351C2 (ru)
UY (1) UY32291A (ru)
WO (1) WO2010065825A2 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202363B2 (en) * 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
WO2010065825A2 (en) * 2008-12-05 2010-06-10 Abbott Laboratories Kinase inhibitors with improved cyp safety profile
ES2559212T3 (es) * 2010-06-09 2016-02-11 Abbvie Bahamas Ltd. Formas cristalinas de inhibidores de cinasas
TWI482770B (zh) * 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
ES2523999T3 (es) * 2010-06-09 2014-12-03 Abbvie Bahamas Ltd. Dispersiones sólidas que contienen inhibidores de cinasas
US8911725B2 (en) 2010-06-23 2014-12-16 University Of Central Florida Research Foundation, Inc. Co-targeting of aurora A kinase and LIM kinase 1 for cancer therapy
WO2013012909A1 (en) 2011-07-20 2013-01-24 Abbott Laboratories Kinase inhibitor with improved aqueous solubility
KR20150000869A (ko) 2011-12-14 2015-01-05 애브비 인코포레이티드 키나제 억제제를 함유하는 조성물
WO2014026243A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
WO2014026242A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
WO2015157360A1 (en) 2014-04-08 2015-10-15 Abbvie Inc. Processes to make protein kinase inhibitors
US20170197980A1 (en) * 2014-06-25 2017-07-13 Abbvie Inc. N-(4-phenyl)-n'-(3-fluorophenyl)urea docusate
US20220040324A1 (en) 2018-12-21 2022-02-10 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
CN114222729A (zh) * 2019-06-12 2022-03-22 范德比尔特大学 氨基酸转运抑制剂及其用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1188529A (en) 1966-06-09 1970-04-15 Wellcome Found Pyramidine Derivatives
US4357535A (en) 1980-04-30 1982-11-02 North American Philips Corporation Apparatus for inspecting hand-held articles and persons carrying same
GB8307154D0 (en) 1983-03-15 1983-04-20 Mk Electric Ltd Terminals
US4767766A (en) 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
EP0300688A1 (en) 1987-07-21 1989-01-25 FISONS plc Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them
JPH0436810Y2 (ru) 1987-12-29 1992-08-31
US4843949A (en) 1988-08-29 1989-07-04 Pneumo Abex Corporation Fluid control valve with variable pressure gain
GB8912498D0 (en) 1989-05-31 1989-07-19 De Beers Ind Diamond Diamond growth
EP0438261A3 (en) 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
DE4129603A1 (de) 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0630031B1 (en) 1993-06-16 2002-08-14 E.I. Du Pont De Nemours And Company Water cleanable thick film paste composition
IL112759A0 (en) 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
DE29511756U1 (de) 1995-07-20 1995-09-28 Ferco Int Usine Ferrures Flügelseitiges Ecklagerbeschlagteil für Drehkippfenster
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
DE19620508A1 (de) 1996-05-22 1997-11-27 Hoechst Ag Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung
WO1998047879A1 (en) 1997-04-22 1998-10-29 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
CN1279682A (zh) 1997-10-20 2001-01-10 霍夫曼-拉罗奇有限公司 双环激酶抑制剂
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
HUP0303363A2 (hu) 1999-09-17 2004-07-28 Abbott Gmbh & Co., Kg Kináz-inhibitor hatású heterociklusos vegyületek alkalmazása gyógyszerkészítmények előállítására
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
US20020004511A1 (en) 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents
KR100908954B1 (ko) 2000-12-15 2009-07-22 브리티쉬 텔리커뮤니케이션즈 파블릭 리미티드 캄퍼니 오디오 또는 비디오 자료의 전송방법 및 장치
WO2002071827A2 (en) 2001-03-14 2002-09-19 Eli Lilly And Company Retinoid x receptor modulators
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7427623B2 (en) 2001-09-11 2008-09-23 Smithkline Beecham Corporation 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof
WO2003059354A2 (en) 2001-12-21 2003-07-24 Bayer Pharmaceuticals Corporation Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
US7265128B2 (en) 2003-01-17 2007-09-04 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
DE10303311A1 (de) 2003-01-28 2004-07-29 Basf Ag Addukte auf Basis cyclischer Verbindungen und ihre Verwendung als Gerbstoffe und Konservierungsmittel
US7592352B2 (en) * 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US7202363B2 (en) * 2003-07-24 2007-04-10 Abbott Laboratories Thienopyridine and furopyridine kinase inhibitors
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AU2005304646A1 (en) 2004-11-11 2006-05-18 Achillion Pharmaceuticals, Inc. Inhibitors of HIV-1 capsid formation: substituted aryl aminomethyl thiazole ureas and analogues thereof
BRPI0610382A2 (pt) 2005-05-20 2010-06-15 Methylgene Inc inibidores de sinalização de receptor de vegf e receptor de hgf
US7566721B2 (en) 2005-08-08 2009-07-28 Osi Pharmaceuticals, Inc. Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
US20070093515A1 (en) 2005-08-16 2007-04-26 Arrington Mark P Phosphodiesterase 10 inhibitors
WO2007056625A2 (en) 2005-11-04 2007-05-18 Smithkline Beecham Corporation Thienopyridine b-raf kinase inhibitors
US20070135387A1 (en) * 2005-12-08 2007-06-14 Michaelides Michael R Inhibitors of protein kinases
JP2009544625A (ja) 2006-07-20 2009-12-17 メーメット・カーラマン Ｒｈｏキナーゼのベンゾチオフェン阻害剤
WO2010065825A2 (en) * 2008-12-05 2010-06-10 Abbott Laboratories Kinase inhibitors with improved cyp safety profile

Also Published As

Publication number Publication date
US8722890B2 (en) 2014-05-13
US20120309783A1 (en) 2012-12-06
ES2524966T3 (es) 2014-12-16
UA103351C2 (ru) 2013-10-10
BRPI0921392A2 (pt) 2016-04-26
UY32291A (es) 2010-07-30
RU2012156958A (ru) 2014-06-27
IL212716A0 (en) 2011-07-31
JP5588458B2 (ja) 2014-09-10
ECSP11011172A (es) 2011-08-31
IL212716A (en) 2013-10-31
TWI441827B (zh) 2014-06-21
KR20110091577A (ko) 2011-08-11
TW201026706A (en) 2010-07-16
DOP2011000153A (es) 2011-06-30
MY179042A (en) 2020-10-26
EP2373662B1 (en) 2014-09-24
MX2011005943A (es) 2011-06-27
WO2010065825A2 (en) 2010-06-10
CA2743592A1 (en) 2010-06-10
AR074481A1 (es) 2011-01-19
CN102239171B (zh) 2014-06-11
WO2010065825A3 (en) 2010-08-26
CN102239171A (zh) 2011-11-09
PE20110830A1 (es) 2011-12-14
TW201431862A (zh) 2014-08-16
TWI500621B (zh) 2015-09-21
CO6382131A2 (es) 2012-02-15
KR101639642B1 (ko) 2016-07-14
JP2012511016A (ja) 2012-05-17
NZ592714A (en) 2013-03-28
AU2009322270B2 (en) 2014-12-18
AU2009322270A1 (en) 2011-07-14
US20100144783A1 (en) 2010-06-10
PA8852401A1 (es) 2010-07-27
RU2011127451A (ru) 2013-01-10
RU2480472C2 (ru) 2013-04-27
CL2011001312A1 (es) 2011-10-07
EP2373662A2 (en) 2011-10-12

Similar Documents

Publication Publication Date Title
HK1159628A1 (en) Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c]
PL2419428T3 (pl) Pochodne imidazo[1,2-A]pirydyny jako inhibitory kinaz FGFR do zastosowania w terapii
ZA201106599B (en) Pyrrolo [2,3-b] pyridine derivatives for the inhibition of raf kinases
IL199323A (en) Converted Pirazolo-Quinazoline History, Process for Preparation and Use as Kinase Inhibitors
AP2939A (en) Thieno [2,3-B] pyridine derivatives as viral replication inhibitors
IL195731A0 (en) Pyrimidine derivatives useful in the treatment of cancer
HK1148284A1 (en) Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions hif
HK1153926A1 (en) Purin derivatives for use in the treatment of fab-related diseases fab-
EP2235004A4 (en) INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
ZA201000075B (en) Purin derivatives for use in the treatment of fab-related diseases
ZA201000085B (en) 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as Met kinase inhibitors for the treatment of tumors
IL194755A0 (en) Pyrimidine derivatives as pi3k inhibitors
PL2120932T3 (pl) Indazolowe pochodne jako inhibitory kinazy do leczenia raka
IL211825A0 (en) Pyridine and pyrimidine based compounds as wnt sigaling pathway inhibitors for the treatment of cancer
IL217798A0 (en) Pyrrolo [1,2-b]pyridazine derivatives as janus kinase inhibitors
EP2331520A4 (en) ROSAMINE DERIVATIVES AS AGENTS FOR CANCER TREATMENT
PL2188289T3 (pl) (7H-pirolo[2,3-D]pirymidyn-4-ylo)-piperazyny jako inhibitory kinaz do leczenia nowotworów i zapalenia
ZA201005554B (en) Furo-and thieno[3,2-c]pyridines
ZA200906648B (en) Pyrido [2,3-D] pyramidin-7-one compounds as inhibitors of P13K-alpha for the treatment of cancer
PL2124944T3 (pl) Pochodne pirazolo[3,4-b]pirydyny jako inhibitory fosfodiesterazy
IL214426A0 (en) [1,2,4] triazollo [1,5-a] pyridines as kinase inhibitors
PL2229369T3 (pl) Pochodne 6,7-dialkoksychinazoliny użyteczne do leczenia zaburzeń związanych z rakiem
HK1139948A1 (en) Pyrido [2, 3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer
IL209840A0 (en) Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
ZA200904912B (en) Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors