HK1145673A1 - Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanamides with high purity degree 2-[4-(3- 2-)] - Google Patents

Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanamides with high purity degree 2-[4-(3- 2-)]

Info

Publication number
HK1145673A1
HK1145673A1 HK10112228.7A HK10112228A HK1145673A1 HK 1145673 A1 HK1145673 A1 HK 1145673A1 HK 10112228 A HK10112228 A HK 10112228A HK 1145673 A1 HK1145673 A1 HK 1145673A1
Authority
HK
Hong Kong
Prior art keywords
propanamides
fluorobenzyloxy
benzylamino
production
high purity
Prior art date
Application number
HK10112228.7A
Other languages
English (en)
Chinese (zh)
Inventor
‧巴爾班蒂
‧法拉維利
‧薩爾瓦蒂
‧卡尼沃蒂
‧龐吉尼
Original Assignee
紐朗製藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 紐朗製藥有限公司 filed Critical 紐朗製藥有限公司
Publication of HK1145673A1 publication Critical patent/HK1145673A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK10112228.7A 2007-12-11 2010-12-30 Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanamides with high purity degree 2-[4-(3- 2-)] HK1145673A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07023937 2007-12-11
PCT/EP2008/066559 WO2009074478A1 (de) 2007-12-11 2008-12-01 Verfahren zur bestimmung des an der kurbelwelle zur verfügung stehenden momentes des verbrennungsmotors eines kraftfahrzeugs

Publications (1)

Publication Number Publication Date
HK1145673A1 true HK1145673A1 (en) 2011-04-29

Family

ID=39301684

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10112228.7A HK1145673A1 (en) 2007-12-11 2010-12-30 Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanamides with high purity degree 2-[4-(3- 2-)]
HK15105708.5A HK1204960A1 (en) 2007-12-11 2015-06-16 Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanami[with high purity degree 2-[4-(3- 2-)]

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15105708.5A HK1204960A1 (en) 2007-12-11 2015-06-16 Process for the production of 2-[4-(3- or 2- fluorobenzyloxy)benzylamino]propanami[with high purity degree 2-[4-(3- 2-)]

Country Status (27)

Country Link
US (2) US8530701B2 (de)
EP (2) EP2229351B1 (de)
JP (2) JP5460613B2 (de)
KR (2) KR101709498B1 (de)
CN (2) CN104523668B (de)
AR (1) AR071267A1 (de)
AU (1) AU2008334778B2 (de)
BR (1) BRPI0820657A2 (de)
CA (2) CA2936209C (de)
CY (1) CY1119991T1 (de)
DK (1) DK2229351T3 (de)
EA (2) EA030250B1 (de)
ES (2) ES2655706T3 (de)
HK (2) HK1145673A1 (de)
HR (1) HRP20180210T1 (de)
HU (1) HUE036232T2 (de)
IL (1) IL205872A (de)
LT (1) LT2229351T (de)
MX (1) MX2010006278A (de)
NO (1) NO2229351T3 (de)
NZ (1) NZ585806A (de)
PL (1) PL2229351T3 (de)
PT (1) PT2229351T (de)
RS (1) RS56803B1 (de)
SI (1) SI2229351T1 (de)
TW (1) TWI429425B (de)
WO (1) WO2009074478A1 (de)

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KR101233711B1 (ko) * 2003-08-25 2013-02-18 뉴론 파마슈티칼즈 에스. 피. 에이. 항염증제로서 유용한 알파-아미노아미드 유도체
LT2474521T (lt) 2006-06-19 2016-11-25 Newron Pharmaceuticals S.P.A. Aukšto grynumo laipsnio 2-[4-(3- ir 2-fluorbenziloksi)benzilamino]propanamidai, skirti naudoti kaip medikamentai, ir juos apimančios farmacinės kompozicijos
DK2229351T3 (en) * 2007-12-11 2018-01-22 Newron Pharm Spa PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY
EP2314569A1 (de) 2009-10-22 2011-04-27 Merck Patent GmbH Neuartige polymorphe Formen von (S)-2-[4-(3-Fluor-benzyloxy)-benzylamino]-Propionamidmesylatsalz und Herstellungsverfahren dafür
MX342697B (es) * 2010-04-27 2016-10-10 Newron Pharmaceuticals S P A * Proceso para produccion de sales de metanosulfonato de ralfinamida o sus enantiomeros r.
EP2638007A2 (de) 2010-11-11 2013-09-18 Redx Pharma Limited Wirkstoffderivate
CN103044279B (zh) * 2012-12-21 2015-07-08 苏州永健生物医药有限公司 一种n-香豆酰多巴胺的合成方法
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN104292128A (zh) * 2014-07-01 2015-01-21 南京正科制药有限公司 一种沙芬酰胺晶型a
CN105017060B (zh) * 2015-07-03 2017-06-16 南京正大天晴制药有限公司 一种沙芬酰胺新晶型及其制备方法
CN113072436A (zh) * 2015-07-24 2021-07-06 上海医药集团股份有限公司 一种苄基芳基醚的制备方法
CN105061245A (zh) * 2015-08-25 2015-11-18 成都维恒医药科技有限公司 一种高纯度沙芬酰胺的制备方法
CN106565442B (zh) * 2016-08-24 2019-07-16 浙江美诺华药物化学有限公司 3-(3-氟苄基)-4-(3-氟苄氧基)苯甲醛的制备方法
CN106565521B (zh) * 2016-08-24 2019-03-08 浙江美诺华药物化学有限公司 (s)-2-[3-(3-氟苄基)-4-(3-氟苄氧基)苄氨基]丙酰胺及其盐的制备方法
CN106632223B (zh) * 2016-08-24 2019-04-23 浙江美诺华药物化学有限公司 2-(3-溴-4-(3-氟苄氧基)苯基)-1,3-二氧戊环及其制备方法
CN106349269B (zh) * 2016-08-24 2018-08-31 浙江美诺华药物化学有限公司 2-(3-氟苄氧基)-5-甲酰基苯硼酸及其制备方法
CN106596828B (zh) * 2016-12-15 2018-09-25 扬子江药业集团有限公司 一种甲磺酸沙芬酰胺有关物质的检测方法
WO2019167085A1 (en) * 2018-03-01 2019-09-06 Msn Laboratories Private Limited, R&D Center Process for the preparation of (s)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino propanamide methanesulfonate
WO2020136671A1 (en) * 2018-12-27 2020-07-02 Natco Pharma Limited Improved process for the preparation of lapatinib base and it's anhydrous ditosylate salt
EP3725768A1 (de) * 2019-04-17 2020-10-21 Newron Pharmaceuticals S.p.A. Verfahren zur herstellung von substituierten 2-[2-(phenyl)ethylamino]alkanamid-derivaten
US11111208B2 (en) 2019-06-17 2021-09-07 RK Pharma Solutions LLC Process for the preparation of safinamide mesylate intermediate
US11225457B2 (en) 2019-08-06 2022-01-18 Medichem, S.A. Process for preparing safinamide
CN113444010B (zh) * 2020-03-28 2023-09-05 南京正大天晴制药有限公司 一种沙芬酰胺有关物质的制备方法
CN112028754A (zh) * 2020-06-17 2020-12-04 浙江美诺华药物化学有限公司 一种甲磺酸沙芬酰胺中间体的制备方法
CN114088830B (zh) * 2021-11-10 2022-09-23 石家庄四药有限公司 一种4-(3-氟苄氧基)苯甲醛中异构体的检测方法

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SI1423168T1 (sl) 2001-09-03 2006-06-30 Newron Pharm Spa Farmacevtski sestavek, ki vsebuje gabapentin ali njegov analog in alfa-aminoamid, in njegova analgetska uporaba
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LT2474521T (lt) * 2006-06-19 2016-11-25 Newron Pharmaceuticals S.P.A. Aukšto grynumo laipsnio 2-[4-(3- ir 2-fluorbenziloksi)benzilamino]propanamidai, skirti naudoti kaip medikamentai, ir juos apimančios farmacinės kompozicijos
DK2229351T3 (en) * 2007-12-11 2018-01-22 Newron Pharm Spa PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY

Also Published As

Publication number Publication date
IL205872A (en) 2015-06-30
EP2229351A1 (de) 2010-09-22
AU2008334778A2 (en) 2010-07-08
EA201400105A1 (ru) 2014-05-30
MX2010006278A (es) 2010-08-31
CA2706789A1 (en) 2009-06-18
JP2014159407A (ja) 2014-09-04
NZ585806A (en) 2011-09-30
EA030250B1 (ru) 2018-07-31
WO2009074478A1 (de) 2009-06-18
SI2229351T1 (en) 2018-02-28
PL2229351T3 (pl) 2018-04-30
CA2936209A1 (en) 2009-06-18
HRP20180210T1 (hr) 2018-03-09
CN104523668A (zh) 2015-04-22
ES2837000T3 (es) 2021-06-29
CN101896456B (zh) 2014-10-22
AU2008334778B2 (en) 2013-05-23
LT2229351T (lt) 2018-01-25
US8530701B2 (en) 2013-09-10
DK2229351T3 (en) 2018-01-22
KR101709498B1 (ko) 2017-02-23
BRPI0820657A2 (pt) 2015-06-16
JP5460613B2 (ja) 2014-04-02
RS56803B1 (sr) 2018-04-30
TW200932209A (en) 2009-08-01
CA2936209C (en) 2020-02-11
CA2706789C (en) 2016-09-06
EA201070719A1 (ru) 2010-12-30
EP3257842B1 (de) 2020-11-18
JP2011506375A (ja) 2011-03-03
TWI429425B (zh) 2014-03-11
NO2229351T3 (de) 2018-04-07
CY1119991T1 (el) 2018-12-12
IL205872A0 (en) 2010-11-30
CN104523668B (zh) 2020-06-09
AR071267A1 (es) 2010-06-09
US8846763B2 (en) 2014-09-30
HUE036232T2 (hu) 2018-06-28
JP6023727B2 (ja) 2016-11-09
ES2655706T3 (es) 2018-02-21
EA019898B1 (ru) 2014-07-30
EP2229351B1 (de) 2017-11-08
US20140051758A1 (en) 2014-02-20
KR20100103571A (ko) 2010-09-27
HK1204960A1 (en) 2015-12-11
US20100324141A1 (en) 2010-12-23
PT2229351T (pt) 2018-01-19
EP3257842A1 (de) 2017-12-20
KR20160017140A (ko) 2016-02-15
CN101896456A (zh) 2010-11-24
KR101593627B1 (ko) 2016-02-11
AU2008334778A1 (en) 2009-06-18

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