HK1139158A1 - Human cytomegalovirus neutralising antibodies and use thereof - Google Patents
Human cytomegalovirus neutralising antibodies and use thereofInfo
- Publication number
- HK1139158A1 HK1139158A1 HK10104864.3A HK10104864A HK1139158A1 HK 1139158 A1 HK1139158 A1 HK 1139158A1 HK 10104864 A HK10104864 A HK 10104864A HK 1139158 A1 HK1139158 A1 HK 1139158A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibodies
- human cytomegalovirus
- neutralising antibodies
- well
- disclosure
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title abstract 2
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/088—Varicella-zoster virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/089—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0700133.2A GB0700133D0 (en) | 2007-01-04 | 2007-01-04 | Human cytomegalovirus neutralising antibodies and use thereof |
PCT/IB2008/001111 WO2008084410A2 (en) | 2007-01-04 | 2008-01-03 | Human cytomegalovirus neutralising antibodies and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1139158A1 true HK1139158A1 (en) | 2010-09-10 |
Family
ID=37801734
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10104864.3A HK1139158A1 (en) | 2007-01-04 | 2010-05-18 | Human cytomegalovirus neutralising antibodies and use thereof |
HK13101783.4A HK1174344A1 (en) | 2007-01-04 | 2013-02-08 | Human cytomegalovirus neutralising antibodies and use thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13101783.4A HK1174344A1 (en) | 2007-01-04 | 2013-02-08 | Human cytomegalovirus neutralising antibodies and use thereof |
Country Status (32)
Country | Link |
---|---|
US (4) | US7955599B2 (xx) |
EP (3) | EP2118140B1 (xx) |
JP (2) | JP5710123B2 (xx) |
KR (2) | KR101659306B1 (xx) |
CN (1) | CN101657467B (xx) |
AU (1) | AU2008204258B2 (xx) |
BR (1) | BRPI0806185A2 (xx) |
CA (1) | CA2673755C (xx) |
CO (1) | CO6220862A2 (xx) |
CR (1) | CR10961A (xx) |
CY (1) | CY1114271T1 (xx) |
DK (1) | DK2118140T3 (xx) |
EC (1) | ECSP099547A (xx) |
ES (2) | ES2526907T3 (xx) |
GB (1) | GB0700133D0 (xx) |
GT (1) | GT200900188A (xx) |
HK (2) | HK1139158A1 (xx) |
HR (1) | HRP20130877T1 (xx) |
IL (1) | IL199585A (xx) |
MA (1) | MA31225B1 (xx) |
MX (1) | MX2009007320A (xx) |
MY (2) | MY161200A (xx) |
NZ (1) | NZ578844A (xx) |
PL (1) | PL2118140T3 (xx) |
PT (2) | PT2487187E (xx) |
RU (1) | RU2469045C2 (xx) |
SG (3) | SG191635A1 (xx) |
SI (1) | SI2118140T1 (xx) |
TN (1) | TN2009000285A1 (xx) |
UA (1) | UA100682C2 (xx) |
WO (1) | WO2008084410A2 (xx) |
ZA (1) | ZA200905408B (xx) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007146024A2 (en) * | 2006-06-07 | 2007-12-21 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
WO2009021150A2 (en) * | 2007-08-08 | 2009-02-12 | California Pacific Medical Center | Platelet derived growth factor receptor supports cytomegalovirus infectivity |
AU2012203417B2 (en) * | 2008-07-16 | 2014-07-10 | Institute For Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
UA106354C2 (ru) * | 2008-07-16 | 2014-08-26 | Инститьют Фо Рисерч Ин Байомедсин | Антитела, нейтрализующие цитомегаловирус человека, и их применение |
NZ591055A (en) * | 2008-07-16 | 2012-08-31 | Inst Research In Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
RU2553325C2 (ru) | 2008-07-25 | 2015-06-10 | Институт Фо Ресёч Ин Биомедицин | Нейтрализующие антитела против вируса гриппа а и их использование |
US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
KR101390015B1 (ko) | 2009-04-01 | 2014-04-29 | 에베크 인코포레이티드 | 인간 사이토메갈로바이러스 gB 당단백질의 AD1 영역에 존재하는 특정한 불연속 에피토프에 결합하는 모노클로날 항체 및 그의 항원 결합성 단편 |
BR112012015523A2 (pt) * | 2009-12-23 | 2017-04-18 | 4-Antibody Ag | membros de ligação do citomegalovirus humano, composição contendo os mesmos, método de tratamento, moléculas de anticorpo, método de produção, molecular de ácido nucléico, célula hospedeira, e, método de neutralização do hcmv. |
AU2011268277B2 (en) | 2010-06-16 | 2016-10-27 | Trellis Bioscience, Llc | High affinity human antibodies to human Cytomegalovirus (CMV) gB protein |
HUE051756T2 (hu) | 2011-07-18 | 2021-03-29 | Inst Res Biomedicine | Influenza A vírus elleni semlegesítõ antitestek és alkalmazásuk |
CA2868161A1 (en) | 2012-03-28 | 2013-10-03 | Genentech,Inc. | Anti-hcmv idiotypic antibodies and uses thereof |
WO2014099908A1 (en) * | 2012-12-17 | 2014-06-26 | Genentech, Inc. | Methods for inhibiting viral infection in transplant patients |
EP3733244A1 (en) | 2013-10-02 | 2020-11-04 | Medlmmune, LLC | Neutralizing anti-influenza a antibodies and uses thereof |
AU2015289805B2 (en) | 2014-07-15 | 2020-06-25 | Humabs Biomed Sa | Neutralizing anti-influenza B antibodies and uses thereof |
US20160069643A1 (en) * | 2014-09-06 | 2016-03-10 | Philip Lyren | Weapon Targeting System |
RS62446B1 (sr) | 2015-06-01 | 2021-11-30 | Medimmune Llc | Neutrališući vezujući molekuli protiv gripa i njihova primena |
MX2018008302A (es) | 2016-01-08 | 2018-09-21 | Aimm Therapeutics Bv | Anticuerpo antigrupo de diferenciacion 9 (anti-cd9) terapeutico. |
CA3010313A1 (en) | 2016-01-13 | 2017-07-20 | Medimmune, Llc | Method of treating influenza a |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
US11230591B2 (en) | 2016-04-20 | 2022-01-25 | Merck Sharp & Dohme Corp. | CMV neutralizing antigen binding proteins |
CN109580944A (zh) * | 2018-12-07 | 2019-04-05 | 潍坊医学院 | 一种人巨细胞病毒检测试纸及其制造方法 |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
CN109738631A (zh) * | 2019-01-21 | 2019-05-10 | 潍坊医学院 | 一种人巨细胞病毒IgM抗体检测试纸的制备方法 |
TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白B(gB)多肽 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1061943A (en) | 1964-09-10 | 1967-03-15 | Carter S Ink Co | Marking composition |
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4294817A (en) | 1977-11-25 | 1981-10-13 | International Diagnostic Technology, Inc. | Method of fluoro immunoassay |
US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
US4313927A (en) | 1979-10-19 | 1982-02-02 | Ames-Yissum Ltd. | Immunoassay method for detecting viral antibodies in whole blood samples |
US4334016A (en) | 1980-06-19 | 1982-06-08 | The Wistar Institute Of Anatomy And Biology | Human osteogenic sarcoma cell line and use thereof for immunofluorescent antibody test |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
FR2543570B1 (fr) | 1983-03-31 | 1985-08-09 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus humains, hybridomes secreteurs de ces anticorps et polypeptides porteurs d'un determinant antigenique sequentiel de cytomegalovirus humains |
US4617379A (en) | 1983-06-14 | 1986-10-14 | Miles Laboratories, Inc. | High titer cytomegalovirus immune serum globulin |
GB8404368D0 (en) | 1984-02-20 | 1984-03-28 | Cogent Ltd | Monoclonal antibodies to human cytomegalovirus |
US6100064A (en) | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
FR2563630B1 (fr) | 1984-04-27 | 1988-02-19 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus et procedes pour le diagnostic in vitro des infections par les cytomegalovirus humains et d'une proteine-kinase inductible par les cytomegalovirus et susceptible d'etre reconnue par les susdits anticorps monoclonaux |
US4783399A (en) | 1984-05-04 | 1988-11-08 | Scripps Clinic And Research Foundation | Diagnostic system for the detection of cytomegalovirus |
US4743562A (en) | 1984-08-21 | 1988-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Purified human cytomegalovirus protein |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
EP0198086B1 (en) | 1984-09-28 | 1991-01-16 | Teijin Limited | Mouse human hybridoma producing antivirus human antibody, process for its preparation, and antivirus human monoclonal antibody |
US4808518A (en) | 1985-02-11 | 1989-02-28 | University Of Tennessee Research Corporation | Recovery of cytomegalovirus antigen and use thereof in an assay |
US4804627A (en) | 1985-05-09 | 1989-02-14 | Sloan-Kettering Institute For Cancer Research | Method for cloning lymphoblastoid cells |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
KR910000736B1 (ko) | 1985-12-06 | 1991-02-06 | 데이진 가부시키가이샤 | 사이토메갈로 바이러스에 대한 사람·모노클로날 항체와 그 제조방법 |
US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
LU86752A1 (fr) | 1987-01-30 | 1988-08-23 | Univ Bruxelles | Procede de production d'anticorps monoclonaux humains(igg)anticytomegalovirus et anticorps monoclonaux ainsi obtenus |
NZ226694A (en) | 1987-10-28 | 1994-04-27 | Oncogen | Human immunoglobulin produced by recombinant dna techniques |
US5180813A (en) | 1989-03-24 | 1993-01-19 | University Of Iowa Research Foundation | Early envelope glycoprotein of human cytomegalovirus (hmcv) and monoclonal antibodies to the glycoproteins |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
WO1991004277A1 (en) | 1989-09-14 | 1991-04-04 | Children's Biomedical Research Institute | Monoclonal antibodies specific to cytomegalovirus glycoprotein |
WO1991005876A1 (en) | 1989-10-20 | 1991-05-02 | Children's Biomedical Research Institute | Human cytomegalovirus-specific monoclonal antibody cocktail |
GB9008223D0 (en) | 1990-04-11 | 1990-06-13 | Royal Free Hosp School Med | Improvements relating to the detection of viruses |
DE4035174A1 (de) | 1990-11-06 | 1992-05-07 | Biotest Ag | Verfahren zur bestimmung von proteinen in koerperfluessigkeiten und mittel zur durchfuehrung des verfahrens |
US5997878A (en) | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
JPH053794A (ja) * | 1991-06-26 | 1993-01-14 | Green Cross Corp:The | 抗サイトメガロウイルスヒトモノクローナル抗体およびその産生細胞 |
DE4128684A1 (de) | 1991-08-29 | 1993-03-04 | Behringwerke Ag | Hcmv-spezifische peptide, mittel dazu und ihre verwendung |
EP0564735B1 (en) | 1992-04-10 | 1998-11-18 | Thomas Totterman | Method for detection of CMV infection |
SE9201281L (sv) | 1992-04-23 | 1993-10-24 | Bioinvent Int Ab | Nya humana monoklonala antikroppar och förfarande för framställning därav |
JPH05260961A (ja) * | 1992-05-21 | 1993-10-12 | Teijin Ltd | サイトメガロウイルスに対するヒト・モノクローナル抗体を産生するハイブリドーマ |
GB9221654D0 (en) * | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
EP0680333B1 (en) | 1993-01-21 | 1999-05-06 | Erna MÖLLER | Prevention and treatment of cytomegalovirus using aminopeptidase |
US5750106A (en) | 1993-01-28 | 1998-05-12 | Novartis Ag | Human monoclonal antibodies to cytomegalovirus |
WO1994016730A1 (en) | 1993-01-28 | 1994-08-04 | Sandoz Pharmaceutical Corporation | Human monoclonal antibodies to cytomegalovirus |
AU6777594A (en) | 1993-04-30 | 1994-11-21 | Scripps Research Institute, The | Human monoclonal antibodies to human cytomegalovirus, and methods therefor |
US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
EP0702083A3 (de) | 1994-07-26 | 1997-01-15 | Biotest Ag | Polypeptide und Fusionsproteine bestehend aus dem UL 57 Leserahmen bzw. dem C-terminalen Bereich des Tegumentproteins pp150 aus HCMV, entsprechende Oligonucleotide und Nachweis reagentien |
US5783383A (en) | 1995-05-23 | 1998-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of detecting cytomegalovirus (CMV) |
US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US5800981A (en) | 1996-02-22 | 1998-09-01 | University Of Limburg | Human cytomegalovirus antigen and its use |
ES2187796T3 (es) | 1996-07-12 | 2003-06-16 | Organon Teknika Bv | Reactivo de peptidos que permiten la deteccion de citomegalovirus (cmv) humano. |
US6291437B1 (en) | 1996-08-14 | 2001-09-18 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for retarding the development of atherosclerotic lesions |
EP1003841A4 (en) | 1997-01-30 | 2002-04-17 | Cedars Sinai Medical Center | CREATION OF A HSV-8 + LYMPHOMATORY CELL LINE, PRODUCT VIRUS, ANTIBODIES, DIAGNOSTIC METHOD AND KIT FOR DETECTING HSV-8 INFECTION |
US6183752B1 (en) | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
WO1998057993A1 (en) | 1997-06-19 | 1998-12-23 | The Regents Of The University Of California | Secretory immunoglobulin produced by single cells and methods for making and using same |
BR9815496A (pt) | 1997-07-18 | 2001-12-18 | Connaught Lab | Vacinas de ácido nucléico que codificam proteìna gde vìrus sincicial respiratório |
JP2002512003A (ja) | 1997-11-14 | 2002-04-23 | コノート ラボラトリーズ リミテッド | パラミキソウイルスワクチンのためのアルファウイルスベクター |
DE19756214C1 (de) | 1997-12-17 | 1999-02-25 | Biotest Ag | Polypeptide mit Aminosäuresequenzen aus dem N-terminalen Bereich von gp116 und deren Verwendung bei der Diagnostik, Prophylaxe und Therapie |
DE69903612T2 (de) | 1998-03-12 | 2003-07-10 | Genentech Inc | Verwendung von fgf-5 polypetiden zur vorbeugung des absterbens retinaler neuronen und behandlung okularer krankheiten |
WO2000000223A2 (de) | 1998-06-29 | 2000-01-06 | Wolfgang Bergter | ANTIVIRALE UND ANTIRETROVIRALE RADIOIMMUNPHARMAKA AUF DER BASIS VON α- UND β-STRAHLERN |
RU2133472C1 (ru) | 1998-09-16 | 1999-07-20 | Унитарное государственное Московское предприятие по производству бактерийных препаратов | Способ диагностики активной стадии цитомегаловирусной инфекции человека |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
ITMI20012160A1 (it) | 2001-10-18 | 2003-04-18 | Edoardo Marchisio | Sistema immunoenzimatico per la caratterizzazione antigenica dell'infezione attiva da cytomegalovirus e cmv confirmation test |
US6828113B2 (en) | 2002-03-21 | 2004-12-07 | Cornell Research Foundation, Inc. | IgM antibodies to the 70 kDa heat shock protein as a marker for cytomegalovirus infection |
IL164326A0 (en) | 2002-04-01 | 2005-12-18 | Agensys Inc | Nucleic acid and corresponding protein entitled 238p1b2 and pharmaceutical compositions containing the same |
RU2239453C2 (ru) * | 2002-12-03 | 2004-11-10 | Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" | Препарат иммуноглобулина человека против цитомегаловируса и способ его получения |
EP1597280B2 (en) | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
WO2004076645A2 (en) | 2003-02-27 | 2004-09-10 | University Of Massachusetts | Compositions and methods for cytomegalovirus treatment |
WO2004078926A2 (en) | 2003-02-28 | 2004-09-16 | Board Of Trustees Operating Michigan State University | Immunologigal markers |
CN101001878B (zh) | 2004-06-21 | 2012-09-26 | 米德列斯公司 | 干扰素α受体1抗体及其用途 |
BE1016287A6 (nl) | 2004-07-14 | 2006-07-04 | Picanol Nv | Gaapvormingsonderdeel voor een weefmachine en weefmachine. |
US7976845B2 (en) | 2004-11-29 | 2011-07-12 | The Council Of The Queensland Institute Of Medical Research | Human cytomegalovirus immunotherapy |
ATE503770T1 (de) | 2005-03-14 | 2011-04-15 | Us Gov Health & Human Serv | Humane monoklonale antikörper gegen hendra- und nipah-viren |
NZ569816A (en) | 2005-12-16 | 2011-10-28 | Ribovax Biotechnologies Sa | Methods for obtaining immortalized antibody secreting cells |
WO2007094423A1 (ja) | 2006-02-15 | 2007-08-23 | Evec Incorporated | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
MX2008014722A (es) | 2006-05-19 | 2011-04-15 | Teva Pharma | Proteinas de fusion, usos de las mismas y procesos para producir las mismas. |
WO2007146024A2 (en) | 2006-06-07 | 2007-12-21 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
ES2363992T3 (es) | 2006-12-15 | 2011-08-22 | Ribovax Biotechnologies Sa | Anticuerpos frente a citomegalovirus humano (cmvh). |
US7947274B2 (en) * | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
WO2008120203A2 (en) | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
US20080248042A1 (en) | 2007-04-05 | 2008-10-09 | Irccs Centro Di Riferimento Oncologico Di Aviano, | Monoclonal antibody cross-reactive against infective agent causing a B-cell expansion and IgG-Fc |
WO2009024445A1 (en) | 2007-08-22 | 2009-02-26 | Ribovax Biotechnologies Sa | Antibodies against human cytomegalovirus (hcmv) |
WO2009085383A1 (en) | 2007-12-19 | 2009-07-09 | Dcb-Usa Llc | Anti-human cytomegalovirus antibodies |
UA106354C2 (ru) * | 2008-07-16 | 2014-08-26 | Инститьют Фо Рисерч Ин Байомедсин | Антитела, нейтрализующие цитомегаловирус человека, и их применение |
NZ591055A (en) | 2008-07-16 | 2012-08-31 | Inst Research In Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
-
2007
- 2007-01-04 GB GBGB0700133.2A patent/GB0700133D0/en not_active Ceased
-
2008
- 2008-01-03 ES ES12156048.6T patent/ES2526907T3/es active Active
- 2008-01-03 SG SG2013042486A patent/SG191635A1/en unknown
- 2008-01-03 UA UAA200908229A patent/UA100682C2/ru unknown
- 2008-01-03 EP EP08737590.3A patent/EP2118140B1/en active Active
- 2008-01-03 US US11/969,104 patent/US7955599B2/en not_active Expired - Fee Related
- 2008-01-03 EP EP12156048.6A patent/EP2487187B1/en not_active Not-in-force
- 2008-01-03 DK DK08737590.3T patent/DK2118140T3/da active
- 2008-01-03 CN CN2008800071531A patent/CN101657467B/zh not_active Expired - Fee Related
- 2008-01-03 EP EP14188865.1A patent/EP2860189A3/en not_active Withdrawn
- 2008-01-03 KR KR1020147021517A patent/KR101659306B1/ko active IP Right Grant
- 2008-01-03 BR BRPI0806185-8A patent/BRPI0806185A2/pt not_active Application Discontinuation
- 2008-01-03 NZ NZ578844A patent/NZ578844A/xx not_active IP Right Cessation
- 2008-01-03 RU RU2009129403/10A patent/RU2469045C2/ru active
- 2008-01-03 MY MYPI2013003538A patent/MY161200A/en unknown
- 2008-01-03 SG SG2013042544A patent/SG192399A1/en unknown
- 2008-01-03 PT PT121560486T patent/PT2487187E/pt unknown
- 2008-01-03 MX MX2009007320A patent/MX2009007320A/es active IP Right Grant
- 2008-01-03 PT PT87375903T patent/PT2118140E/pt unknown
- 2008-01-03 CA CA2673755A patent/CA2673755C/en active Active
- 2008-01-03 JP JP2009544477A patent/JP5710123B2/ja not_active Expired - Fee Related
- 2008-01-03 SI SI200831025T patent/SI2118140T1/sl unknown
- 2008-01-03 SG SG2011097805A patent/SG177943A1/en unknown
- 2008-01-03 ES ES08737590T patent/ES2426987T3/es active Active
- 2008-01-03 AU AU2008204258A patent/AU2008204258B2/en not_active Ceased
- 2008-01-03 WO PCT/IB2008/001111 patent/WO2008084410A2/en active Application Filing
- 2008-01-03 MY MYPI20092825 patent/MY150709A/en unknown
- 2008-01-03 PL PL08737590T patent/PL2118140T3/pl unknown
- 2008-01-03 KR KR1020097016334A patent/KR101541927B1/ko active IP Right Grant
-
2009
- 2009-06-25 IL IL199585A patent/IL199585A/en not_active IP Right Cessation
- 2009-07-01 GT GT200900188A patent/GT200900188A/es unknown
- 2009-07-03 TN TNP2009000285A patent/TN2009000285A1/fr unknown
- 2009-07-29 EC EC2009009547A patent/ECSP099547A/es unknown
- 2009-07-31 CR CR10961A patent/CR10961A/es unknown
- 2009-08-03 ZA ZA200905408A patent/ZA200905408B/xx unknown
- 2009-08-04 MA MA32141A patent/MA31225B1/fr unknown
- 2009-08-04 CO CO09081236A patent/CO6220862A2/es not_active Application Discontinuation
-
2010
- 2010-05-18 HK HK10104864.3A patent/HK1139158A1/xx not_active IP Right Cessation
-
2011
- 2011-04-22 US US13/092,364 patent/US8309089B2/en active Active
-
2012
- 2012-09-14 US US13/619,305 patent/US8545848B2/en active Active
-
2013
- 2013-02-08 HK HK13101783.4A patent/HK1174344A1/xx not_active IP Right Cessation
- 2013-08-26 CY CY20131100726T patent/CY1114271T1/el unknown
- 2013-09-18 HR HRP20130877AT patent/HRP20130877T1/hr unknown
- 2013-09-30 US US14/041,799 patent/US9149524B2/en not_active Expired - Fee Related
-
2014
- 2014-03-05 JP JP2014043126A patent/JP2014141501A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1139158A1 (en) | Human cytomegalovirus neutralising antibodies and use thereof | |
TN2010000616A1 (en) | Human cytomegalovirus neutralising antibodies and use thereof | |
PH12016500658B1 (en) | Human anti-alpha-synuclein autoantibodies | |
WO2010017103A3 (en) | Fully human anti-human nkg2d monoclonal antibodies | |
PH12015500782A1 (en) | Human cytomegalovirus neutralizing antibodies and use thereof | |
MY156286A (en) | Human il-23 antigen binding proteins | |
MY156458A (en) | Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof | |
EP4234581A3 (en) | Therapeutic antibodies and their uses | |
MX355181B (es) | Anticuerpos humanos contra el factor tisular. | |
IL189788A0 (en) | Human monoclonal antibodies to cd70 | |
MX345092B (es) | Anticuerpos anti-tau humanos,. | |
MY184251A (en) | Human anti-tau antibodies | |
EP3539988A3 (en) | Monoclonal antibodies against her2 | |
UA118332C2 (uk) | Білок, що зв'язує антиген cd27l | |
HK1071576A1 (en) | Internalizing anti-cd74 antibodies and methods of use | |
MY160590A (en) | Cd127 binding proteins | |
NZ592432A (en) | Antibodies that specifically block the biological activity of a tumor antigen Kidney associated antigen 1 (KAAG1) | |
SG156668A1 (en) | Angiopoietin-2 specific binding agents | |
MX365387B (es) | Anticuerpos específicos de polipéptido amiloide de islote humano (hiapp) y sus usos. | |
AR121799A2 (es) | Proteínas de unión a antígenos de il-23 humana | |
TN2010000374A1 (en) | Antibodies directed to angiopoietin -1 and angiopoietin-2 and use thereof | |
MX360580B (es) | Autoanticuerpos humanos anti-alfa-sinucleina. | |
TN2010000621A1 (en) | Human cytomegalovirus neutralizing antibodies and use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230103 |