HK1137185A1 - Method for producing soluble thrombomodulin of high purity - Google Patents

Method for producing soluble thrombomodulin of high purity

Info

Publication number
HK1137185A1
HK1137185A1 HK10104518.3A HK10104518A HK1137185A1 HK 1137185 A1 HK1137185 A1 HK 1137185A1 HK 10104518 A HK10104518 A HK 10104518A HK 1137185 A1 HK1137185 A1 HK 1137185A1
Authority
HK
Hong Kong
Prior art keywords
high purity
soluble thrombomodulin
producing soluble
producing
thrombomodulin
Prior art date
Application number
HK10104518.3A
Other languages
English (en)
Inventor
Susumu Ohigashi
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Publication of HK1137185A1 publication Critical patent/HK1137185A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
HK10104518.3A 2007-03-23 2010-05-10 Method for producing soluble thrombomodulin of high purity HK1137185A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007077389 2007-03-23
PCT/JP2008/055211 WO2008117735A1 (ja) 2007-03-23 2008-03-21 高純度可溶性トロンボモジュリンの製造方法

Publications (1)

Publication Number Publication Date
HK1137185A1 true HK1137185A1 (en) 2010-07-23

Family

ID=39788470

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10104518.3A HK1137185A1 (en) 2007-03-23 2010-05-10 Method for producing soluble thrombomodulin of high purity

Country Status (13)

Country Link
US (2) US8258269B2 (ja)
EP (1) EP2138505B1 (ja)
JP (1) JP5117486B2 (ja)
KR (1) KR101238047B1 (ja)
CN (1) CN101641368B (ja)
AU (1) AU2008230465B2 (ja)
CA (1) CA2681294C (ja)
ES (1) ES2496596T3 (ja)
HK (1) HK1137185A1 (ja)
NZ (1) NZ579873A (ja)
SG (1) SG184699A1 (ja)
TW (2) TW201431872A (ja)
WO (1) WO2008117735A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2787009C (en) 2010-01-15 2018-04-03 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
CA2796452C (en) * 2010-04-30 2017-12-05 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin and method for producing same
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
US9592540B2 (en) 2011-02-02 2017-03-14 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
DK2686335T3 (en) * 2011-03-14 2018-07-30 Catalant Pharma Solutions Llc DECORINE COMPOSITIONS AND APPLICATION THEREOF
ES2795439T3 (es) * 2011-11-15 2020-11-23 Asahi Kasei Pharma Corp Medicamento para tratamiento terapéutico y/o mejoría de la sepsis
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
EP3157551B1 (en) 2014-06-23 2023-02-15 Bio-Rad Laboratories, Inc. Apatite in-situ restoration

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62125173A (ja) 1985-11-26 1987-06-06 鹿島建設株式会社 免震構造物のフエ−ルセ−フ装置
JP2738428B2 (ja) 1987-01-08 1998-04-08 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進する作用を有するペプチド
EP0816494A1 (en) 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha DNA coding for a peptide promoting the activation of protein C by thrombin, and process for producing the same
DK299087D0 (da) 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPS646219U (ja) 1987-06-30 1989-01-13
JPH0720997B2 (ja) 1988-08-29 1995-03-08 興和株式会社 新規なトロンビン結合性物質及びその製法
US5202421A (en) 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
JPH0798840B2 (ja) 1988-12-27 1995-10-25 持田製薬株式会社 尿由来の抗血液疑固物質、その製法およびそれを含有する医薬組成物
JPH02255699A (ja) 1989-03-28 1990-10-16 Asahi Chem Ind Co Ltd 新規血液抗凝固物質及びその製法
US5466668A (en) 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US6063763A (en) 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
CA2022713A1 (en) 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
JPH03259084A (ja) 1990-03-06 1991-11-19 Kowa Co トロンビン結合性物質の製造法
WO1992000325A1 (en) 1990-06-27 1992-01-09 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
JPH05213998A (ja) 1990-08-03 1993-08-24 Asahi Chem Ind Co Ltd 新規なポリペプチド及びこれを有効成分とする 医薬組成物
KR930008093B1 (ko) 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
WO1992003149A1 (en) 1990-08-15 1992-03-05 Berlex Laboratories, Inc. Superior thrombomodulin analogs for pharmaceutical use
JP3220174B2 (ja) 1990-12-12 2001-10-22 第一製薬株式会社 組換ヒトトロンボモジュリン誘導体
EP1449849A3 (en) 1992-02-05 2006-01-25 Paion Deutschland GmbH Protease-resistant thrombomodulin analog
JPH05310787A (ja) 1992-05-01 1993-11-22 Asahi Chem Ind Co Ltd 新規なポリペプチド
JP3007785B2 (ja) 1993-03-16 2000-02-07 旭化成工業株式会社 トロンボモジュリン組成物およびその変性防止方法
JPH06321085A (ja) 1993-05-18 1994-11-22 Mazda Motor Corp 車両のスリップ制御装置
JP3822383B2 (ja) 1993-12-17 2006-09-20 持田製薬株式会社 可溶性トロンボモジュリン含有組成物
JPH07173189A (ja) 1993-12-17 1995-07-11 Masashi Kosakai リガンド存在下で二段階に分けて行うヒドロキシアパタイトクロマトグラフィーの用法
JP3537440B2 (ja) 1993-12-17 2004-06-14 持田製薬株式会社 可溶性トロンボモジュリンを長期保存安定化させる方法
JPH11171790A (ja) 1994-03-15 1999-06-29 Asahi Chem Ind Co Ltd トロンボモジュリン用変性防止剤
JP2824392B2 (ja) 1994-05-31 1998-11-11 旭化成工業株式会社 トロンビンによるプロテインｃの活性化を促進する作用を有するペプチドを含有する培養上澄液
JP3745805B2 (ja) 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
PT1029548E (pt) * 1997-10-15 2007-05-31 Asahi Kasei Pharma Corp Método para manutenção da qualidade de uma solução parentérica de trombomodulina em armazenamento e distribuição.
JP4157644B2 (ja) * 1998-03-30 2008-10-01 旭化成ファーマ株式会社 高純度可溶性トロンボモジュリンの製造方法
ATE274522T1 (de) 1998-06-01 2004-09-15 Genentech Inc Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie
EP1475098B1 (en) * 2002-01-18 2015-08-05 Asahi Kasei Pharma Corporation High-concentration preparation of soluble thrombomodulin

Also Published As

Publication number Publication date
TWI461434B (zh) 2014-11-21
TW201431872A (zh) 2014-08-16
KR20090112709A (ko) 2009-10-28
CN101641368B (zh) 2013-05-08
AU2008230465A1 (en) 2008-10-02
EP2138505B1 (en) 2014-08-06
JPWO2008117735A1 (ja) 2010-07-15
JP5117486B2 (ja) 2013-01-16
SG184699A1 (en) 2012-10-30
AU2008230465B2 (en) 2011-10-13
EP2138505A4 (en) 2011-02-09
US8952137B2 (en) 2015-02-10
NZ579873A (en) 2011-11-25
EP2138505A1 (en) 2009-12-30
CA2681294A1 (en) 2008-10-02
US20100145020A1 (en) 2010-06-10
TW200906848A (en) 2009-02-16
CN101641368A (zh) 2010-02-03
US20130237693A1 (en) 2013-09-12
WO2008117735A1 (ja) 2008-10-02
CA2681294C (en) 2014-05-06
US8258269B2 (en) 2012-09-04
KR101238047B1 (ko) 2013-02-27
ES2496596T3 (es) 2014-09-19

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