HK1135691A1 - Camptothecin derivatives with antitumor activity - Google Patents

Camptothecin derivatives with antitumor activity

Info

Publication number
HK1135691A1
HK1135691A1 HK10100446.8A HK10100446A HK1135691A1 HK 1135691 A1 HK1135691 A1 HK 1135691A1 HK 10100446 A HK10100446 A HK 10100446A HK 1135691 A1 HK1135691 A1 HK 1135691A1
Authority
HK
Hong Kong
Prior art keywords
antitumor activity
camptothecin derivatives
camptothecin
derivatives
antitumor
Prior art date
Application number
HK10100446.8A
Other languages
English (en)
Inventor
Gabriele Fontana
Ezio Bombardelli
Carla Manzotti
Battaglia Arturo
Cristian Samori
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of HK1135691A1 publication Critical patent/HK1135691A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
HK10100446.8A 2006-07-26 2010-01-15 Camptothecin derivatives with antitumor activity HK1135691A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001473A ITMI20061473A1 (it) 2006-07-26 2006-07-26 Derivati della camptotecina ad attivita antitumorale
PCT/EP2007/006243 WO2008011994A1 (fr) 2006-07-26 2007-07-13 Dérivés de camptothécine à activité antitumorale

Publications (1)

Publication Number Publication Date
HK1135691A1 true HK1135691A1 (en) 2010-06-11

Family

ID=38668829

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100446.8A HK1135691A1 (en) 2006-07-26 2010-01-15 Camptothecin derivatives with antitumor activity

Country Status (21)

Country Link
US (1) US8217053B2 (fr)
EP (1) EP2044079B1 (fr)
JP (1) JP5313894B2 (fr)
KR (1) KR101412157B1 (fr)
CN (1) CN101495486B (fr)
AU (1) AU2007278500B2 (fr)
BR (1) BRPI0714553B8 (fr)
CA (1) CA2658900C (fr)
DK (1) DK2044079T3 (fr)
ES (1) ES2561356T3 (fr)
HK (1) HK1135691A1 (fr)
HU (1) HUE027890T2 (fr)
IL (1) IL196653A (fr)
IT (1) ITMI20061473A1 (fr)
MX (1) MX2009000827A (fr)
NO (1) NO341812B1 (fr)
PL (1) PL2044079T3 (fr)
PT (1) PT2044079E (fr)
RU (1) RU2450008C2 (fr)
SI (1) SI2044079T1 (fr)
WO (1) WO2008011994A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102540419B1 (ko) 2012-10-11 2023-06-05 다이이찌 산쿄 가부시키가이샤 글리신아미드 화합물의 제조 방법
US9872924B2 (en) 2012-10-19 2018-01-23 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
KR101586030B1 (ko) * 2014-01-22 2016-01-15 주식회사 엘지생활건강 캄프토테신을 유효성분으로 포함하는 체모 성장 억제용 조성물
EP3466976B1 (fr) 2014-01-31 2021-09-08 Daiichi Sankyo Company, Limited Conjugué anticorps-médicament anti-her2
CA2990572C (fr) 2015-06-29 2022-07-26 Daiichi Sankyo Company, Limited Procede pour la preparation selective d'un conjugue anticorps-medicament
US11273155B2 (en) 2016-12-12 2022-03-15 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and immune checkpoint inhibitor
KR102537651B1 (ko) 2017-01-17 2023-05-26 다이이찌 산쿄 가부시키가이샤 항 gpr20 항체 및 항 gpr20 항체-약물 콘쥬게이트
TWI794230B (zh) 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法
JP7366745B2 (ja) 2017-08-31 2023-10-23 第一三共株式会社 抗体－薬物コンジュゲートの改良製造方法
CN117865839A (zh) 2017-08-31 2024-04-12 第一三共株式会社 制备抗体-药物缀合物的新方法
RS64379B1 (sr) 2018-05-18 2023-08-31 Glycotope Gmbh Anti-muc1 antitelo
US10568873B1 (en) * 2019-02-14 2020-02-25 United Arab Emirates University Safranal-sorafenib combination therapy for liver cancer
CN112905237A (zh) 2019-12-04 2021-06-04 北京百度网讯科技有限公司 指令预取方法、装置、设备和介质
CN112225745B (zh) * 2020-11-16 2021-10-12 烟台大学 一种具有抗肿瘤活性的异片螺素类化合物、制备方法及用途
CN117510515A (zh) * 2022-07-28 2024-02-06 明慧医药（杭州）有限公司 适用于抗体-药物偶联物的毒素分子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US5972955A (en) * 1995-06-06 1999-10-26 Dr. Reddy's Research Foundation Water soluble C-ring analogues of 20(S)-camptothecin
FR2757515B1 (fr) * 1996-12-20 2000-05-05 Sod Conseils Rech Applic Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6881555B2 (en) * 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
EP1430059B1 (fr) * 2001-09-25 2006-03-01 Dr. Reddy's Laboratories Ltd. Sels acceptables d'un point de vue pharmaceutique de 20(s)-camptothecines
US20060084167A1 (en) * 2004-10-16 2006-04-20 Cohenford Menashi A Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells

Also Published As

Publication number Publication date
IL196653A0 (en) 2009-11-18
IL196653A (en) 2015-04-30
RU2009102243A (ru) 2010-07-27
JP5313894B2 (ja) 2013-10-09
ES2561356T3 (es) 2016-02-25
CN101495486A (zh) 2009-07-29
CA2658900C (fr) 2015-09-15
MX2009000827A (es) 2009-02-03
PL2044079T3 (pl) 2016-06-30
BRPI0714553B8 (pt) 2021-05-25
JP2009544634A (ja) 2009-12-17
AU2007278500A2 (en) 2010-09-09
KR101412157B1 (ko) 2014-06-25
DK2044079T3 (en) 2016-02-29
EP2044079B1 (fr) 2015-12-09
NO341812B1 (no) 2018-01-29
KR20090033456A (ko) 2009-04-03
BRPI0714553B1 (pt) 2020-11-17
AU2007278500A1 (en) 2008-01-31
AU2007278500B2 (en) 2012-06-07
EP2044079A1 (fr) 2009-04-08
SI2044079T1 (sl) 2016-02-29
PT2044079E (pt) 2016-03-09
BRPI0714553A2 (pt) 2013-03-26
CA2658900A1 (fr) 2008-01-31
US8217053B2 (en) 2012-07-10
CN101495486B (zh) 2013-05-15
HUE027890T2 (en) 2016-11-28
US20100120816A1 (en) 2010-05-13
WO2008011994A1 (fr) 2008-01-31
RU2450008C2 (ru) 2012-05-10
NO20090251L (no) 2009-01-16
ITMI20061473A1 (it) 2008-01-27

Similar Documents

Publication Publication Date Title
HK1135691A1 (en) Camptothecin derivatives with antitumor activity
HK1129100A1 (en) Coumarin derivative having antitumor activity
ZA200806809B (en) Pyridine-2-carboxamide derivatives
IL194367A0 (en) Dihydropyrazolopyrimidinone derivatives
IL196543A0 (en) Pyridizinone derivatives
IL193641A0 (en) Spiroindolinone derivatives
IL195013A0 (en) Pyridopyrimidinone derivatives
EP1973405A4 (fr) Derives d'hydroxyalkymarylamide
IL198319A0 (en) Spiroindolinone derivatives
IL195422A0 (en) 2-pyrazinecarboxamide derivatives
IL192401A0 (en) Indol-3-yl-carbonyl-spiro-piperidine derivatives
IL196364A0 (en) Aminoindazolylurea derivatives
IL198059A0 (en) 2-aminocarbonyl-pyridine derivatives
GB0625842D0 (en) Indolizine derivatives
HK1136276A1 (en) 5-hydroxymethyl-oxazolidin-2-one derivatives 5---2-
IL193211A0 (en) Indazole-heteroaryl derivatives
ZA200903175B (en) Spiro-piperidine derivatives
EP2228376A4 (fr) Dérivé de pyripyropène ayant une activité inhibitrice d'acat2
IL197152A0 (en) 5-phenyl-nicotinamide derivatives
EP2043633A4 (fr) Dérivés de thiadiazolidinone
ZA200901034B (en) Avermectin derivatives
HK1135692A1 (en) Camptothecin derivatives with antitumor activity
TWI339663B (en) Spiro-piperidine derivatives
IL197239A0 (en) Phenyloxyaniline derivatives
IL184113A0 (en) Indole derivatives with antitumor activity

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210713