HK1134820A1 - Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders - Google Patents

Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Info

Publication number
HK1134820A1
HK1134820A1 HK09111965.9A HK09111965A HK1134820A1 HK 1134820 A1 HK1134820 A1 HK 1134820A1 HK 09111965 A HK09111965 A HK 09111965A HK 1134820 A1 HK1134820 A1 HK 1134820A1
Authority
HK
Hong Kong
Prior art keywords
androstenes
androstanes
medicaments
cardiovascular disorders
azaheterocyclyl
Prior art date
Application number
HK09111965.9A
Other languages
English (en)
Chinese (zh)
Inventor
阿爾貝托‧切里
喬治‧費德里奇
亞歷山德拉‧貝尼基奧
朱塞佩‧比安基
帕特里夏‧法拉利
毛羅‧戈比尼
羅莎瑪麗亞‧米凱萊蒂
馬爾科‧波濟
皮耶羅‧恩里科‧斯科蒂
Original Assignee
西格馬-陶工業製藥重組有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 西格馬-陶工業製藥重組有限公司 filed Critical 西格馬-陶工業製藥重組有限公司
Publication of HK1134820A1 publication Critical patent/HK1134820A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
HK09111965.9A 2006-04-13 2009-12-18 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders HK1134820A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06112605 2006-04-13
PCT/EP2007/053521 WO2007118830A1 (en) 2006-04-13 2007-04-11 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Publications (1)

Publication Number Publication Date
HK1134820A1 true HK1134820A1 (en) 2010-05-14

Family

ID=37309533

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09111965.9A HK1134820A1 (en) 2006-04-13 2009-12-18 Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Country Status (16)

Country Link
US (1) US8536160B2 (pl)
EP (1) EP2004669B1 (pl)
JP (1) JP5438502B2 (pl)
KR (1) KR101411280B1 (pl)
CN (1) CN101466726B (pl)
AU (1) AU2007239516B2 (pl)
BR (1) BRPI0710613A2 (pl)
CA (1) CA2649173C (pl)
EA (1) EA015622B1 (pl)
ES (1) ES2403366T3 (pl)
HK (1) HK1134820A1 (pl)
MX (1) MX2008012943A (pl)
PL (1) PL2004669T3 (pl)
PT (1) PT2004669E (pl)
TW (1) TWI389917B (pl)
WO (1) WO2007118830A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1012240A2 (pt) 2009-03-23 2018-06-12 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. derivados de 5-beta, beta-14-androstana úteis para o tratamento de proteinúria, de glomeruloesclerose e de insuficiência renal
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20130303500A1 (en) * 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
CN103304623B (zh) * 2012-03-08 2015-05-20 华东师范大学 一种6β,19-环氧雄甾-3,17-二酮的合成方法
RU2022103033A (ru) 2015-07-02 2022-04-01 ХОРАЙЗОН ОРФАН ЭлЭлСи Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение
CN105237455A (zh) * 2015-10-14 2016-01-13 湖南华腾制药有限公司 一种3-取代氮杂环丁烷的制备方法
CN108707180A (zh) * 2018-08-08 2018-10-26 齐齐哈尔医学院 3β-羟基-5α,8α-过氧雄甾-6-烯-17-(靛红取代)腙衍生物及制备和应用
EP3805243B1 (en) * 2019-10-09 2023-11-15 Windtree Therapeutics, Inc. Androstane derivatives with activity as pure or predominantly pure stimulators of serca2a for the treatment of heart failure
CN113461771B (zh) * 2020-03-31 2022-09-30 南方科技大学 钠钾atp酶抑制剂的制备方法
CN115850359B (zh) * 2022-12-14 2024-06-11 梯尔希（南京）药物研发有限公司 一种孕二烯酮杂质i的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
BE589491A (pl) * 1959-04-10
US3210386A (en) 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
BE621470A (pl) 1961-08-17
GB1175219A (en) 1967-06-22 1969-12-23 Ici Ltd 3-Aminoalkoxycarbonylmethylene Steroid Derivatives
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
US6100279A (en) 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
FR2826011B1 (fr) 2001-06-14 2004-12-10 Oreal Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique
FR2831440B1 (fr) 2001-10-25 2003-12-26 Oreal Composition cosmetique, renfermant un derive de la dhea et un agent apaisant
PT1689410E (pt) * 2003-11-26 2008-08-18 Bayer Schering Pharma Ag Prevenção e tratamento de doenças cardíacas hipertensivas pelos estrogénios selectivos 8beta-vinil-estra-1,3,5(10)-trieno-3,17beta-diol e 17beta-fluoro-9alfa-vinil-estra-1,3,5(10)-trieno-3,16alfa-diol

Also Published As

Publication number Publication date
TWI389917B (zh) 2013-03-21
EP2004669A1 (en) 2008-12-24
CA2649173A1 (en) 2007-10-25
CN101466726A (zh) 2009-06-24
WO2007118830A1 (en) 2007-10-25
AU2007239516A2 (en) 2009-01-08
BRPI0710613A2 (pt) 2011-08-16
JP2009533391A (ja) 2009-09-17
CA2649173C (en) 2013-11-19
EP2004669B1 (en) 2013-01-23
EA200870433A1 (ru) 2009-04-28
PT2004669E (pt) 2013-04-18
AU2007239516B2 (en) 2011-11-17
ES2403366T3 (es) 2013-05-17
AU2007239516A1 (en) 2007-10-25
CN101466726B (zh) 2014-09-24
KR101411280B1 (ko) 2014-06-24
EA015622B1 (ru) 2011-10-31
TW200801032A (en) 2008-01-01
MX2008012943A (es) 2008-10-15
US20090275542A1 (en) 2009-11-05
US8536160B2 (en) 2013-09-17
JP5438502B2 (ja) 2014-03-12
PL2004669T3 (pl) 2013-06-28
KR20080109916A (ko) 2008-12-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190405