HK1127488A1 - Improved method for the production of ramipril - Google Patents
Improved method for the production of ramiprilInfo
- Publication number
- HK1127488A1 HK1127488A1 HK09105159.7A HK09105159A HK1127488A1 HK 1127488 A1 HK1127488 A1 HK 1127488A1 HK 09105159 A HK09105159 A HK 09105159A HK 1127488 A1 HK1127488 A1 HK 1127488A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- reacting
- mixture
- image
- viii
- iii
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cartons (AREA)
- Washing And Drying Of Tableware (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Indole Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005061756A DE102005061756B4 (de) | 2005-12-21 | 2005-12-21 | Verbessertes Verfahren zur Herstellung von Ramipril |
PCT/EP2006/011891 WO2007079871A1 (fr) | 2005-12-21 | 2006-12-11 | Procede ameliore de production de ramipril |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1127488A1 true HK1127488A1 (en) | 2009-09-25 |
Family
ID=37944123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09105159.7A HK1127488A1 (en) | 2005-12-21 | 2009-06-09 | Improved method for the production of ramipril |
Country Status (20)
Country | Link |
---|---|
US (1) | US8119375B2 (fr) |
EP (1) | EP1966118B1 (fr) |
JP (1) | JP5386174B2 (fr) |
KR (1) | KR101426714B1 (fr) |
CN (1) | CN101326151B (fr) |
AT (1) | ATE425135T1 (fr) |
AU (1) | AU2006334781B2 (fr) |
BR (1) | BRPI0620075A2 (fr) |
CA (1) | CA2633559A1 (fr) |
CY (1) | CY1109114T1 (fr) |
DE (2) | DE102005061756B4 (fr) |
DK (1) | DK1966118T3 (fr) |
ES (1) | ES2323555T3 (fr) |
HK (1) | HK1127488A1 (fr) |
IL (1) | IL192066A (fr) |
MY (1) | MY140061A (fr) |
PL (1) | PL1966118T3 (fr) |
PT (1) | PT1966118E (fr) |
SI (1) | SI1966118T1 (fr) |
WO (1) | WO2007079871A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2102353A2 (fr) * | 2006-12-04 | 2009-09-23 | DSM IP Assets B.V. | Système catalytique à cellules entières renfermant une hydantoinase, une racemase et une carbamoylase |
WO2009098251A1 (fr) * | 2008-02-07 | 2009-08-13 | Dsm Ip Assets B.V. | Nouveaux dérivés de cycloalcanonealanine β-substituée |
WO2011121616A2 (fr) * | 2010-03-31 | 2011-10-06 | Promethean Power Systems | Système de refroidissement rapide pour liquides de refroidissement |
CN102984945B (zh) * | 2010-04-20 | 2014-08-20 | 凯瑞斯德生化(苏州)有限公司 | 一种环烯基在β位取代的丙氨酸的不对称合成方法 |
DE11840625T1 (de) * | 2010-11-11 | 2013-11-28 | Aarti Healthcare Ltd. | Verfahren zur Herstellung von Ramipiril |
WO2014202659A1 (fr) | 2013-06-21 | 2014-12-24 | Sanofi-Aventis Deutschland Gmbh | Procédé de préparation d'amides de n-[1-(s)-(éthoxycarbonyl)-3-phénylpropyl]-l-alanine |
CN104513292A (zh) * | 2013-09-29 | 2015-04-15 | 山东新时代药业有限公司 | 一种雷米普利的制备方法 |
CN106536541B (zh) | 2014-06-11 | 2021-01-08 | 赛诺菲-安万特德国有限公司 | 制备雷米普利的方法 |
CN109721524A (zh) * | 2017-10-31 | 2019-05-07 | 鲁南制药集团股份有限公司 | 一种雷米普利的精制方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
SK285228B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén |
CN100387615C (zh) * | 2002-12-30 | 2008-05-14 | 上海医药工业研究院 | N-羧烷基二肽型血管紧张素转化酶抑制剂的制备方法 |
AU2003290400A1 (en) * | 2003-11-24 | 2005-06-08 | Potluri Ramesh Babu | A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates |
WO2005049568A1 (fr) * | 2003-11-24 | 2005-06-02 | Potluri Ramesh Babu | Procede de preparation industriellement viable de (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate |
-
2005
- 2005-12-21 DE DE102005061756A patent/DE102005061756B4/de not_active Expired - Fee Related
-
2006
- 2006-12-11 WO PCT/EP2006/011891 patent/WO2007079871A1/fr active Application Filing
- 2006-12-11 DE DE502006003143T patent/DE502006003143D1/de active Active
- 2006-12-11 BR BRPI0620075-3A patent/BRPI0620075A2/pt not_active IP Right Cessation
- 2006-12-11 PL PL06829483T patent/PL1966118T3/pl unknown
- 2006-12-11 MY MYPI20082137A patent/MY140061A/en unknown
- 2006-12-11 JP JP2008546196A patent/JP5386174B2/ja not_active Expired - Fee Related
- 2006-12-11 SI SI200630268T patent/SI1966118T1/sl unknown
- 2006-12-11 EP EP06829483A patent/EP1966118B1/fr not_active Not-in-force
- 2006-12-11 CN CN200680046668.3A patent/CN101326151B/zh not_active Expired - Fee Related
- 2006-12-11 KR KR1020087015059A patent/KR101426714B1/ko not_active IP Right Cessation
- 2006-12-11 AT AT06829483T patent/ATE425135T1/de active
- 2006-12-11 PT PT06829483T patent/PT1966118E/pt unknown
- 2006-12-11 AU AU2006334781A patent/AU2006334781B2/en not_active Ceased
- 2006-12-11 CA CA002633559A patent/CA2633559A1/fr not_active Abandoned
- 2006-12-11 DK DK06829483T patent/DK1966118T3/da active
- 2006-12-11 ES ES06829483T patent/ES2323555T3/es active Active
-
2008
- 2008-06-11 IL IL192066A patent/IL192066A/en not_active IP Right Cessation
- 2008-06-19 US US12/142,095 patent/US8119375B2/en not_active Expired - Fee Related
-
2009
- 2009-05-28 CY CY20091100573T patent/CY1109114T1/el unknown
- 2009-06-09 HK HK09105159.7A patent/HK1127488A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1966118A1 (fr) | 2008-09-10 |
WO2007079871A1 (fr) | 2007-07-19 |
KR20080086463A (ko) | 2008-09-25 |
US20090017509A1 (en) | 2009-01-15 |
AU2006334781A1 (en) | 2007-07-19 |
BRPI0620075A2 (pt) | 2011-11-01 |
DE102005061756B4 (de) | 2008-01-03 |
CN101326151B (zh) | 2015-01-07 |
CN101326151A (zh) | 2008-12-17 |
PL1966118T3 (pl) | 2009-07-31 |
EP1966118B1 (fr) | 2009-03-11 |
KR101426714B1 (ko) | 2014-08-06 |
DE102005061756A1 (de) | 2007-06-28 |
SI1966118T1 (sl) | 2009-06-30 |
PT1966118E (pt) | 2009-05-18 |
DK1966118T3 (da) | 2009-07-06 |
IL192066A0 (en) | 2008-12-29 |
AU2006334781B2 (en) | 2012-01-19 |
DE502006003143D1 (de) | 2009-04-23 |
US8119375B2 (en) | 2012-02-21 |
IL192066A (en) | 2010-12-30 |
ATE425135T1 (de) | 2009-03-15 |
ES2323555T3 (es) | 2009-07-20 |
JP5386174B2 (ja) | 2014-01-15 |
CY1109114T1 (el) | 2014-07-02 |
MY140061A (en) | 2009-11-30 |
JP2009520473A (ja) | 2009-05-28 |
CA2633559A1 (fr) | 2007-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1127488A1 (en) | Improved method for the production of ramipril | |
TW200846307A (en) | Preparation of pregabalin and related compounds | |
WO2006007406A3 (fr) | Procedes et systemes de conversion de biomasse en acides carboxyliques et en alcools | |
MX2009006932A (es) | Metodo para obtener cristales de un clorhidrato de aminoacido basico. | |
TW200536827A (en) | Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors | |
NL2000374C2 (nl) | Bereiding van gamma-aminozuren met een affiniteit voor het alfa-2-delta-eiwit. | |
Seki | Biological significance and development of practical synthesis of biotin | |
CN106834372A (zh) | 一种转氨酶生物催化制备(s)‑或(r)‑2‑氨基丁酰胺的方法 | |
SI1765770T1 (sl) | Postopek za pripravo gabapentina | |
NZ544004A (en) | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof | |
CN102584622A (zh) | 一种l-2-氨基丁酰胺盐酸盐的制备方法 | |
Schoemaker et al. | Enzymatic Catalysis in Organic Synthesis. Synthesis of Enantiomerically Pure C�-Substituted�-Amino and�-Hydroxy Acids | |
Gotor et al. | Biotransformations of benzoylacetonitrile with the fungus Curvularia lunata: highly diastereo-and enantioselective synthesis of α-alkyl β-hydroxy nitriles and γ-amino alcohols | |
DE60302671D1 (de) | Verfahren zur herstellung von rizatriptan | |
JP2001161392A (ja) | ラセミ化触媒を使用するアミノ酸およびアミノ酸誘導体のエナンチオ選択的な製造方法 | |
EP2725012A1 (fr) | Amide d'acide 1-amino-2-vinyl cyclopropane carboxylique, sel de celui-ci et son procédé de fabrication | |
TWI370123B (en) | Process for preparing 3,4-dichloroisothiazolecarboxylic acid | |
JP4319847B2 (ja) | (1s,2s)−2−フルオロシクロプロパンカルボン酸誘導体の製造方法 | |
AU2001240643A1 (en) | Method of producing 3-aminoalkanoic acid esters | |
Bentley et al. | Enantioselective syntheses of (S)-and (R)-3-hydroxypyrrolidin-2-ones via lactate dehydrogenase catalysed reductions of 4-benzyloxycarbonylamino-2-oxobutanoic acid | |
WO2024092892A1 (fr) | Intermédiaire d'edoxaban et son procédé de préparation | |
Seki | (+)-Biotin: A Challenge for industrially viable total synthesis of natural products | |
JP4396128B2 (ja) | β−アミノ酸の製造方法 | |
WO2002102762A1 (fr) | Nouveau procede de preparation d'hydroxyarylglycines, d'alcoxyarylglycines et de leurs glycinates | |
Strautmanis | The synthesis of N (10)-acetyleudistomin L. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20181207 |