CY1109114T1 - Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης - Google Patents

Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης

Info

Publication number
CY1109114T1
CY1109114T1 CY20091100573T CY091100573T CY1109114T1 CY 1109114 T1 CY1109114 T1 CY 1109114T1 CY 20091100573 T CY20091100573 T CY 20091100573T CY 091100573 T CY091100573 T CY 091100573T CY 1109114 T1 CY1109114 T1 CY 1109114T1
Authority
CY
Cyprus
Prior art keywords
reacting
mixture
image
viii
iii
Prior art date
Application number
CY20091100573T
Other languages
English (en)
Inventor
Holger Berk
Frank Zocher
Hans-Wolfram Flemming
Rainer Gauler
Rudolf Lehnert
Wolfgang Laux
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of CY1109114T1 publication Critical patent/CY1109114T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Cartons (AREA)
  • Washing And Drying Of Tableware (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μία βελτιωμένη μέθοδο διεργασιών για την παρασκευή ραμιπρίλης, ενδιάμεσα προϊόντα που χρησιμοποιούνται στην μέθοδο διεργασιών και την χρήση τους.
CY20091100573T 2005-12-21 2009-05-28 Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης CY1109114T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005061756A DE102005061756B4 (de) 2005-12-21 2005-12-21 Verbessertes Verfahren zur Herstellung von Ramipril
EP06829483A EP1966118B1 (de) 2005-12-21 2006-12-11 Verbessertes verfahren zur herstellung von ramipril

Publications (1)

Publication Number Publication Date
CY1109114T1 true CY1109114T1 (el) 2014-07-02

Family

ID=37944123

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100573T CY1109114T1 (el) 2005-12-21 2009-05-28 Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης

Country Status (20)

Country Link
US (1) US8119375B2 (el)
EP (1) EP1966118B1 (el)
JP (1) JP5386174B2 (el)
KR (1) KR101426714B1 (el)
CN (1) CN101326151B (el)
AT (1) ATE425135T1 (el)
AU (1) AU2006334781B2 (el)
BR (1) BRPI0620075A2 (el)
CA (1) CA2633559A1 (el)
CY (1) CY1109114T1 (el)
DE (2) DE102005061756B4 (el)
DK (1) DK1966118T3 (el)
ES (1) ES2323555T3 (el)
HK (1) HK1127488A1 (el)
IL (1) IL192066A (el)
MY (1) MY140061A (el)
PL (1) PL1966118T3 (el)
PT (1) PT1966118E (el)
SI (1) SI1966118T1 (el)
WO (1) WO2007079871A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2102353A2 (en) * 2006-12-04 2009-09-23 DSM IP Assets B.V. Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase
WO2009098251A1 (en) * 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
WO2011121616A2 (en) * 2010-03-31 2011-10-06 Promethean Power Systems Rapid cooling system for cooling liquids
US8558023B2 (en) 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
DE11840625T1 (de) * 2010-11-11 2013-11-28 Aarti Healthcare Ltd. Verfahren zur Herstellung von Ramipiril
WO2014202659A1 (en) 2013-06-21 2014-12-24 Sanofi-Aventis Deutschland Gmbh Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine
CN104513292A (zh) * 2013-09-29 2015-04-15 山东新时代药业有限公司 一种雷米普利的制备方法
WO2015189108A1 (en) 2014-06-11 2015-12-17 Sanofi-Aventis Deutschland Gmbh Process for the preparation of ramipril
CN109721524A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种雷米普利的精制方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
SK284810B6 (sk) * 1997-05-13 2005-12-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu
CN100387615C (zh) * 2002-12-30 2008-05-14 上海医药工业研究院 N-羧烷基二肽型血管紧张素转化酶抑制剂的制备方法
WO2005049567A1 (en) * 2003-11-24 2005-06-02 Potluri Ramesh Babu A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates
WO2005049568A1 (en) * 2003-11-24 2005-06-02 Potluri Ramesh Babu A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate

Also Published As

Publication number Publication date
KR101426714B1 (ko) 2014-08-06
DE502006003143D1 (de) 2009-04-23
CA2633559A1 (en) 2007-07-19
MY140061A (en) 2009-11-30
AU2006334781B2 (en) 2012-01-19
IL192066A (en) 2010-12-30
ATE425135T1 (de) 2009-03-15
EP1966118A1 (de) 2008-09-10
CN101326151A (zh) 2008-12-17
JP5386174B2 (ja) 2014-01-15
US20090017509A1 (en) 2009-01-15
CN101326151B (zh) 2015-01-07
AU2006334781A1 (en) 2007-07-19
WO2007079871A1 (de) 2007-07-19
EP1966118B1 (de) 2009-03-11
DE102005061756B4 (de) 2008-01-03
US8119375B2 (en) 2012-02-21
JP2009520473A (ja) 2009-05-28
SI1966118T1 (sl) 2009-06-30
DK1966118T3 (da) 2009-07-06
PT1966118E (pt) 2009-05-18
PL1966118T3 (pl) 2009-07-31
HK1127488A1 (en) 2009-09-25
ES2323555T3 (es) 2009-07-20
IL192066A0 (en) 2008-12-29
BRPI0620075A2 (pt) 2011-11-01
DE102005061756A1 (de) 2007-06-28
KR20080086463A (ko) 2008-09-25

Similar Documents

Publication Publication Date Title
CY1109114T1 (el) Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης
Lelais et al. β2‐amino acids—syntheses, occurrence in natural products, and components of β‐peptides1, 2
EE9700262A (et) Meetod troopahappeestrite puhaste enantiomeeride valmistamiseks
ECSP077317A (es) Procedimiento para producir derivados de amina opticamente activos
EA201891964A1 (ru) СПОСОБ ПОЛУЧЕНИЯ МЕТИЛ{4,6-ДИАМИНО-2-[1-(2-ФТОРБЕНЗИЛ)-1H-ПИРАЗОЛО[3,4-b]ПИРИДИН-3-ИЛ]ПИРИМИДИН-5-ИЛ}МЕТИЛКАРБАМАТА И ЕГО ОЧИСТКИ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ФАРМАЦЕВТИЧЕСКОГО БИОЛОГИЧЕСКИ АКТИВНОГО ВЕЩЕСТВА
MY141193A (en) Cleaning compound and method and system for using the cleaning compound
MX2009006865A (es) Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico.
MY156760A (en) Process for manufacturing succinic acid
WO2014072785A3 (en) A process for the preparation of pregabalin
ATE441627T1 (de) Verfahren zur herstellung von valsartan
TW200536827A (en) Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors
DE602005024776D1 (de) Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators
MA32618B1 (fr) Procedes de preparation d'ester methylique d'acide 4-oxo-octahydro-indole-1-carbocylique et de ses derives
NL2000374C2 (nl) Bereiding van gamma-aminozuren met een affiniteit voor het alfa-2-delta-eiwit.
Seki Biological significance and development of practical synthesis of biotin
Xian et al. Chemoenzymatic synthesis of glutamic acid analogues: substrate specificity and synthetic applications of branched chain aminotransferase from Escherichia coli
CN102584622A (zh) 一种l-2-氨基丁酰胺盐酸盐的制备方法
DE602005024809D1 (de) Verfahren zur herstellung von gabapentin
NZ544004A (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
IL190399A0 (en) Novel method for preparing quaternary acid and ammonium salts
Gotor et al. Biotransformations of benzoylacetonitrile with the fungus Curvularia lunata: highly diastereo-and enantioselective synthesis of α-alkyl β-hydroxy nitriles and γ-amino alcohols
TW201204740A (en) Compounds and method for inhibiting the activity of gelatinase and collagenase
JP2001161392A (ja) ラセミ化触媒を使用するアミノ酸およびアミノ酸誘導体のエナンチオ選択的な製造方法
HRP20110489T1 (hr) Postupak kemo-selektivne enzimske hidrolize diesterskog spoja za pripremu spoja monoestera monokiseline
DE502006005668D1 (de) Verfahren zur herstellung von 3,4-dichlor-isothiazolcarbonsäure