CY1109114T1 - Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης - Google Patents
Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριληςInfo
- Publication number
- CY1109114T1 CY1109114T1 CY20091100573T CY091100573T CY1109114T1 CY 1109114 T1 CY1109114 T1 CY 1109114T1 CY 20091100573 T CY20091100573 T CY 20091100573T CY 091100573 T CY091100573 T CY 091100573T CY 1109114 T1 CY1109114 T1 CY 1109114T1
- Authority
- CY
- Cyprus
- Prior art keywords
- reacting
- mixture
- image
- viii
- iii
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
Abstract
Η παρούσα εφεύρεση αφορά μία βελτιωμένη μέθοδο διεργασιών για την παρασκευή ραμιπρίλης, ενδιάμεσα προϊόντα που χρησιμοποιούνται στην μέθοδο διεργασιών και την χρήση τους.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005061756A DE102005061756B4 (de) | 2005-12-21 | 2005-12-21 | Verbessertes Verfahren zur Herstellung von Ramipril |
EP06829483A EP1966118B1 (de) | 2005-12-21 | 2006-12-11 | Verbessertes verfahren zur herstellung von ramipril |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109114T1 true CY1109114T1 (el) | 2014-07-02 |
Family
ID=37944123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100573T CY1109114T1 (el) | 2005-12-21 | 2009-05-28 | Βελτιωμενη μεθοδος διεργασιων για την παρασκευη ραμιπριλης |
Country Status (20)
Country | Link |
---|---|
US (1) | US8119375B2 (el) |
EP (1) | EP1966118B1 (el) |
JP (1) | JP5386174B2 (el) |
KR (1) | KR101426714B1 (el) |
CN (1) | CN101326151B (el) |
AT (1) | ATE425135T1 (el) |
AU (1) | AU2006334781B2 (el) |
BR (1) | BRPI0620075A2 (el) |
CA (1) | CA2633559A1 (el) |
CY (1) | CY1109114T1 (el) |
DE (2) | DE102005061756B4 (el) |
DK (1) | DK1966118T3 (el) |
ES (1) | ES2323555T3 (el) |
HK (1) | HK1127488A1 (el) |
IL (1) | IL192066A (el) |
MY (1) | MY140061A (el) |
PL (1) | PL1966118T3 (el) |
PT (1) | PT1966118E (el) |
SI (1) | SI1966118T1 (el) |
WO (1) | WO2007079871A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100143981A1 (en) * | 2006-12-04 | 2010-06-10 | Rusnak-Mueller Monika | Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase |
WO2009098251A1 (en) * | 2008-02-07 | 2009-08-13 | Dsm Ip Assets B.V. | NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES |
WO2011121616A2 (en) * | 2010-03-31 | 2011-10-06 | Promethean Power Systems | Rapid cooling system for cooling liquids |
EP2560493B1 (en) * | 2010-04-20 | 2018-06-06 | Chiral Quest, Inc. | An enantioselective process for cycloalkenyl b-substituted alanines |
DK2598479T3 (da) * | 2010-11-11 | 2015-05-04 | Aarti Healthcare Ltd | Fremgangsmåde til fremstilling af Ramipril |
WO2014202659A1 (en) | 2013-06-21 | 2014-12-24 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine |
CN104513292A (zh) * | 2013-09-29 | 2015-04-15 | 山东新时代药业有限公司 | 一种雷米普利的制备方法 |
HUE039419T2 (hu) | 2014-06-11 | 2018-12-28 | Sanofi Aventis Deutschland | Eljárás ramipril elõállítására |
CN109721524A (zh) * | 2017-10-31 | 2019-05-07 | 鲁南制药集团股份有限公司 | 一种雷米普利的精制方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
SK285229B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu |
CN100387615C (zh) * | 2002-12-30 | 2008-05-14 | 上海医药工业研究院 | N-羧烷基二肽型血管紧张素转化酶抑制剂的制备方法 |
AU2003290400A1 (en) * | 2003-11-24 | 2005-06-08 | Potluri Ramesh Babu | A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates |
WO2005049568A1 (en) * | 2003-11-24 | 2005-06-02 | Potluri Ramesh Babu | A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate |
-
2005
- 2005-12-21 DE DE102005061756A patent/DE102005061756B4/de not_active Expired - Fee Related
-
2006
- 2006-12-11 CA CA002633559A patent/CA2633559A1/en not_active Abandoned
- 2006-12-11 JP JP2008546196A patent/JP5386174B2/ja not_active Expired - Fee Related
- 2006-12-11 DE DE502006003143T patent/DE502006003143D1/de active Active
- 2006-12-11 WO PCT/EP2006/011891 patent/WO2007079871A1/de active Application Filing
- 2006-12-11 KR KR1020087015059A patent/KR101426714B1/ko not_active IP Right Cessation
- 2006-12-11 CN CN200680046668.3A patent/CN101326151B/zh not_active Expired - Fee Related
- 2006-12-11 AU AU2006334781A patent/AU2006334781B2/en not_active Ceased
- 2006-12-11 DK DK06829483T patent/DK1966118T3/da active
- 2006-12-11 BR BRPI0620075-3A patent/BRPI0620075A2/pt not_active IP Right Cessation
- 2006-12-11 SI SI200630268T patent/SI1966118T1/sl unknown
- 2006-12-11 AT AT06829483T patent/ATE425135T1/de active
- 2006-12-11 MY MYPI20082137A patent/MY140061A/en unknown
- 2006-12-11 ES ES06829483T patent/ES2323555T3/es active Active
- 2006-12-11 PT PT06829483T patent/PT1966118E/pt unknown
- 2006-12-11 EP EP06829483A patent/EP1966118B1/de not_active Not-in-force
- 2006-12-11 PL PL06829483T patent/PL1966118T3/pl unknown
-
2008
- 2008-06-11 IL IL192066A patent/IL192066A/en not_active IP Right Cessation
- 2008-06-19 US US12/142,095 patent/US8119375B2/en not_active Expired - Fee Related
-
2009
- 2009-05-28 CY CY20091100573T patent/CY1109114T1/el unknown
- 2009-06-09 HK HK09105159.7A patent/HK1127488A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20080086463A (ko) | 2008-09-25 |
JP5386174B2 (ja) | 2014-01-15 |
DE102005061756A1 (de) | 2007-06-28 |
CN101326151A (zh) | 2008-12-17 |
DE102005061756B4 (de) | 2008-01-03 |
IL192066A0 (en) | 2008-12-29 |
EP1966118A1 (de) | 2008-09-10 |
HK1127488A1 (en) | 2009-09-25 |
JP2009520473A (ja) | 2009-05-28 |
AU2006334781B2 (en) | 2012-01-19 |
PL1966118T3 (pl) | 2009-07-31 |
ES2323555T3 (es) | 2009-07-20 |
MY140061A (en) | 2009-11-30 |
CN101326151B (zh) | 2015-01-07 |
SI1966118T1 (sl) | 2009-06-30 |
EP1966118B1 (de) | 2009-03-11 |
AU2006334781A1 (en) | 2007-07-19 |
KR101426714B1 (ko) | 2014-08-06 |
ATE425135T1 (de) | 2009-03-15 |
WO2007079871A1 (de) | 2007-07-19 |
US8119375B2 (en) | 2012-02-21 |
IL192066A (en) | 2010-12-30 |
DE502006003143D1 (de) | 2009-04-23 |
US20090017509A1 (en) | 2009-01-15 |
DK1966118T3 (da) | 2009-07-06 |
BRPI0620075A2 (pt) | 2011-11-01 |
CA2633559A1 (en) | 2007-07-19 |
PT1966118E (pt) | 2009-05-18 |
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