HK1127044A1 - Process for the preparation of asenapine and intermediate products used in said process - Google Patents

Process for the preparation of asenapine and intermediate products used in said process

Info

Publication number
HK1127044A1
HK1127044A1 HK09106284.3A HK09106284A HK1127044A1 HK 1127044 A1 HK1127044 A1 HK 1127044A1 HK 09106284 A HK09106284 A HK 09106284A HK 1127044 A1 HK1127044 A1 HK 1127044A1
Authority
HK
Hong Kong
Prior art keywords
asenapine
preparation
intermediate products
products used
products
Prior art date
Application number
HK09106284.3A
Other languages
English (en)
Inventor
Gerardus Johannes Kemperman
Timothy Lee Stuk
Van Der Jacobus Johannes Maria Linden
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of HK1127044A1 publication Critical patent/HK1127044A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK09106284.3A 2006-07-05 2009-07-14 Process for the preparation of asenapine and intermediate products used in said process HK1127044A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116660 2006-07-05
PCT/EP2007/005876 WO2008003460A1 (fr) 2006-07-05 2007-07-03 Procédé pour la préparation de l'asénapine et produits intermédiaires utilisés dans ledit procédé

Publications (1)

Publication Number Publication Date
HK1127044A1 true HK1127044A1 (en) 2009-09-18

Family

ID=37685865

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09106284.3A HK1127044A1 (en) 2006-07-05 2009-07-14 Process for the preparation of asenapine and intermediate products used in said process

Country Status (18)

Country Link
EP (1) EP2044076B1 (fr)
JP (1) JP2010503611A (fr)
CN (1) CN101484456B (fr)
AR (1) AR061811A1 (fr)
AT (1) ATE445620T1 (fr)
CA (1) CA2655670A1 (fr)
CY (1) CY1109707T1 (fr)
DE (1) DE602007002826D1 (fr)
DK (1) DK2044076T3 (fr)
ES (1) ES2333488T3 (fr)
HK (1) HK1127044A1 (fr)
MX (1) MX2008016490A (fr)
PL (1) PL2044076T3 (fr)
PT (1) PT2044076E (fr)
SI (1) SI2044076T1 (fr)
TW (1) TW200817414A (fr)
WO (1) WO2008003460A1 (fr)
ZA (1) ZA200810859B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
MX2010007404A (es) * 2008-01-04 2010-10-05 Organon Nv Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento.
AR077225A1 (es) 2009-06-24 2011-08-10 Organon Nv Formulaciones inyectables que contienen asenapina y metodo de tratamiento que las utiliza
WO2012123325A1 (fr) 2011-03-11 2012-09-20 Medichem S.A. Nouvelles formes cristallines du sel de trans-5-chloro-2-méthyl-2,3,3a,12b-tétrahydro-1h-dibenzo[2,3:6,7] oxépino[4,5-c]pyrrole avec l'acide maléique
CN102229613B (zh) * 2011-04-27 2013-08-07 上海华升生物科技有限公司 阿森纳平的合成工艺
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524919A1 (fr) * 2011-05-17 2012-11-21 Sandoz AG Nouveaux sels cristallins d'asénapine avec des di-acides et des tri-acides cristallins
EP2524921A1 (fr) * 2011-05-17 2012-11-21 Sandoz AG Nouveaux sels cristallins d'asénapine
CN102952144A (zh) * 2011-08-29 2013-03-06 上海华拓医药科技发展股份有限公司 阿森纳平马来酸盐的晶型、制备方法及其药物组合物
WO2013041604A1 (fr) 2011-09-21 2013-03-28 Sandoz Ag Forme cristalline de maléate d'asénapine
EP2572703A1 (fr) 2011-09-21 2013-03-27 Hexal AG Forme pharmaceutique orale compressée pour maléate d'asénapine
GB201121124D0 (en) * 2011-12-08 2012-01-18 Dow Corning Hydrolysable silanes
GB201121128D0 (en) * 2011-12-08 2012-01-18 Dow Corning Treatment of filler with silane
CN103183680A (zh) * 2011-12-27 2013-07-03 上海华拓医药科技发展股份有限公司 阿森那平的制备方法
WO2013190481A1 (fr) * 2012-06-21 2013-12-27 Alembic Pharmaceuticals Limited Procédé pour la préparation d'asénapine et sels d'intermédiaires de celle-ci
CN103772402A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 一种新的阿塞那平马来酸盐粗品精制方法
CN104974167B (zh) * 2014-04-02 2019-01-04 洋浦慧谷医药有限公司 阿塞那平的制备方法以及用于制备阿塞那平的中间体
US10056563B2 (en) 2016-04-08 2018-08-21 Samsung Electronics Co., Ltd. Synthetic method of fused heteroaromatic compound and fused heteroaromatic compound, and intermediate thereof
US10707424B2 (en) 2016-11-08 2020-07-07 Samsung Electronics Co., Ltd. Synthetic method of fused heteroaromatic compound and fused heteroaromatic compound and intermediate therefor and synthetic method of intermediate
AU2017384392B2 (en) 2016-12-20 2023-05-25 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
JP7236389B2 (ja) 2016-12-20 2023-03-09 エルテーエス ローマン テラピー－ジステーメ アーゲー アセナピンを含有する経皮治療システム
EP3644973B1 (fr) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Système thérapeutique transdermique contenant de l'asénapine et polymère hybride acrylique silicone
BR112020026099A2 (pt) 2018-06-20 2021-03-23 Lts Lohmann Therapie-Systeme Ag sistema terapêutico transdérmico que contém asenapina
CN110183457A (zh) * 2019-06-27 2019-08-30 浙江天顺药业有限公司 一种阿塞那平及其制备方法
CN112830931A (zh) 2019-08-13 2021-05-25 浙江奥翔药业股份有限公司 制备阿塞那平的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
WO2006106136A1 (fr) * 2005-04-07 2006-10-12 N.V. Organon Composés intermédiaires pour la synthèse du trans-5-chloro-2-méthyl-2,3,3a,12b-tétrahydro-1h-dibenz[2,3:6,7]oxépino[4,5-c]pyrrole

Also Published As

Publication number Publication date
CA2655670A1 (fr) 2008-01-10
PT2044076E (pt) 2010-01-20
ZA200810859B (en) 2009-09-30
ATE445620T1 (de) 2009-10-15
PL2044076T3 (pl) 2010-03-31
TW200817414A (en) 2008-04-16
AR061811A1 (es) 2008-09-24
CN101484456A (zh) 2009-07-15
JP2010503611A (ja) 2010-02-04
CN101484456B (zh) 2011-09-07
SI2044076T1 (sl) 2010-01-29
DE602007002826D1 (de) 2009-11-26
MX2008016490A (es) 2009-01-22
EP2044076A1 (fr) 2009-04-08
EP2044076B1 (fr) 2009-10-14
DK2044076T3 (da) 2010-02-01
ES2333488T3 (es) 2010-02-22
WO2008003460A1 (fr) 2008-01-10
CY1109707T1 (el) 2014-04-09

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130703