HK1113306A1 - Process for the preparation of galanthamine hydrobromide - Google Patents
Process for the preparation of galanthamine hydrobromideInfo
- Publication number
- HK1113306A1 HK1113306A1 HK08102754.4A HK08102754A HK1113306A1 HK 1113306 A1 HK1113306 A1 HK 1113306A1 HK 08102754 A HK08102754 A HK 08102754A HK 1113306 A1 HK1113306 A1 HK 1113306A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- galanthamine
- hydrobromide
- preparation
- butyl
- galanthamine hydrobromide
- Prior art date
Links
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract 11
- 229960003980 galantamine Drugs 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 4
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 4
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 4
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 abstract 4
- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 4
- 241000234270 Amaryllidaceae Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002413A ITMI20042413A1 (it) | 2004-12-17 | 2004-12-17 | Processo per la preparazione di galantamina bromidrato |
PCT/EP2005/012521 WO2006063666A1 (en) | 2004-12-17 | 2005-11-23 | Process for the preparation of galanthamine hydrobromide |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1113306A1 true HK1113306A1 (en) | 2008-10-03 |
Family
ID=35784718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08102754.4A HK1113306A1 (en) | 2004-12-17 | 2008-03-10 | Process for the preparation of galanthamine hydrobromide |
Country Status (20)
Country | Link |
---|---|
US (1) | US8013151B2 (da) |
EP (1) | EP1861105B1 (da) |
JP (1) | JP5166878B2 (da) |
KR (1) | KR101291446B1 (da) |
CN (1) | CN101080231B (da) |
AT (1) | ATE440607T1 (da) |
AU (1) | AU2005315960B2 (da) |
CA (1) | CA2592288C (da) |
DE (1) | DE602005016308D1 (da) |
DK (1) | DK1861105T3 (da) |
ES (1) | ES2330127T3 (da) |
HK (1) | HK1113306A1 (da) |
IL (1) | IL183933A0 (da) |
IT (1) | ITMI20042413A1 (da) |
NO (1) | NO338724B1 (da) |
PL (1) | PL1861105T3 (da) |
PT (1) | PT1861105E (da) |
RU (1) | RU2387656C2 (da) |
SI (1) | SI1861105T1 (da) |
WO (1) | WO2006063666A1 (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT507256B1 (de) * | 2008-09-04 | 2010-10-15 | Sanochemia Pharmazeutika Ag | Verwendung von galanthaminiumbromid zur herstellung von ophthalmischen formulierungen zur glaukombehandlung |
US8247405B2 (en) * | 2008-12-10 | 2012-08-21 | Conopco, Inc. | Skin lightening compositions with acetylcholinesterase inhibitors |
CN101787028B (zh) * | 2010-01-12 | 2012-01-04 | 恩施清江生物工程有限公司 | 一种从忽地笑中提取加兰他敏的方法 |
BG110754A (bg) | 2010-09-20 | 2012-03-30 | "Ар енд ДИ" ООД | Метод и инсталация за екстракция на растителни суровини |
BG66818B1 (bg) * | 2013-03-07 | 2019-01-31 | Berbee Beheer B. V. | Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки |
CN104177368B (zh) * | 2014-05-27 | 2016-06-08 | 天津梅花医药有限公司 | 一种氢溴酸加兰他敏化合物、制备方法及其药物组合物 |
CN103980284B (zh) * | 2014-05-30 | 2016-03-09 | 天津梅花医药有限公司 | 一种氢溴酸加兰他敏化合物及其制备方法 |
CN107462656A (zh) * | 2017-07-04 | 2017-12-12 | 上海市农业科学院 | 一种快速检测石蒜科植物中加兰他敏含量的方法 |
BG67337B1 (bg) | 2018-05-23 | 2021-06-15 | Софарма Ад | Метод за получаване на пречистен галантамин хидробромид |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB942200A (en) * | 1959-03-02 | 1963-11-20 | Chimiko Pharmazevtitschen Zd | A method of obtaining galanthamine hydrobromide |
GB938767A (en) * | 1961-12-13 | 1963-10-09 | Vni Chimico Pharmatsevtichesky | The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids |
DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
CN1261434C (zh) * | 2003-07-28 | 2006-06-28 | 浙江一新制药股份有限公司 | 从石蒜粗提物中分离高纯度加兰他敏的方法 |
DE102006033591B4 (de) | 2006-07-18 | 2008-10-16 | Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. | Verfahren zur Stabilisierung der Spinnlösung bei der Herstellung von cellulosischen Verbundformkörpern |
-
2004
- 2004-12-17 IT IT002413A patent/ITMI20042413A1/it unknown
-
2005
- 2005-11-23 AT AT05808194T patent/ATE440607T1/de active
- 2005-11-23 JP JP2007545863A patent/JP5166878B2/ja not_active Expired - Fee Related
- 2005-11-23 RU RU2007122353/04A patent/RU2387656C2/ru active
- 2005-11-23 WO PCT/EP2005/012521 patent/WO2006063666A1/en active Application Filing
- 2005-11-23 PT PT05808194T patent/PT1861105E/pt unknown
- 2005-11-23 DK DK05808194T patent/DK1861105T3/da active
- 2005-11-23 SI SI200530788T patent/SI1861105T1/sl unknown
- 2005-11-23 AU AU2005315960A patent/AU2005315960B2/en not_active Ceased
- 2005-11-23 PL PL05808194T patent/PL1861105T3/pl unknown
- 2005-11-23 CA CA2592288A patent/CA2592288C/en active Active
- 2005-11-23 DE DE602005016308T patent/DE602005016308D1/de active Active
- 2005-11-23 US US11/793,097 patent/US8013151B2/en not_active Expired - Fee Related
- 2005-11-23 KR KR1020077013259A patent/KR101291446B1/ko active IP Right Grant
- 2005-11-23 CN CN2005800429800A patent/CN101080231B/zh active Active
- 2005-11-23 EP EP05808194A patent/EP1861105B1/en active Active
- 2005-11-23 ES ES05808194T patent/ES2330127T3/es active Active
-
2007
- 2007-06-14 IL IL183933A patent/IL183933A0/en active IP Right Grant
- 2007-06-15 NO NO20073053A patent/NO338724B1/no unknown
-
2008
- 2008-03-10 HK HK08102754.4A patent/HK1113306A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SI1861105T1 (sl) | 2009-12-31 |
KR20070095897A (ko) | 2007-10-01 |
JP5166878B2 (ja) | 2013-03-21 |
JP2008524125A (ja) | 2008-07-10 |
CA2592288A1 (en) | 2006-06-22 |
AU2005315960A1 (en) | 2006-06-22 |
US20090043092A1 (en) | 2009-02-12 |
CN101080231A (zh) | 2007-11-28 |
CA2592288C (en) | 2014-05-06 |
PL1861105T3 (pl) | 2010-02-26 |
RU2007122353A (ru) | 2008-12-20 |
NO20073053L (no) | 2007-06-15 |
AU2005315960B2 (en) | 2012-01-12 |
EP1861105B1 (en) | 2009-08-26 |
DK1861105T3 (da) | 2009-11-16 |
ES2330127T3 (es) | 2009-12-04 |
US8013151B2 (en) | 2011-09-06 |
RU2387656C2 (ru) | 2010-04-27 |
ITMI20042413A1 (it) | 2005-03-17 |
IL183933A0 (en) | 2007-10-31 |
DE602005016308D1 (de) | 2009-10-08 |
KR101291446B1 (ko) | 2013-07-30 |
WO2006063666A1 (en) | 2006-06-22 |
EP1861105A1 (en) | 2007-12-05 |
NO338724B1 (no) | 2016-10-10 |
PT1861105E (pt) | 2009-10-22 |
CN101080231B (zh) | 2010-11-17 |
ATE440607T1 (de) | 2009-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20231121 |