GB938767A - The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids - Google Patents

The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids

Info

Publication number
GB938767A
GB938767A GB44598/61A GB4459861A GB938767A GB 938767 A GB938767 A GB 938767A GB 44598/61 A GB44598/61 A GB 44598/61A GB 4459861 A GB4459861 A GB 4459861A GB 938767 A GB938767 A GB 938767A
Authority
GB
United Kingdom
Prior art keywords
galanthamine
solution
alkaloids
amaryllidaceae
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44598/61A
Inventor
Nina Feodorovna Prosko Shapiro
Alexandra Pavlovna Iakovleva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VNI CHIMICO PHARMATSEVTICHESKY
Original Assignee
VNI CHIMICO PHARMATSEVTICHESKY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VNI CHIMICO PHARMATSEVTICHESKY filed Critical VNI CHIMICO PHARMATSEVTICHESKY
Priority to GB44598/61A priority Critical patent/GB938767A/en
Publication of GB938767A publication Critical patent/GB938767A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Galanthamine obtained from a member of the Amaryllidaceae is purified by dissolving the impure alkaloid in acetone, treating the solution with aluminium oxide, removing the latter and evaporating the solution to obtain a concentrated solution of purified galanthamine. This may then be treated with an alcoholic solution of hydrogen bromide to obtain galanthamine hydrobromide. The impure galanthamine may be obtained by treating the plant material with ammonia, extracting the alkaloids with a solvent, extracting the resulting solution with sulphuric acid, making the acid extract alkaline with ammonia, and removing the alkaloids other than galanthamine thus precipitated.
GB44598/61A 1961-12-13 1961-12-13 The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids Expired GB938767A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB44598/61A GB938767A (en) 1961-12-13 1961-12-13 The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB44598/61A GB938767A (en) 1961-12-13 1961-12-13 The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids

Publications (1)

Publication Number Publication Date
GB938767A true GB938767A (en) 1963-10-09

Family

ID=10434016

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44598/61A Expired GB938767A (en) 1961-12-13 1961-12-13 The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids

Country Status (1)

Country Link
GB (1) GB938767A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063666A1 (en) * 2004-12-17 2006-06-22 Indena S.P.A. Process for the preparation of galanthamine hydrobromide

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063666A1 (en) * 2004-12-17 2006-06-22 Indena S.P.A. Process for the preparation of galanthamine hydrobromide
US8013151B2 (en) 2004-12-17 2011-09-06 Indena S.P.A. Process for the preparation of galanthamine hydrobromide
AU2005315960B2 (en) * 2004-12-17 2012-01-12 Indena S.P.A. Process for the preparation of galanthamine hydrobromide
NO338724B1 (en) * 2004-12-17 2016-10-10 Indena Spa Process for the preparation of galantamine hydrobromide

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