GB938767A - The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids - Google Patents
The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloidsInfo
- Publication number
- GB938767A GB938767A GB44598/61A GB4459861A GB938767A GB 938767 A GB938767 A GB 938767A GB 44598/61 A GB44598/61 A GB 44598/61A GB 4459861 A GB4459861 A GB 4459861A GB 938767 A GB938767 A GB 938767A
- Authority
- GB
- United Kingdom
- Prior art keywords
- galanthamine
- solution
- alkaloids
- amaryllidaceae
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Galanthamine obtained from a member of the Amaryllidaceae is purified by dissolving the impure alkaloid in acetone, treating the solution with aluminium oxide, removing the latter and evaporating the solution to obtain a concentrated solution of purified galanthamine. This may then be treated with an alcoholic solution of hydrogen bromide to obtain galanthamine hydrobromide. The impure galanthamine may be obtained by treating the plant material with ammonia, extracting the alkaloids with a solvent, extracting the resulting solution with sulphuric acid, making the acid extract alkaline with ammonia, and removing the alkaloids other than galanthamine thus precipitated.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB44598/61A GB938767A (en) | 1961-12-13 | 1961-12-13 | The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB44598/61A GB938767A (en) | 1961-12-13 | 1961-12-13 | The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB938767A true GB938767A (en) | 1963-10-09 |
Family
ID=10434016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB44598/61A Expired GB938767A (en) | 1961-12-13 | 1961-12-13 | The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB938767A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006063666A1 (en) * | 2004-12-17 | 2006-06-22 | Indena S.P.A. | Process for the preparation of galanthamine hydrobromide |
-
1961
- 1961-12-13 GB GB44598/61A patent/GB938767A/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006063666A1 (en) * | 2004-12-17 | 2006-06-22 | Indena S.P.A. | Process for the preparation of galanthamine hydrobromide |
US8013151B2 (en) | 2004-12-17 | 2011-09-06 | Indena S.P.A. | Process for the preparation of galanthamine hydrobromide |
AU2005315960B2 (en) * | 2004-12-17 | 2012-01-12 | Indena S.P.A. | Process for the preparation of galanthamine hydrobromide |
NO338724B1 (en) * | 2004-12-17 | 2016-10-10 | Indena Spa | Process for the preparation of galantamine hydrobromide |
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