SU135186A2 - Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micelline - Google Patents
Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micellineInfo
- Publication number
- SU135186A2 SU135186A2 SU6000667801A SU667801A SU135186A2 SU 135186 A2 SU135186 A2 SU 135186A2 SU 6000667801 A SU6000667801 A SU 6000667801A SU 667801 A SU667801 A SU 667801A SU 135186 A2 SU135186 A2 SU 135186A2
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nistatine
- micelline
- extpactioh
- antnbiotic
- actinomycet
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
В основном авт. св. № 124590 описанспособ получени противогрибкового антибиотика нистатина из мицели актиномицета Sfreptomyses noursei , заключаюшийс в том, что нистатин извлекают из мицели в виде хлоркальциевого комплекса путем обработки спиртовым раствором хлористого кал1)Ци с последующим осаждением водой.Basically auth. St. No. 124590 describes a method for preparing the antifungal antibiotic nystatin from the mycelium of actinomycete Sfreptomyses noursei, which consists in removing nystatin from the mycelium as a chlorine calcium complex by treating with an alcoholic solution of fecal time) Qi) followed by precipitation with water.
Предпагаемый способ извлечени нистатина позвол ет существенно увеличить, выход антибиотика, а также упростить регенерацию растворитеп и заключаетс в том, что нистаТИТ1 извлекают из мицели Slreptomyses noursei в виде комплекса с хлористым кальцием в метаноле, после чего удал ют упариванием в вакууме большую часть метанола, и нистатин выдбл кт из кубового остатка разбавленнием вопой.The nystatin extraction method allows to significantly increase the yield of the antibiotic, as well as simplify the regeneration of solvent and lies in the fact that nestIT1 is removed from the mycelium of Slreptomyses noursei in the form of a complex with calcium chloride in methanol, after which most of the methanol is removed and nystatin vydbl kt from the vat residue dilution by cry.
Путем концентрировани в вакууме при температуре, не превышаюишй 35-4О С,By concentrating in vacuum at a temperature not exceeding 35-4 ° C,
спиртовых растворов комплекса нистатина с хлористым кальцием удаетс отогнать около 80-85% общего количества спирта, содержащего не более 10% воды. После обработки кубового остатка равиым объемом воды выдел етс нистатин, который по своим свойствам полностью соответствует требовани м и техническим услови м на этот препарат.Alcoholic solutions of the nystatin complex with calcium chloride can be used to ward off about 80-85% of the total amount of alcohol containing not more than 10% of water. After the bottom of the bottom is treated with a slave volume of water, nystatin is released, which by its properties fully complies with the requirements and technical conditions for this preparation.
Выход при предварительном концентрировании экстракта в вакууме увеличиваетс в среднем на 10% по сравнению с непосредственным выделением нистатина из спиртового экстракта без предварительного концентрировани .The yield during pre-concentration of the extract in vacuum is increased on average by 10% compared with the direct isolation of nystatin from the alcoholic extract without prior concentration.
ормула изоб))отени formula izob)) otni
Способ извлечени противогрибкового антибиотика нистатина из мицели актииомипета Sfreptomyses noursei по авт. св. № 124590, отличаю лиас тем, что, с цель.ю увеличени выхода, раствор ко тлекса с хлористым кальцием в метаноле упаривают в вакууме до минимального объема при температуре 35-40 С и затем осаждают из кубового остатка добавлением воды.The method of extraction of the antifungal antibiotic nystatin from the mycelium of the Aciomipet Sfreptomyses noursei on the author. St. No. 124590, distinguished by the fact that, with the goal of increasing the yield, the solution of calcium chloride in methanol is evaporated in vacuo to a minimum volume at a temperature of 35–40 ° C and then precipitated from the residue by the addition of water.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU6000667801A SU135186A2 (en) | 1960-05-25 | 1960-05-25 | Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micelline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU6000667801A SU135186A2 (en) | 1960-05-25 | 1960-05-25 | Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micelline |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU124590 Addition |
Publications (1)
Publication Number | Publication Date |
---|---|
SU135186A2 true SU135186A2 (en) | 1977-08-25 |
Family
ID=20437091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU6000667801A SU135186A2 (en) | 1960-05-25 | 1960-05-25 | Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micelline |
Country Status (1)
Country | Link |
---|---|
SU (1) | SU135186A2 (en) |
-
1960
- 1960-05-25 SU SU6000667801A patent/SU135186A2/en active
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