HK1092358A1 - Method for producing medicaments for reducing amyloid deposition, amyloid neurotoxicity and microgloisis - Google Patents
Method for producing medicaments for reducing amyloid deposition, amyloid neurotoxicity and microgloisisInfo
- Publication number
- HK1092358A1 HK1092358A1 HK06109711.3A HK06109711A HK1092358A1 HK 1092358 A1 HK1092358 A1 HK 1092358A1 HK 06109711 A HK06109711 A HK 06109711A HK 1092358 A1 HK1092358 A1 HK 1092358A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- amyloid
- reducing
- animals
- neurotoxicity
- nilvadipine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47069403P | 2003-05-15 | 2003-05-15 | |
PCT/US2004/015417 WO2004110354A2 (en) | 2003-05-15 | 2004-05-17 | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1092358A1 true HK1092358A1 (en) | 2007-02-09 |
Family
ID=33551420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06109711.3A HK1092358A1 (en) | 2003-05-15 | 2006-08-31 | Method for producing medicaments for reducing amyloid deposition, amyloid neurotoxicity and microgloisis |
Country Status (11)
Country | Link |
---|---|
US (1) | US7732467B2 (de) |
EP (1) | EP1628663B1 (de) |
JP (1) | JP4971794B2 (de) |
CN (1) | CN100444840C (de) |
AT (1) | ATE437641T1 (de) |
CA (1) | CA2525970C (de) |
DE (1) | DE602004022284D1 (de) |
DK (1) | DK1628663T3 (de) |
ES (1) | ES2334029T3 (de) |
HK (1) | HK1092358A1 (de) |
WO (1) | WO2004110354A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006203819A1 (en) * | 2005-01-07 | 2006-07-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds |
PT1874311E (pt) * | 2005-04-15 | 2011-11-25 | Res & Innovation S P A | Método para prevenir, retardar ou reverter a deposição anómala de amilóide |
KR20080098049A (ko) * | 2006-03-01 | 2008-11-06 | 로스캄프 리서치 엘엘씨 | 베타-아밀로이드 생성의 억제를 위한 화합물 |
US20100119599A1 (en) * | 2006-12-08 | 2010-05-13 | Archer Pharmaceuticals, Inc. | Polyhydroquinoline compounds and dihydropyridine compounds for inhibiting beta-amyloid production |
US8709394B2 (en) * | 2007-09-28 | 2014-04-29 | Ndsu Research Foundation | Antimicrobial polysiloxane materials containing metal species |
US20100093810A1 (en) * | 2007-10-05 | 2010-04-15 | Alzheimer's Institute Of America, Inc. | Pharmaceutical Compositions for Reducing Amyloid Deposition, Amyloid Neurotoxicity, and Microgliosis |
CA2701620C (en) * | 2007-10-05 | 2014-12-09 | Alzheimer's Institute Of America, Inc. | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
WO2009046338A1 (en) * | 2007-10-05 | 2009-04-09 | Roskamp Research Llc | Method for increasing cerebral blood flow with (+)-nilvadipine enantiomer |
EP2429992A4 (de) * | 2009-05-15 | 2012-11-28 | Univ Kentucky Res Found | Behandlung von leichter kognitiver beeinträchtigung und morbus alzheimer |
EP2311823A1 (de) * | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten |
KR20140128229A (ko) | 2013-04-26 | 2014-11-05 | 한국과학기술연구원 | 체내 단백질 응집체의 용해를 이용한 단백질의 비정상적인 응집 또는 미스폴딩과 관련된 질환 또는 질병을 진단하는 혈액진단키트 |
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US4338322A (en) | 1975-07-02 | 1982-07-06 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same |
JPS6038322A (ja) | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンa物質含有易溶性固形製剤 |
JPS61129140A (ja) | 1984-11-27 | 1986-06-17 | Nitto Electric Ind Co Ltd | 医薬組成物 |
GB8431119D0 (en) | 1984-12-10 | 1985-01-16 | Fujisawa Pharmaceutical Co | Anti-arteriosclerotic composition |
US4940556A (en) | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US5114946A (en) | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
ES2043719T3 (es) | 1987-06-12 | 1994-01-01 | American Cyanamid Co | Administracion de farmacos por via percutanea. |
US5045553A (en) | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
US4820720A (en) | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
EP0317780B1 (de) | 1987-11-25 | 1992-05-20 | American Cyanamid Company | System für die verzögerte (kontrollierte) Freisetzung von substituierten Dihydropyridin-Calciumantagonisten |
US5160734A (en) | 1987-11-25 | 1992-11-03 | American Cyanamid Company | Sustained release delivery system for substituted dihydropyridine calcium channel blockers |
US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
US5053419A (en) | 1989-03-31 | 1991-10-01 | The Children's Medical Center Corporation | Treatment of AIDS dementia, myelopathy and blindness |
JP2867462B2 (ja) | 1989-09-12 | 1999-03-08 | 藤沢薬品工業株式会社 | 経皮吸収用製剤 |
JPH03117658A (ja) | 1989-09-29 | 1991-05-20 | Mazda Motor Corp | 外燃式ロータリピストンエンジン |
JP2920956B2 (ja) | 1989-10-06 | 1999-07-19 | 藤沢薬品工業株式会社 | ニルバジピン含有持続性錠剤 |
WO1992003137A1 (en) | 1990-08-23 | 1992-03-05 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy, peripheral neuropathy, and vision loss |
WO1993005770A1 (en) | 1991-09-20 | 1993-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Long-acting preparation |
JPH05139974A (ja) | 1991-11-26 | 1993-06-08 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンa物質含有易溶性固体分散体の製造法 |
DE4141646A1 (de) | 1991-12-17 | 1993-06-24 | Klinge Co Chem Pharm Fab | Arzneimittelkombination mit synergistischer wirkung, verfahren zu seiner herstellung und seine verwendung |
US5340591A (en) | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
DE4229805A1 (de) * | 1992-09-07 | 1994-03-24 | Werner E G Prof Dr Mueller | Kalzium-Kanal-Antagonisten oder deren Derivate zur Herstellung eines Arzneimittels zur Bekämpfung von Erkrankungen, die durch Prion-Proteine oder Prion-analoge Proteine ausgelöst werden |
US5721263A (en) | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
CA2125251C (en) | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
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US6271259B1 (en) * | 1996-05-07 | 2001-08-07 | Ito En, Ltd. | Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death |
KR100222306B1 (ko) | 1996-11-20 | 1999-10-01 | 이병언 | 닐바디핀 속효성 고형제제 및 이의 제조방법 |
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TR200100062T2 (tr) | 1998-07-10 | 2001-06-21 | Novartis Ag | Valsartan ve kalsiyum kanalı bloklayıcısının anti-hipertensif kombinasyonu |
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JP2001335483A (ja) | 2000-05-30 | 2001-12-04 | Nichiko Pharmaceutical Co Ltd | ニルバジピン含有製剤 |
ATE357257T1 (de) | 2000-07-27 | 2007-04-15 | Pharmacia Corp | Kombinationstherapie mit epoxy-steroidalen aldosteronantagonisten und kalziumkanalblocker zur behandlung von kongestivem herzversagen |
JP3968687B2 (ja) | 2000-09-13 | 2007-08-29 | 東和薬品株式会社 | 易吸収性ニルバジピン錠 |
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WO2002049651A1 (de) | 2000-12-19 | 2002-06-27 | Merck Patent Gmbh | Pharmazeutische formulierung enthaltend pyrazolo[4,3-d]pyrimidine und antithrombotica, calcium-antagonisten, prostaglandine oder prostaglandinderivate |
KR20030059351A (ko) | 2000-12-19 | 2003-07-07 | 메르크 파텐트 게엠베하 | 티에노피리미딘 및 항혈전제, 칼슘 길항제,프로스타글란딘 또는 프로스타글란딘 유도체를 포함하여이루어지는 약제학적 조성물 |
US7083642B2 (en) | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
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JP2006512417A (ja) * | 2002-12-24 | 2006-04-13 | ニューロケム (インターナショナル) リミテッド | β−アミロイド関連疾患の治療のための治療用製剤 |
US20050031651A1 (en) | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
JP2004002460A (ja) | 2003-07-29 | 2004-01-08 | Towa Yakuhin Kk | 易吸収性ニルバジピン錠の製造法 |
-
2004
- 2004-05-17 DK DK04752432.7T patent/DK1628663T3/da active
- 2004-05-17 DE DE602004022284T patent/DE602004022284D1/de not_active Expired - Lifetime
- 2004-05-17 CA CA2525970A patent/CA2525970C/en not_active Expired - Fee Related
- 2004-05-17 US US10/847,630 patent/US7732467B2/en active Active
- 2004-05-17 WO PCT/US2004/015417 patent/WO2004110354A2/en active Search and Examination
- 2004-05-17 EP EP04752432A patent/EP1628663B1/de not_active Expired - Fee Related
- 2004-05-17 CN CNB2004800171974A patent/CN100444840C/zh not_active Expired - Fee Related
- 2004-05-17 AT AT04752432T patent/ATE437641T1/de not_active IP Right Cessation
- 2004-05-17 ES ES04752432T patent/ES2334029T3/es not_active Expired - Lifetime
- 2004-05-17 JP JP2006533144A patent/JP4971794B2/ja not_active Expired - Lifetime
-
2006
- 2006-08-31 HK HK06109711.3A patent/HK1092358A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2004110354A3 (en) | 2005-02-10 |
EP1628663B1 (de) | 2009-07-29 |
JP4971794B2 (ja) | 2012-07-11 |
ATE437641T1 (de) | 2009-08-15 |
DK1628663T3 (da) | 2010-03-08 |
CA2525970A1 (en) | 2004-12-23 |
CN1809352A (zh) | 2006-07-26 |
DE602004022284D1 (de) | 2009-09-10 |
EP1628663A4 (de) | 2006-05-24 |
WO2004110354A2 (en) | 2004-12-23 |
US20050009885A1 (en) | 2005-01-13 |
JP2007501277A (ja) | 2007-01-25 |
ES2334029T3 (es) | 2010-03-04 |
CN100444840C (zh) | 2008-12-24 |
CA2525970C (en) | 2011-03-22 |
US7732467B2 (en) | 2010-06-08 |
EP1628663A2 (de) | 2006-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200517 |