HK1091500A1 - Process for producing antithrombin iii composition - Google Patents
Process for producing antithrombin iii compositionInfo
- Publication number
- HK1091500A1 HK1091500A1 HK06112176.5A HK06112176A HK1091500A1 HK 1091500 A1 HK1091500 A1 HK 1091500A1 HK 06112176 A HK06112176 A HK 06112176A HK 1091500 A1 HK1091500 A1 HK 1091500A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antithrombin iii
- iii composition
- producing
- sugar chains
- producing antithrombin
- Prior art date
Links
- 102000004411 Antithrombin III Human genes 0.000 title abstract 3
- 108090000935 Antithrombin III Proteins 0.000 title abstract 3
- 229960005348 antithrombin iii Drugs 0.000 title abstract 3
- 229930182474 N-glycoside Natural products 0.000 abstract 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
- 229950006780 n-acetylglucosamine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01068—Glycoprotein 6-alpha-L-fucosyltransferase (2.4.1.68), i.e. FUT8
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
- C12Y501/03018—GDP-mannose 3,5-epimerase (5.1.3.18)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003350164 | 2003-10-09 | ||
| PCT/JP2004/015324 WO2005035563A1 (ja) | 2003-10-09 | 2004-10-08 | アンチトロンビンⅲ組成物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1091500A1 true HK1091500A1 (en) | 2007-01-19 |
Family
ID=34431032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK06112176.5A HK1091500A1 (en) | 2003-10-09 | 2006-11-06 | Process for producing antithrombin iii composition |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1676860B1 (es) |
| JP (1) | JP4263191B2 (es) |
| KR (1) | KR101017336B1 (es) |
| CN (2) | CN1890262B (es) |
| AT (1) | ATE554097T1 (es) |
| AU (1) | AU2004279741B2 (es) |
| CA (1) | CA2542035C (es) |
| ES (1) | ES2383371T3 (es) |
| HK (1) | HK1091500A1 (es) |
| WO (1) | WO2005035563A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007099988A1 (ja) * | 2006-02-28 | 2007-09-07 | Kyowa Hakko Kogyo Co., Ltd. | α-1,6-フコシルトランスフェラーゼ変異体とその用途 |
| KR20140072201A (ko) | 2006-07-05 | 2014-06-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
| CN107630011A (zh) * | 2006-07-05 | 2018-01-26 | 催化剂生物科学公司 | 蛋白酶筛选方法及由此鉴别的蛋白酶 |
| KR101510778B1 (ko) | 2007-07-12 | 2015-04-10 | 상가모 바이오사이언스 인코포레이티드 | 알파 1,6 당전이효소(ｆｕｔ8) 유전자 발현을 비활성화시키기 위한 방법 및 조성물 |
| EP2311864A4 (en) | 2008-08-13 | 2013-07-31 | Kyowa Hakko Kirin Co Ltd | RECOMBINANT PROTEIN-S COMPOSITION |
| EP2727930B1 (en) * | 2011-06-29 | 2019-12-25 | Kyowa Kirin Co., Ltd. | Method for purifying antithrombin |
| US9127274B2 (en) * | 2012-04-26 | 2015-09-08 | Alnylam Pharmaceuticals, Inc. | Serpinc1 iRNA compositions and methods of use thereof |
| CN104884952A (zh) | 2012-12-28 | 2015-09-02 | 生化学工业株式会社 | 付之鲎试验的抗凝血酶iii用的前处理剂及前处理方法 |
| EP3218490B1 (en) * | 2014-11-15 | 2018-10-31 | Zumutor Biologics, Inc. | Dna-binding domain of crispr system for production of non-fucosylated and partially fucosylated proteins |
| EP3278814B1 (en) * | 2015-03-31 | 2021-08-18 | Kyowa Kirin Co., Ltd. | Therapeutic composition containing antithrombin gamma |
| JPWO2020166557A1 (ja) | 2019-02-11 | 2021-12-16 | 協和キリン株式会社 | 妊娠高血圧腎症の治療方法 |
| CN111109248A (zh) * | 2019-12-24 | 2020-05-08 | 武汉博士德生物工程有限公司 | 一种杂交瘤细胞冻存液及96孔板冻存复苏方法 |
| CN115247160B (zh) * | 2022-07-28 | 2024-03-15 | 格进(杭州)生物技术有限责任公司 | 蛋白核心岩藻糖基化修饰的检测方法 |
| CN117567597B (zh) * | 2024-01-17 | 2024-03-22 | 成都艾科斯伦医疗科技有限公司 | 一种抗凝血酶Ⅲ及抗Xa活性检测试剂盒 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843705A (en) | 1995-02-21 | 1998-12-01 | Genzyme Transgenic Corporation | Transgenically produced antithrombin III |
| EP0816503B1 (en) * | 1996-01-24 | 2006-07-05 | Toyo Boseki Kabushiki Kaisha | Alpha-1-6 fucosyltransferases |
| EP1298217A4 (en) * | 2000-07-05 | 2004-09-08 | Mitsubishi Pharma Corp | GLYCOPROTEIN PRODUCTION PROCESS |
| EA013224B1 (ru) * | 2000-10-06 | 2010-04-30 | Киова Хакко Кирин Ко., Лтд. | Клетки, продуцирующие композиции антител |
| WO2003085107A1 (fr) * | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Cellules à génome modifié |
| EP1498490A4 (en) * | 2002-04-09 | 2006-11-29 | Kyowa Hakko Kogyo Kk | PROCESS FOR PREPARING ANTIBODY COMPOSITION |
| JP2005058111A (ja) * | 2003-08-14 | 2005-03-10 | Univ Osaka | 糖鎖修飾制御方法 |
-
2004
- 2004-10-08 JP JP2005514674A patent/JP4263191B2/ja not_active Expired - Lifetime
- 2004-10-08 AT AT04773775T patent/ATE554097T1/de active
- 2004-10-08 CA CA2542035A patent/CA2542035C/en not_active Expired - Lifetime
- 2004-10-08 EP EP04773775A patent/EP1676860B1/en not_active Expired - Lifetime
- 2004-10-08 WO PCT/JP2004/015324 patent/WO2005035563A1/ja active Application Filing
- 2004-10-08 CN CN200480035813.9A patent/CN1890262B/zh not_active Expired - Lifetime
- 2004-10-08 AU AU2004279741A patent/AU2004279741B2/en not_active Expired
- 2004-10-08 CN CN201410016193.XA patent/CN103993056A/zh active Pending
- 2004-10-08 KR KR1020067008648A patent/KR101017336B1/ko active IP Right Grant
- 2004-10-08 ES ES04773775T patent/ES2383371T3/es not_active Expired - Lifetime
-
2006
- 2006-11-06 HK HK06112176.5A patent/HK1091500A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2542035C (en) | 2013-02-26 |
| EP1676860B1 (en) | 2012-04-18 |
| ATE554097T1 (de) | 2012-05-15 |
| AU2004279741A1 (en) | 2005-04-21 |
| CN1890262A (zh) | 2007-01-03 |
| ES2383371T3 (es) | 2012-06-20 |
| KR20060125732A (ko) | 2006-12-06 |
| WO2005035563A1 (ja) | 2005-04-21 |
| KR101017336B1 (ko) | 2011-02-28 |
| ES2383371T9 (es) | 2012-12-14 |
| JP4263191B2 (ja) | 2009-05-13 |
| JPWO2005035563A1 (ja) | 2007-11-22 |
| CN1890262B (zh) | 2015-01-28 |
| EP1676860A4 (en) | 2008-12-31 |
| CA2542035A1 (en) | 2005-04-21 |
| EP1676860A1 (en) | 2006-07-05 |
| AU2004279741B2 (en) | 2010-03-11 |
| CN103993056A (zh) | 2014-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE | Patent expired |
Effective date: 20241007 |