ATE554097T1 - Verfahren zur herstellung von antithrombin-iii- zusammensetzungen - Google Patents

Verfahren zur herstellung von antithrombin-iii- zusammensetzungen

Info

Publication number
ATE554097T1
ATE554097T1 AT04773775T AT04773775T ATE554097T1 AT E554097 T1 ATE554097 T1 AT E554097T1 AT 04773775 T AT04773775 T AT 04773775T AT 04773775 T AT04773775 T AT 04773775T AT E554097 T1 ATE554097 T1 AT E554097T1
Authority
AT
Austria
Prior art keywords
antithrombin iii
producing
iii compositions
sugar chains
producing antithrombin
Prior art date
Application number
AT04773775T
Other languages
English (en)
Inventor
Tsuyoshi Yamada
Mitsuo Satoh
Yutaka Kanda
Kazuya Yamano
Original Assignee
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Application granted granted Critical
Publication of ATE554097T1 publication Critical patent/ATE554097T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01068—Glycoprotein 6-alpha-L-fucosyltransferase (2.4.1.68), i.e. FUT8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03018—GDP-mannose 3,5-epimerase (5.1.3.18)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AT04773775T 2003-10-09 2004-10-08 Verfahren zur herstellung von antithrombin-iii- zusammensetzungen ATE554097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003350164 2003-10-09
PCT/JP2004/015324 WO2005035563A1 (ja) 2003-10-09 2004-10-08 アンチトロンビンⅲ組成物の製造方法

Publications (1)

Publication Number Publication Date
ATE554097T1 true ATE554097T1 (de) 2012-05-15

Family

ID=34431032

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04773775T ATE554097T1 (de) 2003-10-09 2004-10-08 Verfahren zur herstellung von antithrombin-iii- zusammensetzungen

Country Status (10)

Country Link
EP (1) EP1676860B1 (de)
JP (1) JP4263191B2 (de)
KR (1) KR101017336B1 (de)
CN (2) CN103993056A (de)
AT (1) ATE554097T1 (de)
AU (1) AU2004279741B2 (de)
CA (1) CA2542035C (de)
ES (1) ES2383371T3 (de)
HK (1) HK1091500A1 (de)
WO (1) WO2005035563A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099988A1 (ja) * 2006-02-28 2007-09-07 Kyowa Hakko Kogyo Co., Ltd. α-1,6-フコシルトランスフェラーゼ変異体とその用途
KR101778174B1 (ko) 2006-07-05 2017-09-13 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제
CN101517074B (zh) * 2006-07-05 2013-07-03 催化剂生物科学公司 蛋白酶筛选方法及由此鉴别的蛋白酶
KR101510778B1 (ko) † 2007-07-12 2015-04-10 상가모 바이오사이언스 인코포레이티드 알파 1,6 당전이효소(ｆｕｔ8) 유전자 발현을 비활성화시키기 위한 방법 및 조성물
JP5662149B2 (ja) 2008-08-13 2015-01-28 協和発酵キリン株式会社 遺伝子組換えプロテインｓ組成物
JP6151640B2 (ja) * 2011-06-29 2017-06-21 協和発酵キリン株式会社 たん白質の精製方法
US9127274B2 (en) * 2012-04-26 2015-09-08 Alnylam Pharmaceuticals, Inc. Serpinc1 iRNA compositions and methods of use thereof
CN104884952A (zh) 2012-12-28 2015-09-02 生化学工业株式会社 付之鲎试验的抗凝血酶iii用的前处理剂及前处理方法
WO2016075662A2 (en) * 2014-11-15 2016-05-19 Zumutor Biologics, Inc. Dna-binding domain, non-fucosylated and partially fucosylated proteins, and methods thereof
EP3278814B1 (de) * 2015-03-31 2021-08-18 Kyowa Kirin Co., Ltd. Therapeutische zusammensetzung mit antithrombin gamma
JPWO2020166557A1 (ja) 2019-02-11 2021-12-16 協和キリン株式会社 妊娠高血圧腎症の治療方法
CN111109248A (zh) * 2019-12-24 2020-05-08 武汉博士德生物工程有限公司 一种杂交瘤细胞冻存液及96孔板冻存复苏方法
CN115247160B (zh) * 2022-07-28 2024-03-15 格进(杭州)生物技术有限责任公司 蛋白核心岩藻糖基化修饰的检测方法
CN117567597B (zh) * 2024-01-17 2024-03-22 成都艾科斯伦医疗科技有限公司 一种抗凝血酶Ⅲ及抗Xa活性检测试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843705A (en) * 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
DE69736261T2 (de) * 1996-01-24 2007-06-06 Toyo Boseki K.K. Alpha-1-6-fucosyltransferasen
WO2002002793A1 (fr) 2000-07-05 2002-01-10 Japan As Represented By Secretary Of Osaka University Processus de production de glycoproteine
CA2785941C (en) * 2000-10-06 2017-01-10 Kyowa Hakko Kirin Co., Ltd. Antibody composition-producing cell
JPWO2003085107A1 (ja) * 2002-04-09 2005-08-11 協和醗酵工業株式会社 ゲノムが改変された細胞
EP1498490A4 (de) * 2002-04-09 2006-11-29 Kyowa Hakko Kogyo Kk Verfahren zur herstellung einer antikörperzusammensetzung
JP2005058111A (ja) * 2003-08-14 2005-03-10 Univ Osaka 糖鎖修飾制御方法

Also Published As

Publication number Publication date
KR101017336B1 (ko) 2011-02-28
JPWO2005035563A1 (ja) 2007-11-22
WO2005035563A1 (ja) 2005-04-21
ES2383371T9 (es) 2012-12-14
CN1890262A (zh) 2007-01-03
CA2542035A1 (en) 2005-04-21
JP4263191B2 (ja) 2009-05-13
KR20060125732A (ko) 2006-12-06
EP1676860B1 (de) 2012-04-18
EP1676860A4 (de) 2008-12-31
EP1676860A1 (de) 2006-07-05
AU2004279741B2 (en) 2010-03-11
CA2542035C (en) 2013-02-26
ES2383371T3 (es) 2012-06-20
CN1890262B (zh) 2015-01-28
HK1091500A1 (en) 2007-01-19
CN103993056A (zh) 2014-08-20
AU2004279741A1 (en) 2005-04-21

Similar Documents

Publication Publication Date Title
HK1091500A1 (en) Process for producing antithrombin iii composition
ATE448231T1 (de) Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen
ATE506356T1 (de) Verfahren zur herstellung von 3-halo-4,5-dihydro- 1h-pyrazolen
DE60031599D1 (de) Tintenstrahl-Harzzusammensetzung für Farbfilter, Verfahren zur Herstellung von Farbfiltern
ATE435231T1 (de) Verfahren zur herstellung verzweigterribonukleoside aus 1,2- anhydroribofuranose-zwischenprodukten
DE60212699D1 (de) Verfahren zur herstellung eines verbundes
DE60308281D1 (de) Verfahren zur Herstellung von elektrolysiertem Wasser
MY142821A (en) Polyvinylammonium compound, method of manufacturing same, acidic solution containing said compound and method of electrolytically depositing a copper deposit
ATE353904T1 (de) Verfahren zur herstellung von mercaptoorganyl (alkoxysilan)
ATE356136T1 (de) Verfahren zur herstellung von 1,2- diaminocyclohexan-platin(ii)-komplexen
DE502005007702D1 (de) Verfahren zur herstellung von terrylen-3,4:11,12-t
DE502005006527D1 (de) Verfahren zur Herstellung von hoch belastbaren Bauteilen durch Präzisionsschmieden
ATE506351T1 (de) Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
DE60219188D1 (de) Verfahren zur herstellung von olefinen.
DE60123334D1 (de) Methode für die Produktion von Nukleotiden durch Fermentierung
ATE275149T1 (de) Verfahren zur herstellung von taxanderivaten
DE60235820D1 (de) Verfahren zur herstellung von azoverbindungen
DE50306700D1 (de) Verfahren zur herstellung einer tür eines kraftfahrzeugs sowie eine nach diesem verfahren hergestellte tür
DE60207623D1 (de) Verfahren zur Verbesserung der Viskositätsstabilität durch Zusatz einer wässrigen Färbungszusammensetzung
ATE341558T1 (de) Verfahren zur herstellung von topiramate
ATE272038T1 (de) Verfahren zur herstellung von 2-alkyl-3- chlorphenolen
EP1669458A4 (de) Verfahren zur herstellung von 1,4-dihydroxy-2-naphthonsäure
ATE446960T1 (de) Verfahren zur herstellung von ziprasidone
DE50206083D1 (de) Verfahren zur herstellung gratarmer formteile
ATE401299T1 (de) Verfahren für die herstellung von hydroxyethylaminen