UA94914C2 - Способ получения солей тиотропия - Google Patents

Способ получения солей тиотропия

Info

Publication number
UA94914C2
UA94914C2 UAA200802325A UAA200802325A UA94914C2 UA 94914 C2 UA94914 C2 UA 94914C2 UA A200802325 A UAA200802325 A UA A200802325A UA A200802325 A UAA200802325 A UA A200802325A UA 94914 C2 UA94914 C2 UA 94914C2
Authority
UA
Ukraine
Prior art keywords
tiotropium salts
producing tiotropium
producing
salts
formula
Prior art date
Application number
UAA200802325A
Other languages
English (en)
Ukrainian (uk)
Inventor
Йорг Бранденбург
Вальдемар Пфренгле
Original Assignee
Бьорингер Ингельхайм Фарма Гмбх & Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бьорингер Ингельхайм Фарма Гмбх & Ко. Кг filed Critical Бьорингер Ингельхайм Фарма Гмбх & Ко. Кг
Publication of UA94914C2 publication Critical patent/UA94914C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

В заявке описан новый способ получения солей тиотропия общей формулы (1), (1)в которой X- может иметь указанные в формуле изобретения и в описании значения.
UAA200802325A 2005-07-27 2006-07-24 Способ получения солей тиотропия UA94914C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005035112A DE102005035112A1 (de) 2005-07-27 2005-07-27 Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen

Publications (1)

Publication Number Publication Date
UA94914C2 true UA94914C2 (ru) 2011-06-25

Family

ID=37110331

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200802325A UA94914C2 (ru) 2005-07-27 2006-07-24 Способ получения солей тиотропия

Country Status (24)

Country Link
US (5) US20070027320A1 (ru)
EP (2) EP1910354B1 (ru)
JP (1) JP5210861B2 (ru)
KR (1) KR101299929B1 (ru)
CN (2) CN104356129A (ru)
AR (1) AR057690A1 (ru)
AU (1) AU2006274012B2 (ru)
BR (1) BRPI0614062B8 (ru)
CA (1) CA2616222C (ru)
DE (1) DE102005035112A1 (ru)
DK (1) DK1910354T3 (ru)
EA (1) EA014271B1 (ru)
EC (1) ECSP088138A (ru)
ES (1) ES2613952T3 (ru)
HU (1) HUE032259T2 (ru)
IL (1) IL188989A (ru)
MX (1) MX2008001093A (ru)
NO (2) NO340877B1 (ru)
NZ (1) NZ566039A (ru)
PL (1) PL1910354T3 (ru)
TW (3) TWI443097B (ru)
UA (1) UA94914C2 (ru)
WO (1) WO2007012626A2 (ru)
ZA (1) ZA200711113B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
US20110028508A1 (en) * 2008-01-10 2011-02-03 Gemerocs [UK] Limited Novel process for the preparation of scopine esters
CA2931876A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
WO2021133280A1 (en) * 2019-12-27 2021-07-01 Deva Holding An improved process for preparation of scopine hydrobromide

Family Cites Families (18)

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DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US7441045B2 (en) * 1999-12-13 2008-10-21 F5 Networks, Inc. Method and system for balancing load distribution on a wide area network
US6934686B1 (en) 2000-06-30 2005-08-23 I2 Technologies Us, Inc. Warranty transaction system and method
US7574499B1 (en) * 2000-07-19 2009-08-11 Akamai Technologies, Inc. Global traffic management system using IP anycast routing and dynamic load-balancing
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US7237017B1 (en) * 2001-03-13 2007-06-26 Panamsat Corporation Micronode in a satellite based content delivery system
US7340505B2 (en) * 2001-04-02 2008-03-04 Akamai Technologies, Inc. Content storage and replication in a managed internet content storage environment
DE60216588T2 (de) * 2001-05-25 2007-09-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen
EP2403219B1 (en) * 2001-09-28 2014-10-22 Level 3 CDN International, Inc. Method for name to address resolution
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7305429B2 (en) * 2002-06-10 2007-12-04 Utstarcom, Inc. Method and apparatus for global server load balancing
EP1504756A1 (en) * 2003-08-06 2005-02-09 Kyowa Hakko Kogyo Co., Ltd Medicament compositions comprising a heterocyclic compound and an anticholinergic
KR20060117334A (ko) * 2003-11-03 2006-11-16 베링거 인겔하임 인터내셔날 게엠베하 티오트로피움 염의 제조방법, 티오트로피움 염 및 이를함유하는 약제학적 조성물
CA2544357A1 (en) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물

Also Published As

Publication number Publication date
MX2008001093A (es) 2008-03-11
TW201418252A (zh) 2014-05-16
TWI443097B (zh) 2014-07-01
AU2006274012A1 (en) 2007-02-01
BRPI0614062A2 (pt) 2011-03-09
NO20076681L (no) 2008-02-13
BRPI0614062B1 (pt) 2020-11-17
DE102005035112A1 (de) 2007-02-15
EA014271B1 (ru) 2010-10-29
AR057690A1 (es) 2007-12-12
US20100210844A1 (en) 2010-08-19
CN101309920A (zh) 2008-11-19
US20070027320A1 (en) 2007-02-01
IL188989A (en) 2012-10-31
BRPI0614062B8 (pt) 2021-05-25
CN104356129A (zh) 2015-02-18
TWI486345B (zh) 2015-06-01
TWI486346B (zh) 2015-06-01
JP5210861B2 (ja) 2013-06-12
ECSP088138A (es) 2008-02-20
HUE032259T2 (en) 2017-09-28
EP1910354A2 (de) 2008-04-16
US20140323732A1 (en) 2014-10-30
KR101299929B1 (ko) 2013-08-27
NZ566039A (en) 2011-07-29
CA2616222A1 (en) 2007-02-01
EP1910354B1 (de) 2016-11-09
EP3153512A1 (de) 2017-04-12
TW200738704A (en) 2007-10-16
AU2006274012B2 (en) 2011-11-03
ES2613952T3 (es) 2017-05-29
KR20080032634A (ko) 2008-04-15
ZA200711113B (en) 2010-08-25
EA200800324A1 (ru) 2008-08-29
CA2616222C (en) 2014-09-23
TW201418253A (zh) 2014-05-16
NO340877B1 (no) 2017-07-03
IL188989A0 (en) 2008-08-07
US20150225395A1 (en) 2015-08-13
WO2007012626A3 (de) 2010-05-06
NO20170613A1 (no) 2008-02-13
JP2009507769A (ja) 2009-02-26
WO2007012626A2 (de) 2007-02-01
PL1910354T3 (pl) 2017-04-28
DK1910354T3 (en) 2017-02-13
US20130116435A1 (en) 2013-05-09

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