HK1088597A1 - Method for the production of substituted 3-aryl-butyl amine compounds - Google Patents
Method for the production of substituted 3-aryl-butyl amine compoundsInfo
- Publication number
- HK1088597A1 HK1088597A1 HK06110185.8A HK06110185A HK1088597A1 HK 1088597 A1 HK1088597 A1 HK 1088597A1 HK 06110185 A HK06110185 A HK 06110185A HK 1088597 A1 HK1088597 A1 HK 1088597A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- aryl
- substituted
- production
- amine compounds
- butyl amine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/70—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by reduction of unsaturated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/62—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10326097A DE10326097A1 (de) | 2003-06-06 | 2003-06-06 | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
PCT/EP2004/006027 WO2004108658A1 (de) | 2003-06-06 | 2004-06-04 | Verfahren zur herstellung substituierter 3-aryl-butyl-aminverbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1088597A1 true HK1088597A1 (en) | 2006-11-10 |
Family
ID=33494923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06110185.8A HK1088597A1 (en) | 2003-06-06 | 2006-09-14 | Method for the production of substituted 3-aryl-butyl amine compounds |
Country Status (26)
Country | Link |
---|---|
US (1) | US7417170B2 (pt) |
EP (1) | EP1633697B1 (pt) |
JP (1) | JP4848268B2 (pt) |
KR (1) | KR101146205B1 (pt) |
CN (1) | CN1829681B (pt) |
AT (1) | ATE425136T1 (pt) |
AU (1) | AU2004245223C1 (pt) |
BR (1) | BRPI0411268C8 (pt) |
CA (1) | CA2528087C (pt) |
CY (1) | CY1109088T1 (pt) |
DE (2) | DE10326097A1 (pt) |
DK (1) | DK1633697T3 (pt) |
EC (1) | ECSP056218A (pt) |
ES (1) | ES2323870T3 (pt) |
HK (1) | HK1088597A1 (pt) |
HR (1) | HRP20090333T1 (pt) |
IL (1) | IL172357A (pt) |
MX (1) | MXPA05013193A (pt) |
NO (1) | NO335587B1 (pt) |
NZ (1) | NZ544231A (pt) |
PL (1) | PL1633697T3 (pt) |
PT (1) | PT1633697E (pt) |
RU (1) | RU2380355C2 (pt) |
SI (1) | SI1633697T1 (pt) |
WO (1) | WO2004108658A1 (pt) |
ZA (1) | ZA200600109B (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE102005052588A1 (de) * | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
WO2008012283A1 (en) | 2006-07-24 | 2008-01-31 | Janssen Pharmaceutica Nv | Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine |
TWI496762B (zh) * | 2006-07-24 | 2015-08-21 | 製備(1r,2r)-3-(3-二甲胺基-1-乙基-2-甲基-丙基)-酚之方法 | |
TWI401237B (zh) | 2006-07-24 | 2013-07-11 | 3-〔(1r,2r)-3-(二甲基氨基)-1-乙基-2-甲基丙基〕酚之製備 | |
HUE031126T2 (en) * | 2007-12-07 | 2017-07-28 | Gruenenthal Gmbh | Crystalline modifications of (1R, 2R) -3- (3-Dimethylamino-1-ethyl-2-methylpropyl) phenol |
WO2010100477A2 (en) * | 2009-03-03 | 2010-09-10 | Shire Llc | Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof |
CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
IT1397189B1 (it) * | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
WO2011080736A1 (en) | 2009-12-29 | 2011-07-07 | Mapi Pharma Hk Limited | Intermediate compounds and processes for the preparation of tapentadol and related compounds |
WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
CA2790519A1 (en) | 2010-03-05 | 2011-09-09 | Actavis Group Ptc Ehf | Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
WO2011128784A2 (en) | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
WO2011157390A2 (en) * | 2010-06-15 | 2011-12-22 | Grünenthal GmbH | Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds |
IT1401109B1 (it) | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
CA3078668A1 (en) * | 2010-07-23 | 2012-01-26 | Grunenthal Gmbh | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
EP2606030B1 (en) | 2010-08-16 | 2016-05-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
US8552219B2 (en) | 2010-09-20 | 2013-10-08 | Ind-Swift Laboratories Limited | Process for preparing L-phenyl-3-dimethylaminopropane derivative |
CN102477016B (zh) * | 2010-11-26 | 2014-12-17 | 中国医学科学院药物研究所 | 他喷他多的中间体的合成与应用 |
CZ302992B6 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
HUP1300623A2 (en) * | 2010-12-30 | 2014-03-28 | Zentiva Ks | O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same |
CZ302993B6 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
US8853393B2 (en) | 2011-07-29 | 2014-10-07 | Anhui New Star Pharmaceutical Development Co., Ltd. | Intermediate for preparing tapentadol or analogues thereof |
WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
WO2013090161A1 (en) | 2011-12-12 | 2013-06-20 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
EP2674414A1 (en) | 2012-06-15 | 2013-12-18 | Siegfried AG | Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds |
CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
WO2015075678A1 (en) | 2013-11-21 | 2015-05-28 | Unimark Remedies Ltd. | A novel process for the preparation of 1-phenyl-3-aminopropane derivatives |
SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
DK3319941T3 (da) | 2015-07-10 | 2022-03-14 | SpecGx LLC | Totrinsfremgangsmåde til fremstilling af 3-substituerede phenylalkylaminer |
EP4269384A1 (en) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | Method for crystallizing tapentadol intermediate, tapentadol intermediate of high purity, method of making tapentadol and tapentadol of high purity |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3978129A (en) * | 1972-01-28 | 1976-08-31 | A. H. Robins Company, Incorporated | Alkenyl- and alkanylamines |
DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19609847A1 (de) | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
DE19857475A1 (de) * | 1998-12-14 | 2000-06-15 | Gruenenthal Gmbh | Substituierte Cycloheptene, deren Herstellung und Verwendung |
DE19933421A1 (de) | 1999-07-16 | 2001-01-25 | Gruenenthal Gmbh | 2-Benzyl-3-dimethylamino-1-phenyl-propanderi- vate |
DE10000311A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
-
2003
- 2003-06-06 DE DE10326097A patent/DE10326097A1/de not_active Withdrawn
-
2004
- 2004-06-04 PL PL04739583T patent/PL1633697T3/pl unknown
- 2004-06-04 ES ES04739583T patent/ES2323870T3/es not_active Expired - Lifetime
- 2004-06-04 DK DK04739583T patent/DK1633697T3/da active
- 2004-06-04 PT PT04739583T patent/PT1633697E/pt unknown
- 2004-06-04 WO PCT/EP2004/006027 patent/WO2004108658A1/de active Application Filing
- 2004-06-04 BR BRPI0411268A patent/BRPI0411268C8/pt active IP Right Grant
- 2004-06-04 AT AT04739583T patent/ATE425136T1/de active
- 2004-06-04 SI SI200431114T patent/SI1633697T1/sl unknown
- 2004-06-04 EP EP04739583A patent/EP1633697B1/de not_active Expired - Lifetime
- 2004-06-04 JP JP2006508271A patent/JP4848268B2/ja not_active Expired - Lifetime
- 2004-06-04 MX MXPA05013193A patent/MXPA05013193A/es active IP Right Grant
- 2004-06-04 CA CA2528087A patent/CA2528087C/en not_active Expired - Lifetime
- 2004-06-04 RU RU2005141518/04A patent/RU2380355C2/ru active
- 2004-06-04 AU AU2004245223A patent/AU2004245223C1/en not_active Expired
- 2004-06-04 CN CN2004800218627A patent/CN1829681B/zh not_active Expired - Lifetime
- 2004-06-04 KR KR1020057023464A patent/KR101146205B1/ko active IP Right Grant
- 2004-06-04 NZ NZ544231A patent/NZ544231A/en unknown
- 2004-06-04 DE DE502004009142T patent/DE502004009142D1/de not_active Expired - Lifetime
-
2005
- 2005-12-05 IL IL172357A patent/IL172357A/en not_active IP Right Cessation
- 2005-12-06 US US11/294,449 patent/US7417170B2/en not_active Expired - Lifetime
- 2005-12-13 EC EC2005006218A patent/ECSP056218A/es unknown
-
2006
- 2006-01-04 NO NO20060044A patent/NO335587B1/no unknown
- 2006-01-05 ZA ZA200600109A patent/ZA200600109B/en unknown
- 2006-09-14 HK HK06110185.8A patent/HK1088597A1/xx not_active IP Right Cessation
-
2009
- 2009-05-21 CY CY20091100536T patent/CY1109088T1/el unknown
- 2009-06-08 HR HR20090333T patent/HRP20090333T1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL172357A0 (en) | Method for the production of substituted 3-aryl-butyl amine compounds | |
TW200617019A (en) | A process for the preparation of 7α-alkylated 19-norsteroids | |
EA200800549A1 (ru) | Региоселективный способ получения бензимидазолтиофенов | |
RS20060250A (en) | 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, method for the production thereof, and their use as antiphlogistics | |
IL175148A0 (en) | Method for the production of fluoromethyl-substituted heterocycles | |
TW200619206A (en) | Chemokine-binding heterocyclic compound salts, and methods of use thereof | |
TW200619205A (en) | A method for preparing irbesartan and intermediates thereof | |
NO20056238L (no) | Forbedrede mater for fremstilling av Alfa-Polymorfisk Eletriptanhydrobromid | |
TW200612959A (en) | Method for preparing hydroxamic acids | |
YU61103A (sh) | Postupci za produkciju supstituisanih 2-(2-piridilmetil) sulfinil-1h-benzimidazola | |
SG144914A1 (en) | A method for the preparation of enantiomerically pure mirtazapine | |
TW200510323A (en) | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives | |
GB0312966D0 (en) | Process for the production of olefins | |
EP1615897A4 (en) | PYRIMIDINONE COMPOUNDS AS CALCILYTICA | |
FR2854402A1 (fr) | Nouveau procede et intermediaires de preparation de composes 19-nor-steroides | |
AU2002358557A1 (en) | Improved method for the production of biphosphites | |
ITRM20010309A1 (it) | Procedimento per la produzione di composti perfluoro-organici mediante florurazione elettrochimica. | |
AU2003267541A1 (en) | Method for the production of substituted trifluoroethylenes | |
MXPA05011169A (es) | Metodo para sintetizar derivados de 5-cloro-1-aril-4 -(4, 5-diciano- 1h-imidazol-2-il)- 3-alquil -1h-pirazola. | |
MXPA03005400A (es) | Metodo para preparacion de 11 (12)-pentadecen-15-olidos. | |
RS51033B (sr) | Postupak i intermedijati za dobijanje olanzapina | |
AU2003245879A1 (en) | Method for the production of substituted trifluoroetylenes | |
TW200407314A (en) | Preparation of 4, 6-dichloro-5-fluoropyrimidine | |
EA200970406A1 (ru) | СПОСОБ ПОЛУЧЕНИЯ 5-АЛКИЛ-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-2-ОЛОВ | |
WO2005012260A3 (en) | Synthetic method for the preparation of quinazolin-4-one derivative |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20240531 |