HK1083351A1 - Site specific incorporation of keto amino acids into proteins - Google Patents

Site specific incorporation of keto amino acids into proteins

Info

Publication number
HK1083351A1
HK1083351A1 HK06103216.6A HK06103216A HK1083351A1 HK 1083351 A1 HK1083351 A1 HK 1083351A1 HK 06103216 A HK06103216 A HK 06103216A HK 1083351 A1 HK1083351 A1 HK 1083351A1
Authority
HK
Hong Kong
Prior art keywords
amino acids
proteins
keto amino
site specific
orthogonal
Prior art date
Application number
HK06103216.6A
Other languages
English (en)
Inventor
Peter G Schultz
Lei Wang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of HK1083351A1 publication Critical patent/HK1083351A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK06103216.6A 2002-10-16 2006-03-13 Site specific incorporation of keto amino acids into proteins HK1083351A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41926502P 2002-10-16 2002-10-16
US42099002P 2002-10-23 2002-10-23
PCT/US2003/032576 WO2004035743A2 (fr) 2002-10-16 2003-10-15 Incorporation dirigee d'aminoacides-cetones dans des proteines

Publications (1)

Publication Number Publication Date
HK1083351A1 true HK1083351A1 (en) 2006-06-30

Family

ID=32110229

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06103216.6A HK1083351A1 (en) 2002-10-16 2006-03-13 Site specific incorporation of keto amino acids into proteins

Country Status (17)

Country Link
US (5) US7432092B2 (fr)
EP (2) EP2062976B1 (fr)
JP (1) JP4444113B2 (fr)
KR (1) KR20050072441A (fr)
AT (2) ATE429500T1 (fr)
AU (2) AU2003277373B2 (fr)
CA (1) CA2502029C (fr)
CY (1) CY1110483T1 (fr)
DE (1) DE60327369D1 (fr)
DK (1) DK1578949T3 (fr)
ES (1) ES2324608T3 (fr)
HK (1) HK1083351A1 (fr)
IL (3) IL167715A (fr)
MX (1) MXPA05003983A (fr)
PT (1) PT1578949E (fr)
SI (1) SI1578949T1 (fr)
WO (1) WO2004035743A2 (fr)

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WO2005007624A2 (fr) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions de paires orthogonales de glutamyl-arnt et d'aminoacyl-arnt synthetases et leurs utilisations
CA2541166A1 (fr) 2003-10-14 2005-04-28 The Scripps Research Institute Integration specifique a un site d'acides amines actifs pour une oxydoreduction, dans des proteines
US8778880B2 (en) 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
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NZ551335A (en) 2004-06-18 2010-03-26 Ambrx Inc Antibodies and fragments thereof comprising an non naturally encoded amino acid coupled to a linker
BRPI0512396A (pt) * 2004-07-21 2008-03-11 Ambrx Inc polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente
BRPI0515547A (pt) 2004-09-21 2008-07-29 Scripps Research Inst incorporação in vivo de aminoácidos alquinil em proteìnas em eubacterias
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
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CA2624290A1 (fr) * 2005-10-12 2007-04-26 Scripps Research Institute Modification selective post-traduction de polypeptides exprimes a la surface des phages
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WO2007092475A2 (fr) * 2006-02-06 2007-08-16 Franklin And Marshall College Incorporation spécifique de site d'acides aminés fluorés dans des protéines
JP5589186B2 (ja) * 2006-03-09 2014-09-17 ザ スクリプス リサーチ インスティテュート 真正細菌宿主細胞における直交翻訳成分の発現システム
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US8420792B2 (en) 2006-09-08 2013-04-16 Ambrx, Inc. Suppressor tRNA transcription in vertebrate cells
EP2069396B1 (fr) 2006-09-08 2015-10-21 Ambrx, Inc. Polypeptide plasmatique humain modifie ou squelettes de fc et leurs utilisations
PT2061878E (pt) * 2006-09-08 2014-04-22 Ambrx Inc Supressor híbrido arnt para células de vertebrados
CA2663052A1 (fr) * 2006-09-21 2008-03-27 The Scripps Research Institute Expression genetiquement programmee de proteines sulfatees selectivement dans des eubacteries
US20100055725A1 (en) * 2006-10-17 2010-03-04 Zymera, Inc. System for assays of aminotransferase
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AU2008232937B2 (en) 2007-03-30 2012-09-27 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
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Also Published As

Publication number Publication date
WO2004035743A2 (fr) 2004-04-29
JP2006507814A (ja) 2006-03-09
EP1578949A4 (fr) 2006-12-20
WO2004035743A8 (fr) 2005-06-09
DE60327369D1 (de) 2009-06-04
US20110318806A1 (en) 2011-12-29
DK1578949T3 (da) 2009-07-27
US20090215117A1 (en) 2009-08-27
US20060068478A1 (en) 2006-03-30
CY1110483T1 (el) 2015-04-29
WO2004035743A3 (fr) 2005-11-10
US7524647B2 (en) 2009-04-28
KR20050072441A (ko) 2005-07-11
US20080227153A1 (en) 2008-09-18
US20080176284A1 (en) 2008-07-24
IL201208A (en) 2011-02-28
CA2502029C (fr) 2014-06-10
AU2009203098B2 (en) 2011-09-08
CA2502029A1 (fr) 2004-04-29
AU2003277373B2 (en) 2009-05-07
EP2062976A3 (fr) 2010-04-07
ES2324608T3 (es) 2009-08-11
US7432092B2 (en) 2008-10-07
AU2003277373A1 (en) 2004-05-04
US8114629B2 (en) 2012-02-14
SI1578949T1 (sl) 2009-08-31
MXPA05003983A (es) 2005-06-22
EP1578949A2 (fr) 2005-09-28
AU2009203098A1 (en) 2009-08-20
US8071344B2 (en) 2011-12-06
PT1578949E (pt) 2009-07-14
ATE526414T1 (de) 2011-10-15
US7910345B2 (en) 2011-03-22
IL167715A (en) 2010-11-30
EP2062976B1 (fr) 2011-09-28
EP1578949B1 (fr) 2009-04-22
IL210359A0 (en) 2011-03-31
ATE429500T1 (de) 2009-05-15
EP2062976A2 (fr) 2009-05-27
JP4444113B2 (ja) 2010-03-31

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