HK1069382A1 - A process for preparing a phenylalanine derivative and intermediates thereof - Google Patents

A process for preparing a phenylalanine derivative and intermediates thereof

Info

Publication number
HK1069382A1
HK1069382A1 HK05102898.4A HK05102898A HK1069382A1 HK 1069382 A1 HK1069382 A1 HK 1069382A1 HK 05102898 A HK05102898 A HK 05102898A HK 1069382 A1 HK1069382 A1 HK 1069382A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
preparing
phenylalanine derivative
phenylalanine
derivative
Prior art date
Application number
HK05102898.4A
Other languages
English (en)
Inventor
Isao Inoue
Toru Kuroda
Ryuzo Yoshioka
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of HK1069382A1 publication Critical patent/HK1069382A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK05102898.4A 2002-02-28 2005-04-07 A process for preparing a phenylalanine derivative and intermediates thereof HK1069382A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002052605 2002-02-28
PCT/JP2003/002181 WO2003072536A1 (en) 2002-02-28 2003-02-27 A process for preparing a phenylalanine derivative and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1069382A1 true HK1069382A1 (en) 2005-05-20

Family

ID=27764341

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05102898.4A HK1069382A1 (en) 2002-02-28 2005-04-07 A process for preparing a phenylalanine derivative and intermediates thereof

Country Status (22)

Country Link
US (1) US7476758B2 (de)
EP (1) EP1478619B1 (de)
KR (1) KR100681224B1 (de)
CN (2) CN100522930C (de)
AR (1) AR038624A1 (de)
AT (1) ATE495147T1 (de)
AU (1) AU2003208618B2 (de)
BR (1) BR0308027A (de)
CA (1) CA2476022C (de)
DE (1) DE60335704D1 (de)
ES (1) ES2359302T3 (de)
HK (1) HK1069382A1 (de)
IL (1) IL163429A (de)
MX (1) MXPA04008359A (de)
MY (1) MY140707A (de)
NO (1) NO331001B1 (de)
NZ (1) NZ534957A (de)
PL (1) PL211046B1 (de)
RU (1) RU2280641C2 (de)
TW (1) TWI327996B (de)
WO (1) WO2003072536A1 (de)
ZA (1) ZA200406747B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
EP1389618B1 (de) 2001-04-27 2011-06-15 Eisai R&D Management Co., Ltd. Pyrazolo 1,5-a pyridine und diese enthaltende arzneimittel
US7122580B2 (en) * 2002-08-09 2006-10-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
ATE426600T1 (de) 2002-10-22 2009-04-15 Eisai R&D Man Co Ltd 7-phenylpyrazolopyridinverbindungen
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
US7459472B2 (en) * 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
AR054129A1 (es) 2005-06-09 2007-06-06 Uc S A Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7
MY152687A (en) 2008-04-15 2014-10-31 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
WO2011048091A1 (en) * 2009-10-21 2011-04-28 Glaxo Group Limited Process for preparing a phenylalanine derivative
CA3115830C (en) 2018-10-30 2023-09-12 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
PE20211866A1 (es) 2018-10-30 2021-09-21 Gilead Sciences Inc Derivados de quinolina como inhibidores de la integrina alfa4beta7
AU2019373244B2 (en) 2018-10-30 2022-05-26 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
KR102652797B1 (ko) 2018-10-30 2024-04-02 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린의 억제를 위한 화합물
JP7491996B2 (ja) 2019-08-14 2024-05-28 ギリアード サイエンシーズ， インコーポレイテッド α４β７インテグリンの阻害のための化合物

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508251A1 (de) 1985-03-08 1986-09-11 Merck Patent Gmbh, 6100 Darmstadt Dipeptide
GB8625941D0 (en) 1986-10-30 1986-12-03 Sandoz Ltd Substituted alpha-amino acids
NZ228855A (en) 1988-04-25 1992-08-26 Hoffmann La Roche Tyrosine analogues and peptides containing them especially cholecystokinin (cck) analogues
JP2868914B2 (ja) 1991-03-04 1999-03-10 日本ケミファ株式会社 α−アミノ酸誘導体
US5294632A (en) 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5455260A (en) 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
RU2126418C1 (ru) 1993-11-01 1999-02-20 Циба-Гейги Джапан Димитед Антагонисты рецепторов эндотелина
US5432186A (en) 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
IL112759A0 (en) 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
US5703106A (en) 1994-03-28 1997-12-30 Japat Ltd. Antagonists of endothelin receptors
US5505244A (en) * 1994-08-08 1996-04-09 Thumann; Pierce A. Retractable covering for a door opening
DE69528197T2 (de) 1994-12-14 2003-06-05 Santen Pharmaceutical Co Ltd Neue 1,3-dialkylharnstoff-derivate
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
WO1996033170A1 (en) 1995-04-21 1996-10-24 Novarits Ag N-aroylamino acid amides as endothelin inhibitors
GB9518553D0 (en) 1995-09-11 1995-11-08 Fujisawa Pharmaceutical Co New urea derivatives processes for the preparation thereof and pharmaceutical composition comprising the same
JPH0987291A (ja) 1995-09-26 1997-03-31 Wakamoto Pharmaceut Co Ltd 新規なアラニン誘導体
WO1997011960A1 (en) 1995-09-28 1997-04-03 Japat Ltd. Antagonists of endothelin receptors
IT1277737B1 (it) 1995-12-28 1997-11-12 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
US5849293A (en) * 1996-01-11 1998-12-15 Cornell Research Foundation, Inc. Use of human transferrin in controlling insulin levels
FR2745571B1 (fr) 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
AU706855B2 (en) 1996-04-24 1999-06-24 Medivir Uk Ltd Substrates and inhibitors of proteolytic enzymes
JPH1036587A (ja) * 1996-07-24 1998-02-10 Chisso Corp 二軸延伸ポリプロピレンフィルム
SE9700934D0 (sv) * 1997-03-14 1997-03-14 Astra Ab New formulation
US6291511B1 (en) 1997-05-29 2001-09-18 Merck & Co., Inc. Biarylalkanoic acids as cell adhesion inhibitors
EP1001764A4 (de) 1997-05-29 2005-08-24 Merck & Co Inc Heterozyklische amide als zelladhäsionshemmern
US6221888B1 (en) 1997-05-29 2001-04-24 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
WO1998054207A1 (en) 1997-05-30 1998-12-03 Celltech Therapeutics Limited Anti-inflammatory tyrosine derivatives
US6127341A (en) 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU8163398A (en) 1997-06-23 1999-01-04 Pharmacia & Upjohn Company Inhibitors of alpha4beta1mediated cell adhesion
BR9812111A (pt) 1997-07-31 2000-07-18 Elan Pharm Inc Dipeptìdeo e compostos correlatos que inibem adesão de leucócito mediada por vla-4
ATE327245T1 (de) 1997-07-31 2006-06-15 Elan Pharm Inc Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren
ZA986827B (en) 1997-07-31 2000-05-02 Athena Neurosciences Inc Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.
PL338506A1 (en) 1997-07-31 2000-11-06 Elan Pharm Inc Compounds inhibiting adhesion of leucocytes occuring through the mediation of vla-4
AR016133A1 (es) 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
CN1265673A (zh) 1997-07-31 2000-09-06 伊兰药品公司 抑制由vla－4介导的白细胞粘着的二肽化合物
EP1001975A1 (de) 1997-07-31 2000-05-24 Elan Pharmaceuticals, Inc. Benzylverbindungen, die die vla-4 vermittelte adhäsion von leukozyten inhibieren
US6229011B1 (en) 1997-08-22 2001-05-08 Hoffman-La Roche Inc. N-aroylphenylalanine derivative VCAM-1 inhibitors
US6455550B1 (en) 1997-08-22 2002-09-24 Hoffmann-La Roche Inc. N-alkanoylphenylalanine derivatives
US5988980A (en) * 1997-09-08 1999-11-23 General Electric Company Blade assembly with splitter shroud
US6069163A (en) 1997-10-21 2000-05-30 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
US6191171B1 (en) 1997-11-20 2001-02-20 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
US6090841A (en) 1997-11-21 2000-07-18 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
WO1999026615A1 (en) 1997-11-24 1999-06-03 Merck & Co., Inc. Cyclic amino acid derivatives as cell adhesion inhibitors
US6197794B1 (en) 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
AU1890399A (en) 1998-01-19 1999-08-02 Takara Shuzo Co., Ltd. Substances capable of inducing apoptosis
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
DE69919334T2 (de) 1998-02-26 2005-08-04 Celltech Therapeutics Ltd., Slough Phenylalaninderivate als inhibitoren von alpha4 integrinen
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
AU8059598A (en) 1998-06-11 1999-12-30 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
US6685617B1 (en) 1998-06-23 2004-02-03 Pharmacia & Upjohn Company Inhibitors of α4β1 mediated cell adhesion
NL1009753C2 (nl) 1998-07-28 2000-02-01 Royalty Bugaboo S A R L Buggy.
DE69915692T2 (de) 1998-12-22 2005-02-10 Tanabe Seiyaku Co., Ltd. Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion
WO2000043369A1 (en) 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by vla-4
GB2354440A (en) 1999-07-20 2001-03-28 Merck & Co Inc Aryl amides as cell adhesion inhibitors
US6420418B1 (en) 1999-08-16 2002-07-16 Merck & Co., Inc. Heterocycle amides as cell adhesion inhibitors
WO2001014328A2 (en) 1999-08-20 2001-03-01 Merck & Co., Inc. Substituted ureas as cell adhesion inhibitors
IL148544A0 (en) 1999-09-24 2002-09-12 Genentech Inc Tyrosine derivatives
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
US6489511B1 (en) * 2001-08-16 2002-12-03 Eastman Kodak Company Azomethine compound manufacture

Also Published As

Publication number Publication date
ATE495147T1 (de) 2011-01-15
EP1478619A1 (de) 2004-11-24
KR20040091665A (ko) 2004-10-28
CA2476022C (en) 2008-07-15
MY140707A (en) 2010-01-15
NO20044087L (no) 2004-09-27
BR0308027A (pt) 2004-12-28
TW200303854A (en) 2003-09-16
ZA200406747B (en) 2005-08-31
US20050165107A1 (en) 2005-07-28
CN100522930C (zh) 2009-08-05
CN100480233C (zh) 2009-04-22
AR038624A1 (es) 2005-01-19
RU2280641C2 (ru) 2006-07-27
AU2003208618A1 (en) 2003-09-09
CN1817853A (zh) 2006-08-16
WO2003072536A1 (en) 2003-09-04
US7476758B2 (en) 2009-01-13
DE60335704D1 (de) 2011-02-24
PL371386A1 (en) 2005-06-13
MXPA04008359A (es) 2004-11-26
AU2003208618B2 (en) 2008-06-19
PL211046B1 (pl) 2012-04-30
IL163429A (en) 2012-07-31
EP1478619B1 (de) 2011-01-12
ES2359302T3 (es) 2011-05-20
TWI327996B (en) 2010-08-01
RU2004128935A (ru) 2006-02-20
CN1646482A (zh) 2005-07-27
CA2476022A1 (en) 2003-09-04
NZ534957A (en) 2006-11-30
NO331001B1 (no) 2011-09-05
KR100681224B1 (ko) 2007-02-09

Similar Documents

Publication Publication Date Title
HK1069382A1 (en) A process for preparing a phenylalanine derivative and intermediates thereof
IL195011A0 (en) Process for preparing piperidine derivatives
AU2003235256A1 (en) Phenylalanine derivative
HK1188993A1 (en) Method for preparing a 2-halo-4-nitroimidazole compound 2--4-
GB0228279D0 (en) A synchronization method
EP1471045A4 (de) Verfahren zur herstellung von fluorenderivaten
AU2003261774A1 (en) PROCESS FOR PRODUCING L-Alpha-METHYLCYSTEINE DERIVATIVE
AU2003253188A8 (en) Novel processes and intermediates for preparing triazolo-pyridines
AU2003283870A1 (en) Process for preparing a composition
AU2003273700A1 (en) Trap-tagging: a novel method for the identification and purification of rna-protein complexes
GB2391814B (en) Stereotactic frame and method for supporting a stereotactic frame
EP1633694A4 (de) Substituierte indole und verfahren zur herstellung substituierter indole
ZA200500422B (en) Process for the preparation of phenylalanine enamide derivatives
AU2003218704A8 (en) Process for preparing 2-aminoindan derivatives
AU2003274518A8 (en) A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
AU2003226138A1 (en) Process for preparing phenylorganosilicon intermediates
HUP0201980A3 (en) Process for preparing a benzamide derivative and intermediates thereof
ZA200501601B (en) Process for producing indolopyrrolocarbazole derivative
IL166514A0 (en) A process for preparing hydroxyazapirone derivatives
AU2003214495A8 (en) Process for transferring a decorative cosmetic product on a basic cosmetic product
IL166087A0 (en) Process for preparing nateglinide and intermediates thereof
GB2386820B (en) A meat forming process
AU2003227616A1 (en) Method for securing a program
AU2003210296A8 (en) Process for the preparation of 4-hetero-substituted phenylalanine derivatives
AU2003255148A1 (en) Process for producing 2-alkyl-3-aminothiophene derivative

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150227