IL166087A0 - Process for preparing nateglinide and intermediates thereof - Google Patents

Process for preparing nateglinide and intermediates thereof

Info

Publication number
IL166087A0
IL166087A0 IL16608705A IL16608705A IL166087A0 IL 166087 A0 IL166087 A0 IL 166087A0 IL 16608705 A IL16608705 A IL 16608705A IL 16608705 A IL16608705 A IL 16608705A IL 166087 A0 IL166087 A0 IL 166087A0
Authority
IL
Israel
Prior art keywords
intermediates
preparing nateglinide
nateglinide
preparing
Prior art date
Application number
IL16608705A
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of IL166087A0 publication Critical patent/IL166087A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL16608705A 2002-07-03 2005-01-02 Process for preparing nateglinide and intermediates thereof IL166087A0 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US39349502P 2002-07-03 2002-07-03
US39690402P 2002-07-18 2002-07-18
US41362202P 2002-09-25 2002-09-25
US41419902P 2002-09-26 2002-09-26
US42375002P 2002-11-05 2002-11-05
US43209302P 2002-12-10 2002-12-10
US43296202P 2002-12-12 2002-12-12
US44210903P 2003-01-23 2003-01-23
US44979103P 2003-02-24 2003-02-24
US47901603P 2003-06-16 2003-06-16
PCT/US2003/021238 WO2004005240A1 (en) 2002-07-03 2003-07-03 Process for preparing nateglinide and intermediates thereof

Publications (1)

Publication Number Publication Date
IL166087A0 true IL166087A0 (en) 2006-01-15

Family

ID=30119568

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16608705A IL166087A0 (en) 2002-07-03 2005-01-02 Process for preparing nateglinide and intermediates thereof

Country Status (5)

Country Link
EP (1) EP1487782A1 (en)
CN (1) CN100384813C (en)
AU (1) AU2003256454A1 (en)
IL (1) IL166087A0 (en)
WO (1) WO2004005240A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0413084D0 (en) 2004-06-11 2004-07-14 Cipla Ltd Process
EP2003113A4 (en) * 2006-03-31 2012-07-18 Ajinomoto Kk Process for production of carboxylic acid chloride compound
CN107505410B (en) * 2017-08-15 2020-05-08 江苏德源药业股份有限公司 Method for resolving nateglinide and stereoisomer thereof by high performance liquid chromatography

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (en) * 1985-03-27 1988-03-08 Ajinomoto Co Inc Blood sugar lowering agent
DE10199058I2 (en) * 1991-07-30 2006-04-27 Alcm Co Crystals of N- (trans-4-isopropylcyclohexylcarbonyl) -D-phenylalanine and process for their preparation
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
DE19943844A1 (en) * 1999-09-13 2001-03-15 Basf Ag Process for the production of carboxylic acid chlorides
PT1334963E (en) * 2000-10-18 2007-09-20 Ajinomoto Kk Process for producing nateglinide crystal

Also Published As

Publication number Publication date
AU2003256454A1 (en) 2004-01-23
EP1487782A1 (en) 2004-12-22
CN1671649A (en) 2005-09-21
CN100384813C (en) 2008-04-30
WO2004005240A1 (en) 2004-01-15

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