DE60335704D1 - Ein verfahren zur herstellung eines phenylalaninderivats und zwischenprodukte davon - Google Patents
Ein verfahren zur herstellung eines phenylalaninderivats und zwischenprodukte davonInfo
- Publication number
- DE60335704D1 DE60335704D1 DE60335704T DE60335704T DE60335704D1 DE 60335704 D1 DE60335704 D1 DE 60335704D1 DE 60335704 T DE60335704 T DE 60335704T DE 60335704 T DE60335704 T DE 60335704T DE 60335704 D1 DE60335704 D1 DE 60335704D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- intermediate products
- phenyl alanine
- alanine derivative
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 150000002993 phenylalanine derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002052605 | 2002-02-28 | ||
PCT/JP2003/002181 WO2003072536A1 (en) | 2002-02-28 | 2003-02-27 | A process for preparing a phenylalanine derivative and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60335704D1 true DE60335704D1 (de) | 2011-02-24 |
Family
ID=27764341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60335704T Expired - Lifetime DE60335704D1 (de) | 2002-02-28 | 2003-02-27 | Ein verfahren zur herstellung eines phenylalaninderivats und zwischenprodukte davon |
Country Status (22)
Country | Link |
---|---|
US (1) | US7476758B2 (de) |
EP (1) | EP1478619B1 (de) |
KR (1) | KR100681224B1 (de) |
CN (2) | CN100522930C (de) |
AR (1) | AR038624A1 (de) |
AT (1) | ATE495147T1 (de) |
AU (1) | AU2003208618B2 (de) |
BR (1) | BR0308027A (de) |
CA (1) | CA2476022C (de) |
DE (1) | DE60335704D1 (de) |
ES (1) | ES2359302T3 (de) |
HK (1) | HK1069382A1 (de) |
IL (1) | IL163429A (de) |
MX (1) | MXPA04008359A (de) |
MY (1) | MY140707A (de) |
NO (1) | NO331001B1 (de) |
NZ (1) | NZ534957A (de) |
PL (1) | PL211046B1 (de) |
RU (1) | RU2280641C2 (de) |
TW (1) | TWI327996B (de) |
WO (1) | WO2003072536A1 (de) |
ZA (1) | ZA200406747B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
EP1389618B1 (de) | 2001-04-27 | 2011-06-15 | Eisai R&D Management Co., Ltd. | Pyrazolo 1,5-a pyridine und diese enthaltende arzneimittel |
US7122580B2 (en) * | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
ATE426600T1 (de) | 2002-10-22 | 2009-04-15 | Eisai R&D Man Co Ltd | 7-phenylpyrazolopyridinverbindungen |
US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
US7459472B2 (en) * | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
AR054129A1 (es) | 2005-06-09 | 2007-06-06 | Uc S A | Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7 |
MY152687A (en) | 2008-04-15 | 2014-10-31 | Eisai R&D Man Co Ltd | 3-phenylpyrazolo[5,1-b]thiazole compound |
AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
WO2011048091A1 (en) * | 2009-10-21 | 2011-04-28 | Glaxo Group Limited | Process for preparing a phenylalanine derivative |
CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
PE20211866A1 (es) | 2018-10-30 | 2021-09-21 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
AU2019373244B2 (en) | 2018-10-30 | 2022-05-26 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
KR102652797B1 (ko) | 2018-10-30 | 2024-04-02 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린의 억제를 위한 화합물 |
JP7491996B2 (ja) | 2019-08-14 | 2024-05-28 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリンの阻害のための化合物 |
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RU2126418C1 (ru) | 1993-11-01 | 1999-02-20 | Циба-Гейги Джапан Димитед | Антагонисты рецепторов эндотелина |
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EP1001764A4 (de) | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterozyklische amide als zelladhäsionshemmern |
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AU8163398A (en) | 1997-06-23 | 1999-01-04 | Pharmacia & Upjohn Company | Inhibitors of alpha4beta1mediated cell adhesion |
BR9812111A (pt) | 1997-07-31 | 2000-07-18 | Elan Pharm Inc | Dipeptìdeo e compostos correlatos que inibem adesão de leucócito mediada por vla-4 |
ATE327245T1 (de) | 1997-07-31 | 2006-06-15 | Elan Pharm Inc | Verbindungen mit einer 4-amino-phenylalaningruppe,die die vla-4 vermittelte adhäsion von leukozyten inhibieren |
ZA986827B (en) | 1997-07-31 | 2000-05-02 | Athena Neurosciences Inc | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. |
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CN1265673A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 抑制由vla-4介导的白细胞粘着的二肽化合物 |
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-
2003
- 2003-02-21 MY MYPI20030607A patent/MY140707A/en unknown
- 2003-02-25 TW TW092103857A patent/TWI327996B/zh not_active IP Right Cessation
- 2003-02-27 US US10/505,723 patent/US7476758B2/en not_active Expired - Fee Related
- 2003-02-27 BR BR0308027-7A patent/BR0308027A/pt not_active IP Right Cessation
- 2003-02-27 WO PCT/JP2003/002181 patent/WO2003072536A1/en active Application Filing
- 2003-02-27 MX MXPA04008359A patent/MXPA04008359A/es active IP Right Grant
- 2003-02-27 CN CNB038089904A patent/CN100522930C/zh not_active Expired - Fee Related
- 2003-02-27 DE DE60335704T patent/DE60335704D1/de not_active Expired - Lifetime
- 2003-02-27 KR KR1020047013246A patent/KR100681224B1/ko not_active IP Right Cessation
- 2003-02-27 CN CNB200610003782XA patent/CN100480233C/zh not_active Expired - Fee Related
- 2003-02-27 NZ NZ534957A patent/NZ534957A/en not_active IP Right Cessation
- 2003-02-27 EP EP03707122A patent/EP1478619B1/de not_active Expired - Lifetime
- 2003-02-27 AU AU2003208618A patent/AU2003208618B2/en not_active Ceased
- 2003-02-27 PL PL371386A patent/PL211046B1/pl unknown
- 2003-02-27 ES ES03707122T patent/ES2359302T3/es not_active Expired - Lifetime
- 2003-02-27 AT AT03707122T patent/ATE495147T1/de not_active IP Right Cessation
- 2003-02-27 CA CA002476022A patent/CA2476022C/en not_active Expired - Fee Related
- 2003-02-27 RU RU2004128935/04A patent/RU2280641C2/ru not_active IP Right Cessation
- 2003-02-28 AR ARP030100662A patent/AR038624A1/es active IP Right Grant
-
2004
- 2004-08-10 IL IL163429A patent/IL163429A/en not_active IP Right Cessation
- 2004-08-25 ZA ZA2004/06747A patent/ZA200406747B/en unknown
- 2004-09-27 NO NO20044087A patent/NO331001B1/no not_active IP Right Cessation
-
2005
- 2005-04-07 HK HK05102898.4A patent/HK1069382A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE495147T1 (de) | 2011-01-15 |
EP1478619A1 (de) | 2004-11-24 |
KR20040091665A (ko) | 2004-10-28 |
CA2476022C (en) | 2008-07-15 |
MY140707A (en) | 2010-01-15 |
NO20044087L (no) | 2004-09-27 |
BR0308027A (pt) | 2004-12-28 |
TW200303854A (en) | 2003-09-16 |
ZA200406747B (en) | 2005-08-31 |
US20050165107A1 (en) | 2005-07-28 |
CN100522930C (zh) | 2009-08-05 |
HK1069382A1 (en) | 2005-05-20 |
CN100480233C (zh) | 2009-04-22 |
AR038624A1 (es) | 2005-01-19 |
RU2280641C2 (ru) | 2006-07-27 |
AU2003208618A1 (en) | 2003-09-09 |
CN1817853A (zh) | 2006-08-16 |
WO2003072536A1 (en) | 2003-09-04 |
US7476758B2 (en) | 2009-01-13 |
PL371386A1 (en) | 2005-06-13 |
MXPA04008359A (es) | 2004-11-26 |
AU2003208618B2 (en) | 2008-06-19 |
PL211046B1 (pl) | 2012-04-30 |
IL163429A (en) | 2012-07-31 |
EP1478619B1 (de) | 2011-01-12 |
ES2359302T3 (es) | 2011-05-20 |
TWI327996B (en) | 2010-08-01 |
RU2004128935A (ru) | 2006-02-20 |
CN1646482A (zh) | 2005-07-27 |
CA2476022A1 (en) | 2003-09-04 |
NZ534957A (en) | 2006-11-30 |
NO331001B1 (no) | 2011-09-05 |
KR100681224B1 (ko) | 2007-02-09 |
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