HK1055741A1 - A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds - Google Patents
A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpoundsInfo
- Publication number
- HK1055741A1 HK1055741A1 HK03108135A HK03108135A HK1055741A1 HK 1055741 A1 HK1055741 A1 HK 1055741A1 HK 03108135 A HK03108135 A HK 03108135A HK 03108135 A HK03108135 A HK 03108135A HK 1055741 A1 HK1055741 A1 HK 1055741A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyridine
- itstransformation
- mpounds
- oxide
- pharmaceutically effective
- Prior art date
Links
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0001583A HUP0001583A2 (hu) | 2000-04-18 | 2000-04-18 | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| PCT/HU2001/000046 WO2001079174A1 (en) | 2000-04-18 | 2001-04-17 | A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1055741A1 true HK1055741A1 (en) | 2004-01-21 |
Family
ID=90001563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK03108135A HK1055741A1 (en) | 2000-04-18 | 2003-11-10 | A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7126002B2 (bg) |
| EP (1) | EP1274685B1 (bg) |
| JP (1) | JP5066638B2 (bg) |
| KR (1) | KR100742482B1 (bg) |
| CN (1) | CN1216868C (bg) |
| AT (1) | ATE332894T1 (bg) |
| AU (2) | AU2001254997B2 (bg) |
| BG (1) | BG65889B1 (bg) |
| BR (1) | BRPI0110184B8 (bg) |
| CA (1) | CA2406266C (bg) |
| CY (1) | CY1107473T1 (bg) |
| CZ (1) | CZ301576B6 (bg) |
| DE (1) | DE60121431T2 (bg) |
| DK (1) | DK1274685T3 (bg) |
| EE (1) | EE05085B1 (bg) |
| ES (1) | ES2267758T3 (bg) |
| HK (1) | HK1055741A1 (bg) |
| HR (1) | HRP20020825A2 (bg) |
| HU (1) | HUP0001583A2 (bg) |
| IL (2) | IL152337A0 (bg) |
| MX (1) | MXPA02010320A (bg) |
| NO (1) | NO323535B1 (bg) |
| NZ (1) | NZ522017A (bg) |
| PL (1) | PL359826A1 (bg) |
| PT (1) | PT1274685E (bg) |
| RS (1) | RS51003B (bg) |
| RU (1) | RU2281282C2 (bg) |
| SI (1) | SI1274685T1 (bg) |
| SK (1) | SK287606B6 (bg) |
| UA (1) | UA75353C2 (bg) |
| WO (1) | WO2001079174A1 (bg) |
| ZA (1) | ZA200208460B (bg) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
| US7384936B2 (en) | 2002-01-11 | 2008-06-10 | Cytrx Corporation | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| TW200831479A (en) * | 2006-09-26 | 2008-08-01 | Cytrx Corp | Pharmaceutical compositions and methods for treating diseases |
| ES2963910T3 (es) | 2008-06-26 | 2024-04-03 | Zevra Denmark As | Uso de Hsp70 como regulador de la actividad enzimática |
| EP2646044B1 (en) | 2010-11-30 | 2019-08-28 | Orphazyme A/S | Methods for increasing intracellular activity of hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| AU2015317447B2 (en) | 2014-09-15 | 2021-02-25 | Zevra Denmark A/S | Arimoclomol formulation |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| HUE052158T2 (hu) | 2016-04-29 | 2021-04-28 | Orphazyme As | Arimoklomol a glükocerebroszidázzal társult rendellenességek kezeléséhez |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| US20230226036A1 (en) | 2020-06-24 | 2023-07-20 | Orphazyme A/S | Arimoclomol for treating gaucher disease |
| JP2024500632A (ja) | 2020-11-19 | 2024-01-10 | ゼブラ デンマーク エー／エス | アリモクロモルクエン酸塩及びその中間体の調製プロセス |
| US20240115558A1 (en) | 2020-12-24 | 2024-04-11 | Zevra Denmark A/S | Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
-
2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
-
2001
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active IP Right Cessation
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
-
2002
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
-
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
-
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110417 |