HK1045653B - 含環丙沙星及地塞米松的局部混懸劑配方 - Google Patents

含環丙沙星及地塞米松的局部混懸劑配方

Info

Publication number
HK1045653B
HK1045653B HK02107186.7A HK02107186A HK1045653B HK 1045653 B HK1045653 B HK 1045653B HK 02107186 A HK02107186 A HK 02107186A HK 1045653 B HK1045653 B HK 1045653B
Authority
HK
Hong Kong
Prior art keywords
dexamethasone
formulations containing
suspension formulations
topical suspension
containing ciprofloxacin
Prior art date
Application number
HK02107186.7A
Other languages
English (en)
Chinese (zh)
Other versions
HK1045653A1 (en
Inventor
N Singh Onkar
G Bhagat Haresh
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22557406&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1045653(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1045653A1 publication Critical patent/HK1045653A1/xx
Publication of HK1045653B publication Critical patent/HK1045653B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK02107186.7A 1999-09-24 2002-09-27 含環丙沙星及地塞米松的局部混懸劑配方 HK1045653B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15594299P 1999-09-24 1999-09-24
PCT/US2000/021961 WO2001022936A1 (en) 1999-09-24 2000-08-10 Topical suspension formulations containing ciprofloxacin and dexamethasone

Publications (2)

Publication Number Publication Date
HK1045653A1 HK1045653A1 (en) 2002-12-06
HK1045653B true HK1045653B (zh) 2004-01-30

Family

ID=22557406

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107186.7A HK1045653B (zh) 1999-09-24 2002-09-27 含環丙沙星及地塞米松的局部混懸劑配方

Country Status (22)

Country Link
US (2) US6284804B1 (und)
EP (1) EP1214056B1 (und)
JP (2) JP2003510263A (und)
KR (1) KR100722502B1 (und)
CN (1) CN1158994C (und)
AR (1) AR025661A1 (und)
AT (1) ATE252887T1 (und)
AU (1) AU776609B2 (und)
BR (1) BR0014203A (und)
CA (1) CA2379605C (und)
DE (1) DE60006262T2 (und)
DK (1) DK1214056T3 (und)
ES (1) ES2207549T3 (und)
HK (1) HK1045653B (und)
MX (1) MXPA02003130A (und)
PL (1) PL201130B1 (und)
PT (1) PT1214056E (und)
SA (1) SA00210418B1 (und)
TR (1) TR200200737T2 (und)
TW (1) TWI228423B (und)
WO (1) WO2001022936A1 (und)
ZA (1) ZA200201904B (und)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60006262T2 (de) * 1999-09-24 2004-05-13 Alcon, Inc. Topische suspensionsformulierungen enthaltend ciprofloxacin und dexamethason
US20040077562A1 (en) * 2000-11-15 2004-04-22 Chandavarkar Mohan A. Combination drug
JP2005502621A (ja) * 2001-07-06 2005-01-27 スキャンポ アーゲー インターロイキン2阻害剤および抗菌剤を含む局所投与用組成物
WO2003026671A1 (en) * 2001-09-21 2003-04-03 Alcon, Inc. Method of treating middle ear infections
US20090215735A1 (en) * 2002-02-25 2009-08-27 Alcon, Inc. Topical solution formulations containing a corticosteroid and a cyclodextrin
EP1575481A4 (en) * 2002-03-01 2010-01-06 Celltech R & D Inc PROCESS FOR INCREASING OR REDUCING THE BONE DENSITY
AU2003280960A1 (en) * 2002-07-15 2004-02-02 Alcon, Inc. Pharmaceutical compositions for otic use
US20040101506A1 (en) * 2002-11-25 2004-05-27 Fust Charles A. Composition for the prevention and treatment of inflammation of the ear
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
UY28126A1 (es) * 2002-12-24 2004-06-30 Alcon Inc Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular
MXPA05008913A (es) * 2003-02-21 2005-10-05 Sun Pharmaceutical Ind Ltd Formulacion oftalmica estable que contiene antibiotico y corticoesteroide.
US20040202687A1 (en) * 2003-04-14 2004-10-14 Babu M.K. Manoj Ciprofloxacin formulations and methods of making and using the same
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
WO2004103373A1 (ja) * 2003-05-23 2004-12-02 Santen Pharmaceutical Co.,Ltd. キノロン系抗菌化合物を含有する点眼液
US8940321B2 (en) * 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US8030362B2 (en) 2003-12-12 2011-10-04 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
ES2245611B1 (es) * 2004-06-29 2007-03-16 Laboratorio Reig Jofre, S.A. Composicion farmaceutica para uso ototopico.
US20060019987A1 (en) * 2004-07-23 2006-01-26 Fust Charles A Methods and compositions for inhibiting, destroying, and/or inactivating viruses
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
WO2008035246A2 (en) 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
CN101317847B (zh) * 2007-06-06 2010-10-13 深圳市瑞谷医药技术有限公司 一种眼用或耳鼻用药物组合物及其用途
US8271101B2 (en) * 2007-08-29 2012-09-18 Advanced Bionics Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead
JP4696251B2 (ja) * 2007-12-28 2011-06-08 防衛省技術研究本部長 多剤耐性緑膿菌の単離方法並びに多剤耐性緑膿菌選択培地の作成方法
WO2009108626A2 (en) 2008-02-25 2009-09-03 Eyegate Pharma S.A.S. Enhanced delivery of a therapeutic to ocular tissues through iontophoresis
EP2303227B1 (en) * 2008-05-14 2021-10-06 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders
AU2009257390B2 (en) 2008-06-12 2014-09-04 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
EP2309980A1 (en) * 2008-07-08 2011-04-20 S.I.F.I. Societa' Industria Farmaceutica Italiana Ophthalmic compositions for treating pathologies of the posterior segment of the eye
US20100016450A1 (en) * 2008-07-21 2010-01-21 Otonomy, Inc. Controlled release delivery devices for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
EP2346324A4 (en) 2008-10-06 2012-10-10 Microbial Defense Systems Llc ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING
TW201023912A (en) 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
WO2010101989A1 (en) * 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
AU2010221438C1 (en) * 2009-03-03 2015-01-29 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
EP3508197A1 (en) * 2009-10-21 2019-07-10 Otonomy, Inc. Modulation of gel temperature of poloxamer-containing formulations
PL2366408T3 (pl) * 2010-03-01 2013-01-31 Salvat Lab Sa Klarowne roztwory wodne acetonidu fluocinolonu do leczenia zapalenia uszu
US8916171B2 (en) 2010-04-27 2014-12-23 Topical Sinus Therapeutics, Inc. Topical delivery of viscous medications for the treatment of diseases associated with chronic sinusitis
WO2012154953A2 (en) 2011-05-10 2012-11-15 Microbial Defense Systems, Llc Antimicrobial solid and methods of making and using same
WO2013084194A1 (en) * 2011-12-09 2013-06-13 Lupin Limited Topical pharmaceutical compositions of anti-microbial agents and anti-inflammatory agents
CN103565816A (zh) * 2012-07-25 2014-02-12 天津金耀集团有限公司 妥布霉素地塞米松滴眼液
CN105025881A (zh) 2012-12-26 2015-11-04 奥蒂科制药有限公司 可发泡耳用药物组合物
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
CA2921816A1 (en) 2013-08-27 2015-03-05 Otonomy, Inc. Treatment of pediatric otic disorders
US20150119371A1 (en) * 2013-10-30 2015-04-30 Micro Labs Limited Topical pharmaceutical compositions of antibiotics and steroidal anti inflammatory agents
JP6297180B2 (ja) 2014-07-03 2018-03-20 オトノミ—,インク. シプロフロキサシン組成物の滅菌
US9393243B1 (en) * 2015-07-14 2016-07-19 Nilesh Parikh Topical Ciprofloxacin compositions
KR20190109604A (ko) * 2016-05-06 2019-09-25 해로우 헬스 인코포레이티드 약학적 안과용 조성물 및 그의 제조 방법
CN109562139A (zh) * 2016-08-24 2019-04-02 奇斯药制品公司 包含重构肺表面活性物质组合物的稳定药物制剂
US11040004B2 (en) 2016-09-16 2021-06-22 Otonomy, Inc. Otic gel formulations for treating otitis externa
CN107970244B (zh) * 2016-10-21 2020-07-14 武汉武药科技有限公司 一种含有环丙沙星和地塞米松的组合物及其制备方法
CN108403700A (zh) * 2018-06-12 2018-08-17 新疆生产建设兵团第师畜牧兽医工作站 一种牛呼吸道疾病治疗用复合注射液
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
CN113797163B (zh) * 2020-06-17 2023-07-14 成都瑞沐生物医药科技有限公司 一种滴眼给药防治干性黄斑病变和视网膜光损伤的眼用制剂
CN113144207A (zh) * 2021-02-07 2021-07-23 山西利普达医药科技有限公司 一种包括聚季铵盐-1的组合物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134718A (en) 1963-12-12 1964-05-26 Schering Corp Pregna-1,4-dienes and compositions containing same
US4670444B1 (en) 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
US5223493A (en) 1984-12-28 1993-06-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
US4686214A (en) 1985-10-30 1987-08-11 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
GB8805268D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
WO1990001933A1 (en) 1988-08-26 1990-03-08 Alcon Laboratories, Inc. Combination of quinolone antibiotics and steroids for topical ophthalmic use
DE69224071T2 (de) 1991-09-17 1998-05-07 Alcon Lab Inc Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen
ES2065846B1 (es) * 1993-04-20 1995-10-01 Cusi Lab Formulacion farmaceutica a base de un agente antiinflamatorio esteroidico o no esteroidico y un antibiotico pertenciente al grupo de los inhibidores de la adn girasa para su utilizacion topica oftalmica.
US5540930A (en) 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
US5420120A (en) 1993-12-17 1995-05-30 Alcon Laboratories, Inc. Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
JP3781792B2 (ja) * 1993-12-27 2006-05-31 千寿製薬株式会社 ジフルプレドナート含有点眼用懸濁液剤
ES2078175B1 (es) 1993-12-31 1996-10-16 Cusi Lab Formulacion farmaceutica conteniendo clobetasona y tobramicina y sus aplicaciones.
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US5843930A (en) 1995-06-06 1998-12-01 Bayer Corporation Method of treating otitis with ciprofloxacin-hydrocortisone suspension
DE19524691A1 (de) 1995-07-06 1997-01-09 Liedtke Pharmed Gmbh Methode und Zusammensetzung einer topischen Therapie von Innenohr und Labyrinth-Symptomen
KR0155950B1 (ko) 1995-08-16 1998-12-01 김광호 플라즈마 확산 제어 방법 및 그 장치
KR100508227B1 (ko) 1997-03-14 2006-03-23 센주 세이야꾸 가부시키가이샤 로테프레드놀에타보네이트수성현탁액
AR020661A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
AR020660A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
JP2002525326A (ja) 1998-09-30 2002-08-13 アルコン ラボラトリーズ,インコーポレイテッド 眼、耳および鼻治療用の抗生物質組成物
DE60006262T2 (de) * 1999-09-24 2004-05-13 Alcon, Inc. Topische suspensionsformulierungen enthaltend ciprofloxacin und dexamethason

Also Published As

Publication number Publication date
AU7057000A (en) 2001-04-30
US6284804B1 (en) 2001-09-04
JP2003510263A (ja) 2003-03-18
SA00210418B1 (ar) 2006-04-22
AU776609B2 (en) 2004-09-16
CA2379605A1 (en) 2001-04-05
PL201130B1 (pl) 2009-03-31
US6359016B2 (en) 2002-03-19
DE60006262D1 (de) 2003-12-04
PT1214056E (pt) 2004-02-27
CN1376054A (zh) 2002-10-23
KR20020069508A (ko) 2002-09-04
MXPA02003130A (es) 2004-04-21
TR200200737T2 (tr) 2002-08-21
TWI228423B (en) 2005-03-01
JP2011032293A (ja) 2011-02-17
US20010034339A1 (en) 2001-10-25
AR025661A1 (es) 2002-12-11
ES2207549T3 (es) 2004-06-01
KR100722502B1 (ko) 2007-05-28
CN1158994C (zh) 2004-07-28
WO2001022936A8 (en) 2002-01-24
ZA200201904B (en) 2003-05-28
WO2001022936A1 (en) 2001-04-05
EP1214056A1 (en) 2002-06-19
DE60006262T2 (de) 2004-05-13
PL359623A1 (en) 2004-08-23
ATE252887T1 (de) 2003-11-15
EP1214056B1 (en) 2003-10-29
CA2379605C (en) 2007-06-26
BR0014203A (pt) 2002-05-21
HK1045653A1 (en) 2002-12-06
DK1214056T3 (da) 2004-02-09

Similar Documents

Publication Publication Date Title
HK1045653A1 (en) Topical suspension formulations containing ciprofloxacin and dexamethasone
EG24066A (en) Novel quinuclidine derivatives and medicinal compositions containing the same
IL147296A0 (en) Imidazoimidazoles and triazoles as anti-inflammatory agents
IL190220A0 (en) Novel composition and use
AU5326100A (en) Pharmaceutical compositions and methods for use
EG22674A (en) Ectroparasiticidal aquequs suspension formulations
HUP0203896A3 (en) Substituted 8-arylquinoline phosphodiesterase-4-inhibitors and use thereof
GB9815532D0 (en) Pharmaceutical suspension formulation
HU0001396D0 (en) 3-amino-3-arylpropan-1-al derivatives and their use
EP1194147A4 (en) DERIVATIVES OF ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE
EG22491A (en) Rest-breaking composition and use thereof
GB2346237B (en) Dynamic voltage sense amplifier
AU6891800A (en) Flint analog compounds and formulations thereof
AU7308300A (en) Agents for reducing cholesterol-uptake and liquid-uptake
AU5974100A (en) 6-carboxyphenyldihydropyridazinone derivatives and use thereof
AU5931300A (en) Ringene compositions and methods for use thereof
AU7053000A (en) Flint compounds and formulations thereof
AU6150400A (en) Tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and use thereof
AU7053100A (en) Flint analog compounds and formulations thereof
EG24062A (en) Novel composition and use
TW428884U (en) Improved structure of the pivot axle
GB9921747D0 (en) Compositions and methods
GB9916506D0 (en) Compositions and methods
GB9928549D0 (en) Compositions and methods
GB9902051D0 (en) Compositions and methods

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20200809