HK1045641B - 指定脂質體遺傳因子傳送 - Google Patents

指定脂質體遺傳因子傳送

Info

Publication number
HK1045641B
HK1045641B HK02104922.3A HK02104922A HK1045641B HK 1045641 B HK1045641 B HK 1045641B HK 02104922 A HK02104922 A HK 02104922A HK 1045641 B HK1045641 B HK 1045641B
Authority
HK
Hong Kong
Prior art keywords
gene delivery
targeted liposome
liposome gene
virus
targeted
Prior art date
Application number
HK02104922.3A
Other languages
English (en)
Other versions
HK1045641A1 (en
Inventor
Liang Xu
Esther H Chang
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of HK1045641A1 publication Critical patent/HK1045641A1/xx
Publication of HK1045641B publication Critical patent/HK1045641B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
HK02104922.3A 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送 HK1045641B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27

Publications (2)

Publication Number Publication Date
HK1045641A1 HK1045641A1 (en) 2002-12-06
HK1045641B true HK1045641B (zh) 2010-10-29

Family

ID=26746455

Family Applications (3)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Country Status (12)

Country Link
EP (2) EP1166775B1 (zh)
JP (2) JP2001522871A (zh)
CN (3) CN1904055A (zh)
AT (2) ATE295722T1 (zh)
AU (1) AU759164C (zh)
CA (1) CA2308584C (zh)
DE (2) DE69841536D1 (zh)
DK (1) DK1166775T3 (zh)
ES (1) ES2339421T3 (zh)
HK (3) HK1035490A1 (zh)
PT (1) PT1166775E (zh)
WO (1) WO1999025320A1 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE511543T1 (de) 1999-02-22 2011-06-15 Univ Georgetown Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
US20040241088A1 (en) * 2003-01-28 2004-12-02 Georgetown University Method for evaluating the efficacy of certain cancer treatments
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
CN103251562B (zh) * 2003-06-04 2016-04-27 乔治敦大学 改良脂质体复合物的稳定性和保存期的方法
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
JP5102630B2 (ja) * 2005-11-24 2012-12-19 ジェノミディア株式会社 改変パラミクソウイルスおよびその作製方法
KR101573928B1 (ko) 2006-05-15 2015-12-03 조지타운 유니버시티 치료제 또는 진단제의 전신 투여를 위한 항체- 또는 항체 단편-표적화 면역리포좀 제제 및 그의 용도
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
MX2014007664A (es) 2011-12-22 2015-05-11 Nuvo Res Gmbh Composiciones liposomicas de clorito o clorato.
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
CA2806896C (en) 2012-09-19 2021-06-15 Georgetown University Targeted liposomes prepared by ethanol injection
KR20150131263A (ko) 2013-03-14 2015-11-24 조지타운 유니버시티 신경 작용제에 대한 노출을 위한 치료
KR102304533B1 (ko) * 2015-10-08 2021-09-28 유니버시티 오브 유타 리서치 파운데이션 암을 예방 또는 치료하기 위한 방법 및 조성물
WO2018087720A1 (en) 2016-11-14 2018-05-17 Novartis Ag Compositions, methods, and therapeutic uses related to fusogenic protein minion

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
MX9701860A (es) * 1994-09-13 1997-06-28 Theratech Inc Suministro intracelular de agentes quimicos, a un tipo especifico de celula.
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
ATE333892T1 (de) * 1996-02-09 2006-08-15 Pi-Wan Cheng Kationisches lipid und rezeptorligand erleichterte gabe von biologisch aktiven molekuelen
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
EP1166775A3 (en) 2003-06-25
JP2001522871A (ja) 2001-11-20
AU759164B2 (en) 2003-04-10
DE69841536D1 (de) 2010-04-15
ATE295722T1 (de) 2005-06-15
CN1904055A (zh) 2007-01-31
HK1045641A1 (en) 2002-12-06
JP2010263920A (ja) 2010-11-25
WO1999025320A1 (en) 1999-05-27
CN1616665A (zh) 2005-05-18
AU759164C (en) 2007-03-29
HK1078608A1 (en) 2006-03-17
DE69830249T2 (de) 2006-05-04
ES2339421T3 (es) 2010-05-20
EP1166775A2 (en) 2002-01-02
CA2308584C (en) 2011-07-19
ATE459340T1 (de) 2010-03-15
CN1616665B (zh) 2010-10-06
AU1464299A (en) 1999-06-07
CN1286630A (zh) 2001-03-07
EP1166775B1 (en) 2010-03-03
DE69830249D1 (de) 2005-06-23
CA2308584A1 (en) 1999-05-27
PT1166775E (pt) 2010-04-16
DK1166775T3 (da) 2010-05-03
EP1032369B1 (en) 2005-05-18
CN1191094C (zh) 2005-03-02
EP1032369A1 (en) 2000-09-06
HK1035490A1 (en) 2001-11-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171119